WO2002102769A3 - Methods for synthesizing substituted pyrimidines - Google Patents

Methods for synthesizing substituted pyrimidines Download PDF

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Publication number
WO2002102769A3
WO2002102769A3 PCT/US2002/019399 US0219399W WO02102769A3 WO 2002102769 A3 WO2002102769 A3 WO 2002102769A3 US 0219399 W US0219399 W US 0219399W WO 02102769 A3 WO02102769 A3 WO 02102769A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
substituted
pyrimidone
amino
substituted pyrimidines
Prior art date
Application number
PCT/US2002/019399
Other languages
French (fr)
Other versions
WO2002102769A2 (en
Inventor
Chengxin Zhi
Zheng-Yu Long
George E Wright
Andrzej Manikowski
Original Assignee
Univ Massachusetts
Chengxin Zhi
Zheng-Yu Long
George E Wright
Andrzej Manikowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massachusetts, Chengxin Zhi, Zheng-Yu Long, George E Wright, Andrzej Manikowski filed Critical Univ Massachusetts
Priority to AU2002344813A priority Critical patent/AU2002344813A1/en
Publication of WO2002102769A2 publication Critical patent/WO2002102769A2/en
Publication of WO2002102769A3 publication Critical patent/WO2002102769A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of preparing N3-substituted-4-pyrimidones are disclosed. The methods include combining a 4-pyrimidone and a non-aqueous base, followed by an alkylating agent, for a time sufficient for the pyrimidone and the alkylating agent to react. Methods of preparing an N3-substituted-6-(substituted amino)uracil are also disclosed. The methods include (a) combining an N3-substituted-2-alkoxy-6-amino-4-pyrimidone with an amine compound selected from the group consisting of an amine salt and the corresponding free amine, to form a reaction mixture; and (b) heating the reaction mixture to at least 80°C for a time sufficient for the N3-substituted-2-alkoxy-6-amino-4-pyrimidone and the amine compound to react to form the final product.
PCT/US2002/019399 2001-06-15 2002-06-17 Methods for synthesizing substituted pyrimidines WO2002102769A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002344813A AU2002344813A1 (en) 2001-06-15 2002-06-17 Methods for synthesizing substituted pyrimidines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29843601P 2001-06-15 2001-06-15
US60/298,436 2001-06-15

Publications (2)

Publication Number Publication Date
WO2002102769A2 WO2002102769A2 (en) 2002-12-27
WO2002102769A3 true WO2002102769A3 (en) 2003-03-20

Family

ID=23150503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019399 WO2002102769A2 (en) 2001-06-15 2002-06-17 Methods for synthesizing substituted pyrimidines

Country Status (2)

Country Link
AU (1) AU2002344813A1 (en)
WO (1) WO2002102769A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201891009A1 (en) 2013-06-21 2018-09-28 Миокардиа, Инк. CONNECTIONS OF PYRIMIDINDION
WO2014205234A1 (en) 2013-06-21 2014-12-24 MyoKardia, Inc. Cycloalkyl-substituted pyrimidinedione compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162326A (en) * 1990-02-15 1992-11-10 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
US6344460B1 (en) * 1999-03-19 2002-02-05 Lonza Inc. Propynyl uracils

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162326A (en) * 1990-02-15 1992-11-10 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
US6344460B1 (en) * 1999-03-19 2002-02-05 Lonza Inc. Propynyl uracils

Also Published As

Publication number Publication date
AU2002344813A1 (en) 2003-01-02
WO2002102769A2 (en) 2002-12-27

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