MX336787B - Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos. - Google Patents

Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos.

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Publication number
MX336787B
MX336787B MX2013007288A MX2013007288A MX336787B MX 336787 B MX336787 B MX 336787B MX 2013007288 A MX2013007288 A MX 2013007288A MX 2013007288 A MX2013007288 A MX 2013007288A MX 336787 B MX336787 B MX 336787B
Authority
MX
Mexico
Prior art keywords
genetically engineered
methods
acid derivatives
hydroxybenzoly
engineered microorganisms
Prior art date
Application number
MX2013007288A
Other languages
English (en)
Other versions
MX2013007288A (es
Inventor
Toby Richardson
Robert Christopher Brown
Rekha Seshadri
Carlos Chavez-Torres
Weidong Xu
Original Assignee
Exxonmobil Res & Eng Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exxonmobil Res & Eng Co filed Critical Exxonmobil Res & Eng Co
Publication of MX2013007288A publication Critical patent/MX2013007288A/es
Publication of MX336787B publication Critical patent/MX336787B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02023—4-Hydroxybenzoyl-CoA thioesterase (3.1.2.23)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6418—Fatty acids by hydrolysis of fatty acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un microorganismo, caracterizado porque comprende una molécula recombinante de ácido nucleico que codifica una 4-hidroxibenzoil-coenzima A (CoA) tioesterasa, en donde la 4-hidroxibenzoil-CoA tioesterasa hidroliza una proteína portador de acilo-acilo (acil-APC), y en donde la expresión de 4-hidroxibenzoil-CoA tioesterasa en el microoganismo tiene como resultado la producción de por lo menos un ácido graso libre y/o derivado de ácido graso, y además en donde por lo menos 30 por ciento en peso de los ácidos grasos libres producidos por el microorganismo son ácidos grasos libre que tienen una longitud de cadena de acilo de 12 carbonos, de 14 carbonos, de 16 carbonos, o cualquier mezcla de los mismo.
MX2013007288A 2010-12-23 2011-12-13 Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos. MX336787B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061426568P 2010-12-23 2010-12-23
PCT/US2011/064641 WO2012087670A2 (en) 2010-12-23 2011-12-13 Genetically engineered microorganisms comprising 4-hydroxybenzoly-coa thioesterases and methods of using the same for producing free fatty acids and fatty acid derivatives

Publications (2)

Publication Number Publication Date
MX2013007288A MX2013007288A (es) 2014-01-31
MX336787B true MX336787B (es) 2016-02-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007288A MX336787B (es) 2010-12-23 2011-12-13 Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos.

Country Status (10)

Country Link
US (1) US8846370B2 (es)
EP (1) EP2655648B1 (es)
CN (1) CN103958692B (es)
AU (1) AU2011349729B2 (es)
BR (1) BR112013016020A2 (es)
ES (1) ES2665516T3 (es)
IL (1) IL226779B (es)
MX (1) MX336787B (es)
PT (1) PT2655648T (es)
WO (1) WO2012087670A2 (es)

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US9222111B2 (en) * 2011-03-24 2015-12-29 Kao Corporation Method of producing lauric acid-containing oil or fat
WO2012135668A1 (en) 2011-03-31 2012-10-04 Exxonmobil Research And Engineering Company Metabolic pathway targeting by transcription factor overexpression
EP2753701B1 (en) 2011-09-27 2018-05-02 ExxonMobil Research and Engineering Company Acyl-acp wax ester synthases
WO2014207043A1 (en) * 2013-06-25 2014-12-31 Cellectis Modified diatoms for biofuel production
WO2015116671A2 (en) 2014-01-28 2015-08-06 Dsm Ip Assets B.V. Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases
US11066653B2 (en) * 2017-07-21 2021-07-20 Basf Se Method of transforming bacterial cells
CN108048425A (zh) * 2017-12-19 2018-05-18 湖北工业大学 一种对羟基苯甲酰-coa硫酯酶及其制备方法
CN109907210B (zh) * 2019-03-25 2021-12-31 河南农业大学 酰基辅酶a硫酯酶及其基因在降解玉米赤霉烯酮中的应用、降解玉米赤霉烯酮的制剂
CN112063645A (zh) * 2020-09-25 2020-12-11 南京工业大学 一种制备c14脂肪酸的方法

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Also Published As

Publication number Publication date
EP2655648A2 (en) 2013-10-30
CN103958692A (zh) 2014-07-30
WO2012087670A2 (en) 2012-06-28
BR112013016020A2 (pt) 2017-07-11
AU2011349729A1 (en) 2013-07-04
ES2665516T3 (es) 2018-04-26
EP2655648A4 (en) 2015-06-03
PT2655648T (pt) 2018-04-16
WO2012087670A3 (en) 2014-04-10
MX2013007288A (es) 2014-01-31
US8846370B2 (en) 2014-09-30
US20120164713A1 (en) 2012-06-28
EP2655648B1 (en) 2018-01-17
AU2011349729B2 (en) 2015-09-24
CN103958692B (zh) 2020-02-21
IL226779B (en) 2018-01-31

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