TR200301959T1 - Bupropion hidroklorürün hazırlanması için proses - Google Patents
Bupropion hidroklorürün hazırlanması için prosesInfo
- Publication number
- TR200301959T1 TR200301959T1 TR2003/01959T TR200301959T TR200301959T1 TR 200301959 T1 TR200301959 T1 TR 200301959T1 TR 2003/01959 T TR2003/01959 T TR 2003/01959T TR 200301959 T TR200301959 T TR 200301959T TR 200301959 T1 TR200301959 T1 TR 200301959T1
- Authority
- TR
- Turkey
- Prior art keywords
- preparation
- bupropion hydrochloride
- bupropion
- butylamine
- tertiary
- Prior art date
Links
- IKBZAUYPBWFMDI-UHFFFAOYSA-N 5-bromo-4-methoxy-7-methyl-2,3-dihydro-1h-indene Chemical compound C1=C(Br)C(OC)=C2CCCC2=C1C IKBZAUYPBWFMDI-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004367 bupropion hydrochloride Drugs 0.000 title abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 2
- PQWGFUFROKIJBO-UHFFFAOYSA-N 1-(3-chlorophenyl)propan-1-one Chemical compound CCC(=O)C1=CC=CC(Cl)=C1 PQWGFUFROKIJBO-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229960001058 bupropion Drugs 0.000 abstract 1
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bu bulus, bupropion hidroklorürün hazirlanmasi ile ilgilidir.Bupropion serbest bazi elde edebilmek için 3'-kloropropiofenon' un tersiyer-butilamin varliginda brom ile reaksiyonu ve sonra hidroklorik asit ilavesi ile bupropion hidroklorür' ün elde edilmesi tanimlanmistir. Bulusun temel özelligi tersiyer-butilamin' in solvent ve reaktan olarak kullanilmasidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/TR2002/000057 WO2004024674A1 (en) | 2002-09-10 | 2002-09-10 | Process for the preparation of bupropion hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200301959T1 true TR200301959T1 (tr) | 2004-10-21 |
Family
ID=31989676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2003/01959T TR200301959T1 (tr) | 2002-09-10 | 2002-09-10 | Bupropion hidroklorürün hazırlanması için proses |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002337634A1 (tr) |
| TR (1) | TR200301959T1 (tr) |
| WO (1) | WO2004024674A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006261788B2 (en) | 2005-06-27 | 2012-05-31 | Valeant International Bermuda | Modified-release formulations of a bupropion salt |
| WO2008099418A2 (en) * | 2007-02-12 | 2008-08-21 | Alembic Limited | An improved process for preparing bupropion hydrochloride |
| CN100560563C (zh) | 2007-07-06 | 2009-11-18 | 浙江普洛医药科技有限公司 | 盐酸安非他酮的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2155194A (en) * | 1938-10-27 | 1939-04-18 | Kamlet Jonas | Preparation of alpha-alkylaminoacylophenones |
| US3885046A (en) * | 1969-12-04 | 1975-05-20 | Burroughs Wellcome Co | Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression |
| BE759838A (fr) * | 1969-12-04 | 1971-06-03 | Wellcome Found | Cetones a activite biologique |
-
2002
- 2002-09-10 TR TR2003/01959T patent/TR200301959T1/tr unknown
- 2002-09-10 AU AU2002337634A patent/AU2002337634A1/en not_active Abandoned
- 2002-09-10 WO PCT/TR2002/000057 patent/WO2004024674A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002337634A1 (en) | 2004-04-30 |
| WO2004024674A1 (en) | 2004-03-25 |
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