RU2694252C3 - Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция - Google Patents

Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция

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RU2694252C3
RU2694252C3 RU0096106055A RU96106055A RU2694252C3 RU 2694252 C3 RU2694252 C3 RU 2694252C3 RU 0096106055 A RU0096106055 A RU 0096106055A RU 96106055 A RU96106055 A RU 96106055A RU 2694252 C3 RU2694252 C3 RU 2694252C3
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Prior art keywords
pharmaceutically acceptable
quinazoline
derivatives
pharmaceutical composition
acceptable salts
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RU0096106055A
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RU96106055A (ru
RU2174977C2 (ru
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Пфайзер Продактс Инк.
ОСИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Application filed by Пфайзер Продактс Инк., ОСИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical Пфайзер Продактс Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (10)

1. Производные 4-(замещенного фениламино)хиназолина формулы
Figure 00000001
,
в которой m представляет 2, n представляет 1,
каждый R1 представляет собой R5O, замещенный 1С алкокси;
R2 представляет собой водород;
R3 представляет собой водород;
R4 представляет собой 2С алкинил;
R5 представляет собой 2С алкил;
или их фармацевтически приемлемые соли.
2. Фармацевтическая композиция, обладающая антипролиферативной активностью и содержащая активный агент и фармацевтически приемлемый носитель, отличающаяся тем, что в качестве активного агента она содержит терапевтически эффективное количество соединения по п. 1.
RU0096106055A 1995-03-30 1996-03-29 Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция RU2694252C3 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41330095A 1995-03-30 1995-03-30
US08/413.300 1995-03-30
US08/413,300 1995-03-30
PCT/IB1995/000436 WO1996030347A1 (en) 1995-03-30 1995-06-06 Quinazoline derivatives
IBPCT/IB95/00436 1995-06-06

Publications (3)

Publication Number Publication Date
RU96106055A RU96106055A (ru) 1998-06-10
RU2174977C2 RU2174977C2 (ru) 2001-10-20
RU2694252C3 true RU2694252C3 (ru) 2019-08-20

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ID=23636708

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RU0096106055A RU2694252C3 (ru) 1995-03-30 1996-03-29 Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция
RU0096106055K RU2694252C2 (ru) 1995-03-30 1996-03-29 Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция

Family Applications After (1)

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RU0096106055K RU2694252C2 (ru) 1995-03-30 1996-03-29 Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция

Country Status (44)

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JP (1) JP3088018B2 (ru)
KR (1) KR100232335B1 (ru)
CN (1) CN1066142C (ru)
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AR (1) AR002723A1 (ru)
AT (2) ATE446955T1 (ru)
AU (2) AU703638B2 (ru)
BR (1) BR9601200B1 (ru)
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ES (2) ES2161290T3 (ru)
FI (1) FI120646B (ru)
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GR (1) GR3037070T3 (ru)
HK (1) HK1038740A1 (ru)
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MX (1) MX9707453A (ru)
MY (1) MY117896A (ru)
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OA (1) OA10277A (ru)
PE (1) PE43897A1 (ru)
PL (1) PL186843B1 (ru)
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RU (2) RU2694252C3 (ru)
SA (1) SA96160707B1 (ru)
SG (1) SG43262A1 (ru)
SI (1) SI9600102A (ru)
SK (2) SK283762B6 (ru)
TR (1) TR199600265A1 (ru)
TW (1) TW454000B (ru)
UA (1) UA44254C2 (ru)
WO (1) WO1996030347A1 (ru)
ZA (1) ZA962522B (ru)

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