CN1066142C - 喹唑啉衍生物 - Google Patents

喹唑啉衍生物 Download PDF

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Publication number
CN1066142C
CN1066142C CN96102992A CN96102992A CN1066142C CN 1066142 C CN1066142 C CN 1066142C CN 96102992 A CN96102992 A CN 96102992A CN 96102992 A CN96102992 A CN 96102992A CN 1066142 C CN1066142 C CN 1066142C
Authority
CN
China
Prior art keywords
amine
phenyl
ethynyl
quinazoline
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96102992A
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English (en)
Chinese (zh)
Other versions
CN1137037A (zh
Inventor
罗伯尼·C·施努尔
李·D·阿诺德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
OSI Pharmaceuticals LLC
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23636708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1066142(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN1137037A publication Critical patent/CN1137037A/zh
Application granted granted Critical
Publication of CN1066142C publication Critical patent/CN1066142C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96102992A 1995-03-30 1996-03-28 喹唑啉衍生物 Expired - Lifetime CN1066142C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41330095A 1995-03-30 1995-03-30
US413300 1995-03-30
US413,300 1995-03-30
WOPCT/IB95/00436 1995-06-06
PCT/IB1995/000436 WO1996030347A1 (en) 1995-03-30 1995-06-06 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
CN1137037A CN1137037A (zh) 1996-12-04
CN1066142C true CN1066142C (zh) 2001-05-23

Family

ID=23636708

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96102992A Expired - Lifetime CN1066142C (zh) 1995-03-30 1996-03-28 喹唑啉衍生物

Country Status (43)

Country Link
EP (5) EP0817775B1 (enExample)
JP (1) JP3088018B2 (enExample)
KR (1) KR100232335B1 (enExample)
CN (1) CN1066142C (enExample)
AP (1) AP735A (enExample)
AR (1) AR002723A1 (enExample)
AT (2) ATE205483T1 (enExample)
AU (2) AU703638B2 (enExample)
BR (1) BR9601200B1 (enExample)
CA (1) CA2216796C (enExample)
CO (1) CO4410333A1 (enExample)
CZ (2) CZ295145B6 (enExample)
DE (3) DE69522717T2 (enExample)
DK (1) DK0817775T3 (enExample)
EG (1) EG24229A (enExample)
ES (2) ES2161290T3 (enExample)
FI (1) FI120646B (enExample)
FR (1) FR06C0010I2 (enExample)
GR (1) GR3037070T3 (enExample)
HR (1) HRP960147B1 (enExample)
HU (2) HU229120B1 (enExample)
IL (7) IL129994A (enExample)
LU (1) LU91209I2 (enExample)
MA (1) MA23831A1 (enExample)
MX (1) MX9707453A (enExample)
MY (1) MY117896A (enExample)
NL (1) NL300214I2 (enExample)
NO (2) NO308740B1 (enExample)
NZ (1) NZ286263A (enExample)
OA (1) OA10277A (enExample)
PE (1) PE43897A1 (enExample)
PL (1) PL186843B1 (enExample)
PT (1) PT817775E (enExample)
RU (2) RU2694252C3 (enExample)
SA (1) SA96160707B1 (enExample)
SG (1) SG43262A1 (enExample)
SI (1) SI9600102A (enExample)
SK (2) SK283763B6 (enExample)
TR (1) TR199600265A1 (enExample)
TW (1) TW454000B (enExample)
UA (1) UA44254C2 (enExample)
WO (1) WO1996030347A1 (enExample)
ZA (1) ZA962522B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104725327A (zh) * 2015-03-03 2015-06-24 山东大学 一种高收率盐酸厄洛替尼的环保制备方法
CN105017162A (zh) * 2015-06-26 2015-11-04 陕西师范大学 4-对丙烯基苯氨基喹唑啉衍生物及其在制备抗肿瘤药物中的应用
CN106928069A (zh) * 2017-03-21 2017-07-07 上海玉函化工有限公司 一种4,5‑二(2‑甲氧基乙氧基)‑2‑硝基苯甲酸乙酯的制备方法
CN107200715A (zh) * 2017-06-22 2017-09-26 陕西师范大学 喹唑啉衍生物及其在制备抗肿瘤药物中的应用

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CN107200715A (zh) * 2017-06-22 2017-09-26 陕西师范大学 喹唑啉衍生物及其在制备抗肿瘤药物中的应用
CN107200715B (zh) * 2017-06-22 2020-05-29 陕西师范大学 喹唑啉衍生物及其在制备抗肿瘤药物中的应用

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