PT3044234T - Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico - Google Patents

Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico

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Publication number
PT3044234T
PT3044234T PT138936364T PT13893636T PT3044234T PT 3044234 T PT3044234 T PT 3044234T PT 138936364 T PT138936364 T PT 138936364T PT 13893636 T PT13893636 T PT 13893636T PT 3044234 T PT3044234 T PT 3044234T
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PT
Portugal
Prior art keywords
therapeutics
diagnostics
antibodies
Prior art date
Application number
PT138936364T
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English (en)
Original Assignee
Beigene Switzerland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Beigene Switzerland Gmbh filed Critical Beigene Switzerland Gmbh
Publication of PT3044234T publication Critical patent/PT3044234T/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT138936364T 2013-09-13 2013-09-13 Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico PT3044234T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13893636.4A EP3044234B9 (en) 2013-09-13 2013-09-13 Anti-pd1 antibodies and their use as therapeutics and diagnostics
PCT/CN2013/083467 WO2015035606A1 (en) 2013-09-13 2013-09-13 Anti-pd1 antibodies and their use as therapeutics and diagnostics

Publications (1)

Publication Number Publication Date
PT3044234T true PT3044234T (pt) 2020-05-27

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PT201543865T PT3702373T (pt) 2013-09-13 2013-09-13 Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico
PT138936364T PT3044234T (pt) 2013-09-13 2013-09-13 Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico

Family Applications Before (1)

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PT201543865T PT3702373T (pt) 2013-09-13 2013-09-13 Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico

Country Status (30)

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US (9) US8735553B1 (pt)
EP (3) EP3702373B9 (pt)
JP (1) JP6623353B2 (pt)
KR (1) KR102100419B1 (pt)
CN (6) CN112552401B (pt)
AU (3) AU2013400609B9 (pt)
BR (1) BR112016005408B1 (pt)
CA (3) CA3080200A1 (pt)
CY (2) CY1125652T1 (pt)
DK (2) DK3702373T3 (pt)
EA (1) EA034666B1 (pt)
ES (2) ES2927567T3 (pt)
FR (1) FR24C1001I1 (pt)
HK (1) HK1217501A1 (pt)
HR (1) HRP20221262T1 (pt)
HU (3) HUE049281T2 (pt)
IL (5) IL312577A (pt)
LT (1) LT3702373T (pt)
MX (1) MX2016003292A (pt)
NL (1) NL301252I2 (pt)
NO (1) NO2023045I1 (pt)
NZ (1) NZ718643A (pt)
PL (2) PL3044234T3 (pt)
PT (2) PT3702373T (pt)
RS (1) RS63571B9 (pt)
SG (1) SG11201601844TA (pt)
SI (1) SI3702373T1 (pt)
TW (1) TWI636995B (pt)
WO (1) WO2015035606A1 (pt)
ZA (1) ZA201601953B (pt)

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KR102100419B1 (ko) 2020-04-14
CA3078121A1 (en) 2015-03-19
CN108715615A (zh) 2018-10-30
EA201690567A1 (ru) 2016-08-31
JP2016533763A (ja) 2016-11-04
EA034666B1 (ru) 2020-03-04
CN107090041B (zh) 2018-11-16
PL3044234T3 (pl) 2020-10-19
AU2013400609B2 (en) 2019-11-14
NZ718643A (en) 2020-02-28
TWI636995B (zh) 2018-10-01
MX2016003292A (es) 2016-06-24
ES2792183T3 (es) 2020-11-10
CN107011441A (zh) 2017-08-04
BR112016005408A8 (pt) 2023-01-10
CA3080200A1 (en) 2015-03-19
PT3702373T (pt) 2022-09-27
CY2023025I1 (el) 2024-02-16
US20220119524A1 (en) 2022-04-21
SI3702373T1 (sl) 2022-11-30
CN108715615B (zh) 2020-11-27
CN107011441B (zh) 2020-12-01
DK3044234T3 (da) 2020-05-18
CN105531288B (zh) 2020-12-11
HRP20221262T1 (hr) 2022-12-09
IL284258A (en) 2021-07-29
AU2022204171A1 (en) 2022-07-07
US11186637B2 (en) 2021-11-30
AU2020201069B2 (en) 2022-03-24
CA2924172C (en) 2020-06-30
IL312577A (en) 2024-07-01
AU2020201069A1 (en) 2020-03-05
RS63571B9 (sr) 2023-02-28
ES2927567T3 (es) 2022-11-08
IL284258B (en) 2022-10-01
EP3044234A1 (en) 2016-07-20
CN112457403B (zh) 2022-11-29
AU2013400609A1 (en) 2016-05-05
ZA201601953B (en) 2017-06-28
IL296026B2 (en) 2024-10-01
US20150315274A1 (en) 2015-11-05
HUS2300041I1 (hu) 2023-12-28
DK3702373T3 (da) 2022-09-12
US20180251551A1 (en) 2018-09-06
LT3702373T (lt) 2022-11-10

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