BR0116468A - Compostos de pirrolina substituìda por indazolila como inibidores de cinase - Google Patents

Compostos de pirrolina substituìda por indazolila como inibidores de cinase

Info

Publication number
BR0116468A
BR0116468A BR0116468-6A BR0116468A BR0116468A BR 0116468 A BR0116468 A BR 0116468A BR 0116468 A BR0116468 A BR 0116468A BR 0116468 A BR0116468 A BR 0116468A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
compounds
indazolyl
kinase
substituted pyrroline
Prior art date
Application number
BR0116468-6A
Other languages
English (en)
Inventor
Han-Cheng Zhang
Bruce Maryanoff
Bruce Conway
Kimberly White
Hong Ye
Leonard R Hecker
David F Mccomsey
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0116468A publication Critical patent/BR0116468A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)

Abstract

"COMPOSTOS DE PIRROLINA SUBSTITUìDA POR INDAZOLILA COMO INIBIDORES DE CINASE". A presente invenção refere-se a novos compostos de pirrolina substituída por indazolila de Fórmula (I) úteis como inibidores de cinase ou cinase dual, métodos para produzir tais compostos e métodos para tratar ou melhorar um distúrbio mediado por cinase ou cinase dual.
BR0116468-6A 2000-12-08 2001-12-06 Compostos de pirrolina substituìda por indazolila como inibidores de cinase BR0116468A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25416600P 2000-12-08 2000-12-08
PCT/US2001/047689 WO2002046183A2 (en) 2000-12-08 2001-12-06 Indazolyl-substituted pyrroline compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0116468A true BR0116468A (pt) 2004-06-29

Family

ID=22963185

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116468-6A BR0116468A (pt) 2000-12-08 2001-12-06 Compostos de pirrolina substituìda por indazolila como inibidores de cinase

Country Status (26)

Country Link
US (4) US6849643B2 (pt)
EP (1) EP1362047B1 (pt)
JP (1) JP2004515499A (pt)
KR (1) KR20040016828A (pt)
CN (1) CN1230434C (pt)
AT (1) ATE326464T1 (pt)
AU (1) AU2002230727A1 (pt)
BR (1) BR0116468A (pt)
CA (1) CA2431166A1 (pt)
CY (1) CY1106125T1 (pt)
CZ (1) CZ20031594A3 (pt)
DE (1) DE60119790T2 (pt)
DK (1) DK1362047T3 (pt)
ES (1) ES2263681T3 (pt)
HK (1) HK1057370A1 (pt)
HU (1) HUP0303855A3 (pt)
IL (1) IL156339A0 (pt)
MX (1) MXPA03005140A (pt)
NO (1) NO20032625L (pt)
NZ (1) NZ526356A (pt)
PL (1) PL362576A1 (pt)
PT (1) PT1362047E (pt)
RU (1) RU2003117078A (pt)
WO (1) WO2002046183A2 (pt)
YU (1) YU46603A (pt)
ZA (1) ZA200305239B (pt)

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IL156339A0 (en) 2004-01-04
HUP0303855A3 (en) 2005-04-28
CA2431166A1 (en) 2002-06-13
AU2002230727A1 (en) 2002-06-18
ES2263681T3 (es) 2006-12-16
CZ20031594A3 (cs) 2004-06-16
DK1362047T3 (da) 2006-09-04
NZ526356A (en) 2005-02-25
DE60119790D1 (de) 2006-06-22
HUP0303855A2 (hu) 2004-03-01
PL362576A1 (en) 2004-11-02
CN1230434C (zh) 2005-12-07
EP1362047A2 (en) 2003-11-19
CY1106125T1 (el) 2011-06-08
US7329657B2 (en) 2008-02-12
ZA200305239B (en) 2004-10-07
CN1489586A (zh) 2004-04-14
PT1362047E (pt) 2006-09-29
KR20040016828A (ko) 2004-02-25
DE60119790T2 (de) 2007-01-25
US7304060B2 (en) 2007-12-04
YU46603A (sh) 2006-05-25
EP1362047B1 (en) 2006-05-17
US20050004202A1 (en) 2005-01-06
ATE326464T1 (de) 2006-06-15
US20080096949A1 (en) 2008-04-24
WO2002046183A3 (en) 2002-09-06
NO20032625L (no) 2003-08-05
NO20032625D0 (no) 2003-06-10
US20040259928A1 (en) 2004-12-23
US6849643B2 (en) 2005-02-01
MXPA03005140A (es) 2004-10-15
HK1057370A1 (en) 2004-04-02
US20030055097A1 (en) 2003-03-20
US7855203B2 (en) 2010-12-21
RU2003117078A (ru) 2004-12-10
WO2002046183A2 (en) 2002-06-13
JP2004515499A (ja) 2004-05-27

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