RU2408368C2 - Препараты соли бупропиона с модифицированным высвобождением - Google Patents

Препараты соли бупропиона с модифицированным высвобождением Download PDF

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RU2408368C2
RU2408368C2 RU2007147343/15A RU2007147343A RU2408368C2 RU 2408368 C2 RU2408368 C2 RU 2408368C2 RU 2007147343/15 A RU2007147343/15 A RU 2007147343/15A RU 2007147343 A RU2007147343 A RU 2007147343A RU 2408368 C2 RU2408368 C2 RU 2408368C2
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composition according
bupropion
composition
drug
release
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Вернер ОБЕРЕГГЕР (CA)
Вернер Обереггер
Фанг ЖУ (US)
Фанг Жу
Паул МАЕС (CA)
Паул МАЕС
Стефано ТУРЧЕТТА (IT)
Стефано ТУРЧЕТТА
Грэхэм ДЖЕКСОН (IE)
Грэхэм ДЖЕКСОН
Пьетро МАССАРДО (IT)
Пьетро МАССАРДО
Мохаммад Ашти САЛЕХ (CA)
Мохаммад Ашти САЛЕХ
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Биовэйл Лэборэториз Интернэшнл С.Р.Л.
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Abstract

Настоящее изобретение относится к лекарственным формам, содержащим действующее количество фармакологически приемлемой соли бупропиона - бупропиона гидробромида, а также к применению таких лекарственных форм при лечении одного или большего числа состояний пациентов, по отношению к которым допустимо применение бупропиона или его фармакологически приемлемых солей. Лекарственные формы с бупропионом гидробромидом обладают более высокой стабильностью по сравнению с лекарственными формами, включающими бупропиона гидрохлорид, что подтверждается меньшим ослаблением активности композиций после хранения в течение минимум 3 или 6 месяцев при форсированных условиях при 40°С и относительной влажности 75%. 6 н. и 75 з.п. ф-лы, 69 ил., 73 табл.

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Claims (81)

1. Существенно чистая полиморфная форма I бупропиона гидробромида, имеющая дифрактограмму рентгеновских лучей на порошке, показанную на фиг.54.
2. Существенно чистая полиморфная форма II бупропиона гидробромида, имеющая дифрактограмму рентгеновских лучей на порошке, показанную на фиг.56.
3. Существенно чистая полиморфная форма III бупропиона гидробромида, имеющая дифрактограмму рентгеновских лучей на порошке, показанную на фиг.58.
4. Стабильная фармацевтическая композиция, содержащая бупропион в качестве активного фармацевтического ингредиента, характеризующаяся тем, что она содержит фармацевтически эффективное количество гидробромидной соли бупропиона.
5. Композиция по п.4, пригодная для перорального введения в организм пациента, нуждающегося в приеме бупропиона.
6. Композиция по п.4, более стабильная, чем эквивалентная в других отношениях композиция бупропиона гидрохлорида, при хранении в течение минимум 3 месяцев при 40°С и относительной влажности 75%.
7. Композиция по п.6, более стабильная при хранении в течение минимум 6 месяцев при 40°С и относительной влажности 75%.
8. Композиция по п.6, которая содержит меньшее количество минимум одного примесного продукта, характерного для разложения бупропиона после хранения при 40°С и относительной влажности 75%, чем аналогичные в других отношениях композиции бупропиона гидрохлорида, хранившиеся в тех же условиях.
9. Композиция бупропиона гидробромида по п.6, на кривой растворения которой in vitro в минимум одной растворяющей среде колебания являются менее выраженными, чем на кривых растворения для аналогичных в других отношениях композиций бупропиона гидрохлорида, после хранения в течение минимум 3 месяцев при 40°С и относительной влажности 75%.
10. Композиция по п.4, покрытая минимум одной оболочкой, препятствующей выбросу дозы при нахождении указанной композиции в 40%-ном этаноле.
11. Композиция по п.10, в которой покрытие включает не растворимый в воде полимер, водорастворимый полимер и, при необходимости, пластификатор.
12. Композиция по п.4, содержащая не менее одного фармакологически приемлемого носителя или вспомогательного вещества.
13. Композиция по п.4, выполненная в виде таблетки, которая биоэквивалентна таблеткам Велбутрина (Wellbutrin™) или Зибана/Велбутрина SR (Zyban™/Wellbutrin™ SR) при однократном в сутки введении нуждающемуся в этом пациенту.
14. Композиция по п.13, не проявляющая лекарственно-пищевого взаимодействия.
15. Композиция по п.13, содержащая 150, 174, 300 или 348 мг бупропиона гидробромида.
16. Композиция по п.4, пригодная для введения с помощью средств местного применения.
17. Композиция по п.4, пригодная для трансмукозальной или трансдермальной доставки.
18. Композиция по п.4, пригодная для инъекции.
19. Композиция по п.4, пригодная для введения ингаляционным путем.
20. Композиция по п.4, в которой не менее 90% присутствующего в ней бупропиона являются одной из энантиомерных форм соли бупропиона.
21. Композиция по п.4, в которой не менее 95-99% присутствующего в ней бупропиона являются одной из энантиомерных форм соли бупропиона.
22. Композиция по п.4, в которой не менее 90% присутствующего в ней бупропиона являются (+)энантиомером.
23. Композиция по п.4, в которой не менее 90% присутствующего в ней бупропиона являются (-)энантиомером.
24. Композиция по п.4, в которой не менее 95-99% присутствующего в ней бупропиона являются (-)энантиомером.
25. Композиция по п.4, в которой не менее 95-99% присутствующего в ней бупропиона являются (+)энантиомером.
26. Композиция по п.4, которая содержит как минимум одну из полиморфных форм I, II и III, охарактеризованных в пп.1-3.
27. Композиция по п.26, содержащая полиморфные формы I, II и III.
28. Композиция по п.4, выполненная в виде таблетированного препарата.
29. Композиция по п.4, выполненная в виде капсулированного препарата.
30. Композиция по п.4, представляющая собой препарат с продолжительным высвобождением.
31. Композиция по п.4, представляющая собой препарат с отсроченным высвобождением.
32. Композиция по п.4, представляющая собой препарат с улучшенным всасыванием.
33. Композиция по п.4, выполненная в виде матричной таблетки с регулируемым высвобождением.
34. Композиция по п.4, выполненная в виде системы доставки с осмотическим высвобождением.
35. Композиция по п.4, пригодная для введения один раз в сутки.
36. Композиция по п.4, пригодная для введения дважды в сутки.
37. Композиция по п.4, содержащая 50-400 мг бупропиона.
38. Композиция по п.4, содержащая 150 или 174 мг бупропиона.
39. Композиция по п.4, содержащая 300 или 348 мг бупропиона.
40. Композиция по п.4, имеющая не менее одного функционального или нефункционального покрытия.
41. Композиция по п.40, в которой указанные покрытия представляют собой гидроизолирующие барьеры, регулирующие высвобождение оболочки, желудочно-резистентные оболочки, покрытия, влияющие на физическую стабильность, и/или покрытия, влияющие на внешний вид композиции.
42. Композиция по п.41, имеющая гидроизолирующий барьер.
43. Композиция по п.4, содержащая ядро, которое включает указанную соль бупропиона, связующее и смазывающее вещество; и имеющее регулирующую высвобождение оболочку, по существу, окружающую указанное ядро, причем указанная композиция обеспечивает регулируемое высвобождение указанной соли бупропиона.
44. Композиция по п.43, имеющая не менее одного дополнительного покрытия.
45. Композиция по п.43, в которой указанные дополнительные покрытия представляют собой гидроизолирующие барьеры, желудочно-резистентные оболочки, регулирующие высвобождение оболочки, покрытия, влияющие на физическую стабильность и/или покрытия, влияющие на внешний вид композиции.
46. Композиция по п.45, в которой указанные дополнительные оболочки, по существу, окружают ядро и/или регулирующую высвобождение оболочку.
47. Композиция по п.43, в которой указанным связующим является поливиниловый спирт.
48. Композиция по п.43, в которой имеется гидроизолирующий барьер, или желудочно-резистентная оболочка вокруг ядра и/или регулирующая высвобождение оболочка,
49. Композиция по п.43, в которой в качестве указанного смазывающего вещества использован глицерилбегенат.
50. Композиция по п.43, в которой указанная регулирующая высвобождение оболочка включает не растворимый в воде полимер, водорастворимый полимер и, при необходимости, пластификатор.
51. Композиция по п.50, в которой в качестве указанного не растворимого в воде полимера использована этилцеллюлоза.
52. Композиция по п.50, в которой в качестве указанного водорастворимого полимера использован поливинилпирролидон.
53. Композиция по п.50, в которой указанный пластификатор, если его наличие предусмотрено, представляет собой смесь полиэтиленгликоля 4000 и дибутилсебацината.
54. Композиция по п.50, в которой указанная регулирующая высвобождение оболочка включает водную дисперсию нейтрального сложноэфирного сополимера без каких-либо функциональных групп, полигликоль с температурой плавления выше прибл. 55°С и одно или большее число фармакологически приемлемых вспомогательных веществ, причем указанная оболочка нанесена на указанные ядра и отверждена при температуре, минимум равной температуре плавления полигликоля или превышающей ее.
55. Композиция по п.54, содержащая минимум одну дополнительную оболочку.
56. Композиция по п.53, в которой указанное ядро является микрочастицей.
57. Композиция по п.53, в которой указанное ядро является ядром с немедленным высвобождением.
58. Композиция по п.4, дополнительно содержащая второе лекарство.
59. Композиция по п.58, в которой указанное второе лекарство выбрано из группы, включающей антидепрессанты, сосудорасширяющие, седативные средства, противовоспалительные, болеутоляющие средства, средства от мигрени, средства для лечения наркомании, алкоголизма или никотиновой зависимости, противовирусные средства, модуляторы сна, антимиметики, подавители или усилители аппетита и невропсихиатрические средства.
60. Композиция по п.58, в которой второе лекарство является антидепрессантом.
61. Композиция по п.58, в которой второе лекарство является немедленно высвобождаемым после введения в организм.
62. Композиция по п.58, в которой второе лекарство не соприкасается с первым лекарством в композиции.
63. Композиция по п.62, в которой бупропион и второе лекарство содержатся в разных слоях, частях композиции или разных микрочастицах, составляющих композицию.
64. Композиция по п.58, в которой указанным вторым лекарством является циталопрам.
65. Композиция по п.58, в которой указанным вторым лекарством является эсциталопрам.
66. Композиция по п.58, в которой указанным вторым лекарством является венлафаксин.
67. Способ лечения пациента, страдающего от состояния, при котором введение бупропиона оказывает благоприятный эффект, включающий введение композиции по любому из пп.4-66.
68. Способ по п.67, в котором указанное состояние выбрано из группы, включающей депрессию, токсикоманию, явления, связанные с отказом от курения, ожирение и сезонное аффективное расстройство.
69. Способ по п.67, в котором указанным состоянием является ожирение.
70. Способ по п.67, в котором состоянием является ожирение.
71. Способ по п.67, в котором состоянием являются явления, связанные с отказом от курения.
72. Способ по п.67, в котором состоянием является сезонное аффективное расстройство.
73. Применение бупропиона гидробромида для приготовления медикамента для лечения состояний, при которых введение бупропиона оказывает благоприятный эффект.
74. Применение по п.73, в котором указанный медикамент содержит меньшее количество минимум одного структурного образования, характерного для разложения бупропиона, чем аналогичные в других отношениях композиции бупропиона гидрохлорида, при хранении указанных композиций в течение минимум 3 или 6 месяцев при 40°С и относительной влажности 75%.
75. Применение по п.73, в котором указанный медикамент характеризуется меньшим разбросом кривой растворения in vitro в минимум одной растворяющей среде по сравнению с аналогичной в других отношениях композицией бупропиона гидрохлорида после хранения указанных композиций в течение минимум 3 и/или 6 месяцев при 40°С и относительной влажности 75%.
76. Применение по п.73, в котором медикамент выполнен в виде таблетки.
77. Применение по п.73, в котором медикамент выполнен в виде капсулы.
78. Применение по п.73, в котором медикамент содержит второе лекарство.
79. Применение по п.78, в котором вторым лекарством является циталопрам.
80. Применение по п.78, в котором вторым лекарством является эсциталопрам.
81. Применение по п.78, в котором вторым лекарством является венлафаксин.
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Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US8323692B2 (en) * 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
MXPA04008100A (es) * 2002-02-21 2005-06-17 Biovail Lab Int Srl Formulaciones de liberacion modificada de al menos una forma de tramadol.
NZ527142A (en) 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
DE602005001873T2 (de) * 2004-03-03 2008-04-24 Chemi S.P.A., Cinisello Balsamo Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung
US7645802B2 (en) * 2005-06-27 2010-01-12 Biovail Laboratories International Srl. Bupropion hydrobromide and therapeutic applications
EP2474308A1 (en) 2005-06-27 2012-07-11 Valeant International (Barbados) SRL Pharmaceutical formulations containing bupropion hydrobromide
US7671094B2 (en) * 2005-06-27 2010-03-02 Biovail Laboratories International S.R.L. Bupropion hydrobromide and therapeutic applications
US20070020228A1 (en) * 2005-07-22 2007-01-25 Williams Terry N Method of using a biosealant device
PL1912650T3 (pl) 2005-08-03 2018-01-31 Sprout Pharmaceuticals Inc Zastosowanie flibanseryny w leczeniu otyłości
WO2007035816A2 (en) * 2005-09-20 2007-03-29 Dr. Reddy's Laboratories Ltd. Paroxetine compositions
US8298601B2 (en) * 2005-10-11 2012-10-30 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070142804A1 (en) * 2005-12-16 2007-06-21 Bernard Bobby L Hollow-core fibers
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
TW200806282A (en) * 2006-05-05 2008-02-01 Wyeth Corp Solid dosage formulations
CA2654798C (en) 2006-06-30 2015-01-13 Boehringer Ingelheim International Gmbh Flibanserin for the treatment of urinary incontinence and related diseases
WO2008015018A1 (en) 2006-08-03 2008-02-07 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid disease
US20100008987A1 (en) * 2006-08-21 2010-01-14 Pasula Basavaiah Chowdary Modified Release Pharmaceutical Composition of Bupropion Hydrochloride
KR20090051240A (ko) * 2006-09-01 2009-05-21 유에스브이 리미티드 세벨라머 염산염의 제조방법 및 그의 제형
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
WO2008112826A1 (en) * 2007-03-12 2008-09-18 Board Of Regents, The University Of Texas System Method and process for the production of multi-coated recognitive and releasing systems
US8741316B2 (en) * 2007-03-12 2014-06-03 Board Of Regents, The University Of Texas System Highly porous, recognitive polymer systems
US8821899B2 (en) * 2007-03-12 2014-09-02 Board Of Regents, The University Of Texas System Method and process for the production of multi-coated recognitive and releasing systems
US8771713B2 (en) * 2007-03-12 2014-07-08 Board Of Regents, The University Of Texas System Method and process for the production of multi-coated recognitive and releasing systems
US20080292683A1 (en) * 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
WO2009050726A2 (en) * 2007-05-28 2009-04-23 Panacea Biotec Limited Compositions and methods for improved delivery of bupropion
US8349033B2 (en) * 2007-05-31 2013-01-08 The Penray Companies, Inc. Diesel fuel, diesel fuel additive, and associated method for using the same
US20090004281A1 (en) * 2007-06-26 2009-01-01 Biovail Laboratories International S.R.L. Multiparticulate osmotic delivery system
US20100203128A1 (en) * 2007-08-07 2010-08-12 Biovail Laboratories International Srl Bupropion hydrobromide and therapeutic applications
UY31335A1 (es) 2007-09-12 2009-04-30 Tratamiento de sintomas vasomotores
US20090136650A1 (en) * 2007-09-18 2009-05-28 Viva Pharmaceuticals Inc. Enteric coatings for orally ingestible compositions
US20090074944A1 (en) * 2007-09-18 2009-03-19 Viva Pharmaceuticals Inc. Enteric coatings for orally ingestible compositions
US20090155354A1 (en) * 2007-12-14 2009-06-18 Mclean Barbara Wanamaker Dispensing encapsulated liquids into body cavities
US20100291225A1 (en) * 2008-01-14 2010-11-18 Jubilant Organosys Ltd. Stabilized Sustained Release Composition of Bupropion Hydrochloride and Process For Preparing the Same
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
FR2927331B1 (fr) * 2008-02-07 2011-05-20 Centre Nat Rech Scient Nouveaux derives anti-infectieux, leur procede de preparation, compositions pharmaceutiques les contenant et leurs utilisations en therapeutique.
EP2090297A1 (en) * 2008-02-13 2009-08-19 Boehringer Ingelheim International GmbH Formulations of flibanserin
US8598719B2 (en) * 2008-06-12 2013-12-03 Sumitomo Bakelite Company Limited Semiconductor element mounting board
US8450376B2 (en) * 2008-06-16 2013-05-28 Glenmark Generics Ltd. Amorphous bupropion hydrobromide and preparation thereof
CA2728734A1 (en) 2008-06-25 2009-12-30 Braasch Biotech Llc Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof
NZ590010A (en) * 2008-06-25 2013-01-25 Braasch Biotech Llc Compositions and methods treating growth hormone deficiency and/or an insulin-like growth factor 1 deficiency with somatostatin and an adjuvant
EP2306987B1 (de) * 2008-07-02 2018-01-24 Basf Se Verfahren zum beschichten von tabletten
CA2934988A1 (en) 2008-08-07 2010-02-11 Valeant International Bermuda Bupropion hydrobromide polymorphs
US20100121256A1 (en) * 2008-11-10 2010-05-13 Med-El Elektromedizinische Geraete Gmbh Implantable and Refillable Drug Delivery Reservoir
FR2938431B1 (fr) 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
US8506936B2 (en) * 2008-11-25 2013-08-13 Watson Laboratories, Inc. Stabilized nicotine chewing gum
CA2686480A1 (en) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh New salts
WO2010077916A1 (en) * 2008-12-16 2010-07-08 Eurand, Inc. Compositions comprising melperone
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
MX2011007760A (es) * 2009-01-22 2011-08-17 Usv Ltd Composiciones farmaceuticas que comprenden polimero vinculante a fosfato.
EP2391369A1 (en) * 2009-01-26 2011-12-07 Nitec Pharma AG Delayed-release glucocorticoid treatment of asthma
NZ582836A (en) * 2009-01-30 2011-06-30 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage
WO2010099508A1 (en) 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
ITMI20090384A1 (it) * 2009-03-13 2010-09-14 Dipharma Francis Srl Bupropione bromidrato amorfo e metodo per la sua preparazione
WO2010106555A2 (en) * 2009-03-17 2010-09-23 Shantilal, Doshi, Bimalkumar Directly compressible pre-granulated cellulose ether polymer and process for preparing the same
EP2419085A4 (en) * 2009-04-14 2013-04-24 Univ California IMPROVED DEVICES FOR ORAL MEDICINAL PRODUCTS AND MEDICINAL PRODUCTS
CN101811975B (zh) * 2009-04-20 2013-01-16 浙江普洛医药科技有限公司 氢溴酸安非他酮的多晶型物及其制备方法
GB2495563B (en) * 2009-04-28 2014-12-03 Isp Investments Inc Co-processed excipient compositions
CN102573811A (zh) * 2009-06-02 2012-07-11 陶氏环球技术有限责任公司 缓释剂型
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US20110027342A1 (en) * 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
FR2949061B1 (fr) 2009-08-12 2013-04-19 Debregeas Et Associes Pharma Microgranules flottants
FR2949062B1 (fr) * 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
US8414950B2 (en) * 2009-10-15 2013-04-09 Purecircle Sdn Bhd High-purity rebaudioside D and low-calorie table top tablet containing the same
RU2556585C2 (ru) * 2009-11-06 2015-07-10 Ск Биофармасъютиклс Ко., Лтд. Способы лечения синдрома дефицита внимания и гиперактивности
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2011077239A2 (en) * 2009-12-23 2011-06-30 Lupin Limited Slow release pharmaceutical compositions of iloperidone
SG183993A1 (en) * 2010-03-09 2012-10-30 Alkermes Pharma Ireland Ltd Alcohol resistant enteric pharmaceutical compositions
LT3650439T (lt) 2010-07-23 2021-03-25 Grünenthal GmbH 3-(3-dimetilamino-1-etil-2-metil-propil)-fenolio druskos arba bendri kristalai
BR112012028368B8 (pt) * 2010-08-24 2022-07-19 Otsuka Pharma Co Ltd Processo para prevenção de aglomeração de partículas de ingrediente ativo em uma suspensão, suspensão e composição de torta contendo derivado carbo estirila e óleo de silicone e/ou derivado de óleo de silicone
EP3485878A1 (en) * 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
FR2967576B1 (fr) * 2010-11-18 2013-07-12 Advicenne Pharma Composition pharmaceutique comprenant du sel precurseur du cycle de krebs, en particulier du sel de citrate, et son utilisation comme medicament
CN102241597B (zh) * 2011-05-04 2014-01-08 浙江普洛家园药业有限公司 一种氢溴酸安非他酮晶型ⅰ的制备方法
WO2013043828A1 (en) * 2011-09-20 2013-03-28 Grain Processing Corporation Microspheres
US9481777B2 (en) 2012-03-30 2016-11-01 The Procter & Gamble Company Method of dewatering in a continuous high internal phase emulsion foam forming process
US9989517B2 (en) 2013-06-27 2018-06-05 Ruprecht Keller Methods and compositions for marking urine samples to identify source
US9504656B2 (en) * 2013-10-21 2016-11-29 Banner Life Sciences, LLC Pharmaceutical compositions for poorly soluble active ingredients
US20200338022A1 (en) 2019-01-07 2020-10-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11571399B2 (en) 2013-11-05 2023-02-07 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9867819B2 (en) 2013-11-05 2018-01-16 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11234946B2 (en) 2013-11-05 2022-02-01 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10945973B2 (en) 2013-11-05 2021-03-16 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11364233B2 (en) 2013-11-05 2022-06-21 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11020389B2 (en) 2013-11-05 2021-06-01 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10966942B2 (en) 2019-01-07 2021-04-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9198905B2 (en) 2013-11-05 2015-12-01 Antecip Bioventures Ii Llc Compositions and methods for reducing dextrorphan plasma levels and related pharmacodynamic effects
US11253491B2 (en) 2013-11-05 2022-02-22 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11298351B2 (en) 2013-11-05 2022-04-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11185515B2 (en) 2013-11-05 2021-11-30 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11065248B2 (en) 2013-11-05 2021-07-20 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10874665B2 (en) 2013-11-05 2020-12-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11141416B2 (en) 2013-11-05 2021-10-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11129826B2 (en) 2013-11-05 2021-09-28 Axsome Therapeutics, Inc. Bupropion as a modulator of drug activity
US20160324807A1 (en) 2013-11-05 2016-11-10 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10966974B2 (en) 2013-11-05 2021-04-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9968568B2 (en) 2013-11-05 2018-05-15 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US10512643B2 (en) 2013-11-05 2019-12-24 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US9474731B1 (en) 2013-11-05 2016-10-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11291665B2 (en) 2013-11-05 2022-04-05 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10894046B2 (en) 2013-11-05 2021-01-19 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9457025B2 (en) 2013-11-05 2016-10-04 Antecip Bioventures Ii Llc Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan
US11419867B2 (en) 2013-11-05 2022-08-23 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11478468B2 (en) 2013-11-05 2022-10-25 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10780064B2 (en) 2019-01-07 2020-09-22 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11517543B2 (en) 2013-11-05 2022-12-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US20160361305A1 (en) * 2013-11-05 2016-12-15 Antecip Bioventures Ii Llc Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan
US11344544B2 (en) 2013-11-05 2022-05-31 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11576909B2 (en) 2013-11-05 2023-02-14 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11123343B2 (en) 2013-11-05 2021-09-21 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11510918B2 (en) 2013-11-05 2022-11-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11524007B2 (en) 2013-11-05 2022-12-13 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11273134B2 (en) 2013-11-05 2022-03-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10980800B2 (en) 2013-11-05 2021-04-20 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10813924B2 (en) 2018-03-20 2020-10-27 Antecip Bioventures Ii Llc Bupropion and dextromethorphan for treating nicotine addiction
US11439636B1 (en) 2013-11-05 2022-09-13 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9700528B2 (en) 2013-11-05 2017-07-11 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11191739B2 (en) 2013-11-05 2021-12-07 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11571417B2 (en) 2013-11-05 2023-02-07 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11596627B2 (en) 2013-11-05 2023-03-07 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10898453B2 (en) 2013-11-05 2021-01-26 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11433067B2 (en) 2013-11-05 2022-09-06 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10799497B2 (en) * 2013-11-05 2020-10-13 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
US9408815B2 (en) 2013-11-05 2016-08-09 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11534414B2 (en) 2013-11-05 2022-12-27 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11426370B2 (en) 2013-11-05 2022-08-30 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11298352B2 (en) 2013-11-05 2022-04-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11285118B2 (en) 2013-11-05 2022-03-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11207281B2 (en) 2013-11-05 2021-12-28 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10881657B2 (en) 2013-11-05 2021-01-05 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11541048B2 (en) 2013-11-05 2023-01-03 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11541021B2 (en) 2013-11-05 2023-01-03 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11311534B2 (en) 2013-11-05 2022-04-26 Antecip Bio Ventures Ii Llc Bupropion as a modulator of drug activity
US11291638B2 (en) 2013-11-05 2022-04-05 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10786469B2 (en) * 2013-11-05 2020-09-29 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US10105361B2 (en) 2013-11-05 2018-10-23 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US10688066B2 (en) 2018-03-20 2020-06-23 Antecip Bioventures Ii Llc Bupropion and dextromethorphan for treating nicotine addiction
US10105327B2 (en) * 2013-11-05 2018-10-23 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphane and related pharmacodynamic effects
US10966941B2 (en) 2013-11-05 2021-04-06 Antecip Bioventures Ii Llp Bupropion as a modulator of drug activity
US11197839B2 (en) 2013-11-05 2021-12-14 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11357744B2 (en) 2013-11-05 2022-06-14 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9457023B1 (en) 2013-11-05 2016-10-04 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11007189B2 (en) 2013-11-05 2021-05-18 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11147808B2 (en) 2013-11-05 2021-10-19 Antecip Bioventures Ii Llc Method of decreasing the fluctuation index of dextromethorphan
US10940124B2 (en) 2019-01-07 2021-03-09 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11253492B2 (en) 2013-11-05 2022-02-22 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10874663B2 (en) 2013-11-05 2020-12-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10874664B2 (en) 2013-11-05 2020-12-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11590124B2 (en) 2013-11-05 2023-02-28 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11273133B2 (en) 2013-11-05 2022-03-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10772850B2 (en) 2013-11-05 2020-09-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11058648B2 (en) 2013-11-05 2021-07-13 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11617747B2 (en) 2013-11-05 2023-04-04 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10933034B2 (en) 2013-11-05 2021-03-02 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9707191B2 (en) 2013-11-05 2017-07-18 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11497721B2 (en) 2013-11-05 2022-11-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11285146B2 (en) 2013-11-05 2022-03-29 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US9861595B2 (en) 2013-11-05 2018-01-09 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11382874B2 (en) 2013-11-05 2022-07-12 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US20220233470A1 (en) 2013-11-05 2022-07-28 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11096937B2 (en) 2013-11-05 2021-08-24 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11576877B2 (en) 2013-11-05 2023-02-14 Antecip Bioventures Ii Llc Bupropion as modulator of drug activity
US10894047B2 (en) 2013-11-05 2021-01-19 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US10080727B2 (en) * 2013-11-05 2018-09-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US11229640B2 (en) 2013-11-05 2022-01-25 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
US9402843B2 (en) 2013-11-05 2016-08-02 Antecip Bioventures Ii Llc Compositions and methods of using threohydroxybupropion for therapeutic purposes
US11123344B2 (en) 2013-11-05 2021-09-21 Axsome Therapeutics, Inc. Bupropion as a modulator of drug activity
US9763932B2 (en) 2013-11-05 2017-09-19 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US10864209B2 (en) 2013-11-05 2020-12-15 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11426401B2 (en) 2013-11-05 2022-08-30 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11090300B2 (en) 2013-11-05 2021-08-17 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11617728B2 (en) 2013-11-05 2023-04-04 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
US11213521B2 (en) 2013-11-05 2022-01-04 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
CA2936409C (en) 2014-02-14 2023-03-14 Mission Pharmacal Company Spray delivery device
CA2936430C (en) 2014-02-14 2022-05-31 Mission Pharmacal Company Sprayable composition containing zinc oxide and a fluoro-olefin propellant
AU2015217275B2 (en) * 2014-02-14 2019-11-21 Mission Pharmacal Company Stabilized, sprayable emulsion containing active agent particles
JP6616780B2 (ja) * 2014-03-11 2019-12-04 デュポン ニュートリション ユーエスエー インコーポレイテッド 放出制御組成物及び方法
EP2957909B1 (en) 2014-06-18 2019-01-30 Ruprecht Keller Method for identifying of a biological sample of a mammal and composition for use in this method
CA2910865C (en) 2014-07-15 2016-11-29 Isa Odidi Compositions and methods for reducing overdose
US10441652B2 (en) 2014-08-21 2019-10-15 Braasch Biotech Llc Methods for improving immunological response in vaccinated animals
JP5941117B2 (ja) * 2014-10-17 2016-06-29 ダウ グローバル テクノロジーズ エルエルシー 徐放製剤
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
WO2016140906A1 (en) * 2015-03-02 2016-09-09 Graphene 3D Lab Inc. Thermoplastic composites comprising water-soluble peo graft polymers useful for 3-dimensional additive manufacturing
JP6466792B2 (ja) * 2015-07-03 2019-02-06 エスケー バイオファーマスティカルズ カンパニー リミテッド 注意欠陥／多動性障害（ａｄｈｄ）の治療方法
US10543174B2 (en) * 2016-04-25 2020-01-28 Synthon B.V. Modified release tablet composition comprising mirabegron
JP2019519487A (ja) 2016-05-05 2019-07-11 アクエスティブ セラピューティクス インコーポレイテッド 送達増強エピネフリン組成物
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
US10478399B2 (en) 2017-10-12 2019-11-19 Synthon B.V. Modified release tablet composition comprising mirabegron
WO2019087084A1 (en) 2017-11-02 2019-05-09 Eman Biodiscoveries Sd. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof
EP3846852A4 (en) * 2018-09-07 2022-06-15 R.P. Scherer Technologies, LLC SOLID OR SEMI-SOLID LIPID-BASED DOSAGE FORM BY HYDROGENATION AND ADDITION OF LOW-HLB TENSIDE(S).
US11291639B2 (en) 2018-09-20 2022-04-05 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11660273B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11660274B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US10925842B2 (en) 2019-01-07 2021-02-23 Antecip Bioventures Ii Llc Bupropion as a modulator of drug activity
WO2021001043A1 (de) 2019-07-04 2021-01-07 Monika Wetzke Ortsunabhängige einnahmekontrolle
CN111830151B (zh) * 2020-07-01 2021-05-04 迪沙药业集团有限公司 盐酸安非他酮组合物质量控制用系统适用性对照品
JP2023536094A (ja) 2020-07-28 2023-08-23 ノベルスター ファーマシューティカルズ， インコーポレイテッド 新規の胃内滞留性持続放出剤形
CN112646624A (zh) * 2020-11-30 2021-04-13 青岛科技大学 一种石墨烯复合水凝胶促进甲烷水合物高效生成的方法
WO2022271167A1 (en) * 2021-06-23 2022-12-29 Elite Pharmaceutical Solution Inc. Oral dosage form of ticagrelor and preparation method thereof
US11717518B1 (en) 2022-06-30 2023-08-08 Antecip Bioventures Ii Llc Bupropion dosage forms with reduced food and alcohol dosing effects
US11730706B1 (en) 2022-07-07 2023-08-22 Antecip Bioventures Ii Llc Treatment of depression in certain patient populations
WO2024073334A1 (en) 2022-09-26 2024-04-04 Rose Research Center, Llc Combination for use in a method of preventing weight gain

Family Cites Families (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US459208A (en) 1891-09-08 Mechanical movement
US3117967A (en) 1962-04-02 1964-01-14 Smith Kline French Lab 2-biphenylyl-2-hydroxy-morpholinium halides
US4132753A (en) 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US4344431A (en) 1969-03-24 1982-08-17 University Of Delaware Polymeric article for dispensing drugs
BE759838A (fr) 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
GB1340032A (en) 1969-12-04 1973-12-05 Wellcome Found Biologically active ketones
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3989586A (en) 1973-05-11 1976-11-02 The Dow Chemical Company Absorbent paper products and method of preparation
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
US3992652A (en) 1974-09-09 1976-11-16 Gte Sylvania Incorporated Bulk electrical surge arrester
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4036788A (en) 1975-02-11 1977-07-19 Plastomedical Sciences, Inc. Anionic hydrogels based on heterocyclic N-vinyl monomers
US4021492A (en) 1975-03-24 1977-05-03 Sandoz, Inc. Dibromination process
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
SE414305B (sv) 1976-08-25 1980-07-21 Astra Laekemedel Ab Analogiforfarande for framstellning av eventuellt substituerade 2-amino-6-fenyl-5,5dimetyl 3-hexanon med antidepressiv aktivitet
US4318791A (en) 1977-12-22 1982-03-09 Ciba-Geigy Corporation Use of aromatic-aliphatic ketones as photo sensitizers
US4230687A (en) 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4235236A (en) 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4347257A (en) 1979-10-09 1982-08-31 Burroughs Wellcome Co. Prolactin suppression in mammals
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4435449A (en) 1981-05-14 1984-03-06 Burroughs Wellcome Co. Treatment of minimal brain dysfunction (MBD)
US4425363A (en) 1981-05-14 1984-01-10 Burroughs Wellcome Co. Treatment of tardive dyskinesia in mammals
US4393078A (en) 1982-03-15 1983-07-12 Burroughs Wellcome Co. Bupropion and ethanol
US4421736A (en) 1982-05-20 1983-12-20 Merrel Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
KR850001149A (ko) 1983-02-03 1985-03-16 마이클 피터 잭슨 2-3차-부틸아미노-3'-클로로프로피오페논 말레에이트의 제조방법
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4576604A (en) 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
USRE33994E (en) 1983-08-16 1992-07-14 Burroughs Wellcome Co. Pharmaceutical delivery system
FR2553413B1 (fr) 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
EP0147479A1 (en) 1983-12-23 1985-07-10 Merck & Co. Inc. A water and drug delivery system for suppository use
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
GB8417170D0 (en) 1984-07-05 1984-08-08 Wellcome Found Heterocyclic pharmaceutical compounds
US4629621A (en) 1984-07-23 1986-12-16 Zetachron, Inc. Erodible matrix for sustained release bioactive composition
US4507323A (en) 1984-07-25 1985-03-26 Burroughs Wellcome Co. Treatment of psychosexual dysfunctions
US4769027A (en) 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
FR2569185B1 (fr) 1984-08-20 1986-09-05 Lafon Labor Derives de 1-(aminophenyl)-2-amino-ethanone, procede de preparation et utilisation en therapeutique
FR2569184A1 (fr) 1984-08-20 1986-02-21 Lafon Labor Derives de 1-(aminophenyl) therapeutique et leur procede de preparation
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
GB8613689D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
ATE107857T1 (de) 1986-06-10 1994-07-15 Euro Celtique Sa Zusammensetzung mit kontrollierter freisetzung von dihydrocodein.
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4970075A (en) 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
GB8626098D0 (en) 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US4886668A (en) 1987-09-24 1989-12-12 Merck & Co., Inc. Multiparticulate controlled porosity osmotic pump
US4816263A (en) 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
US4959208A (en) 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
JP2681373B2 (ja) 1988-07-18 1997-11-26 塩野義製薬株式会社 徐放性製剤の製造法
US5612059A (en) 1988-08-30 1997-03-18 Pfizer Inc. Use of asymmetric membranes in delivery devices
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
US5178868A (en) 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5126145A (en) 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
EP0418596A3 (en) 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5071607A (en) 1990-01-31 1991-12-10 Alza Corporatino Method and apparatus for forming a hole in a drug dispensing device
IE65045B1 (en) 1990-04-28 1995-10-04 Takeda Chemical Industries Ltd Granulated preparations and method of producing the same
US5183690A (en) 1990-06-25 1993-02-02 The United States Of America, As Represented By The Secretary Of Agriculture Starch encapsulation of biologically active agents by a continuous process
DE4031881C2 (de) 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
US5403593A (en) 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
US5273758A (en) 1991-03-18 1993-12-28 Sandoz Ltd. Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms
DE4138513A1 (de) 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5260068A (en) 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
US5350584A (en) 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JPH0657131A (ja) 1992-08-14 1994-03-01 Mitsubishi Petrochem Co Ltd 熱可塑性樹脂組成物
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
WO1994009898A1 (de) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
IL119660A (en) 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
IT1265074B1 (it) 1993-05-18 1996-10-30 Istituto Biochimico Italiano Composizione farmaceutica a lento rilascio contenente come sostanza attiva un acido biliare
US5541231A (en) * 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) * 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
KR100354702B1 (ko) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5476528A (en) 1993-12-20 1995-12-19 Tennessee Valley Authority System for improving material release profiles
US5753712A (en) 1994-02-18 1998-05-19 Pinsker; Walter Treatment of migraine headaches and formulations
US5395626A (en) 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5698224A (en) * 1994-06-27 1997-12-16 Alza Corporation Tacrine therapy
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US5683720A (en) 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5945125A (en) 1995-02-28 1999-08-31 Temple University Controlled release tablet
US5698124A (en) 1995-05-18 1997-12-16 Lucent Technologies Inc. Magnesia fiber draw furnace
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US6096339A (en) 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US6271240B1 (en) * 1996-05-06 2001-08-07 David Lew Simon Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals
US5919826A (en) 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
GB9704064D0 (en) 1997-02-27 1997-04-16 Aromascan Plc Electronic circuits
PT996426E (pt) * 1997-06-05 2007-06-18 Bertex Pharma Gmbh Sistema multifásico
PT998271E (pt) 1997-06-06 2005-10-31 Depomed Inc Formas de dosagem oral de farmacos com retencao gastrica para a libertacao controlada de farmacos altamente soluveis
US5963263A (en) 1997-06-10 1999-10-05 Winbond Electronic Corp. Method and apparatus requiring fewer number of look-up tables for converting luminance-chrominance color space signals to RGB color space signals
ES2263211T3 (es) 1997-07-02 2006-12-01 Euro-Celtique S.A. Formulaciones de tramadol de liberacion sostenida estabilizada.
DE69828289T2 (de) 1997-08-11 2005-06-02 Alza Corp., Mountain View Dosierungsform für verzögerte Freisetzung eines Wirkstoffs
AU750808B2 (en) 1997-10-03 2002-07-25 Cary Medical Corporation Compositon for the treatment of nicotine addiction containing a nicotine receptor antagonist and an anti-depressant or anti-anxiety drug
US6652882B1 (en) 1997-10-06 2003-11-25 Intellipharmaceutics Corp Controlled release formulation containing bupropion
US6066339A (en) 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
US20060141036A1 (en) 1997-12-12 2006-06-29 Andrx Labs Llc HMG-CoA reductase inhibitor extended release formulation
US5968553A (en) 1997-12-30 1999-10-19 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and an inorganic acid stabilizer
US6221917B1 (en) * 1997-12-30 2001-04-24 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
EP1051163A2 (en) 1998-01-29 2000-11-15 Sepracor, Inc. Methods and compositions for aiding in smoking cessation and for treating pain and other disorders using optically pure (-)-bupropion
JP2002501890A (ja) * 1998-01-29 2002-01-22 セプラコア インコーポレーテッド 光学的に純粋な（＋）−ビュープロピオンの薬学的使用
EP1051167A1 (en) 1998-01-29 2000-11-15 Sepracor, Inc. Pharmaceutical uses of optically pure (-) -bupropion
WO1999038503A1 (en) 1998-01-29 1999-08-05 Sepracor Inc. Pharmacological uses of optically pure (+)-bupropion
US6365185B1 (en) 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6156342A (en) 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
US6236697B1 (en) 1998-05-28 2001-05-22 Integrated Device Technology, Inc. Clock recovery for multiple frequency input data
US6150420A (en) 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
US6153223A (en) 1998-06-05 2000-11-28 Watson Pharmaceuticals, Inc. Stabilized pharmaceutical compositions
US6096341A (en) 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
US6033686A (en) * 1998-10-30 2000-03-07 Pharma Pass Llc Controlled release tablet of bupropion hydrochloride
EP2311442A1 (en) 1998-11-02 2011-04-20 Elan Pharma International Limited Multiparticulate modified release composition
CA2350246C (en) * 1998-11-02 2010-04-27 Alza Corporation Controlled delivery of active agents
US6270805B1 (en) 1998-11-06 2001-08-07 Andrx Pharmaceuticals, Inc. Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate
PT1156791E (pt) 1998-12-08 2005-08-31 Planisphere Corp Bupropiona para tratar doencas virais
US6238697B1 (en) 1998-12-21 2001-05-29 Pharmalogix, Inc. Methods and formulations for making bupropion hydrochloride tablets using direct compression
US6342249B1 (en) * 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6734213B2 (en) 1999-01-20 2004-05-11 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
KR100697485B1 (ko) * 1999-02-24 2007-03-20 유니버시티 오브 신시내티 충동 자제 이상 치료를 위한 설파메이트 유도체의 용도
US6210716B1 (en) 1999-02-26 2001-04-03 Andrx Pharmaceuticals, Inc. Controlled release bupropion formulation
US20030035840A1 (en) 2001-02-08 2003-02-20 Boyong Li Controlled release oral dosage form
US8545880B2 (en) 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
US6589553B2 (en) * 2001-02-08 2003-07-08 Andrx Pharmaceuticals, Inc. Controlled release oral dosage form
US6337328B1 (en) 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
US6342496B1 (en) 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
US6280763B1 (en) 1999-05-10 2001-08-28 Pierce Management, Llc Apparatus and method for transdermal delivery of bupropion
SE9902386D0 (sv) 1999-06-22 1999-06-22 Astra Ab New formulation
ATE279186T1 (de) 1999-08-31 2004-10-15 Gruenenthal Gmbh Retardierte darreichungsform enthaltend tramadolsaccharinat
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6352721B1 (en) 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
AR026148A1 (es) 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
UY26615A1 (es) 2000-03-16 2001-10-25 Pfizer Prod Inc Inhibidor de la glucogeno fosforilasa.
SE0001151D0 (sv) 2000-03-31 2000-03-31 Amarin Dev Ab Method for producing a controlled-release composition
US6306436B1 (en) 2000-04-28 2001-10-23 Teva Pharmaceuticals Usa, Inc. Stabilized, acid-free formulation for sustained release of bupropion hydrochloride
GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
MXPA03001001A (es) * 2000-08-02 2003-10-14 Johnson & Johnson Derivados anticonvulsionantes utiles para el tratameinto de la depresion.
US6500457B1 (en) 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
US7241804B1 (en) * 2000-08-18 2007-07-10 Fred Hutchinson Cancer Research Center Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins
US6333332B1 (en) 2000-08-25 2001-12-25 Impax Laboratories, Inc. Stabilized pharmaceutical compositions containing bupropion hydrochloride
US6620439B1 (en) 2000-10-03 2003-09-16 Atul M. Mehta Chrono delivery formulations and method of use thereof
US6749867B2 (en) 2000-11-29 2004-06-15 Joseph R. Robinson Delivery system for omeprazole and its salts
US20030072807A1 (en) 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20020086054A1 (en) 2001-01-02 2002-07-04 Jiajiu Shaw Controlled release system that needs no drilling
US6780871B2 (en) 2001-01-29 2004-08-24 Albany Medical College Methods and compositions for treating addiction disorders
US20030175349A1 (en) 2001-01-30 2003-09-18 Council Of Scientific And Industrial Research Pharmaceutical compostion for extended/sustained release of a therapeutically active ingredient
US20050031670A1 (en) 2001-05-22 2005-02-10 Jamerson Brenda Diane Weight reduction or weight controlling composition
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US6960357B2 (en) 2001-05-25 2005-11-01 Mistral Pharma Inc. Chemical delivery device
US6668449B2 (en) 2001-06-25 2003-12-30 Micron Technology, Inc. Method of making a semiconductor device having an opening in a solder mask
IN192057B (ru) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
US20030044462A1 (en) * 2001-08-20 2003-03-06 Kali Laboratories, Inc. Sustained release tablets containing bupropion hydrochloride
US6582737B2 (en) * 2001-09-25 2003-06-24 Peirce Management, Llc Pharmaceutical composition containing two active ingredients for smoking cessation
JP2005535558A (ja) * 2001-09-28 2005-11-24 マクニール−ピーピーシー・インコーポレイテッド 改質した放出用の投薬形態
US7014868B2 (en) 2001-10-16 2006-03-21 Curators Of The University Of Missouri Hexameric complexes and their preparation
US8329217B2 (en) * 2001-11-06 2012-12-11 Osmotica Kereskedelmi Es Szolgaltato Kft Dual controlled release dosage form
US20030185882A1 (en) 2001-11-06 2003-10-02 Vergez Juan A. Pharmaceutical compositions containing oxybutynin
MXPA04004368A (es) * 2001-11-08 2004-08-11 Sepracor Inc Metodos para tratar depresion y otros transtornos del sistema nervioso central utilizando desmetil-y didesmetil-metabolitos del citalopram enantiomericamente enriquecidos.
US20040102440A1 (en) 2002-07-01 2004-05-27 Wong Erik Ho Fong Method of promoting smoking cessation
US20030158254A1 (en) * 2002-01-24 2003-08-21 Xenoport, Inc. Engineering absorption of therapeutic compounds via colonic transporters
MXPA04008100A (es) 2002-02-21 2005-06-17 Biovail Lab Int Srl Formulaciones de liberacion modificada de al menos una forma de tramadol.
CA2480415A1 (en) * 2002-04-10 2003-10-23 Esperion Therapeutics, Inc. Mimics of acyl coenzyme-a, compositions thereof, and methods of cholesterol management and related uses
IN192747B (ru) * 2002-04-15 2004-05-15 Ranbaxy Lab Ltd
CN1320886C (zh) 2002-05-17 2007-06-13 杜克大学 安非他酮与抗惊厥药在制备治疗肥胖症的药物的用途
TW200414900A (ru) 2002-06-28 2004-08-16
JP5084103B2 (ja) 2002-07-18 2012-11-28 サイトス バイオテクノロジー アーゲー ハプテン担体抱合体およびその用法
GB0218811D0 (en) 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
US20040115263A1 (en) 2002-08-26 2004-06-17 Robertson David W. Use of bupropion for treating restless legs syndrome
AU2003263556A1 (en) 2002-09-03 2004-03-29 Circ Pharma Research And Development Limited Pharmaceuticals formulations and methods for modified release of statin drugs
UA79011C2 (ru) * 2002-09-05 2007-05-10 Гвіда Енд К. С.П.А. Одноразовый самонагревающийся или самоохлаждающийся контейнер, преимущественно для напитков, и способ его осуществления
TR200301959T1 (tr) 2002-09-10 2004-10-21 Bös Eczacibaşi Özgün Ki̇myasal Ürünler San. Ve Ti̇c. A. Ş. Bupropion hidroklorürün hazırlanması için proses
EP1567131A1 (en) * 2002-11-15 2005-08-31 Ranbaxy Laboratories, Ltd. Bupropion hydrochloride solid dosage forms
US6893660B2 (en) 2002-11-21 2005-05-17 Andrx Pharmaceuticals, Inc. Stable pharmaceutical compositions without a stabilizer
AU2003298945A1 (en) 2002-12-10 2004-06-30 Cps Orocel Llc Method of preparing biologically active formulations
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
BRPI0408999A (pt) 2003-04-04 2006-03-28 Pharmacia Corp comprimidos prensados de multiparticulados de liberação oral prolongada
US20040254419A1 (en) * 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
ITMI20030762A1 (it) 2003-04-11 2004-10-12 Erregierre Spa Processo di cristallizzazione del bupropione cloridrato.
US8029822B2 (en) 2003-05-22 2011-10-04 Osmotica Kereskedelmi és Seolgáltató KFT Rupturing controlled release device having a preformed passageway
AU2004251636B2 (en) * 2003-05-27 2006-11-09 Merz Pharma Gmbh & Co. Kgaa Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders
IN2003MU00504A (ru) 2003-06-05 2005-05-13 Alembic Ltd
US20050186276A1 (en) 2003-07-17 2005-08-25 Pfizer Inc Pharmaceutical formulations
US20050031688A1 (en) 2003-08-04 2005-02-10 Ayala William J. Positive wakeup pharmaceutical sleep system with compatible pre-bedtime administration
PL196544B1 (pl) 2003-08-08 2008-01-31 Biovail Lab Int Srl Tabletka o zmodyfikowanym uwalnianiu
EP2343073A3 (en) 2003-12-11 2011-10-12 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
US20050250838A1 (en) 2004-05-04 2005-11-10 Challapalli Prasad V Formulation for sustained delivery
EP1755557A4 (en) 2004-05-19 2007-08-29 Glatt Air Tech Inc GRANULES CONTAINING MICROGRANULES AND PROCESS FOR THE PREPARATION THEREOF
US20070212428A1 (en) * 2004-06-04 2007-09-13 Mood Management Sciences, Inc. Methods and compositions for treating mood disorder
WO2005120523A1 (en) * 2004-06-04 2005-12-22 Mood Management Sciences, Llc Methods and compositions for treating mood disorder
US20060057206A1 (en) 2004-08-19 2006-03-16 Wong Patrick S Controlled release nanoparticle active agent formulation dosage forms and methods
US20060099262A1 (en) 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
US7645802B2 (en) 2005-06-27 2010-01-12 Biovail Laboratories International Srl. Bupropion hydrobromide and therapeutic applications
EP2474308A1 (en) 2005-06-27 2012-07-11 Valeant International (Barbados) SRL Pharmaceutical formulations containing bupropion hydrobromide
US7671094B2 (en) 2005-06-27 2010-03-02 Biovail Laboratories International S.R.L. Bupropion hydrobromide and therapeutic applications
AU2006308635A1 (en) * 2005-10-14 2007-05-10 H. Lundbeck A/S Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
WO2007078895A2 (en) 2005-12-30 2007-07-12 Biovail Laboratories International S.R.L. Modified release formulations of tramadol and uses thereof
US7818264B2 (en) 2006-06-19 2010-10-19 Visa U.S.A. Inc. Track data encryption
US20090004281A1 (en) 2007-06-26 2009-01-01 Biovail Laboratories International S.R.L. Multiparticulate osmotic delivery system
CA2934988A1 (en) 2008-08-07 2010-02-11 Valeant International Bermuda Bupropion hydrobromide polymorphs

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