ATE318274T1 - Prozess zur herstellung von 6 alpa-fluorierten pregnanen - Google Patents

Prozess zur herstellung von 6 alpa-fluorierten pregnanen

Info

Publication number
ATE318274T1
ATE318274T1 AT03796075T AT03796075T ATE318274T1 AT E318274 T1 ATE318274 T1 AT E318274T1 AT 03796075 T AT03796075 T AT 03796075T AT 03796075 T AT03796075 T AT 03796075T AT E318274 T1 ATE318274 T1 AT E318274T1
Authority
AT
Austria
Prior art keywords
pregnans
alpa
fluorinated
producing
formula
Prior art date
Application number
AT03796075T
Other languages
English (en)
Inventor
Peter Macdonald
Pierluigi Rossetto
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE318274T1 publication Critical patent/ATE318274T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03796075T 2002-12-09 2003-12-02 Prozess zur herstellung von 6 alpa-fluorierten pregnanen ATE318274T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02027534 2002-12-09

Publications (1)

Publication Number Publication Date
ATE318274T1 true ATE318274T1 (de) 2006-03-15

Family

ID=32479719

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03796075T ATE318274T1 (de) 2002-12-09 2003-12-02 Prozess zur herstellung von 6 alpa-fluorierten pregnanen

Country Status (10)

Country Link
US (1) US20060252926A1 (de)
EP (1) EP1474435B1 (de)
JP (1) JP4481831B2 (de)
AT (1) ATE318274T1 (de)
AU (1) AU2003298339A1 (de)
CA (1) CA2509366C (de)
DE (1) DE60303687D1 (de)
IL (1) IL169073A (de)
MX (1) MXPA05006279A (de)
WO (1) WO2004052911A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162140A0 (en) 2001-11-29 2005-11-20 Taro Pharmaceuticals Usa Inc Method for the preparation of l-alpha-fluoro corticosteroids
ITMI20122200A1 (it) * 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani
CN103073613B (zh) * 2012-12-31 2016-04-13 浙江工业大学 一种氟替卡松衍生物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2961441A (en) * 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3379743A (en) * 1965-06-07 1968-04-23 Sterling Drug Inc 17-enol esters of 3-oxy-17-hydroxy-polyunsaturated steroids and preparation thereof
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
IT1319654B1 (it) * 2000-11-15 2003-10-23 Farmabios S R L Ora Farmabios Processo di isomerizzazione di 6beta-fluoro steroidi neicorrispondenti 6alfa-fluoro derivati.
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno

Also Published As

Publication number Publication date
US20060252926A1 (en) 2006-11-09
EP1474435A1 (de) 2004-11-10
DE60303687D1 (de) 2006-04-27
AU2003298339A1 (en) 2004-06-30
JP4481831B2 (ja) 2010-06-16
WO2004052911A1 (en) 2004-06-24
MXPA05006279A (es) 2006-01-27
CA2509366A1 (en) 2004-06-24
EP1474435B1 (de) 2006-02-22
IL169073A (en) 2010-04-15
JP2006515582A (ja) 2006-06-01
CA2509366C (en) 2008-04-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties