JP2024516108A - 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 - Google Patents

非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 Download PDF

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Publication number
JP2024516108A
JP2024516108A JP2023562184A JP2023562184A JP2024516108A JP 2024516108 A JP2024516108 A JP 2024516108A JP 2023562184 A JP2023562184 A JP 2023562184A JP 2023562184 A JP2023562184 A JP 2023562184A JP 2024516108 A JP2024516108 A JP 2024516108A
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Prior art keywords
nucleic acid
acid construct
composition
methacrylate
base pairs
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Pending
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JP2023562184A
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Japanese (ja)
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JP2024516108A5 (enExample
Inventor
ディ ズオン，アンソニー
ジェイ ハック，ダニエル
グプタ，チェリー
アール シムズ，ジュニア，ケネス
エス ケーリス，マイケル
アール シャンク，ザッカリー
ジェイ コルバート，アシュリー
ディ マキュー，アンドレア
ケイ シュミッツ，エマ
ティ ヒルリック，ケイレブ
ディ ミラー，シャノン
エル ホイ，ジョアンナ
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Battelle Memorial Institute Inc
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Battelle Memorial Institute Inc
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Publication of JP2024516108A publication Critical patent/JP2024516108A/ja
Publication of JP2024516108A5 publication Critical patent/JP2024516108A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/301—Hairpin oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/313—Branched oligonucleotides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023562184A 2021-04-07 2022-04-07 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 Pending JP2024516108A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163172069P 2021-04-07 2021-04-07
US63/172,069 2021-04-07
PCT/US2022/023902 WO2022216977A1 (en) 2021-04-07 2022-04-07 Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

Publications (2)

Publication Number Publication Date
JP2024516108A true JP2024516108A (ja) 2024-04-12
JP2024516108A5 JP2024516108A5 (enExample) 2025-04-21

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JP2023562184A Pending JP2024516108A (ja) 2021-04-07 2022-04-07 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術

Country Status (8)

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US (2) US12031128B2 (enExample)
EP (1) EP4320233A4 (enExample)
JP (1) JP2024516108A (enExample)
CN (1) CN117500923A (enExample)
AU (1) AU2022253899A1 (enExample)
CA (1) CA3216359A1 (enExample)
IL (2) IL326440A (enExample)
WO (1) WO2022216977A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2023239922A1 (en) * 2022-06-09 2023-12-14 Battelle Memorial Institute Non-viral delivery compositions and screening methods
NL2035538B1 (en) * 2023-08-03 2025-02-18 Univ Eindhoven Tech Lipid-like copolymers and method of producing these and the use thereof, pharmaceutical compositions comprising said copolymers, and the use of said compositions.
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems
WO2025205410A1 (ja) * 2024-03-25 2025-10-02 日油株式会社 核酸増幅促進剤、これを含む核酸増幅用組成物及び核酸増幅法
WO2025250979A1 (en) * 2024-05-31 2025-12-04 Battelle Memorial Institute Polymer nanoparticle compositions for non-viral gene delivery
CN119666949B (zh) * 2024-11-28 2026-02-27 昆明理工大学 一种电化学适配体传感器及其制备方法和应用
CN121550845B (zh) * 2026-01-23 2026-04-21 鲁信天地人环境科技(安徽)集团有限公司 一种双功能化三元聚合物改性聚丙烯腈超滤膜及制备方法和应用

Family Cites Families (565)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1198052A (en) 1965-02-12 1970-07-08 Ici Ltd Polymer Dispersions
SE339105B (enExample) 1966-02-23 1971-09-27 Avisun Corp
US3847857A (en) 1967-11-02 1974-11-12 Rohm & Haas Stain resistant coating composition
US3562806A (en) 1968-09-10 1971-02-09 Eastman Kodak Co Rumen stable medicament and/or nutrient compositions
US3678098A (en) 1969-04-04 1972-07-18 Rohm & Haas Unsaturated quaternary monomers and polymers
GB1324087A (en) 1969-07-18 1973-07-18 Commw Scient Ind Res Org Copolymers and veterinary compositions treated therewith
GB1284489A (en) 1970-03-16 1972-08-09 Ici Ltd Thermoplastic polymer blends
US3744969A (en) 1970-06-09 1973-07-10 Rohm & Haas Break resistant leather
US3829564A (en) 1970-07-17 1974-08-13 Commw Scient Ind Res Org Coated products for veterinary use
US3706565A (en) 1970-10-28 1972-12-19 Eastman Kodak Co Photographic compositions containing an admixture of organic and inorganic silver salts
US3706564A (en) 1970-10-28 1972-12-19 Eastman Kodak Co Process for forming silver halide crystals in the presence of amphiphilic copolymers
GB1314285A (en) 1970-12-16 1973-04-18 Ici Australia Ltd Explosive compositions
US4056559A (en) 1971-04-23 1977-11-01 Rohm And Haas Company Novel polymers of alkyl methacrylates
IL45712A (en) 1973-10-02 1977-10-31 Hydrophilics Int Inc Hydrophilic copolymer salt and its use
JPS5156886A (ja) 1974-11-14 1976-05-18 Unitika Ltd Horiionkonpuretsukusuno seizoho
JPS5320051B2 (enExample) 1975-02-28 1978-06-24
US4036766A (en) 1976-06-14 1977-07-19 Texaco Inc. Polymethacrylate additives and lube compositions thereof
US4237253A (en) 1977-04-21 1980-12-02 L'oreal Copolymers, their process of preparation, and cosmetic compounds containing them
DE2861140D1 (en) 1977-11-29 1981-12-17 Bexford Ltd Vesicular recording materials
KR830001200B1 (ko) 1979-02-05 1983-06-21 이와마 가즈오 자기 헤드의 트랙킹 장치
US4377481A (en) 1980-11-14 1983-03-22 Abcor, Inc. Blended, polymeric, matrix membrane and process of making and using same
DE3271303D1 (en) 1981-03-19 1986-07-03 Ici Plc Process for producing stable dispersions in water-dilutable liquid media of halogen-containing addition polymer, employing a polymeric dispersant, and waterborne coating compositions based on dispersions so made
SE8103843L (sv) 1981-06-18 1982-12-19 Astra Laekemedel Ab Farmaceutisk mixtur
JPS57211146A (en) 1981-06-23 1982-12-24 Fuji Photo Film Co Ltd Photopolymerizable composition
US4544621A (en) 1982-05-19 1985-10-01 Ciba Geigy Corporation Photocrosslinkable water-soluble polymers, containing maleimidyl and quaternary ammonium groups process for their preparation and use thereof
US4559293A (en) 1983-04-08 1985-12-17 Kimoto & Co., Ltd. Photosensitive recording material developable with aqueous neutral salt solution
NZ209347A (en) 1983-09-09 1987-06-30 Dulux Australia Ltd Thermoplastic coating composition containing at least one acrylic polymer and at least two plasticisers
US4592816A (en) 1984-09-26 1986-06-03 Rohm And Haas Company Electrophoretic deposition process
DE3684166D1 (de) 1985-04-22 1992-04-16 Du Pont Synthetische amphoterische polymere enthaltender wash-off-film.
DE3684745D1 (de) 1985-08-29 1992-05-14 Du Pont Photopolymerisierbare zusammensetzung mit dizyklopentylacrylat oder methacrylat enthaltenden acrylcopolymeren.
DE3786415T2 (de) 1986-04-23 1993-10-21 Sumitomo Chemical Co Katalytische Herstellung von Polyamidblockcopolymeren.
US5969046A (en) 1986-11-18 1999-10-19 Rohm And Haas Company Reacting methylene and alkene components in presence of tertiary amine reacted with epoxide
US4755563A (en) 1986-12-29 1988-07-05 E. I. Du Pont De Nemours And Company Block copolymer dispersants containing ionic moieties
JP2697818B2 (ja) 1987-03-13 1998-01-14 株式会社リコー 加熱定着用現像剤
US4834799A (en) 1987-10-27 1989-05-30 Videojet Systems International, Inc. Jet ink for vinyl substrate marking
JP2680594B2 (ja) 1988-03-02 1997-11-19 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー ブロツク共重合体分散剤
US4925764A (en) 1988-12-23 1990-05-15 E. I. Du Pont De Nemours & Co. Positive solid block toner
US4985160A (en) 1989-02-08 1991-01-15 E. I. Du Pont De Nemours And Company Branched polymers as fuel oil additives
CA2055432A1 (en) 1990-02-28 1991-08-29 Dale M. Pickelman Ionizable polymer cleaning compositions and methods for cleaning stains
US5085698A (en) 1990-04-11 1992-02-04 E. I. Du Pont De Nemours And Company Aqueous pigmented inks for ink jet printers
US5124381A (en) 1990-11-08 1992-06-23 Armstrong World Industries, Inc. Acrylic polymer coating compositions for coats and films that have reduced surface resistivity
DE4110027C2 (de) 1991-03-27 1996-08-29 Lohmann Therapie Syst Lts Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster
US5141556A (en) 1991-06-13 1992-08-25 E. I. Du Pont De Nemours And Company Penetrants for aqueous ink jet inks
US5205861A (en) 1991-10-09 1993-04-27 E. I. Du Pont De Nemours And Company Aqueous ink jet inks containing alkylene oxide condensates of certain nitrogen heterocyclic compounds as cosolvents
US5180425A (en) 1991-11-05 1993-01-19 E. I. Du Pont De Nemours And Company Aqueous ink jet inks containing polyol/alkylene oxide condensates as cosolvents
US5519081A (en) 1991-11-15 1996-05-21 Imperial Chemical Industries Plc Polymerisable compositions
US5271765A (en) 1992-02-03 1993-12-21 E. I. Du Pont De Nemours And Company Aqueous cationic dye-based ink jet inks
DE69325401T2 (de) 1992-02-20 1999-11-25 E.I. Du Pont De Nemours & Co., Inc. Dreiblock-Polymer Dispersionsmittel enthaltende Wasserdispersionen
US5428383A (en) 1992-08-05 1995-06-27 Hewlett-Packard Corporation Method and apparatus for preventing color bleed in a multi-ink printing system
US5310778A (en) 1992-08-25 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing ink jet inks having improved properties
CA2104976A1 (en) 1992-09-02 1994-03-03 Stephan D. Daubney Separation of plasma or serum from whole blood using a red blood cell binding component and a polymer containing multiple cationic sites
JPH06145262A (ja) 1992-09-03 1994-05-24 Rohm & Haas Co 多段階ポリマーを含有する耐水性組成物
US5310595A (en) 1992-09-18 1994-05-10 Minnesota Mining And Manufacturing Company Water-based transparent image recording sheet for plain paper copiers
US5432035A (en) 1992-12-18 1995-07-11 Fujitsu Limited Flash fixing color toner and process for producing the same
US5512418A (en) 1993-03-10 1996-04-30 E. I. Du Pont De Nemours And Company Infra-red sensitive aqueous wash-off photoimaging element
US5620883A (en) 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5418277A (en) 1994-04-26 1995-05-23 E. I. Du Pont De Nemours And Company Aqueous ink jet inks containing fluorinated polymers
DE69606592T2 (de) 1995-07-11 2000-09-21 E.I. Du Pont De Nemours And Co., Wilmington Tintensortiment und Verfahren zum Vermindern des Ausblutens in Druckelementen
SG80553A1 (en) 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
TW438608B (en) 1995-08-02 2001-06-07 Hisamitsu Pharmaceutical Co A tablet containing anion exchange resin
US5518534A (en) 1995-08-04 1996-05-21 E. I. Du Pont De Nemours And Company Ink set and process for alleviating bleed in printed elements
US5525450A (en) 1995-09-01 1996-06-11 Xerox Corporation Liquid developer compositions with multiple block copolymers
JP3957084B2 (ja) 1995-10-25 2007-08-08 オクトプルス ベーフェー カチオン性の、アクリル酸エステルポリマー、アルキル置換アクリル酸エステルポリマー及びこれ等に対応するアクリルアミドポリマーを用いた合成トランスフェクション又はブロッキングシステム
US7256020B2 (en) 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US5709714A (en) 1996-03-11 1998-01-20 Rohm And Haas Company Method of treating leather with amphoteric polymers
US5698016A (en) 1996-06-14 1997-12-16 Cabot Corporation Compositions of modified carbon products and amphiphilic ions and methods of using the same
JP4010585B2 (ja) 1996-10-15 2007-11-21 久光製薬株式会社 陰イオン交換樹脂を含有する錠剤
US6040358A (en) 1996-12-27 2000-03-21 E. I. Du Pont De Nemours And Company Ink jet inks containing linear polymer additives
WO1998051749A1 (en) 1997-05-12 1998-11-19 The General Electric Company, Plc Sedimentation free jet ink composition
IL128043A (en) 1997-05-30 2004-08-31 Osmotica Corp Multi-layered osmotic device for controlled delivery of active agents
DE69818912T2 (de) 1997-06-18 2004-08-19 Canon K.K. Toner, Zweikomponenten-Entwickler und Bilderzeugungsverfahren
US6221402B1 (en) 1997-11-20 2001-04-24 Pfizer Inc. Rapidly releasing and taste-masking pharmaceutical dosage form
PL340632A1 (en) 1997-11-21 2001-02-12 Procter & Gamble Detergent compositions containing polymeric froth generation enhancing agents and their application
AU1532199A (en) 1997-11-21 1999-06-15 Procter & Gamble Company, The Liquid detergent compositions comprising polymeric suds enhancers
US6139856A (en) 1997-12-11 2000-10-31 Biomedical Development Corp. Composition useful for providing one-step surgical preparation and drape
US6720387B1 (en) 1998-02-18 2004-04-13 3M Innovative Properties Company Hot-melt adhesive compositions comprising acidic polymer and basic polymer blends
EP0945148B1 (en) 1998-03-26 2003-11-26 Biomat B.V. Endovascular stents with a polymeric coating
US6247808B1 (en) 1998-04-22 2001-06-19 Hewlett-Packard Company Ink-jet printing system for improved print quality
US6022908A (en) 1998-04-22 2000-02-08 Hewlett-Packard Company Printing liquids for improved print quality
JPH11335269A (ja) 1998-05-19 1999-12-07 Hisamitsu Pharmaceut Co Inc 遺伝子関連医薬の経口投与固形製剤
DE19918435A1 (de) 1998-07-23 2000-01-27 Roehm Gmbh Überzugs- und Bindemittel für orale oder dermale Arzneiformen
US6004712A (en) 1998-08-26 1999-12-21 Xerox Corporation Coated carrier
WO2000024423A1 (en) 1998-10-26 2000-05-04 Tanabe Seiyaku Co., Ltd. Sustained-release particles
EP1008634B1 (en) 1998-12-10 2003-10-15 E.I. Du Pont De Nemours And Company Ink jet inks containing star polymer additives
US6245421B1 (en) 1999-02-04 2001-06-12 Kodak Polychrome Graphics Llc Printable media for lithographic printing having a porous, hydrophilic layer and a method for the production thereof
US6903064B1 (en) 1999-05-26 2005-06-07 Procter & Gamble Company Detergent composition comprising polymeric suds volume and suds duration enhancers
US7241729B2 (en) 1999-05-26 2007-07-10 Rhodia Inc. Compositions and methods for using polymeric suds enhancers
US6827795B1 (en) 1999-05-26 2004-12-07 Procter & Gamble Company Detergent composition comprising polymeric suds enhancers which have improved mildness and skin feel
US6276273B1 (en) 1999-06-11 2001-08-21 Kodak Polychrome Graphics Llc Surfactant-pretreated printing plate substrate, lithographic printing plate and method for production thereof
US6413306B1 (en) 1999-10-07 2002-07-02 E. I. Du Pont De Nemours And Company Pigment dispersions containing ABC-block polymer dispersant
WO2001051092A2 (en) 2000-01-07 2001-07-19 University Of Washington Enhanced transport of agents using membrane disruptive agents
US6532871B1 (en) 2000-01-27 2003-03-18 Kodak Polychrome Graphics Llc Method of controlling image resolution on a substrate using an autophobic fluid
US6471349B1 (en) 2000-01-27 2002-10-29 Kodak Polychrome Graphics Llc Method to prepare a printing plate and printing plate
US6132917A (en) 2000-03-29 2000-10-17 Xerox Corporation Coated carrier
US6251554B1 (en) 2000-03-29 2001-06-26 Xerox Corporation Coated carrier
TW594381B (en) 2000-07-12 2004-06-21 Du Pont Process for patterning non-photoimagable ceramic tape
KR20020016069A (ko) 2000-08-24 2002-03-04 민경윤 마크로라이드계 항생제의 경구투여용 조성물 및 이의 제조방법
GB0102342D0 (en) 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
HU229344B1 (en) 2001-02-27 2013-11-28 Evonik Roehm Gmbh Coating and binding agent for pharmaceutical formulations with improved storage stability
DE10110391A1 (de) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff
US20040109869A1 (en) 2001-03-19 2004-06-10 Iomai Corporation Transcutaneous immunostimulation
EP1383656A4 (en) 2001-04-12 2006-07-19 Avery Dennison Corp METALLIZED INK INJECTION MATERIALS AND METHOD FOR PRODUCING THE SAME
DE10127134A1 (de) 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
CN1152067C (zh) 2001-06-20 2004-06-02 山东大学 药物包衣用水性高分子薄膜材料制备工艺
EP1416922A1 (en) 2001-07-16 2004-05-12 AstraZeneca AB Pharmaceutical formulation comprising a proton pump inhibitor and antacids
AR034813A1 (es) 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
CN1168797C (zh) 2001-07-23 2004-09-29 广西南宁博世科工贸有限责任公司 纳米级纸质餐饮具防水剂及其生产方法
US7055943B2 (en) 2001-08-22 2006-06-06 Canon Kabushiki Kaisha Ink set for ink-jet recording, recording unit, ink-jet recording apparatus and ink-jet recording method
DE60204932T2 (de) 2001-09-28 2006-05-18 Canon K.K. Toner und Bildaufzeichnungsmethode
US7048771B2 (en) 2001-10-22 2006-05-23 University Of California Dyeing textiles using nanoparticles
CO5390081A1 (es) 2001-11-28 2004-04-30 Novartis Ag Compuestos organicos
FR2832719B1 (fr) 2001-11-29 2004-02-13 Oreal Copolymeres ethyleniques sequences adhesifs, compositions cosmetiques les contenant, et utilisation de ces copolymeres en cosmetique
FR2832720B1 (fr) 2001-11-29 2004-02-13 Oreal Copolymeres ethyleniques sequences, compositions cosmetiques les contenant, et utilisation de ces copolymeres en cosmetique
DE10160720A1 (de) 2001-12-11 2003-06-18 Basf Ag Kosmetisches Mittel enthaltend wenigstens ein Copolymer mit N-Vinyllactameinheiten
GB0130499D0 (en) 2001-12-20 2002-02-06 Unilever Plc Polymers for laundry cleaning compositions
KR100619380B1 (ko) 2002-03-28 2006-09-05 한미약품 주식회사 마크로라이드계 항생제의 경구투여용 조성물 및 이의제제화 방법
KR20050023239A (ko) 2002-03-29 2005-03-09 알자 코포레이션 용적 효율적인 조절된 방출 투여 형태
US6924259B2 (en) 2002-04-17 2005-08-02 National Starch And Chemical Investment Holding Corporation Amine copolymers for textile and fabric protection
US20050176068A1 (en) * 2002-04-26 2005-08-11 Emmert-Buck Michael R. Direct cell target analysis
JP2003345095A (ja) 2002-05-30 2003-12-03 Canon Inc 電子写真用部材の製造方法及び該方法により製造された電子写真用部材
DE10239999A1 (de) 2002-08-27 2004-03-04 Röhm GmbH & Co. KG Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen
JP4213432B2 (ja) 2002-08-28 2009-01-21 久光製薬株式会社 貼付剤
AU2003287301A1 (en) 2002-10-31 2004-06-07 Alza Corporation Dosage form providing ascending release of liquid formulation
DE10260921A1 (de) 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
DE10304403A1 (de) 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
TR200300510A2 (tr) 2003-04-18 2004-11-22 Sanovel �La� Sanay� Ve T�Caret A.�. Dağılan alendronat mikropartikül formülasyonu
GB2403920A (en) 2003-04-30 2005-01-19 Univ Sussex Particulate emulsifiers
US20050090599A1 (en) 2003-06-06 2005-04-28 Spinelli Harry J. Aqueous ionically stabilized dispersions
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
GB2407500A (en) 2003-11-03 2005-05-04 Ist Superiore Sanita Use of microparticles for antigen delivery
GB2407501A (en) 2003-11-03 2005-05-04 Ist Superiore Sanita Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell
WO2005058988A1 (de) 2003-12-09 2005-06-30 Basf Aktiengesellschaft Anionische ampholytische copolymere
US20090175952A1 (en) 2004-01-09 2009-07-09 Jong Soo Woo Cefuroxime axetil granule and process for the preparation thereof
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
US8603545B2 (en) 2004-03-24 2013-12-10 Basf Beauty Care Solutions France S.A.S. Cosmetic and pharmaceutical uses of an extract of a plant belonging to the genus Buchholzia
ES2435519T3 (es) 2004-06-21 2013-12-20 Basf Se Preparaciones acuosas que contienen un copolímero hidrosoluble o capaz de dispersarse en agua, el cual contiene al menos un monómero con un átomo de nitrógeno protonizable
DE102004035938A1 (de) 2004-07-23 2006-02-16 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil
DE102004051648A1 (de) 2004-10-22 2006-04-27 Basf Ag Anionische Ethylmethacrylat-Copolymere und deren Verwendung
DE102004051541A1 (de) 2004-10-22 2006-05-04 Basf Ag Amphotere Ethylmethacrylat-Copolymere und deren Verwendung
US7499209B2 (en) 2004-10-26 2009-03-03 Xerox Corporation Toner compositions for dry-powder electrophoretic displays
DE102004059792A1 (de) 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
JP2008528749A (ja) 2005-01-28 2008-07-31 ビーエーエスエフ ソシエタス・ヨーロピア 化粧用調製物のための増粘剤の形態の水中水型エマルジョンポリマーの使用
DE102005010255A1 (de) 2005-03-07 2006-09-14 Lts Lohmann Therapie-Systeme Ag Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung
AU2006224619B2 (en) 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
JP2008535212A (ja) 2005-03-22 2008-08-28 エヌエックスピー ビー ヴィ 集積回路ダイ上への導電性配線部構造の形成方法、導電性配線部および集積回路ダイ
CA2605180A1 (en) 2005-04-19 2006-10-26 Alza Corporation Controlled delivery dosage form of tramadol and gabapentin
MY148074A (en) 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
BRPI0608609A2 (pt) 2005-05-10 2010-01-19 Novartis Ag processo de extrusço para preparaÇço de composiÇÕes com compostos terapÊuticos fracamente compressÍveis
MX2007014068A (es) 2005-05-10 2008-02-07 Novartis Ag Composiciones farmaceuticas de liberacion modificada de famciclovir.
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
RU2408368C2 (ru) 2005-06-27 2011-01-10 Биовэйл Лэборэториз Интернэшнл С.Р.Л. Препараты соли бупропиона с модифицированным высвобождением
RU2423997C9 (ru) 2005-07-05 2011-11-20 Эббетт ГмбХ унд Ко. КГ Композиция и лекарственная форма, содержащие твердую или полутвердую матрицу
AR055106A1 (es) 2005-08-05 2007-08-08 Osmotica Pharmaceutical Argent Composicion farmaceutica solida de liberacion extendida que contiene carbidopa y levodopa
ATE420924T1 (de) 2005-08-12 2009-01-15 Ciba Holding Inc Festhaftende beschichtungen
GB0518059D0 (en) 2005-09-06 2005-10-12 Dow Corning Delivery system for releasing active ingredients
US7642329B2 (en) 2005-09-27 2010-01-05 Council Of Scientific & Industrial Research Oligomeric lactide macromer based copolymer and a process for the preparation thereof
PL116330U1 (en) 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
WO2007106182A2 (en) 2005-11-09 2007-09-20 Novartis Ag Process for making pharmaceutical compositions with a transient plasticizer
AU2006316537A1 (en) 2005-11-24 2007-05-31 Basf Se Chimeric keratin-binding effector proteins
GB2432584A (en) 2005-11-28 2007-05-30 Univ Sheffield Particle stabilised foam
WO2007067817A1 (en) 2005-12-07 2007-06-14 Cv Therapeutics, Inc. Abca1 elevating compounds
CN1813683B (zh) 2005-12-07 2011-08-31 范敏华 一种阿奇霉素的干混悬剂及其制备方法
WO2007070682A2 (en) * 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
US20110163469A1 (en) 2005-12-16 2011-07-07 Massachusetts Institute Of Technology High-throughput fabrication of microparticles
GB0525864D0 (en) 2005-12-20 2006-02-01 Novartis Ag Organic compounds
CN100450597C (zh) 2005-12-27 2009-01-14 天津工业大学 一种复合纳滤膜及其制备方法
EP1832281A1 (en) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
WO2007113129A1 (de) 2006-03-31 2007-10-11 Basf Se Verfahren zur herstellung von acrylatcopolymeren
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
JP2009535408A (ja) 2006-05-04 2009-10-01 ノバルティス アクチエンゲゼルシャフト 薬剤を製造するための加熱ローラー圧縮方法
WO2007129427A1 (ja) 2006-05-08 2007-11-15 Teikoku Seiyaku Co., Ltd. 抗認知症薬物の経皮吸収製剤
CN100500716C (zh) 2006-06-21 2009-06-17 苏州大学 无规共聚阳离子大分子乳化剂及其制备方法
MX2009000035A (es) 2006-06-26 2009-05-28 Mutual Pharmaceutical Co Formulaciones de agente activo, procedimientos de preparacion y procedimientos de uso.
KR100857724B1 (ko) 2006-06-30 2008-09-10 한올제약주식회사 용해도와 용출률이 향상된 시부트라민 함유 경구투여용 고체분산체
CA2654529A1 (en) 2006-07-06 2008-01-10 Teva Pharmaceutical Industries Ltd. Compositions with controlled pharmacokinetics
ATE525065T1 (de) 2006-07-10 2011-10-15 Pfleger R Chem Fab Pharmazeutische zubereitung für die orale verabreichung mit gesteuerter wirkstofffreisetzung im dünndarm und verfahren zu ihrer herstellung
EP1880715A1 (en) 2006-07-19 2008-01-23 Abbott GmbH & Co. KG Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
KR100857411B1 (ko) 2006-07-21 2008-09-08 한올제약주식회사 리파아제 저해제의 경구 투여용 방출조절 약학 제제 및이의 제조 방법
PT2046300E (pt) 2006-08-04 2010-07-01 Ethypharm Sa Comprimido multicamadas de desintegraã†o oral
KR101462693B1 (ko) 2006-08-16 2014-11-17 노파르티스 아게 고도 결정질 치료용 화합물의 고체 분산체 제조 방법
WO2008023869A1 (en) 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
JP2010503715A (ja) 2006-09-19 2010-02-04 ビーエーエスエフ ソシエタス・ヨーロピア 分子インプリントポリマーをベースとする化粧用調製物
KR100812538B1 (ko) 2006-10-23 2008-03-11 한올제약주식회사 약물 제어방출형 메트포르민-글리메피리드 복합제제
US8642083B2 (en) 2006-10-30 2014-02-04 Hanall Biopharma Co., Ltd. Controlled release complex composition comprising angiotensin-II-receptor blockers and HMG-CoA reductase inhibitors
CN101534798B (zh) 2006-10-30 2012-02-15 韩诺生物制约株式会社 包含噻嗪类和血管紧张素ⅱ受体阻断剂的控释药物组合物
MX2009004861A (es) 2006-11-09 2009-05-21 Abbott Gmbh & Co Kg Forma de dosificacion farmaceutica para la administracion oral de inhibidor de tirosina quinasa.
CA2669938C (en) 2006-11-15 2016-01-05 Abbott Laboratories Solid pharmaceutical dosage formulations
GB0624729D0 (en) 2006-12-12 2007-01-17 Univ Leeds Reversible micelles and applications for their use
US20080153982A1 (en) 2006-12-20 2008-06-26 John Ta-Yuan Lai Vinyl-Thiocarbonate and Polyol Containing Block Copolymers
CN101652131A (zh) 2007-01-29 2010-02-17 韩兀制药株式会社 N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物
US8298452B2 (en) 2007-02-26 2012-10-30 Dai Nippon Printing Co., Ltd. Negative type resist composition for color filter, color filter using same, and liquid crystal display
JPWO2008117814A1 (ja) 2007-03-26 2010-07-15 帝國製薬株式会社 大腸送達用経口製剤
JP5215642B2 (ja) 2007-03-30 2013-06-19 富士フイルム株式会社 インク組成物、並びに、それを用いた画像記録方法及び画像記録物
JP5215641B2 (ja) 2007-03-30 2013-06-19 富士フイルム株式会社 インク組成物、並びに、それを用いた画像記録方法及び画像記録物
JP5260943B2 (ja) 2007-03-30 2013-08-14 富士フイルム株式会社 粒子分散物及びインク組成物、並びに、それを用いた画像記録方法及び画像記録物
KR101128891B1 (ko) 2007-05-03 2012-03-26 한올바이오파마주식회사 로라타딘 및 슈도에페드린을 함유하는 제어 방출 다층정
US20080299391A1 (en) 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
AU2008262331B2 (en) 2007-06-07 2013-10-17 Wake Forest University Health Sciences Inkjet gene printing
KR100867639B1 (ko) 2007-06-08 2008-11-10 (주)다산메디켐 고미가 차폐된 염산 도네페질-함유 입자, 이를 포함하는약학 조성물, 및 이들의 제조방법
US20100266859A1 (en) 2007-06-18 2010-10-21 Hidetoshi Abe Colored acrylic adhesive and marking film
JP2009016258A (ja) 2007-07-06 2009-01-22 Mitsubishi Electric Corp 固体高分子型燃料電池
WO2009010405A1 (en) 2007-07-18 2009-01-22 Basf Se Laser-sensitive coating formulation
WO2009026461A2 (en) 2007-08-21 2009-02-26 Board Of Regents, The University Of Texas System Thermo-kinetic mixing for pharmaceutical applications
KR101050015B1 (ko) 2007-09-21 2011-07-19 동아제약주식회사 위체류약물전달시스템을 이용한 애엽 추출물의 약학조성물및 이를 이용한 서방성 경구용 제제
WO2009045795A2 (en) 2007-09-28 2009-04-09 Novartis Ag Galenical formulations of aliskiren and valsartan
FR2921835B1 (fr) 2007-10-05 2012-05-04 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Composition d'enrobage comprenant du polydextrose, procede pour sa preparation et utilisation pour enrober les formes solides ingerables
CN101932322A (zh) 2007-10-10 2010-12-29 韩诺生物制约株式会社 用于治疗丙型肝炎病毒感染的包含HMG-CoA还原酶抑制剂和胆汁酸的药物组合物
CN101444513B (zh) 2007-11-27 2011-05-11 上官清 一种头孢克洛口腔崩解片及其制备方法
CN101883559B (zh) 2007-12-06 2011-12-28 琳得科株式会社 可食性薄膜
US7932306B2 (en) 2007-12-12 2011-04-26 E. I. Du Pont De Nemours And Company Amphoteric dispersants and their use in inkjet inks
DE102007060175A1 (de) 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
US8034254B2 (en) 2007-12-21 2011-10-11 3M Innovative Properties Company Optical adhesive for liquid crystal display
CA2708554C (en) 2007-12-21 2014-04-22 Basf Se Anti-dandruff compositions containing peptides
JP5631005B2 (ja) 2007-12-25 2014-11-26 日本曹達株式会社 オニウム塩含有ポリマー
WO2009088220A2 (ko) 2008-01-08 2009-07-16 Hanall Pharmaceutical Company. Ltd Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
EP2246052B1 (en) 2008-01-31 2017-03-08 Kyorin Pharmaceutical Co., Ltd. Orally rapidly disintegrating tablet comprising imidafenacin
CA2713677A1 (en) 2008-01-31 2009-08-06 Kyorin Pharmaceutical Co., Ltd. Method for production of orally rapidly disintegrating tablet comprising imidafenacin as active ingredient
US20110052699A1 (en) 2008-02-13 2011-03-03 Adrian Funke Drug delivery system with stabilising effect
WO2009103735A1 (de) 2008-02-21 2009-08-27 Basf Se Zusammensetzung, enthaltend ein ampholytisches copolymer auf der basis quaternisierter stickstoffhaltiger monomere und mindestens ein hiervon verschiedenes polymer, und ihre verwendung
EP2255796A2 (en) 2008-02-22 2010-12-01 HanAll Biopharma Co., Ltd. Pharmaceutical preparation
US20110052683A1 (en) 2008-02-22 2011-03-03 Hanall Biopharma Co., Ltd. Pharmaceutical preparation for treating cardiovascular disease
WO2009127922A2 (ko) 2008-02-22 2009-10-22 한올제약 주식회사 심혈관계 질환 치료용 약제학적 제제
CA2717947C (en) 2008-03-11 2020-07-07 Takeda Pharmaceutical Company Limited Orally-disintegrating solid preparation
WO2009125987A2 (ko) 2008-04-10 2009-10-15 한올제약주식회사 약제학적 제제
CN101990428A (zh) 2008-04-10 2011-03-23 韩兀生物制药株式会社 药物制剂
KR20090114190A (ko) 2008-04-29 2009-11-03 한올제약주식회사 방출성이 제어된 ＨＭＧ―ＣｏＡ 환원 효소 억제제와안지오텐신―Ⅱ―수용체 차단제의 복합 조성물
WO2009134056A2 (ko) 2008-04-29 2009-11-05 한올제약주식회사 약제학적 제제
US20110117194A1 (en) 2008-04-29 2011-05-19 Hanall Biopharma Co., Ltd. Pharmaceutical formulation containing angiotensin-ii receptor blocker
KR20090114320A (ko) 2008-04-29 2009-11-03 한올제약주식회사 심혈관계 질환 치료용 약제학적 제제
ES2404136T3 (es) 2008-05-13 2013-05-24 University Of Washington Ensamblajes micelares
WO2009142421A2 (ko) 2008-05-17 2009-11-26 한올제약주식회사 약제학적 제제
US8556402B2 (en) 2008-05-22 2013-10-15 E I Du Pont De Nemours And Company Fixer inks for use with ink jet inks
GB0809314D0 (en) 2008-05-22 2008-07-02 Summit Corp Plc Compounds for treating muscular dystrophy
WO2009151295A2 (ko) 2008-06-13 2009-12-17 한올제약주식회사 아젤니디핀과 ＨＭＧ－ＣｏＡ 환원효소 억제제 또는 안지오텐신 Ⅱ 수용체 차단제를 포함하는 약제학적 제제
US8366600B2 (en) 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
WO2009156277A1 (en) 2008-06-23 2009-12-30 Basf Se Pigment dispersants with modified copolymers
WO2010008203A2 (ko) 2008-07-15 2010-01-21 한올제약주식회사 칼슘채널길항제를 포함하는 약제학적 제제
WO2010008244A2 (ko) 2008-07-18 2010-01-21 한올제약주식회사 약제학적 제제
US8575285B2 (en) 2008-09-08 2013-11-05 Kyoto University Catalyst for living radical polymerization
WO2010038046A1 (en) 2008-10-03 2010-04-08 Chamelic Ltd Ab diblock copolymers and applications for their use
US9267042B2 (en) 2008-10-27 2016-02-23 Datalase Ltd. Coating composition for marking substrates
CA2742516C (en) 2008-11-05 2019-06-04 The Lubrizol Corporation Composition containing a block copolymer and a method of lubricating an internal combustion engine
JP2010111781A (ja) 2008-11-06 2010-05-20 Kao Corp 非水系顔料分散剤
DE102008043662A1 (de) 2008-11-12 2010-05-20 Evonik Röhm Gmbh Verfahren zur Herstellung von Telechelen mit breiter Molekulargewichtsverteilung
WO2010077678A2 (en) 2008-12-08 2010-07-08 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
JP5576393B2 (ja) 2008-12-12 2014-08-20 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 両性分散剤およびインクジェットインクにおけるその使用
CN102300558A (zh) 2009-01-28 2011-12-28 诺瓦提斯公司 有机化合物的盖伦制剂
CN101643412B (zh) 2009-03-17 2013-03-13 江苏工业学院 一种端羟基聚丙烯酸酯类齐聚物及制备方法与用途
US9555002B2 (en) 2009-05-13 2017-01-31 Basf Se Solid pharmaceutical preparations containing copolymers based on polyethers combined with poorly water-soluble polymers
US7992656B2 (en) 2009-07-09 2011-08-09 Halliburton Energy Services, Inc. Self healing filter-cake removal system for open hole completions
KR101326900B1 (ko) 2009-08-21 2013-11-11 이화여자대학교 산학협력단 신규한 항암제 보조용 화합물, 이의 제조방법 및 이를 포함하는 항암제 보조용 조성물
KR20110021691A (ko) 2009-08-25 2011-03-04 한올바이오파마주식회사 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
KR101190957B1 (ko) 2009-08-25 2012-10-15 한올바이오파마주식회사 메트포르민 카페익산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
KR101211227B1 (ko) 2009-08-25 2012-12-11 한올바이오파마주식회사 메트포르민 아스코르브산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
KR101190953B1 (ko) 2009-08-25 2012-10-12 한올바이오파마주식회사 메트포르민 타우린염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제
EP2289971A1 (en) * 2009-08-27 2011-03-02 Total Petrochemicals Research Feluy Ring opening polymerisation of cyclic carbonates with organic catalyst systems
KR101630432B1 (ko) 2009-08-28 2016-06-15 한국생명공학연구원 2, 6-위치가 치환된 3-니트로피리딘 유도체 화합물 또는 이의 약제학적으로 허용되는 염을 포함하는 암 예방 또는 치료용 약학 조성물
WO2011028043A2 (ko) 2009-09-02 2011-03-10 이화여자대학교 산학협력단 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물
US8637674B2 (en) 2009-09-02 2014-01-28 Ewha University-Industry Collaboration Foundation Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same
JP5868319B2 (ja) 2009-09-03 2016-02-24 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ Ｒｏｅｈｍ ＧｍｂＨ １つ以上の生物学的活性物質、調合補助物質および磁化可能粒子を包含する経口剤形
CN102030871B (zh) 2009-09-25 2012-10-10 天津大学 聚乙二醇嵌段可生物降解聚酯梳型接枝共聚物及其制备方法和应用
JP5531022B2 (ja) 2009-09-29 2014-06-25 リンテック株式会社 粘着剤および粘着シート
JP5583379B2 (ja) 2009-09-30 2014-09-03 富士フイルム株式会社 顔料分散物及びそれを用いたインク組成物
KR101110845B1 (ko) 2009-10-21 2012-02-15 주식회사 케이씨씨 내수성 및 내후성이 우수한 방담 코팅용 조성물
EP2490665B1 (en) 2009-10-22 2016-09-07 L'Oréal Photoprotective compositions and films, and a preparation method
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
CN102834092A (zh) 2009-12-16 2012-12-19 后藤武 抗痴呆药物的经皮吸收制剂
JP2012236773A (ja) 2009-12-16 2012-12-06 Goto Takeshi 抗認知症薬物の経皮吸収製剤
WO2011074635A1 (ja) 2009-12-16 2011-06-23 後藤　武 抗認知症薬物の経皮吸収製剤
SG181446A1 (en) 2009-12-23 2012-07-30 Defiante Farmaceutica Sa Combination composition useful for treating cardiovascular diseases
CN101735383B (zh) 2009-12-25 2014-08-13 天津大学 聚甲基丙烯酸二甲胺基乙酯-聚甲基丙烯酸盐包裹氧化锌量子点及制备和应用
JP5863670B2 (ja) 2010-01-19 2016-02-17 ノースウェスタン ユニバーシティ 核酸および／または他の構成要素を含有している合成ナノ構造体
JP2011184582A (ja) 2010-03-09 2011-09-22 Three M Innovative Properties Co 光学用粘着シート
JP5717768B2 (ja) 2010-03-10 2015-05-13 アッヴィ・バハマズ・リミテッド 固体組成物
WO2011114691A1 (ja) 2010-03-15 2011-09-22 大正製薬株式会社 顔料組成物
JP4620171B1 (ja) 2010-03-19 2011-01-26 株式会社ツキオカ 可食フィルム
WO2011118453A1 (ja) 2010-03-23 2011-09-29 リンテック株式会社 固形製剤
JP2011207963A (ja) 2010-03-29 2011-10-20 Fujifilm Corp 顔料分散物、インク組成物、インクジェット記録方法、および印刷物
US20130317096A1 (en) 2010-04-16 2013-11-28 Davos Life Science Pte Ltd Synergistic interaction of at least one vitamin e component and tyrosinase inhibitors for dermatological applications
KR20110117758A (ko) 2010-04-22 2011-10-28 한올바이오파마주식회사 베타 아드레날린 차단제 및 ＨＭＧ－ＣｏＡ 환원 효소 억제제를 함유하는 약제학적 제제
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
GB201008364D0 (en) 2010-05-20 2010-07-07 Geneve De Composition and method
CN101890185B (zh) 2010-05-21 2012-12-12 天津大学 含有ZnO量子点载体/DNA复合物的胶原基复合角膜替代物及其制备方法和应用
KR20130109092A (ko) 2010-06-09 2013-10-07 아보트 러보러터리즈 키나제 억제제를 함유하는 고체 분산물
WO2011154331A1 (en) * 2010-06-10 2011-12-15 F. Hoffmann-La Roche Ag Polymers for delivery of nucleic acids
KR20110135018A (ko) 2010-06-10 2011-12-16 연세대학교 산학협력단 암의 치료 또는 예방을 위한 약제학적 조성물
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
KR101372721B1 (ko) 2010-06-18 2014-03-14 이화여자대학교 산학협력단 Ｉｎｔｅｒｌｅｕｋｉｎ―６ 억제 작용을 갖는 신규한 벤즈옥사졸 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물
NZ605352A (en) 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
EP2589614A4 (en) 2010-06-30 2014-07-23 Nippon Soda Co NEW COPOLYMER
KR100994148B1 (ko) 2010-07-14 2010-11-15 (주)아팩 그라비아 인쇄용 양이온성 수성 수지 조성물 및 그의 제조방법
WO2012021516A2 (en) 2010-08-09 2012-02-16 The Trustees Of The University Of Pennsylvania Nanoparticle-oligonucletide hybrid structures and methods of use thereof
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
KR101659785B1 (ko) 2010-10-22 2016-09-26 한국생명공학연구원 Ｉｌ-6 활성 억제 작용을 갖는 화합물 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 ｉｌ-6로 매개되는 질환의 예방 또는 치료용 조성물
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
US9765341B2 (en) 2010-11-04 2017-09-19 President And Fellows Of Harvard College DNA origami devices
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
MX354210B (es) 2010-12-16 2018-02-16 Celgene Corp Formas farmaceuticas orales de liberacion controlada de farmacos escasamente solubles y los usos de estas.
IE20100799A1 (en) 2010-12-22 2012-08-01 Eurand Pharmaceuticals Ltd Pharmaceutical composites of poorly water soluble drugs and polymers
JP2014505064A (ja) 2011-01-26 2014-02-27 セニックス バイオサイエンス ゲーエムベーハー 自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
KR101730865B1 (ko) 2011-02-11 2017-04-27 주식회사유한양행 레바프라잔-함유 나노입자를 포함하는 경구투여용 약학 조성물 및 그의 제조방법
EP2675434A1 (en) 2011-02-17 2013-12-25 F.Hoffmann-La Roche Ag A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion
KR20120098462A (ko) 2011-02-28 2012-09-05 이화여자대학교 산학협력단 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물
KR20120098489A (ko) 2011-02-28 2012-09-05 이화여자대학교 산학협력단 피라졸 유도체를 포함하는 심혈관 질환 예방 및 치료용 조성물
EP2683365A1 (de) 2011-03-09 2014-01-15 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
KR101314579B1 (ko) 2011-04-07 2013-10-10 광주과학기술원 파크리탁셀이 선적된 고분자 나노입자 및 그 제조방법
GB201106433D0 (en) 2011-04-15 2011-06-01 Reckitt & Colman Overseas Composition and method
WO2012158610A1 (en) 2011-05-13 2012-11-22 William Marsh Rice University Temperature-assisted migration of amphiphilic nanoparticles through liquid interfaces
EP2522689A1 (en) 2011-05-13 2012-11-14 Universität Bayreuth Non-viral transfection systems
EP2523002A1 (en) 2011-05-13 2012-11-14 Universität Bayreuth Utilization of magnetic nanoparticles as intracellular pull-down system
CN102250278B (zh) 2011-05-26 2013-04-10 华东理工大学 用于水溶性固定化纤维素酶的pH敏感再生型聚合物及其制备方法与应用
KR101337672B1 (ko) 2011-06-02 2013-12-31 경희대학교 산학협력단 베타―ｄ―글루코스 펜타키스（３，４―디하이드록시―5―（（３，４，5―트리하이드록시벤조일）옥시）벤조에이트）를 유효성분으로 포함하는 신장결석 예방 및 치료용 조성물
KR101280720B1 (ko) 2011-06-03 2013-07-26 경희대학교 산학협력단 1，2，3，4，6―펜타―오―갈로일―베타―디―글루코오스및 이마티니브를 유효성분으로 포함하는 만성 골수성 백혈병 치료용 조성물
US20140235790A1 (en) 2011-06-10 2014-08-21 University Of Washington Through Its Center For Commercialization Carbohydrate-based compositions and methods for targeted drug delivery
JP2013029832A (ja) 2011-06-22 2013-02-07 Dainippon Printing Co Ltd カラーフィルタ用硬化性樹脂組成物、カラーフィルタ、液晶表示装置及び有機発光表示装置、並びにカラーフィルタ用顔料分散液
GB201111216D0 (en) 2011-07-01 2011-08-17 Reckitt & Colman Overseas Composition and method
KR101302315B1 (ko) 2011-07-19 2013-08-30 이화여자대학교 산학협력단 피라졸 유도체를 포함하는 호흡기 질환 예방 및 치료용 조성물
KR101282847B1 (ko) 2011-07-27 2013-07-05 조선대학교산학협력단 실로스타졸을 함유하는 고체분산체 및 이를 포함하는 약학 조성물
JP5807438B2 (ja) 2011-08-12 2015-11-10 富士ゼロックス株式会社 二成分現像剤用キャリア、二成分現像剤、画像形成方法、及び、画像形成装置
CN102949342A (zh) 2011-08-24 2013-03-06 天津金耀集团有限公司 一种含有睾酮的透皮吸收药物组合物
WO2013027419A1 (ja) 2011-08-25 2013-02-28 国立大学法人京都大学 リビングラジカル重合触媒および重合方法
KR101454066B1 (ko) 2011-09-08 2014-10-24 경희대학교 산학협력단 아스퍼질러스 나이저의 배양액에서 분리한 인삼 사포닌 전환활성을 갖는 효소, 이의 제조방법, 이를 이용한 효소처리 인삼 추출물, 효소처리 인삼 추출물의 제조방법 및 효소처리 인삼 추출물을 포함하는 피부미용 개선용 조성물
KR101384873B1 (ko) 2011-09-20 2014-04-16 경희대학교 산학협력단 인삼(Ｐａｎａｘ ｇｉｎｓｅｎｇ) 및 산사(Ｃｒａｔａｅｇｉｓ ｆｒｕｃｔｕｓ) 추출물을 포함하는 피부미용 개선용 조성물
US20130129869A1 (en) 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
JP5735405B2 (ja) 2011-11-30 2015-06-17 株式会社Ｄｎｐファインケミカル 着色樹脂組成物、カラーフィルタ、及び液晶表示装置
HK1201186A1 (en) 2011-12-29 2015-08-28 Abbvie Inc. Solid compositions comprising an hcv inhibitor
WO2013135853A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical packaging product for the veterinary medical sector
AU2012377385A1 (en) 2012-04-18 2014-01-23 Arrowhead Research Corporation Poly(acrylate) polymers for in vivo nucleic acid delivery
JP2013237821A (ja) 2012-05-17 2013-11-28 Teijin Ltd （メタ）アクリル酸共重合体
US9320718B2 (en) 2012-05-22 2016-04-26 Kuhnil Pharm. Co., Ltd. Multilayer coating form of orally administered pharmaceutical composition containing omega-3 fatty acid or alkyl ester thereof and statin based drug
KR102141256B1 (ko) 2012-05-22 2020-08-05 디에스엠 아이피 어셋츠 비.브이. 하이브리드 유기-무기 나노-입자
JP2014024537A (ja) 2012-06-19 2014-02-06 3M Innovative Properties Co ナンバープレート用シート、ナンバープレート用積層体、ナンバープレートおよびナンバープレート用装飾部材
TWI506064B (zh) 2012-07-23 2015-11-01 Innocom Tech Shenzhen Co Ltd 量子點高分子複合膜及其製造方法
KR101633957B1 (ko) 2012-08-27 2016-06-27 이화여자대학교 산학협력단 피라졸 유도체를 포함하는 신장질환 예방 또는 치료용 조성물
SI2897611T1 (sl) 2012-09-18 2019-12-31 Abbvie Inc. Postopki zdravljenja hepatitisa C
US20140080886A1 (en) 2012-09-18 2014-03-20 Abbvie Inc. Methods for Treating HCV
AU2013318309A1 (en) 2012-09-18 2015-04-02 Abbvie Inc. Methods for treating hepatitis C
US10172956B2 (en) 2012-10-26 2019-01-08 Vanderbilt University Polymeric nanoparticles
US9585826B2 (en) 2012-11-07 2017-03-07 Kimberly-Clark Worldwide, Inc. Triggerable compositions for two-stage, controlled release of active chemistry
US8758860B1 (en) 2012-11-07 2014-06-24 Bayer Materialscience Llc Process for incorporating an ion-conducting polymer into a polymeric article to achieve anti-static behavior
US9447220B2 (en) 2012-11-19 2016-09-20 Rohm And Haas Electronic Materials Llc Self-assembled structures, method of manufacture thereof and articles comprising the same
KR101312286B1 (ko) 2012-11-26 2013-09-27 (주)비씨월드제약 즉시방출 및 조절방출 특성을 갖고 d-트레오-메틸페니데이트를 포함하는 약학 조성물
WO2014085599A1 (en) 2012-11-30 2014-06-05 Acura Pharmaceuticals, Inc. Self-regulated release of active pharmaceutical ingredient
RU2505286C1 (ru) 2012-12-29 2014-01-27 Открытое Акционерное Общество "Фармасинтез" Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения
TW201434936A (zh) 2013-01-11 2014-09-16 Nippon Soda Co 無機粒子用分散劑、含有該分散劑之組成物、硬化性組成物、硬化物及薄膜
SG11201504499VA (en) 2013-01-22 2015-08-28 Hoffmann La Roche Pharmaceutical composition with improved bioavailability
KR101431957B1 (ko) 2013-01-25 2014-08-19 경희대학교 산학협력단 피세틴 및 설퍼레틴을 유효성분으로 포함하는 염증성 질환 개선용 조성물
CN103113509B (zh) 2013-01-30 2016-05-04 华东理工大学 以l-甲状腺素为亲和配基的再生型亲和沉淀剂及制备方法和应用以及相关再生型聚合物
KR20140105941A (ko) 2013-02-25 2014-09-03 건양대학교산학협력단 어류 양식용 부상성(浮上性) 사료 및 그 제조 방법
EP2958557B1 (en) 2013-02-25 2019-11-27 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents
AU2014223658B2 (en) 2013-03-01 2018-10-18 Bpsi Holdings, Llc. Delayed release film coatings containing calcium silicate and substrates coated therewith
US9180104B2 (en) 2013-03-13 2015-11-10 Tris Pharma, Inc. Benzonatate modified release solid tablets and capsules
JP6392207B2 (ja) 2013-03-26 2018-09-19 キッセイ薬品工業株式会社 シロドシンの苦味をマスキングした経口投与製剤
KR101502588B1 (ko) 2013-05-01 2015-03-16 한국유나이티드제약 주식회사 클로피도그렐 및 아스피린의 복합제제
CN103255174B (zh) 2013-05-02 2015-10-28 天津大学 以聚乙二醇接枝的透明质酸为外层的三元复合物及三元复合物的液体与应用
CN103319668B (zh) 2013-06-25 2015-11-11 常州大学 一种甲基丙烯酸丁酯-甲基丙烯酸二甲氨基乙酯嵌段共聚物的制备方法
KR101458468B1 (ko) 2013-06-27 2014-11-10 한국화학연구원 신규한 공중합체를 함유하는 제조가 용이한 리튬 이차전지용 겔 고분자 전해질
CN103536972B (zh) 2013-07-05 2016-01-13 北京大学 磁共振成像可检测的液体栓塞组合物及其制备和应用
CN103333283B (zh) 2013-07-15 2015-09-09 华东理工大学 可形成偏碱性两水相体系的两种pH响应再生型聚合物及其制备方法与应用
US20150045353A1 (en) 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators, methods for preparation and delivery thereof
US20140161893A1 (en) 2013-08-16 2014-06-12 University Of Washington Through Its Center For Commercialization Polymer blend particles for intracellular delivery of agents
EP2842548A1 (en) 2013-08-29 2015-03-04 Universite De Liege Polymeric synthetic antidote
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
US20160194625A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Chimeric polynucleotides
CN105530998B (zh) 2013-09-11 2018-09-21 3M创新有限公司 口腔组合物
US9970040B2 (en) 2013-09-26 2018-05-15 Massachusetts Institute Of Technology Engineering DNA assembly in vivo and methods of making and using the reverse transcriptase technology
GB201317299D0 (en) 2013-09-30 2013-11-13 Lucite Int Uk Ltd A hardenable multi-part acrylic composition
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
MX366896B (es) 2013-09-30 2019-07-30 Lucite International Speciality Polymers & Resins Ltd Composición acrílica de múltiples partes endurecible.
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
PL3054929T3 (pl) 2013-10-07 2021-05-31 Impax Laboratories, Llc Mukoadhezyjne preparaty lewodopy i / lub estrów lewodopy o kontrolowanym uwalnianiu oraz ich zastosowania
US20160243221A1 (en) 2013-10-18 2016-08-25 Moderna Therapeutics, Inc. Compositions and methods for tolerizing cellular systems
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9119780B2 (en) 2013-10-30 2015-09-01 Kimberly-Clark Worldwide, Inc. Triggerable compositions for two-stage, controlled release of proactive chemistry
US20160279251A1 (en) * 2013-11-12 2016-09-29 University Of Washington Through Its Center For Commercialization Random copolymer therapeutic agent carriers and assemblies thereof
WO2015085318A2 (en) 2013-12-06 2015-06-11 Moderna Therapeutics, Inc. Targeted adaptive vaccines
BR112016013213A2 (pt) 2013-12-12 2017-12-05 Massachusetts Inst Technology administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
ES2647791T3 (es) 2013-12-16 2017-12-26 Massachusetts Institute Of Technology Formulaciones de sales enriquecidas en micronutrientes
JP6599337B2 (ja) 2013-12-23 2019-10-30 スリーエム イノベイティブ プロパティズ カンパニー 集積光学部品及び製造方法
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CN103755870B (zh) 2014-01-06 2016-10-26 苏州大学 一种含多巴胺无规共聚物及其精细制备方法和应用
US20170002060A1 (en) 2014-01-08 2017-01-05 Moderna Therapeutics, Inc. Polynucleotides for the in vivo production of antibodies
US20150232729A1 (en) 2014-02-20 2015-08-20 Georgia Southern Research and Service Foundation Antifogging compositions and methods of making the same
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
KR101663791B1 (ko) 2014-03-07 2016-10-10 한국과학기술원 생체분자를 타겟팅하는 하이브리드 나노구조체
US9750814B2 (en) 2014-03-12 2017-09-05 University Of Washington Polypeptides to inhibit epstein barr viral protein BHRF1 and B cell lymphoma family proteins
DK3134131T3 (en) 2014-04-23 2022-02-07 Modernatx Inc Nucleic acid vaccines
JP6895755B2 (ja) 2014-05-20 2021-06-30 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システムにおける活性薬剤の放出を調節するための方法
JP6573913B2 (ja) 2014-05-20 2019-09-11 エルテーエス ローマン テラピー−ジステーメ アーゲー ロチゴチンを含む経皮送達システム
EP4238580A3 (en) 2014-05-20 2023-10-25 LTS Lohmann Therapie-Systeme AG Transdermal delivery system including an interface mediator
CN103976972B (zh) 2014-05-26 2017-09-12 中国药科大学 酒石酸唑吡坦口服脉冲控释给药系统及其制备方法
MX2016015688A (es) 2014-06-10 2017-05-30 Dermtreat Aps Composiciones que comprenden fibras obtenidas electrohidrodinamicamente para la administracion de dosificaciones especificas de una sustancia activa a piel o mucosa.
KR20190018052A (ko) 2014-07-03 2019-02-20 화이자 인코포레이티드 표적화된 치료 나노입자 및 그의 제조 및 사용 방법
GB201412955D0 (en) 2014-07-22 2014-09-03 Aqdot Ltd Supramolecular capsules
WO2016025747A1 (en) 2014-08-13 2016-02-18 Stayton Patrick S Nonlinear copolymers as intracellular delivery vehicles and related methods
JP6265093B2 (ja) 2014-09-22 2018-01-24 Jsr株式会社 着色組成物、着色硬化膜、並びに表示素子及び固体撮像素子
EP3209726B1 (en) 2014-10-21 2020-07-01 DSM IP Assets B.V. Polymer, process and use
WO2016065306A1 (en) 2014-10-23 2016-04-28 The Brigham And Women's Hospital, Inc. Amphiphile-polymer particles
FR3027802B1 (fr) 2014-10-31 2018-03-02 Ethypharm Granules de principe actif a double masquage de gout, leur procede de preparation et comprimes orodispersibles les contenant
KR20170083071A (ko) 2014-11-11 2017-07-17 시오노기 앤드 컴파니, 리미티드 광에 대해서 불안정한 약물을 함유하는 다층 정제
RU2582704C1 (ru) 2014-12-15 2016-04-27 Общество с ограниченной ответственностью "СКИФ Спешиал Кемикалз" Состав для поверхностной проклейки бумаги и картона
CN104479064B (zh) 2014-12-18 2016-08-24 中国海洋石油总公司 一种聚驱采出液处理用反相破乳剂及其制备方法
JP2016126154A (ja) 2014-12-26 2016-07-11 花王株式会社 カラーフィルター用顔料分散体
CN114642735A (zh) 2015-01-21 2022-06-21 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
WO2016134121A1 (en) 2015-02-20 2016-08-25 Cytec Industries Inc. Dialkyl sulfosuccinate compositions, method of making, and method of use
CN104772051A (zh) 2015-03-25 2015-07-15 浙江工业大学 一种共聚物亲水改性超滤膜及其制备方法与应用
WO2016164762A1 (en) 2015-04-08 2016-10-13 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same
CN104784155B (zh) 2015-05-15 2018-02-23 中国药科大学 一种盐酸普拉克索组合微丸胶囊及其制备方法
KR101764785B1 (ko) 2015-05-29 2017-08-07 한국유나이티드제약 주식회사 약제학적 복합제제
CN104971073B (zh) 2015-05-29 2018-01-12 西南药业股份有限公司 法莫替丁钙镁咀嚼片的制备方法及其产品
CA2989581A1 (en) 2015-06-17 2016-12-22 Biogen Ma Inc. Dimethyl fumarate particles and pharmaceutical compositions thereof
CN104922078B (zh) 2015-06-23 2018-10-23 上海市计划生育科学研究所 非诺贝特迟释微丸、制备方法及应用
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
AU2016293508A1 (en) 2015-07-10 2018-02-01 Sun Pharma Advanced Research Company Ltd. Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone
JP2017058405A (ja) 2015-09-14 2017-03-23 富士ゼロックス株式会社 静電荷像現像剤、現像剤カートリッジ、プロセスカートリッジ、画像形成装置、及び、画像形成方法
US20180237800A1 (en) 2015-09-21 2018-08-23 The Regents Of The University Of California Compositions and methods for target nucleic acid modification
EA201890818A1 (ru) 2015-09-29 2018-09-28 Янссен Фармасьютикалс, Инк. Режим комбинированной терапии для лечения hcv
CN108135934B (zh) 2015-10-19 2024-09-10 永恒生物科技股份有限公司 通过组合疗法治疗实体或淋巴肿瘤的方法
EP3368054A4 (en) 2015-10-28 2019-07-03 Voyager Therapeutics, Inc. REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
RU2701513C2 (ru) 2015-11-19 2019-09-27 Афикс Терапьютикс А/С Фармацевтическая композиция, содержащая электрогидродинамически полученные волокна, композиция, имеющая улучшенное время удержания в месте применения
WO2017091739A1 (en) 2015-11-23 2017-06-01 Grace Therapeutics Llc Topical film-forming spray
US10874991B2 (en) 2015-11-27 2020-12-29 Queen's University At Kingston Functional filters for hydrophobic liquid/hydrophilic liquid separations
CN105504923B (zh) 2015-12-07 2017-11-21 常州大学 一种快干型无溶剂涂料及其制备方法
KR102408645B1 (ko) 2015-12-24 2022-06-14 (주)휴온스 안정성이 증가된 에스오메프라졸 함유 이중코팅정 조성물 및 이의 제조방법
EP3398588A4 (en) 2015-12-28 2019-10-02 Nippon Shinyaku Co., Ltd. FORM-PREPARED PREPARATION
HRP20250913T1 (hr) 2016-02-03 2025-09-26 Novartis Ag Nova upotreba kombinacije sakubitrila i valsartana
CN113925833A (zh) 2016-02-29 2022-01-14 豪夫迈·罗氏有限公司 包含酪氨酸蛋白激酶抑制剂的剂型组合物
FR3048700B1 (fr) 2016-03-08 2019-11-08 Arkema France Films poreux obtenus a partir de latex de polymeres
ES3041500T3 (en) 2016-03-10 2025-11-12 Cg Oncology Inc Methods of treating solid tumors by combination therapy
CN109475553A (zh) 2016-03-17 2019-03-15 太阳制药工业公司 尼洛替尼的药物组合物
KR102304478B1 (ko) 2016-04-04 2021-09-24 주식회사 바오밥에이바이오 Ras를 분해하는 이종원자고리화합물 및 이의 용도
EP3443001B1 (en) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
SG11201810179RA (en) 2016-04-19 2018-12-28 Broad Inst Inc Novel crispr enzymes and systems
CN105833272B (zh) 2016-04-20 2020-08-21 国家纳米科学中心 一种多功能纳米药物组合物及其制备方法与应用
CN105833287B (zh) 2016-04-20 2020-07-10 国家纳米科学中心 一种缓释纳米药物载体及其制备方法与应用
US20190224339A1 (en) 2016-04-29 2019-07-25 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
TWI753910B (zh) 2016-05-16 2022-02-01 美商拜歐斯瑞克斯公司 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途
CN109310639A (zh) 2016-05-27 2019-02-05 林德拉有限公司 用于胃驻留系统的材料结构
CN105949365B (zh) 2016-05-30 2018-10-19 山东鲁岳化工有限公司 一种珠状超高粘度水溶性阳离子聚合物及其制备方法
US20210154323A1 (en) * 2016-06-03 2021-05-27 Stemgenics, Inc. Functionalized nanoparticles for the intracellular delivery of biologically active molecules and methods for their manufacture and use
CN106117580A (zh) 2016-06-23 2016-11-16 广州新克力生物科技有限公司 一种用于滤除白细胞的滤膜改性剂及其改性方法
US9910353B2 (en) 2016-07-29 2018-03-06 Dow Global Technologies Llc Method of negative tone development using a copolymer multilayer electrolyte and articles made therefrom
US9910355B2 (en) 2016-07-29 2018-03-06 Rohm And Haas Electronic Materials Llc Method of negative tone development using a copolymer multilayer electrolyte and articles made therefrom
WO2018026764A1 (en) 2016-08-01 2018-02-08 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents and methods of use
JP6638706B2 (ja) 2016-08-03 2020-01-29 東ソー株式会社 ブロック共重合体およびそれを用いた表面処理剤
CN106236785B (zh) 2016-08-28 2019-08-27 福州海王金象中药制药有限公司 多糖蛋白片制备工艺
KR101847604B1 (ko) 2016-09-09 2018-04-11 주식회사 웨피 자외선 차단 성능이 우수한 수성 열반사 보온 단열도료 및 그 제조방법
CN106478904B (zh) 2016-09-26 2018-10-26 同济大学 一种具有温度和pH敏感性的多嵌段共聚物材料的制备方法
KR20190065344A (ko) 2016-10-03 2019-06-11 회가내스 아베 (피유비엘) 백색 철 식품 첨가제
KR102072546B1 (ko) 2016-10-14 2020-02-04 주식회사 삼양바이오팜 레날리도마이드의 경구용 정제 조성물
TW201829017A (zh) 2016-10-26 2018-08-16 日商味之素股份有限公司 於消化道之吸收降低的改善用組成物、及於消化道之吸收的促進用組成物
KR101827744B1 (ko) 2016-10-31 2018-02-09 부광약품 주식회사 톨리미돈의 대량 제조 방법
CA3047197A1 (en) 2016-12-16 2018-06-21 Basf Se Multi-layered film, method for the production and use thereof
KR20190090875A (ko) 2016-12-22 2019-08-02 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 수성 중합체 조성물
KR101850629B1 (ko) 2016-12-28 2018-04-20 연세대학교 원주산학협력단 항균제가 담지된 금속이중층수산화물 나노구조체를 함유하는 신선편이 농산물의 선도 유지용 조성물
JP2020507621A (ja) 2017-01-23 2020-03-12 ドン ファ ファーマシューティカル カンパニー リミテッド ＨＭＧ−ＣｏＡ還元酵素阻害剤およびクロピドグレルを含む複合製剤
CA3051614A1 (en) 2017-01-26 2018-08-02 Triastek, Inc. Dosage forms of controlled release at specific gastrointestinal sites
US10953016B2 (en) 2017-01-30 2021-03-23 Shionogi & Co., Ltd. Solid dosage form containing quinazoline derivative
CN106811998B (zh) 2017-02-15 2019-09-24 山东聚发生物科技有限公司 一种交联型无醛固色剂乳液及其制备方法
WO2018155555A1 (ja) 2017-02-27 2018-08-30 Jsr株式会社 基材表面の選択的修飾方法
KR20180099263A (ko) 2017-02-28 2018-09-05 경남대학교 산학협력단 피세틴을 포함하는 피부건강용 조성물
JP2018154752A (ja) 2017-03-17 2018-10-04 東ソー株式会社 共重合体およびその製造方法
JP7127330B2 (ja) 2017-04-12 2022-08-30 東ソー株式会社 ブロック共重合体およびそれを用いた表面処理剤
CN110506090B (zh) 2017-04-13 2022-05-31 王子控股株式会社 装饰成型用粘合片
CN110709479A (zh) 2017-04-18 2020-01-17 帝斯曼知识产权资产管理有限公司 制备防污涂料组合物的方法和由所述方法制备的涂料
US11219593B2 (en) 2017-04-28 2022-01-11 Symrise Ag Yarrow fresh-plant pressed juice concentrate, production, and use
KR102082775B1 (ko) 2017-05-02 2020-02-28 주식회사 삼양바이오팜 수용해도 및 생체이용율이 개선된 조성물
US20200171169A1 (en) 2017-05-15 2020-06-04 Vanderbilt University LONG-CIRCULATING ZWITTERIONIC POLYPLEXES FOR siRNA DELIVERY
JP2018203987A (ja) 2017-05-30 2018-12-27 東ソー株式会社 表面処理剤のコート方法
CN110945103A (zh) 2017-06-02 2020-03-31 沙特阿拉伯石油公司 包覆的二氧化硅粒子
CN107173546A (zh) 2017-06-12 2017-09-19 揭阳市润达肠衣有限公司 一种含大蒜精油的掩味控释颗粒及其制备方法和应用
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
FR3068704B1 (fr) 2017-07-06 2021-02-19 Centre Nat Rech Scient Materiau solide organique antibacterien
EP3662482A1 (en) * 2017-07-31 2020-06-10 Illumina Inc. Sequencing system with multiplexed biological sample aggregation
TWI832036B (zh) 2017-08-03 2024-02-11 美商航海家醫療公司 用於aav之遞送之組合物及方法
WO2019034712A1 (en) 2017-08-17 2019-02-21 F. Hoffmann-La Roche Ag NOVEL PHARMACEUTICAL COMPOSITIONS FOR BASIC OR NEUTRAL COMPOUNDS OF LOW MOLECULAR WEIGHT
CN111246846B (zh) 2017-08-28 2022-06-17 威斯康星校友研究基金会 用于递送核糖核蛋白的纳米胶囊
US11125748B2 (en) 2017-09-01 2021-09-21 University Of British Columbia Method for organizing individual molecules on a patterned substrate and structures assembled thereby
CN111050854A (zh) 2017-09-08 2020-04-21 3M创新有限公司 口腔护理氟化物水性治疗组合物和方法
JP2020534320A (ja) 2017-09-22 2020-11-26 ディスパーソル テクノロジーズ リミテッド ライアビリティ カンパニー アビラテロン環状オリゴマー薬学的製剤ならびにその形成法および投与法
CN107596368B (zh) 2017-10-11 2020-02-14 华南师范大学 一种细菌靶向纳米粒子的制备及其抑杀细菌的应用
CA3081163A1 (en) 2017-10-30 2019-05-09 Kaken Pharmaceutical Co., Ltd. External preparation for treating trichophytosis unguium
KR102184117B1 (ko) 2017-10-31 2020-11-30 주식회사 삼양바이오팜 수용해도 및 생체이용율이 개선된 소라페닙 나노입자 경구용 조성물 및 이의 제조 방법
KR102333609B1 (ko) 2017-10-31 2021-12-01 주식회사 삼양홀딩스 붕해가 개선된 경구용 고형 제제 조성물 및 이의 제조 방법
KR101840702B1 (ko) 2017-11-01 2018-03-22 압타바이오 주식회사 간질환 치료제
WO2019126209A1 (en) * 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
WO2019126627A1 (en) 2017-12-22 2019-06-27 Rensselaer Polytechnic Institute Dna origami nanoparticle delivery of programmed chromosome breakage machinery
US10920061B2 (en) 2017-12-29 2021-02-16 Kyungpook National University Industry-Academic Cooperation Foundation Self-healing acrylic copolymer, crosslinked copolymer prepared from the acrylic copolymer and method for low-temperature self-healing of the crosslinked copolymer
US10201503B1 (en) 2018-01-09 2019-02-12 Triastek, Inc. Precision pharmaceutical 3D printing device
JP6959154B2 (ja) 2018-01-23 2021-11-02 大阪有機化学工業株式会社 化粧料組成物
JP7219623B2 (ja) 2018-01-30 2023-02-08 日東電工株式会社 経皮吸収型製剤
WO2019152957A1 (en) 2018-02-02 2019-08-08 Arizona Board Of Regents On Behalf Of Arizona State University Dna-chimeric antigen receptor t cells for immunotherapy
EP3759225A1 (en) 2018-03-02 2021-01-06 Sixfold Bioscience Ltd. Compositions for delivery of cargo to cells
KR20190111448A (ko) 2018-03-23 2019-10-02 주식회사 제이와이에스앤텍 부착용 방담필름
JP7581052B2 (ja) 2018-04-13 2024-11-12 サムヤン ホールディングス コーポレイション レナリドミドの経口用コーティング錠剤組成物
GB201807853D0 (en) 2018-05-15 2018-06-27 Univ College Cardiff Consultants Ltd Polymers
WO2019226648A1 (en) 2018-05-21 2019-11-28 Battelle Memorial Institute Methods and control compositions for sequencing and chemical analyses
KR101923028B1 (ko) 2018-05-28 2018-11-29 (주)무량기술 용융형 도로 표시용 조성물 및 이의 시공 방법
LT3804714T (lt) 2018-05-31 2025-03-10 Hua Medicine (Shanghai) Ltd. Farmacinis derinys ir kompozicija, ir derinio preparatas, kurio sudėtyje yra gliukokinazės aktyvatorius ir biguanido hipoglikeminis vaistas, taip pat jų gamybos būdas ir panaudojimas
JP7353364B2 (ja) 2018-07-11 2023-09-29 キュア ファーマシューティカル， インコーポレイテッド 口腔内速崩壊性フィルム剤マトリックス
KR102120720B1 (ko) 2018-07-16 2020-06-10 연성정밀화학(주) 날푸라핀 함유 구강붕해정
KR101943270B1 (ko) 2018-07-17 2019-01-28 코오롱제약주식회사 맛차폐된 시나칼셋 구강붕해정 및 그 제조방법
KR20200009744A (ko) 2018-07-20 2020-01-30 크리스탈지노믹스(주) Fab I 저해제를 포함하는 경구투여용 약제학적 조성물 및 그 제조방법
JP2021530548A (ja) 2018-07-24 2021-11-11 ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics, Inc. 遺伝子治療製剤を生産するための系および方法
CN112912420A (zh) 2018-08-16 2021-06-04 巴斯夫欧洲公司 聚合物组合物
WO2020040438A1 (ko) 2018-08-23 2020-02-27 주식회사 종근당 에스오메프라졸 및 탄산수소나트륨을 포함하는 우수한 방출특성을 갖는 약제학적 제제
US20200069696A1 (en) 2018-08-30 2020-03-05 Yunxiang Liu Ophthalmic injectable formulation preparing and oculopathy treating and preventing
US20210317479A1 (en) 2018-09-06 2021-10-14 The Broad Institute, Inc. Nucleic acid assemblies for use in targeted delivery
WO2020077165A1 (en) 2018-10-12 2020-04-16 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
WO2020080875A1 (ko) 2018-10-19 2020-04-23 주식회사 삼양바이오팜 아프레피탄트의 경구용 조성물
US12508233B2 (en) 2018-10-30 2025-12-30 Vanderbilt University Graft copolymers, methods of forming graft copolymers, and methods of use thereof
SG11202104208RA (en) 2018-10-30 2021-05-28 Peloton Therapeutics Inc Solid dispersions and pharmaceutical compositions comprising a substituted indane and methods for the preparation and use thereof
CN113164897A (zh) 2018-10-30 2021-07-23 巴斯夫欧洲公司 制备被活性材料填充的微粒的方法
WO2020092987A1 (en) 2018-11-01 2020-05-07 Molecular Infusions, Llc Polymer-based oral cannabinoid and/or terpene formulations
JP7262206B2 (ja) 2018-11-07 2023-04-21 東ソー株式会社 溶出物試験方法
AU2019385506A1 (en) 2018-11-21 2021-06-03 Takeda Pharmaceutical Company Limited Recombinant viral vectors and nucleic acids for producing the same
WO2020123661A1 (en) 2018-12-11 2020-06-18 Farokhzad Omid C Methods for treating cancer
KR20200090359A (ko) 2019-01-21 2020-07-29 크리스탈지노믹스(주) Fab I 저해제를 포함하는 주사제용 조성물 및 그 제조방법
JP2022523794A (ja) 2019-03-04 2022-04-26 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 環状ポリリボヌクレオチド及びその医薬組成物
KR102107332B1 (ko) 2019-03-20 2020-05-07 (주)제이비바이오텍 CRISPR/Cas9 기반 Bacillus subtillis 유전체 편집 메커니즘을 이용한 콜레라 백신
US20200308331A1 (en) 2019-03-28 2020-10-01 Penn Color, Inc. Water compatible cationic graft copolymers and ink compositions comprising same
WO2020223274A1 (en) 2019-04-29 2020-11-05 Voyager Therapeutics, Inc. SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS
US20220233580A1 (en) 2019-05-28 2022-07-28 Toymedical Co., Ltd. Sodium excretion particles
CN114144521A (zh) * 2019-05-31 2022-03-04 儿童医院医学中心 基于聚合物的细胞标记、条形码化和组装
US20220233459A1 (en) 2019-06-05 2022-07-28 Guide Therapeutics, Inc. Analysis of materials for tissue delivery
KR102157964B1 (ko) 2019-06-13 2020-09-22 (주)제이비바이오텍 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 돼지의 아프리카 돼지열병 백신
WO2021007382A1 (en) 2019-07-09 2021-01-14 Voyager Therapeutics, Inc. Compositions and methods for the treatment of parkinson's disease
KR102207353B1 (ko) 2019-08-28 2021-01-27 (주)제이비바이오텍 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 돼지의 괴사성장염 백신
KR102207354B1 (ko) 2019-09-02 2021-01-27 (주)제이비바이오텍 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 닭의 괴사성장염 백신
US11564884B2 (en) 2019-09-09 2023-01-31 Regents Of The University Of Minnesota Cationic block polymer micelles for delivery of biological agents
AU2020365129A1 (en) 2019-10-16 2022-05-05 King Abdullah University Of Science And Technology Methods for modulating human L1 retrotransposons RNA and compositions for use therein
KR102212505B1 (ko) 2019-10-28 2021-02-05 주식회사 제이비바이오텍 농업회사법인 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 벌의 낭충봉아부패 백신
KR102212504B1 (ko) 2019-10-28 2021-02-08 주식회사 제이비바이오텍 농업회사법인 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 개의 켄넬코프 백신
KR102212503B1 (ko) 2019-10-28 2021-02-05 주식회사 제이비바이오텍 농업회사법인 CRISPR/Cas9 기반 Bacillus subtilis 유전체 편집 메커니즘을 이용한 넙치의 스쿠티카증 백신
KR102842351B1 (ko) 2019-11-05 2025-08-04 아주대학교산학협력단 레바미피드 또는 이의 약학적으로 허용가능한 염을 포함하는 경구투여용 서방성 약학 조성물
EP4079295A4 (en) 2019-12-20 2023-12-06 Samyang Holdings Corporation COMPOSITION HAVING IMPROVED SOLUBILITY AND BIOAVAILABILITY OF OLAPARIB
CN114945561A (zh) 2020-01-13 2022-08-26 阿普塔生物治疗公司 新吡唑衍生物
WO2021146397A1 (en) 2020-01-14 2021-07-22 Synlogic Operating Company, Inc. Bacteria engineered to treat disorders in which oxalate is detrimental
KR102366598B1 (ko) 2020-03-20 2022-02-24 광주과학기술원 양쪽 이온성 관능기를 가지는 랜덤 공중합체를 포함하는 공기 필터용 나노섬유 및 그 제조방법
KR20210119906A (ko) 2020-03-25 2021-10-06 주식회사 삼양홀딩스 포말리도마이드의 경구용 정제 조성물 및 이의 제조 방법
KR102672103B1 (ko) 2020-04-01 2024-06-04 연세대학교 산학협력단 노로바이러스성 질환의 치료용 조성물
DE102020002360A1 (de) 2020-04-18 2021-10-21 Friedrich-Schiller-Universität Jena Nanopartikel enthaltend Komplexe aus Nukleinsäuren und kationischen Copolymeren, Verfahren zu deren Herstellung und deren Verwendung zum Gentransfer in Zellen
AU2021276502B2 (en) 2020-05-20 2024-10-31 Ennis-Flint, Inc. Ketone functionalized polymers, methods of making ketone functionalized polymers, and compositions including the same
WO2021255262A1 (en) 2020-06-19 2021-12-23 Sylentis Sau siRNA AND COMPOSITIONS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VIRUS DISEASES
EP3960203A1 (en) 2020-08-25 2022-03-02 Université de Liège Complexes for the delivery of proteinaceous agents
JP7533087B2 (ja) 2020-09-30 2024-08-14 日油株式会社 共重合体、共重合体の製造方法、細胞凍結保存材及び細胞凍結保存液
WO2022091971A1 (ja) 2020-10-27 2022-05-05 三菱鉛筆株式会社 皮膚用マーカー組成物
JP2022076360A (ja) 2020-11-09 2022-05-19 日本電信電話株式会社 形状記憶性高分子積層膜およびその製造方法
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
EP4015634A1 (en) 2020-12-15 2022-06-22 Sylentis, S.A.U. Sirna and compositions for prophylactic and therapeutic treatment of virus diseases
WO2022139687A1 (en) 2020-12-23 2022-06-30 Croda Singapore Pte Limited Soot dispersant comprising block copolymer and lubricant composition containing the same
JP2022117407A (ja) 2021-01-29 2022-08-10 花王株式会社 外用剤組成物
TWI903153B (zh) 2021-03-15 2025-11-01 美商電子墨水股份有限公司 具有不同不透明度的區域之可切換光調變器
WO2022245307A1 (en) 2021-05-21 2022-11-24 Ilko Ilac Sanayi Ve Ticaret A.S. Composition of mesalazine enteric tablet formulation
EP4355267A1 (en) 2021-06-16 2024-04-24 Edwards Lifesciences Corporation Multifunctional sealing member for improved endothelialization and paravalvular leakage
WO2023023055A1 (en) 2021-08-16 2023-02-23 Renagade Therapeutics Management Inc. Compositions and methods for optimizing tropism of delivery systems for rna
US20250041325A1 (en) 2021-12-07 2025-02-06 The Brigham And Women's Hospital, Inc. Lipid-based compositions and methods thereof
PL245677B1 (pl) 2022-02-23 2024-09-16 Podkarpackie Centrum Innowacji Spolka Z Ograniczona Odpowiedzialnoscia Polimery gwiaździste, sposób otrzymywania polimerów gwiaździstych oraz ich zastosowanie
US20250339399A1 (en) 2022-04-08 2025-11-06 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Supramolecular self-assembly system
WO2023239922A1 (en) 2022-06-09 2023-12-14 Battelle Memorial Institute Non-viral delivery compositions and screening methods
EP4536291A1 (en) 2022-06-09 2025-04-16 Battelle Memorial Institute Non-viral delivery of small molecule therapeutics
CN115714187A (zh) 2022-10-12 2023-02-24 池州学院 一种中间催化层改性的双极膜及其制备方法

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