CR11598A - Nuevas piridinonas y piridazinonas - Google Patents

Nuevas piridinonas y piridazinonas

Info

Publication number
CR11598A
CR11598A CR11598A CR11598A CR11598A CR 11598 A CR11598 A CR 11598A CR 11598 A CR11598 A CR 11598A CR 11598 A CR11598 A CR 11598A CR 11598 A CR11598 A CR 11598A
Authority
CR
Costa Rica
Prior art keywords
btk
piridinonas
piridazinonas
new
phenyl
Prior art date
Application number
CR11598A
Other languages
English (en)
Inventor
James Dewdney Nolan
Kennedy-Smith Joshua
K Kondru Rama
E Loe Bradley
Lou Yan
Mcintosg Joel
d owens Timothy
Soth Michael
Kevin Sweeney Zachary
Paul Gergely Taygerly Joshua
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR11598A publication Critical patent/CR11598A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Esta solicitud se refiere a derivados de 5-fenil-1H-piridin-2-ona y 6-fenil-2H-piridazin-3-ona de las formulas genericas I-III;en las que las variables R, X, Y1, Y2, Y3, Y4, n y m tienen los significados definidos anteriormente, que inhiben la Btk. Los compuestos aqui descritos son utiles para modular la actividad de la Btk y tratar enfermedades asociadas con una actividad excesiva de la Btk.
CR11598A 2008-02-05 2010-07-27 Nuevas piridinonas y piridazinonas CR11598A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2620408P 2008-02-05 2008-02-05
US12251008P 2008-12-15 2008-12-15

Publications (1)

Publication Number Publication Date
CR11598A true CR11598A (es) 2010-10-27

Family

ID=40413736

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11598A CR11598A (es) 2008-02-05 2010-07-27 Nuevas piridinonas y piridazinonas

Country Status (30)

Country Link
EP (1) EP2242749B1 (es)
JP (1) JP5259739B2 (es)
KR (1) KR101308803B1 (es)
CN (1) CN101932573B (es)
AR (1) AR070408A1 (es)
AU (1) AU2009211514B2 (es)
BR (1) BRPI0907915A2 (es)
CA (1) CA2710462C (es)
CL (1) CL2009000229A1 (es)
CO (1) CO6290767A2 (es)
CR (1) CR11598A (es)
CY (1) CY1114114T1 (es)
DK (1) DK2242749T3 (es)
EC (1) ECSP10010384A (es)
ES (1) ES2420846T3 (es)
HK (1) HK1146826A1 (es)
HR (1) HRP20130615T1 (es)
IL (1) IL206357A (es)
MA (1) MA32064B1 (es)
MX (1) MX2010008197A (es)
MY (1) MY158411A (es)
NZ (1) NZ586916A (es)
PE (1) PE20091484A1 (es)
PL (1) PL2242749T3 (es)
PT (1) PT2242749E (es)
RU (1) RU2505538C2 (es)
SI (1) SI2242749T1 (es)
TW (1) TWI382024B (es)
WO (1) WO2009098144A1 (es)
ZA (1) ZA201005539B (es)

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AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
CN103582637B (zh) * 2011-05-17 2015-08-12 弗·哈夫曼-拉罗切有限公司 酪氨酸激酶抑制剂
EP2744804B1 (en) * 2011-08-17 2017-05-17 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase
UA111756C2 (uk) * 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
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AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
KR20150054994A (ko) * 2012-09-13 2015-05-20 에프. 호프만-라 로슈 아게 브루톤 티로신 키나아제의 억제제
RU2015120216A (ru) * 2012-11-16 2017-01-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
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US9556147B2 (en) 2013-03-05 2017-01-31 Hoffmann-La Inc. Inhibitors of bruton's tyrosine kinase
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JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
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CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
EP3016943B1 (en) * 2013-07-03 2019-08-21 F. Hoffmann-La Roche AG Heteroaryl pyridone and aza-pyridone amide compounds
HUE049281T2 (hu) 2013-09-13 2020-09-28 Beigene Switzerland Gmbh Anti-PD1 antitestek, valamint terapeutikumként és diagnosztikumként történõ alkalmazásuk
JP6275846B2 (ja) * 2013-12-05 2018-02-07 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物
WO2016000619A1 (en) 2014-07-03 2016-01-07 Beigene, Ltd. Anti-pd-l1 antibodies and their use as therapeutics and diagnostics
CN106922146B (zh) * 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
EP3402789B1 (en) * 2016-01-13 2020-03-18 Boehringer Ingelheim International Gmbh Isoquinolones as btk inhibitors
JP7305352B2 (ja) 2016-03-31 2023-07-10 武田薬品工業株式会社 イソキノリニルトリアゾロン錯体
EP3481393B1 (en) 2016-07-05 2021-04-14 Beigene, Ltd. Combination of a pd-1 antagonist and a raf inhibitor for treating cancer
MX2019000884A (es) 2016-07-21 2019-09-04 Biogen Ma Inc Formas de succinato y composiciones de inhibidores de la tirosina cinasa de bruton.
TW202233628A (zh) 2016-08-16 2022-09-01 英屬開曼群島商百濟神州有限公司 (s)-7-(1-丙烯醯基六氫吡啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑並[1,5-a]嘧啶-3-甲醯胺的晶型、其製備和用途
FI3500299T3 (fi) 2016-08-19 2024-02-14 Beigene Switzerland Gmbh Tsanubrutinibin yhdistelmä cd20-tai pd-1-vasta-aineen kanssa käytettäväksi syövän hoidossa
MA46285A (fr) 2016-09-19 2019-07-31 Mei Pharma Inc Polythérapie
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CN106967073A (zh) * 2017-04-24 2017-07-21 刘双伟 一种治疗类风湿性关节炎的药物
CN106946891B (zh) * 2017-05-08 2018-07-13 宿州市徽腾知识产权咨询有限公司 一种用于治疗类风湿性关节炎的药物
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US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
KR20210077719A (ko) 2018-10-15 2021-06-25 누릭스 테라퓨틱스 인코포레이티드 유비퀴틴 프로테오좀 경로를 통해 btk를 분해시키기 위한 이작용성 화합물
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EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
WO2021091575A1 (en) * 2019-11-08 2021-05-14 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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Also Published As

Publication number Publication date
DK2242749T3 (da) 2013-06-17
MX2010008197A (es) 2010-08-23
EP2242749B1 (en) 2013-04-10
NZ586916A (en) 2012-06-29
BRPI0907915A2 (pt) 2015-07-28
CY1114114T1 (el) 2016-07-27
RU2010136665A (ru) 2012-03-20
AU2009211514B2 (en) 2014-02-20
MY158411A (en) 2016-10-14
AR070408A1 (es) 2010-04-07
ES2420846T3 (es) 2013-08-27
AU2009211514A1 (en) 2009-08-13
CN101932573A (zh) 2010-12-29
RU2505538C2 (ru) 2014-01-27
ECSP10010384A (es) 2010-09-30
MA32064B1 (fr) 2011-02-01
PE20091484A1 (es) 2009-10-03
IL206357A (en) 2013-12-31
TW200938538A (en) 2009-09-16
PL2242749T3 (pl) 2013-09-30
EP2242749A1 (en) 2010-10-27
KR20100093130A (ko) 2010-08-24
PT2242749E (pt) 2013-07-16
HRP20130615T1 (en) 2013-08-31
SI2242749T1 (sl) 2013-07-31
TWI382024B (zh) 2013-01-11
JP5259739B2 (ja) 2013-08-07
CA2710462C (en) 2015-11-24
WO2009098144A1 (en) 2009-08-13
CA2710462A1 (en) 2009-08-13
ZA201005539B (en) 2011-04-28
CO6290767A2 (es) 2011-06-20
HK1146826A1 (en) 2011-07-15
JP2011511027A (ja) 2011-04-07
CL2009000229A1 (es) 2010-06-04
IL206357A0 (en) 2010-12-30
KR101308803B1 (ko) 2013-09-13
CN101932573B (zh) 2014-06-11

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