NO20073958L - Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer - Google Patents
Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorerInfo
- Publication number
- NO20073958L NO20073958L NO20073958A NO20073958A NO20073958L NO 20073958 L NO20073958 L NO 20073958L NO 20073958 A NO20073958 A NO 20073958A NO 20073958 A NO20073958 A NO 20073958A NO 20073958 L NO20073958 L NO 20073958L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- relates
- disorders
- phosphodiesterase inhibitors
- heteroaromatic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Foreliggende oppfinnelse angår nye pyrrolidylderivater av benzosammensmeltede azaheteroaromatiske forbindelser som tjener som effektive fosfodiesterase (PDE)-inhibitorer. Oppfinnelsen angår også forbindelser som er selektive inhibitorer av PDE-IO. Oppfinnelsen angår videre intermediater for fremstilling av slike forbindelser; farmasøytiske sammensetninger som innbefatter slike forbindelser; og anvendelse av slike forbindelser i fremgangsmåter for behandling av visse sentralnervesystem (CNS) og andre forstyrrelser. Oppfinnelsen angår også fremgangsmåter for behandling av neurodegenerative og psykiatriske forstyrrelser, for eksempel psykose og forstyrrelser som innbefatter svekket kognisjon som et symptom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64040504P | 2004-12-31 | 2004-12-31 | |
PCT/IB2005/003989 WO2006070284A1 (en) | 2004-12-31 | 2005-12-19 | Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073958L true NO20073958L (no) | 2007-09-27 |
Family
ID=36046318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073958A NO20073958L (no) | 2004-12-31 | 2007-07-27 | Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer |
Country Status (23)
Country | Link |
---|---|
US (1) | US20060183763A1 (no) |
EP (1) | EP1838702A1 (no) |
JP (1) | JP2008526726A (no) |
KR (1) | KR20070086841A (no) |
CN (1) | CN101087778A (no) |
AP (1) | AP2007004004A0 (no) |
AR (1) | AR055298A1 (no) |
AU (1) | AU2005321015A1 (no) |
BR (1) | BRPI0519760A2 (no) |
CA (1) | CA2594251A1 (no) |
CR (1) | CR9135A (no) |
EA (1) | EA200701118A1 (no) |
GT (1) | GT200500367A (no) |
IL (1) | IL183188A0 (no) |
MA (1) | MA29119B1 (no) |
MX (1) | MX2007006301A (no) |
NL (1) | NL1030819C2 (no) |
NO (1) | NO20073958L (no) |
PE (1) | PE20060775A1 (no) |
TN (1) | TNSN07248A1 (no) |
TW (1) | TW200637851A (no) |
UY (1) | UY29317A1 (no) |
WO (1) | WO2006070284A1 (no) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7700595B2 (en) * | 2005-03-01 | 2010-04-20 | Wyeth Llc | Cinnoline compounds |
GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
WO2007085954A2 (en) * | 2006-01-27 | 2007-08-02 | Pfizer Products Inc. | Aminophthalazine derivative compounds |
JP2009527562A (ja) * | 2006-02-21 | 2009-07-30 | アムゲン インコーポレイティッド | ホスホジエステラーゼ10阻害剤としてのシンノリン誘導体 |
WO2007098169A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
US20090099175A1 (en) * | 2006-03-01 | 2009-04-16 | Arrington Mark P | Phosphodiesterase 10 inhibitors |
EP1996574A1 (en) * | 2006-03-08 | 2008-12-03 | Amgen Inc. | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
WO2008020302A2 (en) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
MX2009012390A (es) * | 2007-05-17 | 2010-06-23 | Helperby Therapeutics Ltd | Uso de compuestos de 4-(pirrolidin-1-il)quinolina para exterminar microorganismos clinicamente latentes. |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
UA102693C2 (ru) * | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI396689B (zh) * | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶10抑制劑之吡衍生物 |
KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
SG10201403841QA (en) | 2009-07-06 | 2014-09-26 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
EP2620428B1 (en) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
DE102010042833B4 (de) | 2010-10-22 | 2018-11-08 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung |
CN103547267A (zh) * | 2010-11-08 | 2014-01-29 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
JP2014510055A (ja) | 2011-02-18 | 2014-04-24 | アラーガン インコーポレイテッド | ホスホジエステラーゼ10(pde10a)阻害剤としての置換6,7−ジアルコキシ−3−イソキノリノール誘導体 |
JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | 官能化核酸の合成のための方法 |
JP2015521177A (ja) * | 2012-05-07 | 2015-07-27 | オメロス コーポレーション | Pde7インヒビターを用いる嗜癖および衝動制御障害の処置 |
US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
EP4219516A3 (en) | 2012-07-13 | 2024-01-10 | Wave Life Sciences Ltd. | Chiral control |
BR112015000723A2 (pt) | 2012-07-13 | 2017-06-27 | Shin Nippon Biomedical Laboratories Ltd | adjuvante de ácido nucléico quiral |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
ITVI20130032A1 (it) * | 2013-02-14 | 2014-08-15 | F I S Fabbrica Italiana Sint I S P A | Procedimento per la preparazione di n-boc-pirrolidinone |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
TW201611834A (en) * | 2014-02-07 | 2016-04-01 | Lundbeck & Co As H | Hexahydrofuropyrroles as PDE1 inhibitors |
MA39837B1 (fr) * | 2014-04-04 | 2020-05-29 | H Lundbeck As | Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 |
WO2016116900A1 (en) * | 2015-01-23 | 2016-07-28 | Gvk Biosciences Private Limited | Inhibitors of trka kinase |
SG11201900349VA (en) | 2016-07-14 | 2019-02-27 | Crinetics Pharmaceuticals Inc | Somatostatin modulators and uses thereof |
CN106632089B (zh) * | 2016-11-04 | 2019-06-18 | 中山大学 | 一类喹唑啉类化合物及其制备方法与应用 |
JP2021509682A (ja) * | 2017-12-26 | 2021-04-01 | メディコンズ (シャンハイ) バイオファーマスーティカル カンパニー リミテッド | テトラヒドロピロール系化合物、その調製方法、薬学的組成物および使用 |
MX2023002761A (es) | 2020-09-09 | 2023-04-03 | Crinetics Pharmaceuticals Inc | Formulaciones de un modulador de somatostatina. |
CN115417802A (zh) * | 2021-05-16 | 2022-12-02 | 上海鼎雅药物化学科技有限公司 | 乌帕替尼及其中间体的制备方法 |
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US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
US4306065A (en) * | 1979-12-19 | 1981-12-15 | A. H. Robins Company, Incorporated | 2-Aryl-4-substituted quinazolines |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
JP3919272B2 (ja) * | 1996-12-18 | 2007-05-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キナゾリン系化合物 |
JP2002523413A (ja) * | 1998-08-25 | 2002-07-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ニコチン性アセチルコリン受容体のリガンドとしてのピリジルエーテルおよびチオエーテル、ならびにその治療的用途 |
US20020151712A1 (en) * | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
ES2300478T3 (es) * | 2001-05-21 | 2008-06-16 | F. Hoffmann-La Roche Ag | Derivados de quinolina como ligandos para el receptor de neuropeptido y. |
US20070021404A1 (en) * | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1755611A1 (en) * | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
-
2005
- 2005-10-24 US US11/257,179 patent/US20060183763A1/en not_active Abandoned
- 2005-12-14 PE PE2005001461A patent/PE20060775A1/es not_active Application Discontinuation
- 2005-12-15 GT GT200500367A patent/GT200500367A/es unknown
- 2005-12-19 KR KR1020077015027A patent/KR20070086841A/ko not_active Application Discontinuation
- 2005-12-19 AP AP2007004004A patent/AP2007004004A0/xx unknown
- 2005-12-19 WO PCT/IB2005/003989 patent/WO2006070284A1/en active Application Filing
- 2005-12-19 EP EP05826591A patent/EP1838702A1/en not_active Withdrawn
- 2005-12-19 CA CA002594251A patent/CA2594251A1/en not_active Abandoned
- 2005-12-19 MX MX2007006301A patent/MX2007006301A/es unknown
- 2005-12-19 AU AU2005321015A patent/AU2005321015A1/en not_active Abandoned
- 2005-12-19 CN CNA2005800447584A patent/CN101087778A/zh active Pending
- 2005-12-19 JP JP2007548917A patent/JP2008526726A/ja not_active Withdrawn
- 2005-12-19 EA EA200701118A patent/EA200701118A1/ru unknown
- 2005-12-19 BR BRPI0519760-0A patent/BRPI0519760A2/pt not_active Application Discontinuation
- 2005-12-26 AR ARP050105532A patent/AR055298A1/es unknown
- 2005-12-27 UY UY29317A patent/UY29317A1/es not_active Application Discontinuation
- 2005-12-30 NL NL1030819A patent/NL1030819C2/nl not_active IP Right Cessation
- 2005-12-30 TW TW094147577A patent/TW200637851A/zh unknown
-
2007
- 2007-05-14 IL IL183188A patent/IL183188A0/en unknown
- 2007-05-18 CR CR9135A patent/CR9135A/es not_active Application Discontinuation
- 2007-06-29 MA MA30040A patent/MA29119B1/fr unknown
- 2007-06-29 TN TNP2007000248A patent/TNSN07248A1/fr unknown
- 2007-07-27 NO NO20073958A patent/NO20073958L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2594251A1 (en) | 2006-07-06 |
NL1030819C2 (nl) | 2007-01-04 |
EP1838702A1 (en) | 2007-10-03 |
AP2007004004A0 (en) | 2007-06-30 |
BRPI0519760A2 (pt) | 2009-03-10 |
CN101087778A (zh) | 2007-12-12 |
EA200701118A1 (ru) | 2007-12-28 |
US20060183763A1 (en) | 2006-08-17 |
KR20070086841A (ko) | 2007-08-27 |
UY29317A1 (es) | 2006-07-31 |
AU2005321015A1 (en) | 2006-07-06 |
MA29119B1 (fr) | 2007-12-03 |
CR9135A (es) | 2007-08-14 |
GT200500367A (es) | 2006-08-16 |
JP2008526726A (ja) | 2008-07-24 |
NL1030819A1 (nl) | 2006-07-03 |
IL183188A0 (en) | 2007-08-19 |
WO2006070284A1 (en) | 2006-07-06 |
TNSN07248A1 (fr) | 2008-11-21 |
TW200637851A (en) | 2006-11-01 |
PE20060775A1 (es) | 2006-09-01 |
AR055298A1 (es) | 2007-08-15 |
MX2007006301A (es) | 2007-06-15 |
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