ATE292628T1 - Chinazolinderivate - Google Patents
ChinazolinderivateInfo
- Publication number
- ATE292628T1 ATE292628T1 AT00962682T AT00962682T ATE292628T1 AT E292628 T1 ATE292628 T1 AT E292628T1 AT 00962682 T AT00962682 T AT 00962682T AT 00962682 T AT00962682 T AT 00962682T AT E292628 T1 ATE292628 T1 AT E292628T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- quinazoline derivatives
- aurora
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catching Or Destruction (AREA)
- Ropes Or Cables (AREA)
- Earth Drilling (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922173.1A GB9922173D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
| PCT/GB2000/003562 WO2001021595A1 (en) | 1999-09-21 | 2000-09-18 | Quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE292628T1 true ATE292628T1 (de) | 2005-04-15 |
Family
ID=10861219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00962682T ATE292628T1 (de) | 1999-09-21 | 2000-09-18 | Chinazolinderivate |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7105669B1 (de) |
| EP (1) | EP1218357B1 (de) |
| JP (1) | JP2003509498A (de) |
| KR (1) | KR20020029136A (de) |
| CN (1) | CN1391560A (de) |
| AT (1) | ATE292628T1 (de) |
| AU (1) | AU7433000A (de) |
| BG (1) | BG106535A (de) |
| BR (1) | BR0014136A (de) |
| CA (1) | CA2384284A1 (de) |
| CZ (1) | CZ20021007A3 (de) |
| DE (1) | DE60019317T2 (de) |
| EE (1) | EE200200148A (de) |
| GB (1) | GB9922173D0 (de) |
| HK (1) | HK1046687A1 (de) |
| HU (1) | HUP0204226A3 (de) |
| IL (1) | IL148498A0 (de) |
| IS (1) | IS6309A (de) |
| NO (1) | NO20021395L (de) |
| PL (1) | PL354972A1 (de) |
| SK (1) | SK3842002A3 (de) |
| WO (1) | WO2001021595A1 (de) |
| ZA (1) | ZA200201831B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| RU2267489C2 (ru) | 2000-08-21 | 2006-01-10 | Астразенека Аб | Производные хиназолина, способ их получения и фармацевтическая композиция |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| AU2002217999A1 (en) | 2000-11-01 | 2002-05-15 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
| DE60233736D1 (de) * | 2001-06-22 | 2009-10-29 | Kirin Pharma K K | Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung |
| EP1471910A2 (de) | 2002-01-17 | 2004-11-03 | Neurogen Corporation | Substituirte chinazolin-4-ylamine analogue als capsaicinreceptoren-modulatoren |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| ES2400339T3 (es) | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| WO2005072731A1 (en) * | 2004-01-29 | 2005-08-11 | X-Ceptor Therapeutics, Inc. | 3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders |
| AR050948A1 (es) | 2004-09-24 | 2006-12-06 | Hoffmann La Roche | Derivados de ftalazinona; su obtencion y su utilizacion en la fabricacion de medicamentos para el tratamiento del cancer. |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| JP4237242B2 (ja) | 2004-10-12 | 2009-03-11 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1856053A1 (de) * | 2005-01-14 | 2007-11-21 | Millennium Pharmaceuticals, Inc. | Cinnamid- und hydrocinnamid-derivate mit raf-kinase hemmender aktivität |
| US7462639B2 (en) | 2005-04-14 | 2008-12-09 | Hoffmann-La Roche Inc. | Aminopyrazole derivatives |
| WO2006118231A1 (ja) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | シアノピリジン誘導体及びその医薬としての用途 |
| GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US20090076075A1 (en) * | 2006-03-02 | 2009-03-19 | Frederic Henri Jung | Quinoline derivatives |
| UY30183A1 (es) * | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| CA2652341A1 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc. | Identification of cdki pathway inhibitors |
| US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| WO2008095847A1 (de) | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| EP2247579B1 (de) * | 2008-01-17 | 2012-04-18 | Bayer Pharma Aktiengesellschaft | Sulfoximinsubstituierte chinazolinderivate als immunmodulatoren, ihre herstellung und ihre verwendung als medikamente |
| EP2245026B1 (de) | 2008-02-07 | 2012-08-01 | Boehringer Ingelheim International GmbH | Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| JP5739802B2 (ja) | 2008-05-13 | 2015-06-24 | アストラゼネカ アクチボラグ | ４−（３−クロロ−２−フルオロアニリノ）−７−メトキシ−６−｛［１−（ｎ−メチルカルバモイルメチル）ピペリジン−４−イル］オキシ｝キナゾリンのフマル酸塩 |
| EP2313397B1 (de) | 2008-08-08 | 2016-04-20 | Boehringer Ingelheim International GmbH | Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| CN105777654B (zh) * | 2016-03-28 | 2018-03-27 | 贵州大学 | 一种含喹唑啉的阿魏酸酯类衍生物、其制备方法和用途 |
| EP3762379A1 (de) | 2018-03-07 | 2021-01-13 | Bayer Aktiengesellschaft | Identifizierung und verwendung von erk5-inhibitoren |
| JP2024515204A (ja) * | 2021-04-22 | 2024-04-05 | ボロノイ インコーポレイテッド | ヘテロアリール誘導体化合物およびその用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT817775E (pt) | 1995-03-30 | 2002-01-30 | Pfizer | Derivados de quinazolina |
| GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| WO2004013091A2 (en) * | 2002-08-01 | 2004-02-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
-
1999
- 1999-09-21 GB GBGB9922173.1A patent/GB9922173D0/en not_active Ceased
-
2000
- 2000-09-18 PL PL00354972A patent/PL354972A1/xx not_active Application Discontinuation
- 2000-09-18 AU AU74330/00A patent/AU7433000A/en not_active Abandoned
- 2000-09-18 WO PCT/GB2000/003562 patent/WO2001021595A1/en active IP Right Grant
- 2000-09-18 EP EP00962682A patent/EP1218357B1/de not_active Expired - Lifetime
- 2000-09-18 US US10/088,852 patent/US7105669B1/en not_active Expired - Fee Related
- 2000-09-18 BR BR0014136-4A patent/BR0014136A/pt not_active IP Right Cessation
- 2000-09-18 DE DE60019317T patent/DE60019317T2/de not_active Expired - Fee Related
- 2000-09-18 IL IL14849800A patent/IL148498A0/xx unknown
- 2000-09-18 AT AT00962682T patent/ATE292628T1/de not_active IP Right Cessation
- 2000-09-18 CN CN00816000A patent/CN1391560A/zh active Pending
- 2000-09-18 SK SK384-2002A patent/SK3842002A3/sk unknown
- 2000-09-18 EE EEP200200148A patent/EE200200148A/xx unknown
- 2000-09-18 JP JP2001524974A patent/JP2003509498A/ja active Pending
- 2000-09-18 CA CA002384284A patent/CA2384284A1/en not_active Abandoned
- 2000-09-18 CZ CZ20021007A patent/CZ20021007A3/cs unknown
- 2000-09-18 HU HU0204226A patent/HUP0204226A3/hu unknown
- 2000-09-18 KR KR1020027003679A patent/KR20020029136A/ko not_active Application Discontinuation
-
2002
- 2002-03-05 ZA ZA200201831A patent/ZA200201831B/xx unknown
- 2002-03-19 IS IS6309A patent/IS6309A/is unknown
- 2002-03-20 NO NO20021395A patent/NO20021395L/no unknown
- 2002-03-20 BG BG106535A patent/BG106535A/bg unknown
- 2002-11-19 HK HK02108373.8A patent/HK1046687A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204226A3 (en) | 2003-07-28 |
| PL354972A1 (en) | 2004-03-22 |
| HUP0204226A2 (en) | 2003-05-28 |
| NO20021395L (no) | 2002-05-15 |
| CZ20021007A3 (cs) | 2002-06-12 |
| EP1218357A1 (de) | 2002-07-03 |
| ZA200201831B (en) | 2003-08-27 |
| JP2003509498A (ja) | 2003-03-11 |
| SK3842002A3 (en) | 2002-10-08 |
| IL148498A0 (en) | 2002-09-12 |
| IS6309A (is) | 2002-03-19 |
| WO2001021595A1 (en) | 2001-03-29 |
| BG106535A (bg) | 2002-12-29 |
| US7105669B1 (en) | 2006-09-12 |
| DE60019317D1 (de) | 2005-05-12 |
| EE200200148A (et) | 2003-04-15 |
| KR20020029136A (ko) | 2002-04-17 |
| EP1218357B1 (de) | 2005-04-06 |
| AU7433000A (en) | 2001-04-24 |
| CA2384284A1 (en) | 2001-03-29 |
| DE60019317T2 (de) | 2006-03-09 |
| NO20021395D0 (no) | 2002-03-20 |
| BR0014136A (pt) | 2002-05-21 |
| HK1046687A1 (zh) | 2003-01-24 |
| GB9922173D0 (en) | 1999-11-17 |
| CN1391560A (zh) | 2003-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |