DE60121425D1 - Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin - Google Patents

Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin

Info

Publication number
DE60121425D1
DE60121425D1 DE60121425T DE60121425T DE60121425D1 DE 60121425 D1 DE60121425 D1 DE 60121425D1 DE 60121425 T DE60121425 T DE 60121425T DE 60121425 T DE60121425 T DE 60121425T DE 60121425 D1 DE60121425 D1 DE 60121425D1
Authority
DE
Germany
Prior art keywords
deoxy
fluoro
chloro
arabinofuranosyl
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60121425T
Other languages
English (en)
Other versions
DE60121425T2 (de
Inventor
A Montgomery
T Fowler
A Secrist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Research Institute
Original Assignee
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Research Institute filed Critical Southern Research Institute
Publication of DE60121425D1 publication Critical patent/DE60121425D1/de
Application granted granted Critical
Publication of DE60121425T2 publication Critical patent/DE60121425T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60121425T 2000-02-18 2001-02-16 Verfahren zur Herstellung von 2-Chlor-9-(2-deoxy-2-flour-ß-D-arabinofuranosyl)-9H-purin-6-amin Expired - Lifetime DE60121425T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18342200P 2000-02-18 2000-02-18
US183422P 2000-02-18
PCT/US2001/005320 WO2001060383A1 (en) 2000-02-18 2001-02-16 METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE

Publications (2)

Publication Number Publication Date
DE60121425D1 true DE60121425D1 (de) 2006-08-24
DE60121425T2 DE60121425T2 (de) 2007-02-01

Family

ID=22672724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60121425T Expired - Lifetime DE60121425T2 (de) 2000-02-18 2001-02-16 Verfahren zur Herstellung von 2-Chlor-9-(2-deoxy-2-flour-ß-D-arabinofuranosyl)-9H-purin-6-amin

Country Status (15)

Country Link
US (2) US6949640B2 (de)
EP (1) EP1261350B1 (de)
JP (2) JP4555536B2 (de)
KR (1) KR100695717B1 (de)
AT (1) ATE332910T1 (de)
AU (2) AU2001238516B2 (de)
CA (1) CA2400470C (de)
CY (1) CY1105636T1 (de)
DE (1) DE60121425T2 (de)
DK (1) DK1261350T3 (de)
ES (1) ES2267725T3 (de)
MX (1) MXPA02008075A (de)
NZ (1) NZ520852A (de)
PT (1) PT1261350E (de)
WO (1) WO2001060383A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001238516B2 (en) * 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
ES2306783T3 (es) 2001-08-02 2008-11-16 Ilex Oncology, Inc. Procedimiento para preparar nucleosidos purinicos.
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
AU2006259431B2 (en) * 2005-06-14 2011-09-29 Brigham Young University Methods for selective N-9 glycosylation of purines
EP2070938A1 (de) 2007-12-13 2009-06-17 Heidelberg Pharma AG Clofarabin-Dietherphospholipid-Derivate
CN101497640B (zh) * 2008-01-30 2011-09-14 江苏正大天晴药业股份有限公司 一种氯法拉滨的晶型
CN102311472B (zh) * 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
WO2015118558A2 (en) * 2014-02-04 2015-08-13 Msn Laboratories Private Limited Process for the preparation of clofarabine
EP2937420A1 (de) 2014-04-23 2015-10-28 Synbias Pharma AG Verfahren zur Synthese von Clofarabin
WO2018085307A1 (en) * 2016-11-03 2018-05-11 Wu Laurence I Prodrugs of clofarabine

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903073A (en) * 1973-12-26 1975-09-02 Abbott Lab 2-Substituted adenosine-5{40 {0 carboxylates
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
EP0267878A1 (de) * 1986-11-14 1988-05-18 Ciba-Geigy Ag N9-Cyclopentylsubstituierte Adeninderivate
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
ATE128141T1 (de) * 1988-03-16 1995-10-15 Scripps Research Inst Als therapeutische mittel verwendbare substituierte adeninderivate.
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
US5180824A (en) * 1990-11-29 1993-01-19 Berlex Biosciences Inc. 6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
UA41261C2 (uk) 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5401838A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
FI932871A (fi) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anjonglykosylationsprocess
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
AU2001238516B2 (en) * 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine

Also Published As

Publication number Publication date
EP1261350A4 (de) 2003-04-16
US7470784B2 (en) 2008-12-30
EP1261350B1 (de) 2006-07-12
CA2400470C (en) 2008-11-18
WO2001060383A1 (en) 2001-08-23
JP2003522798A (ja) 2003-07-29
DK1261350T3 (da) 2006-11-13
JP4555536B2 (ja) 2010-10-06
DE60121425T2 (de) 2007-02-01
ES2267725T3 (es) 2007-03-16
KR100695717B1 (ko) 2007-03-15
NZ520852A (en) 2004-03-26
US20030023078A1 (en) 2003-01-30
EP1261350A1 (de) 2002-12-04
AU3851601A (en) 2001-08-27
MXPA02008075A (es) 2005-06-06
CA2400470A1 (en) 2001-08-23
AU2001238516B2 (en) 2005-08-04
JP2010070560A (ja) 2010-04-02
KR20030032920A (ko) 2003-04-26
US6949640B2 (en) 2005-09-27
PT1261350E (pt) 2006-11-30
CY1105636T1 (el) 2010-12-22
ATE332910T1 (de) 2006-08-15
US20050288500A1 (en) 2005-12-29

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