AR047447A1 - Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. - Google Patents
Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas.Info
- Publication number
- AR047447A1 AR047447A1 ARP050100229A ARP050100229A AR047447A1 AR 047447 A1 AR047447 A1 AR 047447A1 AR P050100229 A ARP050100229 A AR P050100229A AR P050100229 A ARP050100229 A AR P050100229A AR 047447 A1 AR047447 A1 AR 047447A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- alkylamino
- alkoxycarbonyl
- alkanoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
La presente se refiere a derivados de amino alcohol, uso de estos compuestos en la preparacion de composiciones farmacéuticas en las cuales actuan como inhibidores de la renina. Reivindicacion 1: Compuesto de formula (1) donde: R1 es a) H, hidroxilo o amino, o b) alquilo C1-8, cicloalquilo C3-8, alcanoilo C1-8, alcoxicarbonilo C1-8, aril-alquilo C0-4 o heterociclilalquilo C0-4, cuyos radicales pueden estar sustituidos por 1-4 alquilo C1-8, halogeno, oxo, ciano, trifluorometilo, alcoxi C1-8, alcoxicarbonilo C1-8, arilo o heterociclilo; R2es a) alquilo C1-8, cicloalquilo C3-8, alquilsulfonilo C1-8, cicloalquilsulfonilo C3-8, aril-alquilsulfonilo C0-8, heterociclilsulfonilo, cicloalquil C3-12-alcanoilo C1-8, aril-cicloalcanoilo C3- 8, alcanoilo C1-8, alcoxicarbonilo C1-8, carbamoil-alquilo C0-8 opcionalmente N-mono- o N,N-di-alquilado C1-8, aril-alquilo C0-4 o heterociclilalquilo C0-4, cuyos radicales pueden estar sustituidos por 1-4 alquilos C1-8, cicloalquilo C3-8, cicloalcoxi C3-8, amino, alquilamino C1-6, di-alquilamino C1-6, alcanoilamino C1-6, alcoxicarbonilamino C1-8, halogeno, oxo, ciano, hidroxilo, trifluorometilo, alcoxi C1-8, alcoxicarbonilo C1-8, arilo o heterociclilo; o b) junto con R1 y e átomo de N al cual están unidos es un anillo heterocíclico saturado o parcialmente insaturado, de 4-8 miembros que puede contener un átomo de N, O o S adicional o un grupo -SO- o -SO2-, y el átomo de N adicional puede estar sustituido en forma opcional por alquilo C1-8, alcanoilo C1-8, alcoxicarbonilo C1-8, radicales arilo o heteroarilo, en cuyo caso este anillo heterocíclico puede ser parte de un sistema anular bicíclico o tricíclico que tiene un total de hasta 16 miembros y el segundo anillo puede contener también un átomo de N, O o S o un grupo -SO- o -SO2-, y el átomo de N en el segundo anillo puede estar sustituido en forma opcional por alquilo C1-8, alcanoilo C1-8, alcoxicarbonilo C1-8, radicales arilo o heteroarilo, y todos los sistemas anulares mencionados pueden estar sustituidos por 1-4 alquilo C1-8, halogeno, hidroxilo, oxo, trifluorometilo, alcoxi C1-8, alcoxi C1-8-alquilo C1-8, alcoxi C1-8-alcoxi C1-8, alcoxicarbonilamino C1-8, alcanoilamino C1-8, alquilamino C1-8, N,N- dialquilamino C1-8, aril-alquilo C0-4, ariloxi-alquilo C0-4, aril-alquilo C0-4-alcoxi C1-8, ariloxi-alquil C0-4-alcoxi C1-8, heterociclilalquilo C0-4, heterocicliloxi-alquilo C0-4, heteroaril-alquil C0-4-alcoxi C1-8 o heterocicliloxi-alquil C0-4- alcoxi C1-8; R3 es H, alquilo C1-4, alcoxicarbonilo C1-8 o alcanoilo C1-8; R4 es H, alquilo C1-4, alcoxicarbonilo C1-8 o alcanoilo C1-8; R5 es en cada caso en forma independiente H, alquilo C1-8, o, junto con el átomo de C al cual están unidos, son un radical cicloalquilideno C3-8; R6 es H o hidroxilo; R, en cada caso en forma independiente, son 1-4 radicales seleccionados de: H, halogeno, alquilo c1-8, cicloalquilo de 3 a 8 miembros, polihaloalquilo C1-4, alcoxi C1-4-alquilo C1-4, alcoxi C1-4- alcoxi C1-4-alquilo C1-4, cicloalcoxi alquilo C1-4 e 3 a 8 miembros, hidroxilo, alcanoiloxi C1-8-alquilo C1-4, hidroxialquilo C2-8, alquiltio C1-4-alquilo C1-4, alquilsulfonilo C1-8-alquilo C1-4, tiazoliltio-alquilo C1-4, tiazoliniltio-alquilo C1-4, imidazoliltio-alquilo C1-4, piridiltio-alquilo C1-4 N-oxidado en forma opcional, pirimidiniltio-alquilo C1-4, piridil- o N-oxidopiridil-alquilo C1-4 parcialmente hidrogenado en forma opcional, alquilsulfonilamino C1-4-alquilo C1-4, trifluoro- alquilsulfonilamino C1-8-alquilo C1-4, pirrolidin- alquilo C1-4, piperidin-alquilo C1-4, piperazin-alquilo C1-4, N??-alquilpiperazin C1-4-alquilo C1-4, N??-alcanoilpiperazin C2-8-alquilo C1-4, morfolin-alquilo C1-4, tiomorfolin-alquilo C1-4, S- oxotiomorfolin-alquilo C1-4, S,S-dioxotiomorfolin-alquilo C1-4, ciano-alquilo C1-4, carboxi-alquilo C1-4, alcoxicarbonil C1-4-alquilo C1-4, carbamoil-alquilo C1-8, N-mono- o N,N-dialquilcarbamoil C1-4-alquilo C1-4, mono-, di- o tri-alquilo C1-4- o no sustituido-alcoxi C1-4, -hidroxi-, -alquilamino C1-4, -di-alquilamino C1-4-, -halogeno- o fenilo o naftilo -trifluorometil-sustituidos, hidroxi-alcoxi C2-8, halo-(hidroxi)alcoxi C2-8, alquilsulfonilo C1-8-(hidroxi)alcoxi C1-4, amino-alquilo C1-4, alquilamino C1-4-alquilo C1-4, N, N-di-alquilamino C1-4-alquilo C1-4, N-alcanoilamino C1-4-alquilo C1-4, alcoxicarbonilamino C1-8-alquilo C1-4, piridil- o N-oxidopiridil-alquilo C1-4 parcialmente hidrogenado en forma opcional, piperazin-alquilo C1- 4, N??-alquilpiperazin C1-4-alquilo C1-4, N??-alcanoilpiperazin C2-8-alquilo C1-4, morfolin-alquilo C1-4, tiomorfolin-alquilo C1-4, S-oxo-tiomorfolin-alquilo C1-4, S,S-dioxotiomorfolin-alquilo C1-4, amino-alcoxi C1-4, alquilamino C1-4-alcoxi C1-4, N,N- di-alquilamino C1-4-alcoxi C1-4, alcanoilamino C1-4-alcoxi C1-4, alcoxicarbonilamino C1-8-alcoxi C1-4, alcanoilo C1-8-alcoxi C2-4 que lleva el grupo alcanoilo en una posicion más alta que la posicion alfa, alcoxi c1-8, cicloalcoxi de 3 a 8 miembros, alqueniloxi C2-8, cicloalcoxi de 3 a 8 miembros-alcoxi C1-4, alcoxi C1-8-alcoxi C1-8, alcoxi C1-4-alquenilo C2-4, alqueniloxi C2-8-alcoxi C1-4, alcoxi C1-4-alqueniloxi C2-4, alqueniloxi C2-8-alquilo C1-4, alquiltio C1-4-alcoxi C1-4,, alquilsulfonilo C1-8-alcoxi C1-4, alquiltio C1-4-(hidroxi)alcoxi C1-4, mono-, di- o tri-alquilo C1-4- o no sustituido -alcoxi C1-4, -hidroxi-, -alquilamino C1-4-, di-alquilamino C1-4-, -halo- y/o fenil- o naftil-alcoxi C1-4, trifluorometil-sustituido, polihalo- alcoxi C1-4, piridil- o N-oxidopiridil-alcoxi C1-4 parcialmente hidrogenado en forma opcional, tiazolil-alcoxi C1-4, morfolin-alcoxi C1-4 N-oxidado en forma opcional, tiazoliltio-alcoxi C1-4, tiazoliniltio-alcoxi C1-4, imidazoliltio-alcoxi C1-4, piridiltio-alcoxi C1-4 N-oxidado en forma opcional, pirimidiniltio-alcoxi C1-4, amino-alcoxi C1-4, alquilamino C1-4-alcoxi C1-4, N,N-di-alquilamino C1-4-alcoxi C1-4, alcanoilamino C1-8-alcoxi C1-4, alquilsulfonilamino C1-8-alcoxi C1-4, trifluoroalquilsulfonil C1-8-alcoxi C1-4, pirrolidin-alcoxi C1-4, piperidin-alcoxi C1-4, ciano-alcoxi C1-4, carboxi-alcoxi C1-4, alcoxicarbonil C1-4-alcoxi C1-4, carbamoil-alcoxi C1-4, N-alquilcarbamoil C1-8-alcoxi C1-4 o N-mono- o N,N-di- alquilcarbamoil C1-4-alcoxi C1-4, carboxi-alquilo C1-4, alcoxicarbonil C1-4-alquilo C1-4, carbamoil-alquilo C1-8, N-mono- o N,N-di-alquilcarbamoil C1-4-alquilo C1-4, carboxi-alcoxi C1-4, alcoxicarbonil C1-4-alcoxi C1-4, carbamoil-alcoxi C1-8, N-mono- o N,N-di-alquilcarbamoil C1-4-alcoxi C1-4, alquilamino C1-4 o N,N-di-alquilamino C1-4, o una de sus sales, con preferencia su sal util desde el punto de vista farmacéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH942004 | 2004-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047447A1 true AR047447A1 (es) | 2006-01-18 |
Family
ID=34800314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100229A AR047447A1 (es) | 2004-01-23 | 2005-01-21 | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7718675B2 (es) |
EP (1) | EP1735270B1 (es) |
JP (1) | JP4764833B2 (es) |
CN (1) | CN1910141A (es) |
AR (1) | AR047447A1 (es) |
AT (1) | ATE472524T1 (es) |
BR (1) | BRPI0507067A (es) |
CA (1) | CA2553831A1 (es) |
DE (1) | DE602005022060D1 (es) |
ES (1) | ES2348016T3 (es) |
HK (1) | HK1097517A1 (es) |
IL (1) | IL176900A0 (es) |
PL (1) | PL1735270T3 (es) |
PT (1) | PT1735270E (es) |
TW (1) | TW200535131A (es) |
WO (1) | WO2005070877A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080293701A1 (en) * | 2005-02-02 | 2008-11-27 | Baldwin John J | 1-Acylamino-2-Hydroxy-3-Amino- -Arylalkanes as Renin Inhibitors |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
EP1745778A3 (en) | 2005-07-20 | 2007-03-07 | Speedel Experimenta AG | Diaminoalcohols as therapeutic compounds |
EP1764099A3 (en) * | 2005-09-17 | 2007-05-09 | Speedel Experimenta AG | Diaminoalcohol derivatives for the treatment of Alzheimer, malaria, HIV |
ES2430139T3 (es) | 2005-12-30 | 2013-11-19 | Novartis Ag | Compuestos de piperidina 3,5-sustituido como inhibidores de renina |
WO2007123718A1 (en) * | 2006-03-31 | 2007-11-01 | Vitae Pharmaceuticals, Inc. | 1-HETEROCYCLYLAMINO-2-HYDROXY-3-AMINO-ω-ARYLALKANES |
WO2007120523A2 (en) | 2006-03-31 | 2007-10-25 | Vitae Pharmaceuticals, Inc. | 6-(aminoalkyl)indazoles |
GB0611697D0 (en) * | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
GB0611696D0 (en) * | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
EP1958666A1 (en) * | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
ES2541107T3 (es) | 2007-06-25 | 2015-07-16 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina |
CA2791226C (en) * | 2009-12-22 | 2014-04-15 | Dow Global Technologies, Inc. | Novel diamino-alcohol compounds and processes for their manufacture |
CN108218735A (zh) * | 2018-02-08 | 2018-06-29 | 陕西师范大学 | 1,4-氨基醇衍生物的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272268A (en) * | 1990-06-28 | 1993-12-21 | Shionogi & Co., Ltd. | Dipeptide derivatives |
US5223615A (en) * | 1990-06-28 | 1993-06-29 | Shionogi & Co., Ltd. | Dipeptide derivatives |
JP2997095B2 (ja) * | 1990-06-28 | 2000-01-11 | 塩野義製薬株式会社 | レニン阻害活性を有するジペプチド誘導体 |
TW225540B (es) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
US20020002152A1 (en) * | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
US8168616B1 (en) * | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
EP1453788A1 (en) * | 2001-12-06 | 2004-09-08 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamines |
JP4519640B2 (ja) * | 2002-06-28 | 2010-08-04 | シュペーデル・ファルマ・アーゲー | 非ペプチドレニン阻害薬及び界面活性剤を含有する医薬製剤 |
-
2005
- 2005-01-21 DE DE602005022060T patent/DE602005022060D1/de active Active
- 2005-01-21 US US10/586,814 patent/US7718675B2/en not_active Expired - Fee Related
- 2005-01-21 EP EP05701590A patent/EP1735270B1/en not_active Not-in-force
- 2005-01-21 AT AT05701590T patent/ATE472524T1/de active
- 2005-01-21 BR BRPI0507067-8A patent/BRPI0507067A/pt not_active IP Right Cessation
- 2005-01-21 AR ARP050100229A patent/AR047447A1/es not_active Application Discontinuation
- 2005-01-21 JP JP2006550176A patent/JP4764833B2/ja not_active Expired - Fee Related
- 2005-01-21 CA CA002553831A patent/CA2553831A1/en not_active Abandoned
- 2005-01-21 WO PCT/EP2005/050272 patent/WO2005070877A1/en active Application Filing
- 2005-01-21 PT PT05701590T patent/PT1735270E/pt unknown
- 2005-01-21 TW TW094101795A patent/TW200535131A/zh unknown
- 2005-01-21 ES ES05701590T patent/ES2348016T3/es active Active
- 2005-01-21 CN CNA2005800029206A patent/CN1910141A/zh active Pending
- 2005-01-21 PL PL05701590T patent/PL1735270T3/pl unknown
-
2006
- 2006-07-17 IL IL176900A patent/IL176900A0/en unknown
-
2007
- 2007-04-03 HK HK07103597.4A patent/HK1097517A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE472524T1 (de) | 2010-07-15 |
IL176900A0 (en) | 2006-12-10 |
BRPI0507067A (pt) | 2007-06-12 |
EP1735270B1 (en) | 2010-06-30 |
CA2553831A1 (en) | 2005-08-04 |
PL1735270T3 (pl) | 2010-12-31 |
HK1097517A1 (en) | 2007-06-29 |
EP1735270A1 (en) | 2006-12-27 |
JP4764833B2 (ja) | 2011-09-07 |
TW200535131A (en) | 2005-11-01 |
US7718675B2 (en) | 2010-05-18 |
CN1910141A (zh) | 2007-02-07 |
JP2007522123A (ja) | 2007-08-09 |
US20070161622A1 (en) | 2007-07-12 |
WO2005070877A1 (en) | 2005-08-04 |
DE602005022060D1 (de) | 2010-08-12 |
ES2348016T3 (es) | 2010-11-26 |
PT1735270E (pt) | 2010-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR047447A1 (es) | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. | |
CY1124284T1 (el) | Ενωσεις σπειρο[3η-ινδολο-3,2'-πυρρολιδιν]-2(1η)-ονης και παραγωγα ως αναστολεις mdm2-p53 | |
ES2515194T3 (es) | Derivados de pirrolidina | |
AR079510A1 (es) | Derivados de quinolinamida moduladores alostericos positivos de receptores muscarinicos m1, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del alzheimer, esquizofrenia y otras patologias del sistema nervioso central. | |
ECSP056115A (es) | ANTAGONISTAS DEL RECEPTOR A2a DE 2-ALQUINIL- Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIMIDINA ADENOSINA | |
AR045414A1 (es) | Derivados de 2 - piridincarboxamida y composiciones farmaceuticas que las contienen. | |
AR043434A1 (es) | Derivados de piperizacina acilados como agonistas del receptor de melanocortina-4. composiciones farmaceuticas y usos | |
AR049126A1 (es) | Derivados de 5, 6, 7, 8 - tetrahidroimidazo[1,5a]piridina con actividad inhibitoria de la aldosterona sintasa, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del hiperaldosterismo y del sindrome de cushing. | |
AR052943A1 (es) | Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida | |
PE20090648A1 (es) | Compuestos para el tratamiento de la hepatitis c | |
AR046992A1 (es) | Derivados de espiro-dihidrobenzofuranos | |
AR064608A1 (es) | Derivados de pirazolo-quinazolina sustituidos, composiciones farmaceuticas que los contienen. proceso para su preparacion y uso de los mismos como agentes anticancer. | |
AR037243A1 (es) | Antagonistas del receptor de adenosina a2a,a5-amino-imidazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]pirimidina, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento | |
AR050433A1 (es) | Derivados piperidilo de quinazolina e isoquinolina | |
AR058699A1 (es) | Derivados de sulfonamidoanilina como inhibidores de tirosina-quinasas jak-2 y jak-3 | |
AR049898A1 (es) | Compuestos aminocarbonil fenilo sustituidos, composicion farmaceutica,uso y proceso para prepararlos | |
AR067757A1 (es) | Derivados de imidazo[4,5-c]piridin-2-ona, composiciones farmaceuticas que los contienen, procedimiento para su preparacion y uso de los mismos como agentes antivirales. | |
AR048241A1 (es) | Compuestos azufrados como inhibidores de la serina proteasa ns3 del virus de la hepatitis c . | |
AR051293A1 (es) | Inhibidores bace | |
AR047901A1 (es) | Inhibidores de proteasa ns3 del virus de la hepatitis c | |
AR072374A1 (es) | Pirazolo-quinazolinas, composicion farmaceutica que las comprende y su uso en la preparacion de medicamentos para el tratamiento de enfermedades asociadas a la actividad de la proteina quinasa alterada. | |
AR059905A1 (es) | Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto | |
AR080785A1 (es) | Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros. | |
AR049711A1 (es) | Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso | |
AR066691A1 (es) | Compuestos espiro heterociclicos derivados de imidazol. composiciones farmaceuticas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |