BR112015000723A2 - adjuvante de ácido nucléico quiral - Google Patents

adjuvante de ácido nucléico quiral

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Publication number
BR112015000723A2
BR112015000723A2 BR112015000723A BR112015000723A BR112015000723A2 BR 112015000723 A2 BR112015000723 A2 BR 112015000723A2 BR 112015000723 A BR112015000723 A BR 112015000723A BR 112015000723 A BR112015000723 A BR 112015000723A BR 112015000723 A2 BR112015000723 A2 BR 112015000723A2
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BR
Brazil
Prior art keywords
cpg
oligonucleotide
nucleic acid
formula
acid adjuvant
Prior art date
Application number
BR112015000723A
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English (en)
Inventor
Gemba Takefumi
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Shin Nippon Biomedical Laboratories Ltd
Wave Life Sciences Japan
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Publication date
Application filed by Shin Nippon Biomedical Laboratories Ltd, Wave Life Sciences Japan filed Critical Shin Nippon Biomedical Laboratories Ltd
Publication of BR112015000723A2 publication Critical patent/BR112015000723A2/pt

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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/17Immunomodulatory nucleic acids
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

adjuvante de ácido nucléico quiral problema o objetivo da presente invenção é fornecer: um estereoisômero de um novo oligonucleotídeo cpg, que possui excelente estabilidade; e um oligonucleotídeo cpg que possui uma capacidade de produção de interferon-a (ifna). solução a presente invenção está relacionada a um oligonucleotídeo que contém duas a quatro seqüências, cada uma representada pela fórmula 5’-x1x2cpgx3x4-3’ (formula (i)) e possui um comprimento de 14 a 32 nucleotídeos. na fórmula (i), cpg representa um resíduo de cpg não metilado que possui uma modificação do esqueleto de fosfato, x1x2 representa qualquer um de aa, at, ga e gt, e x3x4 representa qualquer um de tt, at, ac e cg. o oligonucleotídeo possui pelo menos uma modificação do esqueleto de fosfato em um estereoisômero de forma s localizado em um local diferente do cpg.
BR112015000723A 2012-07-13 2013-07-12 adjuvante de ácido nucléico quiral BR112015000723A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261671654P 2012-07-13 2012-07-13
PCT/JP2013/069107 WO2014010718A1 (ja) 2012-07-13 2013-07-12 キラル核酸アジュバント

Publications (1)

Publication Number Publication Date
BR112015000723A2 true BR112015000723A2 (pt) 2017-06-27

Family

ID=49916157

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000723A BR112015000723A2 (pt) 2012-07-13 2013-07-12 adjuvante de ácido nucléico quiral

Country Status (13)

Country Link
US (1) US9617547B2 (pt)
EP (1) EP2873674B1 (pt)
JP (1) JP6246121B2 (pt)
KR (1) KR101835401B1 (pt)
CN (1) CN104684923B (pt)
AU (1) AU2013287630B2 (pt)
BR (1) BR112015000723A2 (pt)
CA (1) CA2879066C (pt)
IL (1) IL236685B (pt)
MX (1) MX356830B (pt)
RU (1) RU2677639C2 (pt)
SG (1) SG11201500243WA (pt)
WO (1) WO2014010718A1 (pt)

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WO2014010718A1 (ja) 2014-01-16
AU2013287630B2 (en) 2017-05-25
US20150166999A1 (en) 2015-06-18
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IL236685B (en) 2019-05-30
AU2013287630A1 (en) 2015-02-05
MX356830B (es) 2018-06-15
EP2873674A4 (en) 2016-04-20
US9617547B2 (en) 2017-04-11
IL236685A0 (en) 2015-02-26
KR101835401B1 (ko) 2018-03-08
MX2015000497A (es) 2015-06-05
SG11201500243WA (en) 2015-04-29
EP2873674B1 (en) 2020-05-06
CN104684923A (zh) 2015-06-03
EP2873674A1 (en) 2015-05-20
KR20150028352A (ko) 2015-03-13
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JPWO2014010718A1 (ja) 2016-06-23
JP6246121B2 (ja) 2017-12-13

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