BRPI0519760A2 - derivados de pirrolidila de compostos heteroaromÁticos como inibidores de fosfodiesterasse - Google Patents

derivados de pirrolidila de compostos heteroaromÁticos como inibidores de fosfodiesterasse

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Publication number
BRPI0519760A2
BRPI0519760A2 BRPI0519760-0A BRPI0519760A BRPI0519760A2 BR PI0519760 A2 BRPI0519760 A2 BR PI0519760A2 BR PI0519760 A BRPI0519760 A BR PI0519760A BR PI0519760 A2 BRPI0519760 A2 BR PI0519760A2
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BR
Brazil
Prior art keywords
compounds
relates
inhibitors
derivatives
disorders
Prior art date
Application number
BRPI0519760-0A
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English (en)
Inventor
Thomas Allen Chappie
John Michael Humphrey
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36046318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519760(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0519760A2 publication Critical patent/BRPI0519760A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE PIRROLIDILA DE COMPOSTOS HETEROAROMÁTICOS COMO INIBIDORES DE FOSFODIESTERASE. A invenção refere-se a novos derivados de pirrolidila de compostos aza heteroaromáticos benzo fundidos que servem como inibidores de fosfodiesterase (PDE) eficazes. A invenção também se refere a compostos que são inibidores seletivos de PDE-1O. A invenção também se refere a intermediários para preparação de tais compostos; composições farmacêuticas que compreendem tais compostos; e o uso de tais compostos em métodos para tratar certos trasntornos do sistema nervoso central (CNS) ou outros. A invenção também se refere a métodos para tratar transtomos neurodegenerativos e psiquiátricos, por exemplo psicose e distúrbios que compreendem cognição deficiente como um sintoma. Fórmula I.
BRPI0519760-0A 2004-12-31 2005-12-19 derivados de pirrolidila de compostos heteroaromÁticos como inibidores de fosfodiesterasse BRPI0519760A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64040504P 2004-12-31 2004-12-31
PCT/IB2005/003989 WO2006070284A1 (en) 2004-12-31 2005-12-19 Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0519760A2 true BRPI0519760A2 (pt) 2009-03-10

Family

ID=36046318

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519760-0A BRPI0519760A2 (pt) 2004-12-31 2005-12-19 derivados de pirrolidila de compostos heteroaromÁticos como inibidores de fosfodiesterasse

Country Status (23)

Country Link
US (1) US20060183763A1 (pt)
EP (1) EP1838702A1 (pt)
JP (1) JP2008526726A (pt)
KR (1) KR20070086841A (pt)
CN (1) CN101087778A (pt)
AP (1) AP2007004004A0 (pt)
AR (1) AR055298A1 (pt)
AU (1) AU2005321015A1 (pt)
BR (1) BRPI0519760A2 (pt)
CA (1) CA2594251A1 (pt)
CR (1) CR9135A (pt)
EA (1) EA200701118A1 (pt)
GT (1) GT200500367A (pt)
IL (1) IL183188A0 (pt)
MA (1) MA29119B1 (pt)
MX (1) MX2007006301A (pt)
NL (1) NL1030819C2 (pt)
NO (1) NO20073958L (pt)
PE (1) PE20060775A1 (pt)
TN (1) TNSN07248A1 (pt)
TW (1) TW200637851A (pt)
UY (1) UY29317A1 (pt)
WO (1) WO2006070284A1 (pt)

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Also Published As

Publication number Publication date
AU2005321015A1 (en) 2006-07-06
KR20070086841A (ko) 2007-08-27
TW200637851A (en) 2006-11-01
WO2006070284A1 (en) 2006-07-06
CA2594251A1 (en) 2006-07-06
NL1030819C2 (nl) 2007-01-04
MA29119B1 (fr) 2007-12-03
PE20060775A1 (es) 2006-09-01
UY29317A1 (es) 2006-07-31
EP1838702A1 (en) 2007-10-03
GT200500367A (es) 2006-08-16
CR9135A (es) 2007-08-14
EA200701118A1 (ru) 2007-12-28
TNSN07248A1 (fr) 2008-11-21
NL1030819A1 (nl) 2006-07-03
AR055298A1 (es) 2007-08-15
JP2008526726A (ja) 2008-07-24
CN101087778A (zh) 2007-12-12
IL183188A0 (en) 2007-08-19
AP2007004004A0 (en) 2007-06-30
NO20073958L (no) 2007-09-27
MX2007006301A (es) 2007-06-15
US20060183763A1 (en) 2006-08-17

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