AR047682A1 - Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina - Google Patents

Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina

Info

Publication number
AR047682A1
AR047682A1 ARP050100564A ARP050100564A AR047682A1 AR 047682 A1 AR047682 A1 AR 047682A1 AR P050100564 A ARP050100564 A AR P050100564A AR P050100564 A ARP050100564 A AR P050100564A AR 047682 A1 AR047682 A1 AR 047682A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkenyl
independently
substituted
halogens
Prior art date
Application number
ARP050100564A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US54556504P priority Critical
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR047682A1 publication Critical patent/AR047682A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Abstract

Productos intermedios para la preparacion de dichos compuestos; composiciones farmacéuticas que comprenden dichos compuestos y al uso de dichos compuestos en un procedimiento para tratar ciertos trastornos del sistema nervioso central (SNC) u otros. Reivindicacion 1: Un compuesto de la formula (1), o una sal, solvato o profármaco del mismo farmacéuticamente aceptable; donde Q es N o CH; donde R1, R2 y R3 son cada uno de forma independiente hidrogeno, halogeno, alquilo C1-9, alquenilo C2- 9, alquinilo C2-9, cicloalquilo C3-8, -O-alquilo C1-9, -O-alquenilo C2-9, alquil C1-8-O-alquilo C1-6, C:::N,-NO2, -COOR4, -CONR4R5, -NR4R5, -COR5 o -COOH, donde dichos alquilo, alquenilo y alquinilo están opcionalmente sustituidos con de 1 a 3 halogenos; donde R4 y R5 son de forma independiente H, alquilo C1-6 o alquenilo C2-8, donde dichos alquilo y alquenilo están opcionalmente sustituidos con de 1 a 3 átomos de halogeno; y, cuando R1, R2 y R3 son de forma independiente -O-alquilo, -O- alquenilo, o alquilo, alquenilo o alquinilo, R2 y R1, o R1 y R3, pueden estar opcionalmente conectados para formar un anillo de 5 a 6 miembros; R6 y R7 son de forma independiente hidrogeno; -C(=O)-X; -S(=O)2-X, -N(Y)-S(=O)2-X o -N(Y)-C(=O)-X, donde X es un grupo alquilo C1-6 insustituido o sustituido con uno o más halogenos, O-alquilo C1-6 insustituido o sustituido con uno o más halogenos, un grupo arilo C6-14 insustituido o sustituido con uno o dos sustituyentes, un grupo -NR8R9 o una formula (2), donde dichos sustituyentes del grupo arilo C6-14 se seleccionan de forma independiente de alquilo C1-6, -O-alquilo C1-6, halogeno, -C:::N, -NO2, -COOR4, -CONR4R5, -NR4R5, -COR4 y -COOH, y alquilo C1-6 sustituido con de 1 a 3 halogenos; Y es hidrogeno o alquilo C1-6; n es 0 o 1; R8 y R9 son cada uno de forma independiente alquilo C1-6 o hidrogeno; Z es oxígeno o NR10, donde R10 es hidrogeno o alquilo C1-6; donde R11 y R12 son de forma independiente H, halogeno, C:::N, -COOH, -COOR4, - CONR4R5, COR4, -NR4R5, -OH, arilo C6-14, heteroarilo de 5 a 12 miembros, alquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8, donde dichos alquilo, alquenilo y alquinilo están opcionalmente sustituidos de forma independiente con de 1 a 3 halogenos.
ARP050100564A 2004-02-18 2005-02-17 Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina AR047682A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US54556504P true 2004-02-18 2004-02-18

Publications (1)

Publication Number Publication Date
AR047682A1 true AR047682A1 (es) 2006-02-01

Family

ID=34910729

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100564A AR047682A1 (es) 2004-02-18 2005-02-17 Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina

Country Status (14)

Country Link
US (1) US7268142B2 (es)
EP (1) EP1723134A2 (es)
JP (1) JP2007523152A (es)
AR (1) AR047682A1 (es)
BR (1) BRPI0507839A (es)
CA (1) CA2556413A1 (es)
DO (1) DOP2005000022A (es)
GT (1) GT200500027A (es)
NL (1) NL1028321C2 (es)
PA (1) PA8624101A1 (es)
PE (1) PE20050694A1 (es)
TW (1) TW200528446A (es)
UY (1) UY28750A1 (es)
WO (1) WO2005082883A2 (es)

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RU2388751C2 (ru) 2004-07-15 2010-05-10 Амр Текнолоджи, Инк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
CA2619462A1 (en) * 2005-08-16 2007-02-22 Amgen, Inc. Phosphodiesterase 10 inhibitors
WO2007096743A1 (en) * 2006-02-23 2007-08-30 Pfizer Products Inc. Substituted quinazolines as pde10 inhibitors
MX2008010953A (es) * 2006-02-28 2008-09-08 Amgen Inc Derivados de cinolina y quinoxalina como inhibidores de la fosfodiesterasa 10.
US20090099175A1 (en) * 2006-03-01 2009-04-16 Arrington Mark P Phosphodiesterase 10 inhibitors
US20070265258A1 (en) * 2006-03-06 2007-11-15 Ruiping Liu Quinazoline derivatives as phosphodiesterase 10 inhibitors
CA2644850A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
DK2057153T3 (da) 2006-07-10 2012-10-15 Lundbeck & Co As H (3-aryl-piperazin-1-yl)-derivater af 6,7 dialkoxyquinazolin, 6,7- dialkoxyphtalazin og 6,7-dialkoxyisoquinolin
US7786139B2 (en) 2006-11-21 2010-08-31 Omeros Corporation PDE10 inhibitors and related compositions and methods
BRPI0811091A2 (pt) * 2007-05-18 2014-12-09 Wyeth Corp Composto, composição farmacêutica, métodos para prevenir ou tratar uma doença, distúrbio ou condição, para aumentar níveis de colesterol hdl no soro em um indivíduo, para reduzir níveis de colestetol ldl no soro em um indivíduo, para aumentar o transporte invertido de colesterol em um indivíduo, e para reduzir a absorção do colesterol em um indivíduo, e, uso de um composto.
US7858620B2 (en) 2007-09-19 2010-12-28 H. Lundbeck A/S Cyanoisoquinoline
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA102693C2 (ru) * 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
EP2429293B1 (en) * 2009-05-12 2014-10-29 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
WO2010132437A1 (en) * 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CA2760837C (en) * 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
TW201200516A (en) 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI487705B (zh) 2009-12-17 2015-06-11 Lundbeck & Co As H 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物
TWI481607B (zh) 2009-12-17 2015-04-21 Lundbeck & Co As H 作為pde10a酵素抑制劑的2-芳基咪唑衍生物
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物
RU2543386C2 (ru) 2010-02-26 2015-02-27 Мицубиси Танабе Фарма Коропорейшн Производные пиразолопиримидина и их применение в качестве ингибиторов pde10
TW201215607A (en) 2010-07-02 2012-04-16 Lundbeck & Co As H Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
TW201206935A (en) 2010-07-16 2012-02-16 Lundbeck & Co As H Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
DE102010042833B4 (de) 2010-10-22 2018-11-08 Helmholtz-Zentrum Dresden - Rossendorf E.V. Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung
JO3089B1 (ar) 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
EP2675791B1 (en) 2011-02-18 2016-02-17 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
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WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
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ES2723876T3 (es) 2013-02-27 2019-09-03 Mochida Pharm Co Ltd Nuevos derivados de pirazol
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CN107206004A (zh) * 2014-10-22 2017-09-26 德克萨斯大学系统董事会 靶向盘状结构域受体1的小分子抑制剂及其用途
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PE20030008A1 (es) * 2001-06-19 2003-01-22 Squibb Bristol Myers Co Inhibidores duales de pde 7 y pde 4

Also Published As

Publication number Publication date
NL1028321A1 (nl) 2005-08-19
US20050182079A1 (en) 2005-08-18
BRPI0507839A (pt) 2007-05-08
NL1028321C2 (nl) 2006-05-23
PE20050694A1 (es) 2005-10-04
GT200500027A (es) 2005-10-24
US7268142B2 (en) 2007-09-11
PA8624101A1 (es) 2005-11-25
WO2005082883A3 (en) 2007-04-26
CA2556413A1 (en) 2005-09-09
JP2007523152A (ja) 2007-08-16
TW200528446A (en) 2005-09-01
UY28750A1 (es) 2005-09-30
EP1723134A2 (en) 2006-11-22
WO2005082883A2 (en) 2005-09-09
DOP2005000022A (es) 2005-08-30

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