EA200700097A1 - Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс - Google Patents

Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс

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Publication number
EA200700097A1
EA200700097A1 EA200700097A EA200700097A EA200700097A1 EA 200700097 A1 EA200700097 A1 EA 200700097A1 EA 200700097 A EA200700097 A EA 200700097A EA 200700097 A EA200700097 A EA 200700097A EA 200700097 A1 EA200700097 A1 EA 200700097A1
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EA
Eurasian Patent Office
Prior art keywords
ilpiperidin
compounds
derivatives
zinnolin
hinazolin
Prior art date
Application number
EA200700097A
Other languages
English (en)
Inventor
Томас Аллен Чаппи
Джон Майкл Хамфри
Спирос Лирас
Original Assignee
Пфайзер Продактс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34972555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200700097(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс, Инк. filed Critical Пфайзер Продактс, Инк.
Publication of EA200700097A1 publication Critical patent/EA200700097A1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к новым пиперидилзамещенным производным хиназолина и изохинолина, которые выполняют функцию эффективных ингибиторов фосфодиэстеразы (PDE). Изобретение также относится к соединениям, которые являются селективными ингибиторами PDE10. Далее изобретение относится к промежуточным соединениям для получения таких соединений; фармацевтическим композициям, включающим такие соединения; и применению таких соединений в способах лечения определенных расстройств центральной нервной системы (ЦНС) или других расстройств.
EA200700097A 2004-07-23 2005-07-11 Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс EA200700097A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59094304P 2004-07-23 2004-07-23
PCT/IB2005/002177 WO2006011040A1 (en) 2004-07-23 2005-07-11 Quinazolin-4-yl- piperidine and cinnolin-4-yl- piperidine derivatives as pde10 inhibitors for the treatment of cns disorders

Publications (1)

Publication Number Publication Date
EA200700097A1 true EA200700097A1 (ru) 2007-06-29

Family

ID=34972555

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700097A EA200700097A1 (ru) 2004-07-23 2005-07-11 Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс

Country Status (25)

Country Link
US (1) US20060019975A1 (ru)
EP (1) EP1773805A1 (ru)
JP (1) JP2008507500A (ru)
CN (1) CN1989124A (ru)
AP (1) AP2007003891A0 (ru)
AR (1) AR050433A1 (ru)
AU (1) AU2005266080A1 (ru)
BR (1) BRPI0513475A (ru)
CA (1) CA2574685A1 (ru)
CR (1) CR8861A (ru)
EA (1) EA200700097A1 (ru)
EC (1) ECSP077193A (ru)
GT (1) GT200500198A (ru)
IL (1) IL180205A0 (ru)
MA (1) MA28746B1 (ru)
MX (1) MX2007000878A (ru)
NL (1) NL1029596C2 (ru)
NO (1) NO20065948L (ru)
PE (1) PE20060570A1 (ru)
SV (1) SV2006002175A (ru)
TN (1) TNSN07021A1 (ru)
TW (1) TW200616641A (ru)
UY (1) UY29028A1 (ru)
WO (1) WO2006011040A1 (ru)
ZA (1) ZA200700223B (ru)

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AP2007003891A0 (en) 2007-02-28
WO2006011040A1 (en) 2006-02-02
GT200500198A (es) 2006-03-02
TNSN07021A1 (fr) 2008-06-02
NL1029596A1 (nl) 2006-01-24
MX2007000878A (es) 2007-03-12
ZA200700223B (en) 2008-08-27
EP1773805A1 (en) 2007-04-18
CN1989124A (zh) 2007-06-27
NO20065948L (no) 2007-01-23
UY29028A1 (es) 2006-02-24
TW200616641A (en) 2006-06-01
CR8861A (es) 2007-03-02
US20060019975A1 (en) 2006-01-26
AR050433A1 (es) 2006-10-25
PE20060570A1 (es) 2006-07-14
AU2005266080A1 (en) 2006-02-02
JP2008507500A (ja) 2008-03-13
NL1029596C2 (nl) 2006-09-06
SV2006002175A (es) 2006-02-15
IL180205A0 (en) 2007-07-04
BRPI0513475A (pt) 2008-05-06
CA2574685A1 (en) 2006-02-02
MA28746B1 (fr) 2007-07-02
ECSP077193A (es) 2007-02-28

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