CY1106125T1 - Ενωσεις πυρρολινης υποκατεστημενες με ινδαζολυλιο ως αναστολεις κινασης - Google Patents

Ενωσεις πυρρολινης υποκατεστημενες με ινδαζολυλιο ως αναστολεις κινασης

Info

Publication number
CY1106125T1
CY1106125T1 CY20061101017T CY061101017T CY1106125T1 CY 1106125 T1 CY1106125 T1 CY 1106125T1 CY 20061101017 T CY20061101017 T CY 20061101017T CY 061101017 T CY061101017 T CY 061101017T CY 1106125 T1 CY1106125 T1 CY 1106125T1
Authority
CY
Cyprus
Prior art keywords
indazolilu
kinase inhibitors
substituted pyrroline
compounds
kinase
Prior art date
Application number
CY20061101017T
Other languages
English (en)
Inventor
Han-Cheng Zhang
Bruce E. Maryanoff
Bruce Conway
Kimberly White
Hong Ye
Leonard R. Hecker
David F. Mccomsey
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of CY1106125T1 publication Critical patent/CY1106125T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με νέες υποκατεστημένες με ινδαζολύλιο ενώσεις πυρρολίνης του Τύπου (I) χρησίμων ως αναστολέων κινάσης ή διπλής κινάσης, μεθόδους παραγωγής τέτοιων ενώσεων και μεθόδους αγωγής ή βελτίωσης μιας διαταραχής στην οποία μεσολαβεί μια κινάση ή μια διπλή κινάση.
CY20061101017T 2000-12-08 2006-07-21 Ενωσεις πυρρολινης υποκατεστημενες με ινδαζολυλιο ως αναστολεις κινασης CY1106125T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25416600P 2000-12-08 2000-12-08
PCT/US2001/047689 WO2002046183A2 (en) 2000-12-08 2001-12-06 Indazolyl-substituted pyrroline compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1106125T1 true CY1106125T1 (el) 2011-06-08

Family

ID=22963185

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101017T CY1106125T1 (el) 2000-12-08 2006-07-21 Ενωσεις πυρρολινης υποκατεστημενες με ινδαζολυλιο ως αναστολεις κινασης

Country Status (26)

Country Link
US (4) US6849643B2 (el)
EP (1) EP1362047B1 (el)
JP (1) JP2004515499A (el)
KR (1) KR20040016828A (el)
CN (1) CN1230434C (el)
AT (1) ATE326464T1 (el)
AU (1) AU2002230727A1 (el)
BR (1) BR0116468A (el)
CA (1) CA2431166A1 (el)
CY (1) CY1106125T1 (el)
CZ (1) CZ20031594A3 (el)
DE (1) DE60119790T2 (el)
DK (1) DK1362047T3 (el)
ES (1) ES2263681T3 (el)
HK (1) HK1057370A1 (el)
HU (1) HUP0303855A3 (el)
IL (1) IL156339A0 (el)
MX (1) MXPA03005140A (el)
NO (1) NO20032625L (el)
NZ (1) NZ526356A (el)
PL (1) PL362576A1 (el)
PT (1) PT1362047E (el)
RU (1) RU2003117078A (el)
WO (1) WO2002046183A2 (el)
YU (1) YU46603A (el)
ZA (1) ZA200305239B (el)

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US7855203B2 (en) 2010-12-21
US20050004202A1 (en) 2005-01-06
HUP0303855A3 (en) 2005-04-28
CZ20031594A3 (cs) 2004-06-16
ZA200305239B (en) 2004-10-07
DE60119790D1 (de) 2006-06-22
MXPA03005140A (es) 2004-10-15
US7329657B2 (en) 2008-02-12
CA2431166A1 (en) 2002-06-13
YU46603A (sh) 2006-05-25
DK1362047T3 (da) 2006-09-04
PT1362047E (pt) 2006-09-29
JP2004515499A (ja) 2004-05-27
CN1230434C (zh) 2005-12-07
CN1489586A (zh) 2004-04-14
DE60119790T2 (de) 2007-01-25
NZ526356A (en) 2005-02-25
EP1362047A2 (en) 2003-11-19
US20040259928A1 (en) 2004-12-23
BR0116468A (pt) 2004-06-29
HUP0303855A2 (hu) 2004-03-01
US20030055097A1 (en) 2003-03-20
US6849643B2 (en) 2005-02-01
KR20040016828A (ko) 2004-02-25
HK1057370A1 (en) 2004-04-02
AU2002230727A1 (en) 2002-06-18
US20080096949A1 (en) 2008-04-24
WO2002046183A3 (en) 2002-09-06
ES2263681T3 (es) 2006-12-16
EP1362047B1 (en) 2006-05-17
WO2002046183A2 (en) 2002-06-13
PL362576A1 (en) 2004-11-02
RU2003117078A (ru) 2004-12-10
IL156339A0 (en) 2004-01-04
ATE326464T1 (de) 2006-06-15
US7304060B2 (en) 2007-12-04
NO20032625D0 (no) 2003-06-10
NO20032625L (no) 2003-08-05

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