NO309472B1 - Kinazolin-derivater, anvendelse og fremstilling derav, samt farmasöytisk preparat - Google Patents
Kinazolin-derivater, anvendelse og fremstilling derav, samt farmasöytisk preparat Download PDFInfo
- Publication number
- NO309472B1 NO309472B1 NO974940A NO974940A NO309472B1 NO 309472 B1 NO309472 B1 NO 309472B1 NO 974940 A NO974940 A NO 974940A NO 974940 A NO974940 A NO 974940A NO 309472 B1 NO309472 B1 NO 309472B1
- Authority
- NO
- Norway
- Prior art keywords
- formula
- chloro
- quinazoline
- pharmaceutically acceptable
- quinazoline derivative
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 5
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title description 2
- 150000003246 quinazolines Chemical class 0.000 claims description 59
- -1 2-dimethylaminoethoxy, 2-diethylaminoethoxy, 3-dimethylaminopropoxy, 3-diethylaminopropoxy, 2-(pyrrolidin-1-yl)ethoxy, 3-(pyrrolidin-1-yl)propoxy Chemical group 0.000 claims description 53
- 150000001875 compounds Chemical class 0.000 claims description 49
- 150000003839 salts Chemical class 0.000 claims description 41
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
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- 238000006243 chemical reaction Methods 0.000 claims description 7
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- 125000001424 substituent group Chemical group 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 5
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- 238000011200 topical administration Methods 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9508538.7A GB9508538D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivatives |
PCT/GB1996/000961 WO1996033980A1 (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
NO974940D0 NO974940D0 (no) | 1997-10-24 |
NO974940L NO974940L (no) | 1997-10-24 |
NO309472B1 true NO309472B1 (no) | 2001-02-05 |
Family
ID=10773597
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974940A NO309472B1 (no) | 1995-04-27 | 1997-10-24 | Kinazolin-derivater, anvendelse og fremstilling derav, samt farmasöytisk preparat |
NO2009028C NO2009028I1 (no) | 1995-04-27 | 2009-12-16 | Kinazolin-derivater, anvendelse og fremstilling derav, samt farmasøytisk preparat |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2009028C NO2009028I1 (no) | 1995-04-27 | 2009-12-16 | Kinazolin-derivater, anvendelse og fremstilling derav, samt farmasøytisk preparat |
Country Status (39)
Country | Link |
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US (1) | US5770599A (hu) |
EP (1) | EP0823900B1 (hu) |
JP (1) | JP3040486B2 (hu) |
KR (1) | KR100296656B1 (hu) |
CN (1) | CN1100046C (hu) |
AR (1) | AR003944A1 (hu) |
AT (1) | ATE198329T1 (hu) |
AU (1) | AU699163B2 (hu) |
BG (1) | BG62730B1 (hu) |
BR (1) | BRPI9608082B8 (hu) |
CA (1) | CA2215732C (hu) |
CZ (1) | CZ288489B6 (hu) |
DE (2) | DE122009000076I1 (hu) |
DK (1) | DK0823900T3 (hu) |
EE (1) | EE03482B1 (hu) |
EG (1) | EG24134A (hu) |
ES (1) | ES2153098T3 (hu) |
FR (1) | FR09C0065I2 (hu) |
GB (1) | GB9508538D0 (hu) |
GR (1) | GR3035211T3 (hu) |
HK (1) | HK1005371A1 (hu) |
HR (1) | HRP960204B1 (hu) |
HU (1) | HU223313B1 (hu) |
IL (1) | IL118045A (hu) |
LU (1) | LU91631I2 (hu) |
MY (1) | MY114425A (hu) |
NL (1) | NL300429I1 (hu) |
NO (2) | NO309472B1 (hu) |
NZ (1) | NZ305444A (hu) |
PL (1) | PL189182B1 (hu) |
PT (1) | PT823900E (hu) |
RO (1) | RO117849B1 (hu) |
RU (1) | RU2153495C2 (hu) |
SI (1) | SI0823900T1 (hu) |
SK (1) | SK282236B6 (hu) |
TW (1) | TW436486B (hu) |
UA (1) | UA52602C2 (hu) |
WO (1) | WO1996033980A1 (hu) |
ZA (1) | ZA963358B (hu) |
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GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
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