DE60303687D1 - Prozess zur herstellung von 6 alpa-fluorierten pregnanen - Google Patents
Prozess zur herstellung von 6 alpa-fluorierten pregnanenInfo
- Publication number
- DE60303687D1 DE60303687D1 DE60303687T DE60303687T DE60303687D1 DE 60303687 D1 DE60303687 D1 DE 60303687D1 DE 60303687 T DE60303687 T DE 60303687T DE 60303687 T DE60303687 T DE 60303687T DE 60303687 D1 DE60303687 D1 DE 60303687D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- pregnanes
- alpa
- fluorinated
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003128 pregnanes Chemical class 0.000 title 1
- ZSBRCARGLKISSY-TUXYUONUSA-N (6s,8s,9s,10r,13r,14s,17s)-17-ethyl-6-fluoro-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene Chemical class C1([C@@H](F)C2)CCCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 ZSBRCARGLKISSY-TUXYUONUSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02027534 | 2002-12-09 | ||
| PCT/EP2003/050925 WO2004052911A1 (en) | 2002-12-09 | 2003-12-02 | Process for the preparation of pregnanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60303687D1 true DE60303687D1 (de) | 2006-04-27 |
Family
ID=32479719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60303687T Expired - Lifetime DE60303687D1 (de) | 2002-12-09 | 2003-12-02 | Prozess zur herstellung von 6 alpa-fluorierten pregnanen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060252926A1 (de) |
| EP (1) | EP1474435B1 (de) |
| JP (1) | JP4481831B2 (de) |
| AT (1) | ATE318274T1 (de) |
| AU (1) | AU2003298339A1 (de) |
| CA (1) | CA2509366C (de) |
| DE (1) | DE60303687D1 (de) |
| IL (1) | IL169073A (de) |
| MX (1) | MXPA05006279A (de) |
| WO (1) | WO2004052911A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003047329A2 (en) | 2001-11-29 | 2003-06-12 | Taro Pharmaceuticals U.S.A., Inc. | Method for the preparation of 6-alpha-fluoro corticosteroids |
| ITMI20122200A1 (it) * | 2012-12-20 | 2014-06-21 | Trifarma Spa | Processo per la preparazione di 6-alfa-fluoro pregnani |
| CN103073613B (zh) * | 2012-12-31 | 2016-04-13 | 浙江工业大学 | 一种氟替卡松衍生物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2961441A (en) * | 1959-08-07 | 1960-11-22 | Pfizer & Co C | Process for producing 6beta-fluorosteroids |
| US3379743A (en) * | 1965-06-07 | 1968-04-23 | Sterling Drug Inc | 17-enol esters of 3-oxy-17-hydroxy-polyunsaturated steroids and preparation thereof |
| NL187577C (nl) * | 1978-04-05 | 1991-11-18 | Sibla Srl | 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen. |
| US4188322A (en) * | 1978-04-28 | 1980-02-12 | Blasinachim S.P.A. | Process for the preparation of 6-halo-pregnanes |
| FR2701262B1 (fr) * | 1993-02-05 | 1995-03-24 | Roussel Uclaf | Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires. |
| IT1319654B1 (it) * | 2000-11-15 | 2003-10-23 | Farmabios S R L Ora Farmabios | Processo di isomerizzazione di 6beta-fluoro steroidi neicorrispondenti 6alfa-fluoro derivati. |
| IT1319663B1 (it) * | 2000-11-17 | 2003-10-23 | Farmabios Srl | Processo per la preparazione di fluoro-steroidi. |
| PT102628B (pt) * | 2001-06-12 | 2010-09-09 | Hovione Farmaciencia S A | Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno |
-
2003
- 2003-12-02 WO PCT/EP2003/050925 patent/WO2004052911A1/en active Application Filing
- 2003-12-02 DE DE60303687T patent/DE60303687D1/de not_active Expired - Lifetime
- 2003-12-02 JP JP2004558103A patent/JP4481831B2/ja not_active Expired - Lifetime
- 2003-12-02 AT AT03796075T patent/ATE318274T1/de not_active IP Right Cessation
- 2003-12-02 EP EP03796075A patent/EP1474435B1/de not_active Expired - Lifetime
- 2003-12-02 AU AU2003298339A patent/AU2003298339A1/en not_active Abandoned
- 2003-12-02 CA CA002509366A patent/CA2509366C/en not_active Expired - Fee Related
- 2003-12-02 MX MXPA05006279A patent/MXPA05006279A/es active IP Right Grant
- 2003-12-02 US US10/537,916 patent/US20060252926A1/en not_active Abandoned
-
2005
- 2005-06-08 IL IL169073A patent/IL169073A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4481831B2 (ja) | 2010-06-16 |
| CA2509366A1 (en) | 2004-06-24 |
| ATE318274T1 (de) | 2006-03-15 |
| IL169073A (en) | 2010-04-15 |
| MXPA05006279A (es) | 2006-01-27 |
| WO2004052911A1 (en) | 2004-06-24 |
| CA2509366C (en) | 2008-04-15 |
| EP1474435B1 (de) | 2006-02-22 |
| JP2006515582A (ja) | 2006-06-01 |
| EP1474435A1 (de) | 2004-11-10 |
| US20060252926A1 (en) | 2006-11-09 |
| AU2003298339A1 (en) | 2004-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1023987A1 (en) | Sulphinic acid derivatives, method for producing, and their use | |
| DE69922703D1 (de) | Ureido-thiobuttersäurederivate als ppar-agonisten | |
| ATE317912T1 (de) | Verfahren zur herstellung von beta-lactamen | |
| DK1563041T3 (da) | Anvendelse af 2,6-di-tert-butyl-p-cresol til forögelse af lagerstabiliteten af biodiesel | |
| DE60120979D1 (de) | Verfahren zur herstellung von 4-thioalkylbrombenzol derivaten | |
| BR0115121A (pt) | Compostos n-((1,2,4)triazoloazinil)tiofenossulfonamida como herbicidas | |
| TR200001102T2 (tr) | İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları. | |
| DE60008400D1 (de) | Triazolopyrimidinderivate | |
| DE60303687D1 (de) | Prozess zur herstellung von 6 alpa-fluorierten pregnanen | |
| DE69925992D1 (de) | VERFAHREN ZUR HERSTELLUNG VON 5-HYDROXYBENZO[b]THIOPHEN-3-CARBONSÄURE | |
| DE60020130D1 (de) | Verfahren zur herstellung 3-amino-gallensaurer derivate | |
| CY1106051T1 (el) | ΔΙΑΔΙΚΑΣΙΑ ΓΙΑ ΤΗΝ ΠΑΡΑΓΩΓΗ Ν-ΠΡΟΣΤΑΤΕΥΜΕΝΩΝ ΑΖΕΤΙΔΙΝΟ-2-ΚΑΡΒΟΞΥΛΙΚΩΝ ΟΞΕΩΝ (AzeOHs) | |
| CO5540298A2 (es) | Proceso para preparar un ligando de ppar de tiazol y polimorfos del mismo | |
| DE60034672D1 (de) | Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle | |
| ATE260923T1 (de) | Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure | |
| SE0201938D0 (sv) | New process | |
| DE59502219D1 (de) | Verfahren zur Herstellung von 2-Amino-4,6-dichloro-pyrimidin | |
| ID27656A (id) | Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya | |
| BRPI0416411A (pt) | uso de deoxipeganina | |
| DE50203367D1 (de) | Verfahren zur herstellung von orthocarbonsäuretrialkylestern | |
| DE69612237T2 (de) | Verfahren zur Herstellung von alpha-Methyl-2-thiophenessigsäure-Derivaten | |
| DE69702171D1 (de) | Verfahren zur Herstellung von Aminoalkynen | |
| DE60308170D1 (de) | Verfahren zur herstellung von chinolinderivaten | |
| EE200100242A (et) | Alfa-arüülalkaanhapete valmistamismeetod | |
| SE9901712D0 (sv) | New process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |