CR7606A - Derivados de bisindolil-maleimida como inhibidores de cinasa - Google Patents

Derivados de bisindolil-maleimida como inhibidores de cinasa

Info

Publication number
CR7606A
CR7606A CR7606A CR7606A CR7606A CR 7606 A CR7606 A CR 7606A CR 7606 A CR7606 A CR 7606A CR 7606 A CR7606 A CR 7606A CR 7606 A CR7606 A CR 7606A
Authority
CR
Costa Rica
Prior art keywords
kinase
bisindolil
maleimida
derivatives
methods
Prior art date
Application number
CR7606A
Other languages
English (en)
Inventor
Zhang Hang-Chen
Maryanoff Bruce
Ye Hong
Conway Bruce
Demarest Keith
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR7606A publication Critical patent/CR7606A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)

Abstract

La presente invencion esta dirigida a compuestos novedosos de pirrolina sustituida de formual (I), en donde R1 se selecciona del grupo que consiste de un anillo de piridinil-R5, pirimidinil-R5, pirazinil-R5, furil-R5, tienil-R5, benzofuril-R5, benzotienil-R5, quinolinil-R5 e isoquinolinil-R5, unido al atomo de nitrogeno del indol por medio de un atomo de carbono de anillo; utiles como inhibidores de cinasa o doble cinasa, metodos para producir dichos compuestos y metodos para tratar o mejorar trastornos mediados por cinasa o doble cinasa, tales como trastornos caridovasculares, inflamatorios, inmunologicos, dermatologicos, oncologicos, del SNC, y diabetes.
CR7606A 2002-06-05 2004-12-06 Derivados de bisindolil-maleimida como inhibidores de cinasa CR7606A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38593502P 2002-06-05 2002-06-05

Publications (1)

Publication Number Publication Date
CR7606A true CR7606A (es) 2009-01-16

Family

ID=29736126

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7606A CR7606A (es) 2002-06-05 2004-12-06 Derivados de bisindolil-maleimida como inhibidores de cinasa

Country Status (14)

Country Link
US (1) US6987110B2 (es)
EP (1) EP1513830A1 (es)
JP (1) JP2005531609A (es)
KR (1) KR20050008787A (es)
CN (1) CN1671694A (es)
AU (1) AU2003238874A1 (es)
BR (1) BR0311821A (es)
CA (1) CA2488602A1 (es)
CR (1) CR7606A (es)
IL (1) IL165515A0 (es)
MX (1) MXPA04012188A (es)
NO (1) NO20045699L (es)
RU (1) RU2004135382A (es)
WO (1) WO2003104222A1 (es)

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CN1320123A (zh) 1998-07-30 2001-10-31 日本烟草产业株式会社 二取代马来酰亚胺化合物及其医药用途
JP2002527419A (ja) 1998-10-08 2002-08-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Ｇｓｋ−３阻害物質としてのピロール−２，５−ジオン類
DE60107857T2 (de) 2000-07-27 2005-12-08 F. Hoffmann-La Roche Ag 3-Indolyl-4-Phenyl-1H-Pyrrol-2,5-Dion-Derivate als Glycogen Synthase-Kinase 3Beta Inhibitoren
KR100916613B1 (ko) 2000-11-07 2009-09-14 노파르티스 아게 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체

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EP1513830A1 (en) 2005-03-16
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JP2005531609A (ja) 2005-10-20
CN1671694A (zh) 2005-09-21
AU2003238874A1 (en) 2003-12-22
US20040059113A1 (en) 2004-03-25
IL165515A0 (en) 2006-01-15
KR20050008787A (ko) 2005-01-21
WO2003104222A1 (en) 2003-12-18
BR0311821A (pt) 2005-04-05
RU2004135382A (ru) 2005-06-27
US6987110B2 (en) 2006-01-17
NO20045699L (no) 2005-01-28

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