DK1261350T3 - Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin - Google Patents

Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin

Info

Publication number
DK1261350T3
DK1261350T3 DK01910961T DK01910961T DK1261350T3 DK 1261350 T3 DK1261350 T3 DK 1261350T3 DK 01910961 T DK01910961 T DK 01910961T DK 01910961 T DK01910961 T DK 01910961T DK 1261350 T3 DK1261350 T3 DK 1261350T3
Authority
DK
Denmark
Prior art keywords
deoxy
fluoro
chloro
arabinofuranosyl
purin
Prior art date
Application number
DK01910961T
Other languages
Danish (da)
English (en)
Inventor
John A Montgomery
Anita T Fowler
John A Secrist Iii
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of DK1261350T3 publication Critical patent/DK1261350T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01910961T 2000-02-18 2001-02-16 Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin DK1261350T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18342200P 2000-02-18 2000-02-18

Publications (1)

Publication Number Publication Date
DK1261350T3 true DK1261350T3 (da) 2006-11-13

Family

ID=22672724

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01910961T DK1261350T3 (da) 2000-02-18 2001-02-16 Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin

Country Status (15)

Country Link
US (2) US6949640B2 (el)
EP (1) EP1261350B1 (el)
JP (2) JP4555536B2 (el)
KR (1) KR100695717B1 (el)
AT (1) ATE332910T1 (el)
AU (2) AU3851601A (el)
CA (1) CA2400470C (el)
CY (1) CY1105636T1 (el)
DE (1) DE60121425T2 (el)
DK (1) DK1261350T3 (el)
ES (1) ES2267725T3 (el)
MX (1) MXPA02008075A (el)
NZ (1) NZ520852A (el)
PT (1) PT1261350E (el)
WO (1) WO2001060383A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02008075A (es) * 2000-02-18 2005-06-06 Southern Res Inst Metodos para sintetizar 2-cloro -9-(2 -deoxi-2 -fluoro -beta- arabinofura-nosil)- 9h- purin- 6-amina.
US7528247B2 (en) 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
DE60226447D1 (de) 2001-08-02 2008-06-19 Ilex Oncology Inc Verfahren zur herstellung von purinnukleosiden
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
EP1895841A4 (en) * 2005-06-14 2010-08-18 Univ Brigham Young METHODS OF SELECTIVE N-9 GLYCOSYLATION OF PURINES
EP2070938A1 (en) 2007-12-13 2009-06-17 Heidelberg Pharma AG Clofarabine dietherphospholipid derivatives
CN101497640B (zh) * 2008-01-30 2011-09-14 江苏正大天晴药业股份有限公司 一种氯法拉滨的晶型
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
WO2015118558A2 (en) * 2014-02-04 2015-08-13 Msn Laboratories Private Limited Process for the preparation of clofarabine
EP2937420A1 (en) 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
CN110325542A (zh) * 2016-11-03 2019-10-11 劳伦斯·I·吴 克罗拉滨的前体药物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903073A (en) * 1973-12-26 1975-09-02 Abbott Lab 2-Substituted adenosine-5{40 {0 carboxylates
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
NZ226672A (en) 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
KR0138996B1 (ko) * 1988-03-16 1998-04-30 레이몬드 에이치. 칸 치환된 아데닌 유도체 및 이를 함유하는 약제학적 조성물
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
US5180824A (en) * 1990-11-29 1993-01-19 Berlex Biosciences Inc. 6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
US5401838A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
HUT64359A (en) * 1992-06-22 1993-12-28 Lilly Co Eli A stereoselective glycosyling procedure
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
MXPA02008075A (es) * 2000-02-18 2005-06-06 Southern Res Inst Metodos para sintetizar 2-cloro -9-(2 -deoxi-2 -fluoro -beta- arabinofura-nosil)- 9h- purin- 6-amina.

Also Published As

Publication number Publication date
PT1261350E (pt) 2006-11-30
NZ520852A (en) 2004-03-26
AU2001238516B2 (en) 2005-08-04
CA2400470C (en) 2008-11-18
AU3851601A (en) 2001-08-27
MXPA02008075A (es) 2005-06-06
ES2267725T3 (es) 2007-03-16
US7470784B2 (en) 2008-12-30
US6949640B2 (en) 2005-09-27
KR100695717B1 (ko) 2007-03-15
ATE332910T1 (de) 2006-08-15
DE60121425D1 (de) 2006-08-24
CY1105636T1 (el) 2010-12-22
JP4555536B2 (ja) 2010-10-06
US20030023078A1 (en) 2003-01-30
KR20030032920A (ko) 2003-04-26
WO2001060383A1 (en) 2001-08-23
EP1261350A4 (en) 2003-04-16
US20050288500A1 (en) 2005-12-29
JP2003522798A (ja) 2003-07-29
CA2400470A1 (en) 2001-08-23
EP1261350B1 (en) 2006-07-12
JP2010070560A (ja) 2010-04-02
DE60121425T2 (de) 2007-02-01
EP1261350A1 (en) 2002-12-04

Similar Documents

Publication Publication Date Title
CY1105636T1 (el) Μεθοδοι για τη συνθεση της 2-χλωρο-9-(δεοξυ-2-φθορο-βητα -d-αραβινοφουρανοσυλ)-6h-πουριν-6-αμινης
UA83910C2 (ru) Способ получения 5-гидрокси-4-тиометилпиразольного соединения
WO2002024902A1 (fr) Procede permettant de synthetiser un polynucleotide
MXPA04002993A (es) Compuestos de espiro-hidantoina utiles como agentes anti-inflamatorios.
DE602006005741D1 (de) Verfahren zur Herstellung von Boranen
MXPA03008076A (es) Isoflavonas dimericas.
MXPA03009548A (es) Arilsulfonamidas como agentes antivirales.
TW200508178A (en) Process for continuously preparing alkylamino(meth)-acrylamides
HU0302444D0 (en) Process for monomethylation of nitrogen containing heterocyclic compounds
BR0115121A (pt) Compostos n-((1,2,4)triazoloazinil)tiofenossulfonamida como herbicidas
MXPA03009215A (es) Proceso para producir tiosemicarbazidas.
MXPA04003884A (es) Metodo y aparato para preparar hudrazo-dicarbonamida utilizando urea como materia inicial.
ITMI20020933A1 (it) Procedimento per la sintesi di clopidogrel
AU2003261853A1 (en) Process for preparing azo compound
PT1019347E (pt) Metodo para a sintese de taxanos
WO2002055026A3 (en) Perfluoro sulfonyl halides and related species as polymer support modifiers
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona
GB0112748D0 (en) Uncatalysed addition reactions
EP1010695A4 (en) METHOD FOR PRODUCING CHINAZOLINE DERIVATIVES
SE9802939D0 (sv) New process
NO20010625D0 (no) Fremgangsmåte for fremstilling av atropasyreetylester
DK1007517T3 (da) Fremgangsmåde til fremstilling af 5-hydroxymethylthiazoler
WO2002102769A3 (en) Methods for synthesizing substituted pyrimidines
ES2161602B1 (es) Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
ES2194745T3 (es) Procedimiento para la obtencion de 4,6-dicloropirimidi-na.