AR050433A1 - Derivados piperidilo de quinazolina e isoquinolina - Google Patents

Derivados piperidilo de quinazolina e isoquinolina

Info

Publication number
AR050433A1
AR050433A1 ARP050103018A ARP050103018A AR050433A1 AR 050433 A1 AR050433 A1 AR 050433A1 AR P050103018 A ARP050103018 A AR P050103018A AR P050103018 A ARP050103018 A AR P050103018A AR 050433 A1 AR050433 A1 AR 050433A1
Authority
AR
Argentina
Prior art keywords
nitrogen
alkyl
ring
alkoxy
optionally
Prior art date
Application number
ARP050103018A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34972555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR050433A1 publication Critical patent/AR050433A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se refiere derivados de quinazolina e isoquinolina sustituidos con piperidilo que sirven como eficaces inhibidores de la fosfodiesterasa (PDE). También se refiere a compuestos que son inhibidores selectivos de la PDE-10. la presente además se refiere a productos intermedios para la prepararcion de dichos compuestos; composiciones farmacéuticas que comprenden dichos compuestos; y al uso de dichos compuestos en procedimientos para tratar ciertos trastornos del sistema nervioso (SNC) u otros. Reivindicacion 1: Un compuesto de la (1), o una sal, solvato o profármaco del mismo farmacéuticamente aceptable, en la que X, Y y Z son, cada uno de forma independiente, N o CH, siempre que al menos uno de X, Y y Z sean de X, Y y Z sean N o CH y siempre que cuando Z sea nitrogeno, Y es CH; y cuando Y es nitrogeno, X es nitrogeno y Z es CH; en la que R1, R2, y R5 son de forma independiente hidrogeno, halogeno, CN, -COHH, -COOR3, CONR3R4, -COR3, -NR3R4, -OH, -NO2, arilo C6-14, heteroarilo de 5 a 12 miembros, alquilo C1-9, alcoxiC1-9alqueniloC2-9, alqueniloxiC2-9alquiniloC2-9 o cicloalquilo C3-9; donde dichos alquilo, alquenilo, alqueniloxi, alquinilo y alcoxi están opcional e independientemente sustituidos con de 1 a 3 halogenos; y cuando R1, R2, y R5 son de forma independiente alcoxi, alqueniloxi o alquilo, R1 y R2 o R1 y R5 pueden estar opcionalmente conectados para formar un anillo de 5 a 8 miembros; y cuando R1, R2 y R5 son -NR3R4, R3 y R4 pueden combinarse opcionalmente con el nitrogeno en el que están unidos para formar un anillo de 5 a 8 miembros; en la que R es H, -COOR3, CONR3R4, -COR4, -NR3R4, -NHCOR3, -OH, -HNCOOR3, -CN, -HNCONHR4, alquilo C1-6 o alcoxi C2-6; en la que R3 y R4 son de forma independiente H, alquilo C1-6, alquenilo, arilo o arilo sustituido; en la que B es hidrogeno, fenilo, naftilo o un anillo heteroarilo de 5 a 6 miembros opcionalmente condensado con un grupo benzo o anillo heteroarilo, que contiene de uno a cuatro heteroátomos seleccionados de oxígeno, nitrogeno y azufre, con la condicion de que dicho anillo heteroarilo no puede contener dos átomos de oxígeno adyacentes o dos átomos de azufre adyacentes, y donde cada uno de los anteriores anillos fenilo, naftilo, heteroarilo o heteroarilo condensado con benzo opcionalmente puede estar sustituidos con de uno a tres sustituyentes seleccionados de forma independiente de alquilo C1-8, alcoxi C1-8, cloro-, bromo-, yodo-, fluor-, haloalquilo C1-8, hidroxialquiloC1-8-, alcoxiC1-8-alquiloC1-8-, hidroxicicloalquiloC3-8-, cicloalcoxiC3-8-, alcoxiC1-8-cicloalquiloC3-8-, heterocicloalquilo, hidroxiheterocicloalquilo y alcoxiC1-8-heterocicloalquilo, donde cada resto cicloalquilo C3-8 o heterocicloalquilo puede estar sustituido de forma independiente con de uno a tres grupos alquilo C1-6 o bencilo; o cuando B es un anillo fenilo, naftilo o heteroarilo, cada anillo puede estar opcionalmente sustituido con de uno a tres sustituyentes seleccionados de forma independiente de a) lactona formada a partir de -(CH2)tOH con un -COOH en posicion orto, donde t es uno, dos o tres; b) -CONR14R15, donde R14 y R15 se seleccionan de forma independiente de alquilo C1-8 y bencilo, o R14 y R15 junto con el nitrogeno al que están unidos forman un anillo heteroalquilo de 5 a 7 miembros que puede contener de cero a tres heteroátomos seleccionados de nitrogeno, azufre y oxígeno además del nitrogeno del grupo -CONR14R15, donde cuando cualquiera de dichos heteroátomos es nitrogeno puede estar opcionalmente sustituido con alquilo C1-8 o bencilo, con la condicion de que dicho anillo no puede contener dos átomos de oxígeno adyacentes o dos átomos de azufre adyacentes; c) - (CH2)vNCOR16R17, donde v es cero, uno, dos o tres y -COR16 y R17 junto con el nitrogeno al que están unidos pueden formar un anillo lactama de 4 a 6 miembros.
ARP050103018A 2004-07-23 2005-07-21 Derivados piperidilo de quinazolina e isoquinolina AR050433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59094304P 2004-07-23 2004-07-23

Publications (1)

Publication Number Publication Date
AR050433A1 true AR050433A1 (es) 2006-10-25

Family

ID=34972555

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103018A AR050433A1 (es) 2004-07-23 2005-07-21 Derivados piperidilo de quinazolina e isoquinolina

Country Status (25)

Country Link
US (1) US20060019975A1 (es)
EP (1) EP1773805A1 (es)
JP (1) JP2008507500A (es)
CN (1) CN1989124A (es)
AP (1) AP2007003891A0 (es)
AR (1) AR050433A1 (es)
AU (1) AU2005266080A1 (es)
BR (1) BRPI0513475A (es)
CA (1) CA2574685A1 (es)
CR (1) CR8861A (es)
EA (1) EA200700097A1 (es)
EC (1) ECSP077193A (es)
GT (1) GT200500198A (es)
IL (1) IL180205A0 (es)
MA (1) MA28746B1 (es)
MX (1) MX2007000878A (es)
NL (1) NL1029596C2 (es)
NO (1) NO20065948L (es)
PE (1) PE20060570A1 (es)
SV (1) SV2006002175A (es)
TN (1) TNSN07021A1 (es)
TW (1) TW200616641A (es)
UY (1) UY29028A1 (es)
WO (1) WO2006011040A1 (es)
ZA (1) ZA200700223B (es)

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MA28746B1 (fr) 2007-07-02
GT200500198A (es) 2006-03-02
WO2006011040A1 (en) 2006-02-02
ZA200700223B (en) 2008-08-27
UY29028A1 (es) 2006-02-24
MX2007000878A (es) 2007-03-12
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BRPI0513475A (pt) 2008-05-06
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NL1029596A1 (nl) 2006-01-24
TNSN07021A1 (fr) 2008-06-02
EA200700097A1 (ru) 2007-06-29
CR8861A (es) 2007-03-02
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