BR0311821A - Derivados de bisindolil-maleimid como inibidores de cinase - Google Patents

Derivados de bisindolil-maleimid como inibidores de cinase

Info

Publication number
BR0311821A
BR0311821A BR0311821-5A BR0311821A BR0311821A BR 0311821 A BR0311821 A BR 0311821A BR 0311821 A BR0311821 A BR 0311821A BR 0311821 A BR0311821 A BR 0311821A
Authority
BR
Brazil
Prior art keywords
kinase
kinase inhibitors
bisindolyl
maleimid
derivatives
Prior art date
Application number
BR0311821-5A
Other languages
English (en)
Inventor
Han-Cheng Zhang
Bruce E Maryanoff
Hong Ye
Bruce R Conway
Keith T Demarest
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0311821A publication Critical patent/BR0311821A/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)

Abstract

"DERIVADOS DE BISINDOLIL-MALEIMID COMO INIBIDORES DE CINASE". A presente invenção refere-se a novos compostos pirrolina substituídos de Fórmula (I) em que R^ 1^ é selecionado do grupo que consiste em um anel piridinil-R^ 5^, pirimidinil-R^ 5^, pirazinil-R^ 5^, furil-R^ 5^, tienil-R^ 5^, benzofuril-R^ 5^, benzotienil-R^ 5^, quinolinil-R^ 5^ e isoquinolinil-R^ 5^ ligado ao átomo de nitrogênio do indol via um átomo de carbono no anel, úteis como inibidores quinase ou quinase dupla, métodos para produção de tais composto e métodos para tratamento ou melhora de um distúrbio mediado por quinase ou quinase dupla, tal como distúrbios cardiovasculares, inflamatórios, imunológicos, dermatológicos, oncológicos do SNC e diabetes.
BR0311821-5A 2002-06-05 2003-06-04 Derivados de bisindolil-maleimid como inibidores de cinase BR0311821A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38593502P 2002-06-05 2002-06-05
PCT/US2003/017569 WO2003104222A1 (en) 2002-06-05 2003-06-04 Bisindolyl-maleimid derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0311821A true BR0311821A (pt) 2005-04-05

Family

ID=29736126

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311821-5A BR0311821A (pt) 2002-06-05 2003-06-04 Derivados de bisindolil-maleimid como inibidores de cinase

Country Status (14)

Country Link
US (1) US6987110B2 (pt)
EP (1) EP1513830A1 (pt)
JP (1) JP2005531609A (pt)
KR (1) KR20050008787A (pt)
CN (1) CN1671694A (pt)
AU (1) AU2003238874A1 (pt)
BR (1) BR0311821A (pt)
CA (1) CA2488602A1 (pt)
CR (1) CR7606A (pt)
IL (1) IL165515A0 (pt)
MX (1) MXPA04012188A (pt)
NO (1) NO20045699L (pt)
RU (1) RU2004135382A (pt)
WO (1) WO2003104222A1 (pt)

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EP1513830A1 (en) 2005-03-16
WO2003104222A1 (en) 2003-12-18
CR7606A (es) 2009-01-16
IL165515A0 (en) 2006-01-15
AU2003238874A1 (en) 2003-12-22
NO20045699L (no) 2005-01-28
CN1671694A (zh) 2005-09-21
CA2488602A1 (en) 2003-12-18
US20040059113A1 (en) 2004-03-25
KR20050008787A (ko) 2005-01-21
RU2004135382A (ru) 2005-06-27
US6987110B2 (en) 2006-01-17
JP2005531609A (ja) 2005-10-20

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