EA200701118A1 - Пирролидильные производные гетероароматических соединений в качестве ингибиторов фосфодиэстеразы - Google Patents

Пирролидильные производные гетероароматических соединений в качестве ингибиторов фосфодиэстеразы

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Publication number
EA200701118A1
EA200701118A1 EA200701118A EA200701118A EA200701118A1 EA 200701118 A1 EA200701118 A1 EA 200701118A1 EA 200701118 A EA200701118 A EA 200701118A EA 200701118 A EA200701118 A EA 200701118A EA 200701118 A1 EA200701118 A1 EA 200701118A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
inhibitors
relates
disorders
derivatives
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Application number
EA200701118A
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English (en)
Inventor
Томас Аллен Чаппи
Джон Майкл Хамфри
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Пфайзер Продактс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36046318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200701118(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс, Инк. filed Critical Пфайзер Продактс, Инк.
Publication of EA200701118A1 publication Critical patent/EA200701118A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к новым пирролидильным производным бензоконденсированных азагетероароматических соединений, служащих в качестве эффективных ингибиторов фосфодиэстеразы (PDE). Изобретение также относится к соединениям, представляющим собой селективные ингибиторы PDE-10. Кроме того, изобретение относится к промежуточным соединениям для получения таких соединений; фармацевтическим композициям, содержащим такие соединения; и применению таких соединений в способах лечения некоторых расстройств центральной нервной системы (ЦНС) или других расстройств. Изобретение также относится к способам лечения нейродегенеративных и психиатрических расстройств, например психоза, и расстройств, включающих в качестве симптома дефицит познавательной способности.
EA200701118A 2004-12-31 2005-12-19 Пирролидильные производные гетероароматических соединений в качестве ингибиторов фосфодиэстеразы EA200701118A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64040504P 2004-12-31 2004-12-31
PCT/IB2005/003989 WO2006070284A1 (en) 2004-12-31 2005-12-19 Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
EA200701118A1 true EA200701118A1 (ru) 2007-12-28

Family

ID=36046318

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701118A EA200701118A1 (ru) 2004-12-31 2005-12-19 Пирролидильные производные гетероароматических соединений в качестве ингибиторов фосфодиэстеразы

Country Status (23)

Country Link
US (1) US20060183763A1 (ru)
EP (1) EP1838702A1 (ru)
JP (1) JP2008526726A (ru)
KR (1) KR20070086841A (ru)
CN (1) CN101087778A (ru)
AP (1) AP2007004004A0 (ru)
AR (1) AR055298A1 (ru)
AU (1) AU2005321015A1 (ru)
BR (1) BRPI0519760A2 (ru)
CA (1) CA2594251A1 (ru)
CR (1) CR9135A (ru)
EA (1) EA200701118A1 (ru)
GT (1) GT200500367A (ru)
IL (1) IL183188A0 (ru)
MA (1) MA29119B1 (ru)
MX (1) MX2007006301A (ru)
NL (1) NL1030819C2 (ru)
NO (1) NO20073958L (ru)
PE (1) PE20060775A1 (ru)
TN (1) TNSN07248A1 (ru)
TW (1) TW200637851A (ru)
UY (1) UY29317A1 (ru)
WO (1) WO2006070284A1 (ru)

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Also Published As

Publication number Publication date
CA2594251A1 (en) 2006-07-06
NL1030819C2 (nl) 2007-01-04
EP1838702A1 (en) 2007-10-03
AP2007004004A0 (en) 2007-06-30
BRPI0519760A2 (pt) 2009-03-10
CN101087778A (zh) 2007-12-12
US20060183763A1 (en) 2006-08-17
KR20070086841A (ko) 2007-08-27
NO20073958L (no) 2007-09-27
UY29317A1 (es) 2006-07-31
AU2005321015A1 (en) 2006-07-06
MA29119B1 (fr) 2007-12-03
CR9135A (es) 2007-08-14
GT200500367A (es) 2006-08-16
JP2008526726A (ja) 2008-07-24
NL1030819A1 (nl) 2006-07-03
IL183188A0 (en) 2007-08-19
WO2006070284A1 (en) 2006-07-06
TNSN07248A1 (fr) 2008-11-21
TW200637851A (en) 2006-11-01
PE20060775A1 (es) 2006-09-01
AR055298A1 (es) 2007-08-15
MX2007006301A (es) 2007-06-15

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