DK2242749T3 - Nye pyridinoner og pyridazinoner - Google Patents

Nye pyridinoner og pyridazinoner

Info

Publication number
DK2242749T3
DK2242749T3 DK09709135.9T DK09709135T DK2242749T3 DK 2242749 T3 DK2242749 T3 DK 2242749T3 DK 09709135 T DK09709135 T DK 09709135T DK 2242749 T3 DK2242749 T3 DK 2242749T3
Authority
DK
Denmark
Prior art keywords
pyridinones
pyridazinones
new
new pyridinones
Prior art date
Application number
DK09709135.9T
Other languages
English (en)
Inventor
Nolan James Dewdney
Joshua Kennedy-Smith
Bradley E Loe
Yan Lou
Joel Mcintosh
Timothy D Owens
Michael Soth
Zachary Kevin Sweeney
Joshua Paul Gergely Taygerly
Rama K Kondru
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2242749T3 publication Critical patent/DK2242749T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
DK09709135.9T 2008-02-05 2009-01-27 Nye pyridinoner og pyridazinoner DK2242749T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2620408P 2008-02-05 2008-02-05
US12251008P 2008-12-15 2008-12-15
PCT/EP2009/050875 WO2009098144A1 (en) 2008-02-05 2009-01-27 Novel pyridinones and pyridazinones

Publications (1)

Publication Number Publication Date
DK2242749T3 true DK2242749T3 (da) 2013-06-17

Family

ID=40413736

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09709135.9T DK2242749T3 (da) 2008-02-05 2009-01-27 Nye pyridinoner og pyridazinoner

Country Status (30)

Country Link
EP (1) EP2242749B1 (da)
JP (1) JP5259739B2 (da)
KR (1) KR101308803B1 (da)
CN (1) CN101932573B (da)
AR (1) AR070408A1 (da)
AU (1) AU2009211514B2 (da)
BR (1) BRPI0907915A2 (da)
CA (1) CA2710462C (da)
CL (1) CL2009000229A1 (da)
CO (1) CO6290767A2 (da)
CR (1) CR11598A (da)
CY (1) CY1114114T1 (da)
DK (1) DK2242749T3 (da)
EC (1) ECSP10010384A (da)
ES (1) ES2420846T3 (da)
HK (1) HK1146826A1 (da)
HR (1) HRP20130615T1 (da)
IL (1) IL206357A (da)
MA (1) MA32064B1 (da)
MX (1) MX2010008197A (da)
MY (1) MY158411A (da)
NZ (1) NZ586916A (da)
PE (1) PE20091484A1 (da)
PL (1) PL2242749T3 (da)
PT (1) PT2242749E (da)
RU (1) RU2505538C2 (da)
SI (1) SI2242749T1 (da)
TW (1) TWI382024B (da)
WO (1) WO2009098144A1 (da)
ZA (1) ZA201005539B (da)

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AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
AU2012257802A1 (en) 2011-05-17 2013-10-31 F. Hoffmann-La Roche Ag Inhibitors of Bruton's tyrosine kinase
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UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
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JP6088063B2 (ja) * 2012-11-16 2017-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトン型チロシンキナーゼの阻害剤
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CA2902038C (en) * 2013-03-05 2017-05-16 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
WO2014135474A1 (en) * 2013-03-05 2014-09-12 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
PL2989106T3 (pl) 2013-04-25 2017-08-31 Beigene, Ltd. Połączone związki heterocykliczne jako inhibitory kinazy białkowej
CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
EP3016943B1 (en) * 2013-07-03 2019-08-21 F. Hoffmann-La Roche AG Heteroaryl pyridone and aza-pyridone amide compounds
KR102100419B1 (ko) 2013-09-13 2020-04-14 베이진 스위찰랜드 게엠베하 항-pd1 항체 및 이의 치료 및 진단 용도
WO2015082583A1 (en) * 2013-12-05 2015-06-11 F. Hoffmann-La Roche Ag Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
CN106604742B (zh) 2014-07-03 2019-01-11 百济神州有限公司 抗pd-l1抗体及其作为治疗剂及诊断剂的用途
CN106922146B (zh) * 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
JP6916185B2 (ja) * 2016-01-13 2021-08-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのイソキノロン類
EP3436447B1 (en) 2016-03-31 2021-07-14 Takeda Pharmaceutical Company Limited Isoquinolinyl triazolone complexes
WO2018007885A1 (en) 2016-07-05 2018-01-11 Beigene, Ltd. COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
CA3031443A1 (en) 2016-07-21 2018-01-25 Biogen Ma Inc. Succinate of pyrimidinyl derivatives and solid forms thereof as bruton's tyrosine kinase inhibitors
CN116478166A (zh) 2016-08-16 2023-07-25 百济神州(苏州)生物科技有限公司 一种化合物的晶型、其制备和用途
AU2017313085A1 (en) 2016-08-19 2019-03-14 Beigene Switzerland Gmbh Use of a combination comprising a Btk inhibitor for treating cancers
MX2019003134A (es) 2016-09-19 2019-08-29 Mei Pharma Inc Terapia de combinacion.
EP3573989A4 (en) 2017-01-25 2020-11-18 Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF
CN106967073A (zh) * 2017-04-24 2017-07-21 刘双伟 一种治疗类风湿性关节炎的药物
CN106946891B (zh) * 2017-05-08 2018-07-13 宿州市徽腾知识产权咨询有限公司 一种用于治疗类风湿性关节炎的药物
EP3645569A4 (en) 2017-06-26 2021-03-24 BeiGene, Ltd. IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
WO2019034009A1 (en) 2017-08-12 2019-02-21 Beigene, Ltd. BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
CA3115526A1 (en) 2018-10-15 2020-04-23 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
EP3953346A1 (en) 2019-04-09 2022-02-16 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
US20230024442A1 (en) * 2019-11-08 2023-01-26 Nurix Therapeutics, Inc. Bifunctional compounds for grading btk via ubiquitin proteosome pathway
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
JP2023504147A (ja) 2019-12-04 2023-02-01 ニューリックス セラピューティクス，インコーポレイテッド ユビキチンプロテオソーム経路を介したｂｔｋの分解のための二官能性化合物
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
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Also Published As

Publication number Publication date
KR20100093130A (ko) 2010-08-24
ZA201005539B (en) 2011-04-28
PL2242749T3 (pl) 2013-09-30
IL206357A0 (en) 2010-12-30
HK1146826A1 (en) 2011-07-15
CL2009000229A1 (es) 2010-06-04
AU2009211514B2 (en) 2014-02-20
CY1114114T1 (el) 2016-07-27
MY158411A (en) 2016-10-14
ES2420846T3 (es) 2013-08-27
RU2010136665A (ru) 2012-03-20
JP2011511027A (ja) 2011-04-07
CN101932573B (zh) 2014-06-11
MA32064B1 (fr) 2011-02-01
CR11598A (es) 2010-10-27
MX2010008197A (es) 2010-08-23
AR070408A1 (es) 2010-04-07
TW200938538A (en) 2009-09-16
IL206357A (en) 2013-12-31
TWI382024B (zh) 2013-01-11
PT2242749E (pt) 2013-07-16
EP2242749A1 (en) 2010-10-27
CA2710462C (en) 2015-11-24
CO6290767A2 (es) 2011-06-20
RU2505538C2 (ru) 2014-01-27
CN101932573A (zh) 2010-12-29
HRP20130615T1 (en) 2013-08-31
WO2009098144A1 (en) 2009-08-13
KR101308803B1 (ko) 2013-09-13
SI2242749T1 (sl) 2013-07-31
CA2710462A1 (en) 2009-08-13
ECSP10010384A (es) 2010-09-30
EP2242749B1 (en) 2013-04-10
JP5259739B2 (ja) 2013-08-07
AU2009211514A1 (en) 2009-08-13
BRPI0907915A2 (pt) 2015-07-28
PE20091484A1 (es) 2009-10-03
NZ586916A (en) 2012-06-29

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