CY1105636T1 - Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης - Google Patents

Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης

Info

Publication number
CY1105636T1
CY1105636T1 CY20061101407T CY061101407T CY1105636T1 CY 1105636 T1 CY1105636 T1 CY 1105636T1 CY 20061101407 T CY20061101407 T CY 20061101407T CY 061101407 T CY061101407 T CY 061101407T CY 1105636 T1 CY1105636 T1 CY 1105636T1
Authority
CY
Cyprus
Prior art keywords
deoxy
fluoro
chloro
purine
amine
Prior art date
Application number
CY20061101407T
Other languages
English (en)
Inventor
John A. Montgomery
Anita T. Fowler
John A. Secrist, Iii
Original Assignee
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Research Institute filed Critical Southern Research Institute
Publication of CY1105636T1 publication Critical patent/CY1105636T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η 2-χλωρο-9-(2-δεοξυ-2-φθορο-β-D-αραβινοφουρασυλ)-9H -πουριν-6-αμίνης συνθέτεται με την αντίδραση μίας 2-χλωρο-6-υποκατεστημένης πουρίνης με μία προστατευμένη και ενεργοποιημένη 2-δεοξυ-2-φθορο-D-αραβινοφουρανόση και αντιδρά με μία βάση όπως η αμμωνία ώστε να προκύψει η 2-χλωρο-9-(2-δεοξύ-2-φθορο-β-D-αραβινοφουρασυλ)-9Η-πουριν-6-αμίνη. Όταν η αντίδραση της πουρίνης αντικαθίσταται στη θέση 6 με ένα αλογόνο, ένα βήμα αντίδρασης με ένα αλκοξείδιο πραγματοποιείται πριν την αντίδραση με την αμμωνία.
CY20061101407T 2000-02-18 2006-09-28 Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης CY1105636T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18342200P 2000-02-18 2000-02-18
PCT/US2001/005320 WO2001060383A1 (en) 2000-02-18 2001-02-16 METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE

Publications (1)

Publication Number Publication Date
CY1105636T1 true CY1105636T1 (el) 2010-12-22

Family

ID=22672724

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101407T CY1105636T1 (el) 2000-02-18 2006-09-28 Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης

Country Status (15)

Country Link
US (2) US6949640B2 (el)
EP (1) EP1261350B1 (el)
JP (2) JP4555536B2 (el)
KR (1) KR100695717B1 (el)
AT (1) ATE332910T1 (el)
AU (2) AU2001238516B2 (el)
CA (1) CA2400470C (el)
CY (1) CY1105636T1 (el)
DE (1) DE60121425T2 (el)
DK (1) DK1261350T3 (el)
ES (1) ES2267725T3 (el)
MX (1) MXPA02008075A (el)
NZ (1) NZ520852A (el)
PT (1) PT1261350E (el)
WO (1) WO2001060383A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US6680382B2 (en) 2001-08-02 2004-01-20 Ilex Products, Inc. Process for preparing purine nucleosides
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
CA2653247C (en) * 2005-06-14 2012-12-18 Brigham Young University Methods for selective n-9 glycosylation of purines
EP2070938A1 (en) 2007-12-13 2009-06-17 Heidelberg Pharma AG Clofarabine dietherphospholipid derivatives
CN101497640B (zh) * 2008-01-30 2011-09-14 江苏正大天晴药业股份有限公司 一种氯法拉滨的晶型
CN102311472B (zh) * 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
WO2015118558A2 (en) * 2014-02-04 2015-08-13 Msn Laboratories Private Limited Process for the preparation of clofarabine
EP2937420A1 (en) 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
WO2018085307A1 (en) * 2016-11-03 2018-05-11 Wu Laurence I Prodrugs of clofarabine

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903073A (en) * 1973-12-26 1975-09-02 Abbott Lab 2-Substituted adenosine-5{40 {0 carboxylates
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
ATE128141T1 (de) * 1988-03-16 1995-10-15 Scripps Research Inst Als therapeutische mittel verwendbare substituierte adeninderivate.
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
US5180824A (en) * 1990-11-29 1993-01-19 Berlex Biosciences Inc. 6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Also Published As

Publication number Publication date
CA2400470A1 (en) 2001-08-23
US20050288500A1 (en) 2005-12-29
DE60121425T2 (de) 2007-02-01
PT1261350E (pt) 2006-11-30
NZ520852A (en) 2004-03-26
AU2001238516B2 (en) 2005-08-04
KR20030032920A (ko) 2003-04-26
EP1261350A1 (en) 2002-12-04
KR100695717B1 (ko) 2007-03-15
AU3851601A (en) 2001-08-27
JP2010070560A (ja) 2010-04-02
ATE332910T1 (de) 2006-08-15
CA2400470C (en) 2008-11-18
ES2267725T3 (es) 2007-03-16
EP1261350A4 (en) 2003-04-16
US20030023078A1 (en) 2003-01-30
EP1261350B1 (en) 2006-07-12
DK1261350T3 (da) 2006-11-13
JP4555536B2 (ja) 2010-10-06
JP2003522798A (ja) 2003-07-29
WO2001060383A1 (en) 2001-08-23
US6949640B2 (en) 2005-09-27
DE60121425D1 (de) 2006-08-24
US7470784B2 (en) 2008-12-30
MXPA02008075A (es) 2005-06-06

Similar Documents

Publication Publication Date Title
CY1105636T1 (el) Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης
BR0211169A (pt) Processo para preparação de derivados de amidina
HUP0001843A2 (hu) Eljárás nukleozid analógok szintézisére
CY1106125T1 (el) Ενωσεις πυρρολινης υποκατεστημενες με ινδαζολυλιο ως αναστολεις κινασης
BR0208126A (pt) Conjugados de ingrediente ativo de has
FR2733244B1 (fr) Systeme de stabilisants a base de derives de polyalkylpiperidine
RS49673B (sr) Inhibitori sintaze azot-monoksida
DE59903442D1 (de) Azidfreie, gaserzeugende Zusammensetzung
ATE292628T1 (de) Chinazolinderivate
CY1105387T1 (el) Υποκατεστημενα παραγωγα 2-διαλκυλαμινοαλκυλοδιφαινθλιου
CY1107681T1 (el) Χρηση παραγωγων τροπινεστερα για την παραγωγη φαρμακευτικων μεσων
CY1106745T1 (el) Μικροσφαιριδια που περιεχουν ενα παραγωγο πλευρομουτιλινης
AU4913800A (en) Method for condensing polyamides
IT1307787B1 (it) Processo per incrementare la motilita' degli spermatozoi e spermatozoia motilita' superiore cosi' ottenuti.
NO981658L (no) Kondensert piperidinforbindelse
GT199700118A (es) Procedimiento para piridinas sustituidas.
CO4940435A1 (es) Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6- (ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol o un solvato del mismo
CY1105345T1 (el) Φαινυλαλκινια
CY1117806T1 (el) Διαταξη ελατηριου αεριου με προστατευτικο χιτωνιο που τοποθετειται πριν το βαψιμο
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
BR9808740A (pt) Método para fabricação de sertindol
EP1433782A4 (en) PROCESS FOR PRODUCING A PIPECOLAMIDE DERIVATIVE
AP2001002207A0 (en) Antiviral nucleoside analogues.
DE60026769D1 (de) Rückhaltesystem mit mehrstufigem Gasgenerator
DK0625985T3 (da) Fremgangsmåde og ringåbnede purinforbindelser til mærkning af polynukleotider