CY1106745T1 - Μικροσφαιριδια που περιεχουν ενα παραγωγο πλευρομουτιλινης - Google Patents
Μικροσφαιριδια που περιεχουν ενα παραγωγο πλευρομουτιλινηςInfo
- Publication number
- CY1106745T1 CY1106745T1 CY20071100963T CY071100963T CY1106745T1 CY 1106745 T1 CY1106745 T1 CY 1106745T1 CY 20071100963 T CY20071100963 T CY 20071100963T CY 071100963 T CY071100963 T CY 071100963T CY 1106745 T1 CY1106745 T1 CY 1106745T1
- Authority
- CY
- Cyprus
- Prior art keywords
- microspherds
- pleuromutilin
- pleuromutilin derivative
- derivative
- pellets
- Prior art date
Links
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical class C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title abstract 3
- 239000008188 pellet Substances 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
Abstract
Περιγράφεται η παροχή σφαιριδίων ζωικής τροφής, τα οποία σφαιρίδια περιλαμβάνουν, ως αντιβιοτικό, ένα παράγωγο πλευρομουτιλίνης σε σταθεροποιημένη μορφή, συγκεκριμένα σε μορφή μικροσφαιριδίων. Τα εν λόγω παράγωγα πλευρομουτιλίνης έχουν τον γενικό χημικό τύπο (Ι) όπου το R1 είναι αιθύλ ή βινύλ, υπάρχει είτε ένας διπλός δεσμός ή ένας απλός δεσμός μεταξύ των ατόμων άνθρακα 1 και 2, τα Ra και Rb είναι το καθένα ανεξάρτητα από το άλλο υδρογόνο ή αλογόνο, και το Τ είναι μια βραχείας ή μακριάς- αλύσου οργανική ελεύθερη ρίζα.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01128276 | 2001-11-28 | ||
| PCT/EP2002/013388 WO2003045354A1 (en) | 2001-11-28 | 2002-11-27 | Micropherules containing a pleuromutilin derivative |
| EP02803802A EP1450767B1 (en) | 2001-11-28 | 2002-11-27 | Microspherules containing a pleuromutilin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106745T1 true CY1106745T1 (el) | 2012-05-23 |
Family
ID=8179384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100963T CY1106745T1 (el) | 2001-11-28 | 2007-07-19 | Μικροσφαιριδια που περιεχουν ενα παραγωγο πλευρομουτιλινης |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8236851B2 (el) |
| EP (1) | EP1450767B1 (el) |
| JP (1) | JP4537708B2 (el) |
| KR (1) | KR100965017B1 (el) |
| CN (1) | CN100348185C (el) |
| AR (1) | AR038367A1 (el) |
| AT (1) | ATE363270T1 (el) |
| AU (1) | AU2002356740B2 (el) |
| BR (1) | BR0214521B1 (el) |
| CA (1) | CA2466671C (el) |
| CO (1) | CO5390081A1 (el) |
| CY (1) | CY1106745T1 (el) |
| DE (1) | DE60220436T2 (el) |
| DK (1) | DK1450767T3 (el) |
| ES (1) | ES2284980T3 (el) |
| MX (1) | MXPA04005186A (el) |
| NZ (1) | NZ533085A (el) |
| PT (1) | PT1450767E (el) |
| RU (1) | RU2296004C2 (el) |
| WO (1) | WO2003045354A1 (el) |
| ZA (1) | ZA200403801B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690717B (zh) * | 2009-09-30 | 2013-03-06 | 北京大北农动物保健科技有限责任公司 | 一种兽用沃尼妙林及其盐的预混剂及制备方法 |
| US20110269657A1 (en) * | 2010-04-28 | 2011-11-03 | Jiten Odhavji Dihora | Delivery particles |
| CZ308210B6 (cs) * | 2011-11-02 | 2020-03-04 | Veterinární A Farmaceutická Univerzita Brno | Farmaceutická kompozice ve formě pelet majících velikost částic v rozmezí od 0,1 do 10 mm pro perorální podání vodním živočichům a způsob její výroby |
| CN102512376A (zh) * | 2011-11-29 | 2012-06-27 | 河南牧翔动物药业有限公司 | 一种沃尼妙林凝胶微球及其制备方法 |
| CN102579364B (zh) * | 2012-03-05 | 2013-10-09 | 河北科技大学 | 沃尼妙林/沃尼妙林盐的缓控释微球及其制备方法 |
| CN103948567B (zh) * | 2014-04-17 | 2015-10-14 | 江苏省家禽科学研究所 | 一种泰妙菌素微囊制剂的制备方法 |
| CN108926536A (zh) * | 2017-05-22 | 2018-12-04 | 北京科百大科技有限责任公司 | 一种稳定的盐酸沃尼妙林组合物的制备方法 |
| CN108484424A (zh) * | 2018-04-08 | 2018-09-04 | 中国农业科学院兰州畜牧与兽药研究所 | 侧链含有季铵盐基团的截短侧耳素类衍生物及其用途 |
| KR102098289B1 (ko) * | 2018-04-11 | 2020-04-07 | 경북대학교 산학협력단 | 발네물린을 유효성분으로 함유하는 골 질환 예방 또는 치료용 조성물 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA923384A (en) | 1970-02-03 | 1973-03-27 | Abe Jinnosuke | Process for preparing a micro capsule |
| US3919290A (en) * | 1972-10-03 | 1975-11-11 | Sandoz Ltd | Substituted 14-desoxy-mutilins |
| US3987194A (en) * | 1975-05-12 | 1976-10-19 | E. R. Squibb & Sons, Inc. | Use of pleuromutilin derivatives for the treatment of swine dysentery |
| US4086359A (en) * | 1975-09-30 | 1978-04-25 | E. R. Squibb & Sons, Inc. | Derivatives of pleuromutilin and compositions |
| JPS58148816A (ja) * | 1982-02-27 | 1983-09-05 | Nippon Zenyaku Kogyo Kk | 低刺激性チアムリン注射剤 |
| DE3560511D1 (en) | 1984-02-17 | 1987-10-01 | Sandoz Ag | Pleuromutilin derivatives, process for their preparation and their use |
| DE3422782A1 (de) | 1984-06-20 | 1986-01-02 | Boehringer Ingelheim Vetmedica GmbH, 6507 Ingelheim | Zinkbacitracin enthaltender futtermittelzusatz |
| JPH072638B2 (ja) | 1986-07-28 | 1995-01-18 | 日本化薬株式会社 | 経口投与用製剤 |
| US5460817A (en) * | 1988-01-19 | 1995-10-24 | Allied Colloids Ltd. | Particulate composition comprising a core of matrix polymer with active ingredient distributed therein |
| JP2854034B2 (ja) * | 1989-09-13 | 1999-02-03 | ノバルティス アクチエンゲゼルシャフト | 粒状動物用医薬組成物 |
| JPH041132A (ja) * | 1990-04-18 | 1992-01-06 | Sds Biotech Kk | 魚類の細菌性疾患の予防・治療剤 |
| AT400674B (de) * | 1991-07-24 | 1996-02-26 | Biochemie Gmbh | Pharmazeutische pleuromutilin-zubereitung |
| DE4308282C2 (de) * | 1993-03-16 | 1994-12-22 | Beiersdorf Ag | Vorzugsweise in Form von Mikrosphärulen vorliegende galenische Matrices |
| IT1265290B1 (it) * | 1993-12-17 | 1996-10-31 | Dox Al Italia Spa | Miscele ad elevato contenuto di sostanze attive idonee ad essere distribuite in modo omogeneo nei mangimi per animali. |
| GB9406094D0 (en) * | 1994-03-28 | 1994-05-18 | Univ Nottingham And University | Polymer microspheres and a method of production thereof |
| DE59410220D1 (de) | 1994-10-20 | 2003-01-16 | Chevita Tierarzneimittel Ges M | Verfahren zur Herstellung von Futtermitteln, die pharmakologisch wirksame Substanzen enthalten |
| US5614222A (en) * | 1994-10-25 | 1997-03-25 | Kaplan; Milton R. | Stable aqueous drug suspensions and methods for preparation thereof |
| GB9500863D0 (en) * | 1995-01-17 | 1995-03-08 | Grampian Pharm Ltd | Medicated animal foodstuffs |
| US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| GB9614017D0 (en) | 1996-07-04 | 1996-09-04 | Biochemie Gmbh | Organic compounds |
| KR100516418B1 (ko) * | 1996-07-04 | 2005-12-20 | 바이오케미 게젤샤프트 엠베하 | 플루로뮤틸린유도체의수의학적용도 |
| KR100302314B1 (ko) * | 1998-05-12 | 2002-04-24 | 김종인 | 세파클로르의서방성매트릭스제형 |
| TWI260220B (en) | 1999-11-22 | 2006-08-21 | Novartis Ag | A pharmaceutical composition for the transdermal treatment of bacterial infections in animals |
| TWI228048B (en) * | 1999-12-09 | 2005-02-21 | Novartis Ag | New formulation |
-
2002
- 2002-11-22 CO CO02106178A patent/CO5390081A1/es not_active Application Discontinuation
- 2002-11-26 AR ARP020104541A patent/AR038367A1/es not_active Application Discontinuation
- 2002-11-27 DK DK02803802T patent/DK1450767T3/da active
- 2002-11-27 WO PCT/EP2002/013388 patent/WO2003045354A1/en active IP Right Grant
- 2002-11-27 CA CA2466671A patent/CA2466671C/en not_active Expired - Lifetime
- 2002-11-27 MX MXPA04005186A patent/MXPA04005186A/es active IP Right Grant
- 2002-11-27 ES ES02803802T patent/ES2284980T3/es not_active Expired - Lifetime
- 2002-11-27 NZ NZ533085A patent/NZ533085A/en not_active IP Right Cessation
- 2002-11-27 RU RU2004119815/04A patent/RU2296004C2/ru active
- 2002-11-27 DE DE60220436T patent/DE60220436T2/de not_active Expired - Lifetime
- 2002-11-27 BR BRPI0214521-9B1A patent/BR0214521B1/pt active IP Right Grant
- 2002-11-27 JP JP2003546857A patent/JP4537708B2/ja not_active Expired - Lifetime
- 2002-11-27 KR KR1020047008032A patent/KR100965017B1/ko active IP Right Grant
- 2002-11-27 CN CNB028233050A patent/CN100348185C/zh not_active Expired - Lifetime
- 2002-11-27 AT AT02803802T patent/ATE363270T1/de active
- 2002-11-27 PT PT02803802T patent/PT1450767E/pt unknown
- 2002-11-27 EP EP02803802A patent/EP1450767B1/en not_active Expired - Lifetime
- 2002-11-27 US US10/496,610 patent/US8236851B2/en not_active Expired - Lifetime
- 2002-11-27 AU AU2002356740A patent/AU2002356740B2/en not_active Expired
-
2004
- 2004-05-18 ZA ZA200403801A patent/ZA200403801B/en unknown
-
2007
- 2007-07-19 CY CY20071100963T patent/CY1106745T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1450767A1 (en) | 2004-09-01 |
| WO2003045354A8 (en) | 2004-08-26 |
| ES2284980T3 (es) | 2007-11-16 |
| WO2003045354A1 (en) | 2003-06-05 |
| DK1450767T3 (da) | 2007-08-13 |
| AU2002356740B2 (en) | 2006-06-15 |
| BR0214521B1 (pt) | 2014-05-27 |
| KR20040058334A (ko) | 2004-07-03 |
| RU2004119815A (ru) | 2006-01-10 |
| DE60220436T2 (de) | 2008-01-31 |
| CA2466671C (en) | 2011-03-29 |
| JP4537708B2 (ja) | 2010-09-08 |
| ZA200403801B (en) | 2006-05-31 |
| KR100965017B1 (ko) | 2010-06-21 |
| BR0214521A (pt) | 2004-10-26 |
| NZ533085A (en) | 2005-10-28 |
| CO5390081A1 (es) | 2004-04-30 |
| ATE363270T1 (de) | 2007-06-15 |
| PT1450767E (pt) | 2007-09-05 |
| JP2005523243A (ja) | 2005-08-04 |
| CA2466671A1 (en) | 2003-06-05 |
| RU2296004C2 (ru) | 2007-03-27 |
| DE60220436D1 (de) | 2007-07-12 |
| US20050070486A1 (en) | 2005-03-31 |
| AU2002356740A1 (en) | 2003-06-10 |
| MXPA04005186A (es) | 2004-08-11 |
| CN100348185C (zh) | 2007-11-14 |
| AR038367A1 (es) | 2005-01-12 |
| CN1592608A (zh) | 2005-03-09 |
| EP1450767B1 (en) | 2007-05-30 |
| US8236851B2 (en) | 2012-08-07 |
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