MX340952B - Diferenciacion de celulas madre embrionarias humanas. - Google Patents

Diferenciacion de celulas madre embrionarias humanas.

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Publication number
MX340952B
MX340952B MX2012000899A MX2012000899A MX340952B MX 340952 B MX340952 B MX 340952B MX 2012000899 A MX2012000899 A MX 2012000899A MX 2012000899 A MX2012000899 A MX 2012000899A MX 340952 B MX340952 B MX 340952B
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MX
Mexico
Prior art keywords
differentiation
stem cells
embryonic stem
human embryonic
present
Prior art date
Application number
MX2012000899A
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English (en)
Other versions
MX2012000899A (es
Inventor
Jean Xu
Original Assignee
Janssen Biotech Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43465585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX340952(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2012000899A publication Critical patent/MX2012000899A/es
Publication of MX340952B publication Critical patent/MX340952B/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0613—Cells from endocrine organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Abstract

La presente invención se refiere a un proceso para realizar una evaluación de riesgo molecular (MRA) en una muestra sospechosa de contener una Escherichia coli enterohemorrágica (EHEC), que comprende los pasos: a) poner en contacto dicha muestra o ADN aislado de la misma con un par de cebadores derivados de por lo menos los siguientes genes objetivo: -stx1; .stx2; y por lo menos uno de los siguientes genes objetivo: -eae; -espK; y con un par de cebadores derivados de por lo menos uno de los siguientes genes objetivo: -nleB; nleH1-2; nleE; -ent/espL2; y detectar la presencia o la ausencia de un producto de amplificación apra cada uno de dichos genes objetivo; en donde la ausencia de uno o más de los productos de amplificación para dichos genes objetivo indica un abajo riesgo de que la muestra esté contaminada con una cepa EHEC, mientras que la presencia de un producto de amplificación para cada uno de dichos genes objetivo indica un alto riesgo de que la muestra esté contaminada con una cepa EHEC; y si los productos de amplificación ara cada uno de dichos genes del paso a) son detectados, entonces; b) poner en contacto dicha muestra o ADN aislado de la misma con uno o más pares de cebadores derivados del gen eae objetivo y determinar el subtipo de eae.
MX2012000899A 2009-07-20 2010-07-19 Diferenciacion de celulas madre embrionarias humanas. MX340952B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22693609P 2009-07-20 2009-07-20
PCT/US2010/042393 WO2011011302A2 (en) 2009-07-20 2010-07-19 Differentiation of human embryonic stem cells

Publications (2)

Publication Number Publication Date
MX2012000899A MX2012000899A (es) 2012-02-13
MX340952B true MX340952B (es) 2016-07-29

Family

ID=43465585

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000899A MX340952B (es) 2009-07-20 2010-07-19 Diferenciacion de celulas madre embrionarias humanas.

Country Status (18)

Country Link
US (1) US8785184B2 (es)
EP (1) EP2456858B1 (es)
JP (1) JP5819825B2 (es)
KR (2) KR101785626B1 (es)
CN (1) CN102482640B (es)
AR (1) AR077767A1 (es)
AU (1) AU2010276440B2 (es)
BR (1) BR112012001557A2 (es)
CA (1) CA2768644A1 (es)
ES (1) ES2693088T3 (es)
GB (1) GB2485112B (es)
HK (1) HK1170262A1 (es)
MX (1) MX340952B (es)
PL (1) PL2456858T3 (es)
RU (1) RU2540021C2 (es)
SG (1) SG177483A1 (es)
WO (1) WO2011011302A2 (es)
ZA (1) ZA201201221B (es)

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