PL2242749T3 - Nowe pirydynony i pirydazynony - Google Patents

Nowe pirydynony i pirydazynony

Info

Publication number
PL2242749T3
PL2242749T3 PL09709135T PL09709135T PL2242749T3 PL 2242749 T3 PL2242749 T3 PL 2242749T3 PL 09709135 T PL09709135 T PL 09709135T PL 09709135 T PL09709135 T PL 09709135T PL 2242749 T3 PL2242749 T3 PL 2242749T3
Authority
PL
Poland
Prior art keywords
pyridazinones
pyridinones
novel
novel pyridinones
Prior art date
Application number
PL09709135T
Other languages
English (en)
Inventor
Nolan James Dewdney
Joshua Kennedy-Smith
Rama K Kondru
Bradley E Loe
Yan Lou
Joel Mcintosh
Timothy D Owens
Michael Soth
Zachary Kevin Sweeney
Joshua Paul Gergely Taygerly
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL2242749T3 publication Critical patent/PL2242749T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL09709135T 2008-02-05 2009-01-27 Nowe pirydynony i pirydazynony PL2242749T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2620408P 2008-02-05 2008-02-05
US12251008P 2008-12-15 2008-12-15
PCT/EP2009/050875 WO2009098144A1 (en) 2008-02-05 2009-01-27 Novel pyridinones and pyridazinones
EP09709135.9A EP2242749B1 (en) 2008-02-05 2009-01-27 Novel pyridinones and pyridazinones

Publications (1)

Publication Number Publication Date
PL2242749T3 true PL2242749T3 (pl) 2013-09-30

Family

ID=40413736

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09709135T PL2242749T3 (pl) 2008-02-05 2009-01-27 Nowe pirydynony i pirydazynony

Country Status (30)

Country Link
EP (1) EP2242749B1 (pl)
JP (1) JP5259739B2 (pl)
KR (1) KR101308803B1 (pl)
CN (1) CN101932573B (pl)
AR (1) AR070408A1 (pl)
AU (1) AU2009211514B2 (pl)
BR (1) BRPI0907915A2 (pl)
CA (1) CA2710462C (pl)
CL (1) CL2009000229A1 (pl)
CO (1) CO6290767A2 (pl)
CR (1) CR11598A (pl)
CY (1) CY1114114T1 (pl)
DK (1) DK2242749T3 (pl)
EC (1) ECSP10010384A (pl)
ES (1) ES2420846T3 (pl)
HK (1) HK1146826A1 (pl)
HR (1) HRP20130615T1 (pl)
IL (1) IL206357A (pl)
MA (1) MA32064B1 (pl)
MX (1) MX2010008197A (pl)
MY (1) MY158411A (pl)
NZ (1) NZ586916A (pl)
PE (1) PE20091484A1 (pl)
PL (1) PL2242749T3 (pl)
PT (1) PT2242749E (pl)
RU (1) RU2505538C2 (pl)
SI (1) SI2242749T1 (pl)
TW (1) TWI382024B (pl)
WO (1) WO2009098144A1 (pl)
ZA (1) ZA201005539B (pl)

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US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
EP2421854B1 (en) * 2009-04-24 2014-07-23 F.Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
US8785440B2 (en) 2009-09-04 2014-07-22 Biogen Idec Ma, Inc. Bruton's tyrosine kinase inhibitors
CN103038233B (zh) * 2010-05-07 2017-06-20 吉利德康涅狄格有限公司 吡啶酮和氮杂吡啶酮化合物及使用方法
EP2394998A1 (en) * 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
EP2709997B1 (en) * 2011-05-17 2016-06-29 F.Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
MX349372B (es) * 2011-08-17 2017-07-26 Hoffmann La Roche Inhibidores de la tirosina-cinasa de bruton.
UA111756C2 (uk) * 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
WO2013148603A1 (en) 2012-03-27 2013-10-03 Takeda Pharmaceutical Company Limited Cinnoline derivatives as as btk inhibitors
BR112014024693A2 (pt) 2012-04-05 2017-07-11 Chdi Foundation Inc composto de fórmula / ou um sal farmaceuticamente aceitável ou pró-fármaco do mesmo; composto; composição farmacêutica; método de tratamento de uma afecção ou distúrbio mediado por atividade de quinurenina 3-mono-oxigenase em um indivíduo que necessita de tal tratamento
CN104662018B (zh) 2012-04-20 2017-10-24 阿迪维纳斯治疗有限公司 取代的杂双环化合物、组合物及其医疗应用
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
KR20150054994A (ko) * 2012-09-13 2015-05-20 에프. 호프만-라 로슈 아게 브루톤 티로신 키나아제의 억제제
EP2920162B1 (en) * 2012-11-16 2017-04-19 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase
EP2925323B1 (en) * 2012-11-30 2017-05-17 F. Hoffmann-La Roche AG An inhibitor of bruton's tyrosine kinase
KR101763504B1 (ko) * 2013-03-05 2017-07-31 에프. 호프만-라 로슈 아게 브루톤 티로신 키나아제의 억제제
JP6089124B2 (ja) * 2013-03-05 2017-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトン型チロシンキナーゼの阻害薬
JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
ES2619125T3 (es) 2013-04-25 2017-06-23 Beigene, Ltd. Compuestos heterocíclicos fusionados como inhibidores de proteína cinasa
CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
CN110698481B (zh) * 2013-07-03 2023-02-28 豪夫迈·罗氏有限公司 杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物
ES2927567T3 (es) 2013-09-13 2022-11-08 Beigene Switzerland Gmbh Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico
CN105793251B (zh) * 2013-12-05 2018-10-12 豪夫迈·罗氏有限公司 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物
TWI726608B (zh) 2014-07-03 2021-05-01 英屬開曼群島商百濟神州有限公司 抗pd-l1抗體及其作為治療及診斷之用途
JP6507234B2 (ja) * 2014-10-02 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトンチロシンキナーゼ（ｂｔｋ）によって介入される障害の処置における使用のためのピラゾールカルボキサミド化合物
WO2017123695A1 (en) * 2016-01-13 2017-07-20 Boehringer Ingelheim International Gmbh Isoquinolones as btk inhibitors
WO2017173111A1 (en) 2016-03-31 2017-10-05 Takeda Pharmaceutical Company Limited Isoquinolinyl triazolone complexes
EP3481393B1 (en) 2016-07-05 2021-04-14 Beigene, Ltd. Combination of a pd-1 antagonist and a raf inhibitor for treating cancer
CN110049976A (zh) 2016-07-21 2019-07-23 比奥根Ma公司 布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物
KR20230162137A (ko) 2016-08-16 2023-11-28 베이진 스위찰랜드 게엠베하 (s)-7-(1-아크릴로일피페리딘-4-일)-2-(4-페녹시페닐)-4,5,6,7-테트라-하이드로피라졸로 [1,5-a] 피리미딘-3-카르복스아미드의 제조 및 그 용도
EP4353747A3 (en) 2016-08-19 2024-06-26 BeiGene Switzerland GmbH Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
WO2018053437A1 (en) 2016-09-19 2018-03-22 Mei Pharma, Inc. Combination therapy
TWI774726B (zh) 2017-01-25 2022-08-21 英屬開曼群島商百濟神州有限公司 (S)-7-(1-(丁-2-炔醯基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑并[1,5-a]嘧啶-3-甲醯胺的晶型、及其製備和用途
CN106967073A (zh) * 2017-04-24 2017-07-21 刘双伟 一种治疗类风湿性关节炎的药物
CN106946891B (zh) * 2017-05-08 2018-07-13 宿州市徽腾知识产权咨询有限公司 一种用于治疗类风湿性关节炎的药物
EP3645569A4 (en) 2017-06-26 2021-03-24 BeiGene, Ltd. IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
US11377449B2 (en) 2017-08-12 2022-07-05 Beigene, Ltd. BTK inhibitors with improved dual selectivity
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
MX2021004191A (es) 2018-10-15 2021-05-27 Nurix Therapeutics Inc Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
IL287049B1 (en) 2019-04-09 2024-09-01 Nurix Therapeutics Inc Trisubstituted pepidine compounds for CBL-B inhibition, and use of a CBL-B inhibitor in combination with a cancer vaccine and/or an oncolytic virus
JP2022532247A (ja) 2019-05-17 2022-07-13 ニューリックス セラピューティクス，インコーポレイテッド Ｃｂｌ－ｂ阻害のためのシアノシクロブチル化合物及びその使用
US20230024442A1 (en) * 2019-11-08 2023-01-26 Nurix Therapeutics, Inc. Bifunctional compounds for grading btk via ubiquitin proteosome pathway
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RU2423351C2 (ru) * 2004-12-16 2011-07-10 Вертекс Фармасьютикалз Инкорпорейтед Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний
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Also Published As

Publication number Publication date
CL2009000229A1 (es) 2010-06-04
PT2242749E (pt) 2013-07-16
JP2011511027A (ja) 2011-04-07
MY158411A (en) 2016-10-14
MX2010008197A (es) 2010-08-23
CN101932573B (zh) 2014-06-11
CY1114114T1 (el) 2016-07-27
HK1146826A1 (en) 2011-07-15
EP2242749A1 (en) 2010-10-27
CA2710462C (en) 2015-11-24
AR070408A1 (es) 2010-04-07
WO2009098144A1 (en) 2009-08-13
IL206357A0 (en) 2010-12-30
PE20091484A1 (es) 2009-10-03
CR11598A (es) 2010-10-27
MA32064B1 (fr) 2011-02-01
EP2242749B1 (en) 2013-04-10
BRPI0907915A2 (pt) 2015-07-28
NZ586916A (en) 2012-06-29
RU2505538C2 (ru) 2014-01-27
ECSP10010384A (es) 2010-09-30
ZA201005539B (en) 2011-04-28
CO6290767A2 (es) 2011-06-20
CA2710462A1 (en) 2009-08-13
TWI382024B (zh) 2013-01-11
AU2009211514A1 (en) 2009-08-13
DK2242749T3 (da) 2013-06-17
JP5259739B2 (ja) 2013-08-07
KR101308803B1 (ko) 2013-09-13
SI2242749T1 (sl) 2013-07-31
CN101932573A (zh) 2010-12-29
AU2009211514B2 (en) 2014-02-20
IL206357A (en) 2013-12-31
ES2420846T3 (es) 2013-08-27
TW200938538A (en) 2009-09-16
RU2010136665A (ru) 2012-03-20
HRP20130615T1 (en) 2013-08-31
KR20100093130A (ko) 2010-08-24

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