BRPI0507067A - diamino álcoois e seu uso como inibidores de renina - Google Patents

diamino álcoois e seu uso como inibidores de renina

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Publication number
BRPI0507067A
BRPI0507067A BRPI0507067-8A BRPI0507067A BRPI0507067A BR PI0507067 A BRPI0507067 A BR PI0507067A BR PI0507067 A BRPI0507067 A BR PI0507067A BR PI0507067 A BRPI0507067 A BR PI0507067A
Authority
BR
Brazil
Prior art keywords
renin inhibitors
alcohols
diamino alcohols
diamino
inhibitors
Prior art date
Application number
BRPI0507067-8A
Other languages
English (en)
Inventor
Peter Herold
Stefan Stutz
Aleksandar Stojanovic
Vincenzo Tschinke
Christiane Marti
Michael Quirmbach
Original Assignee
Speedel Experimenta Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Experimenta Ag filed Critical Speedel Experimenta Ag
Publication of BRPI0507067A publication Critical patent/BRPI0507067A/pt

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P13/00—Drugs for disorders of the urinary system
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DIAMINO áLCOOIS E SEU USO COMO INIBIDORES DE RENINA". A presente invenção refere-se a novos amino álcoois da fórmula geral onde R, R1, R2, R3, R4, R5, R6, têm as definições ilustradas em detalhes no relatório descritivo, a um processo para sua preparação, e ao uso desses compostos como medicamentos, em particular como inibidores de renina.
BRPI0507067-8A 2004-01-23 2005-01-21 diamino álcoois e seu uso como inibidores de renina BRPI0507067A (pt)

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PCT/EP2005/050272 WO2005070877A1 (en) 2004-01-23 2005-01-21 Diamino alcohols and their use as renin inhibitors

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2596444A1 (en) * 2005-02-02 2006-08-10 Vitae Pharmaceuticals, Inc. 1-acylamino-2-hydroxy-3-amino-w-arylalkanes as renin inhibitors
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
EP1745778A3 (en) 2005-07-20 2007-03-07 Speedel Experimenta AG Diaminoalcohols as therapeutic compounds
EP1764099A3 (en) * 2005-09-17 2007-05-09 Speedel Experimenta AG Diaminoalcohol derivatives for the treatment of Alzheimer, malaria, HIV
ES2476422T3 (es) 2005-12-30 2014-07-14 Novartis Ag Compuestos de piperidina 3,5-sustituida como inhibidores de renina
US8084485B2 (en) 2006-03-31 2011-12-27 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
WO2007123718A1 (en) * 2006-03-31 2007-11-01 Vitae Pharmaceuticals, Inc. 1-HETEROCYCLYLAMINO-2-HYDROXY-3-AMINO-ω-ARYLALKANES
GB0611696D0 (en) * 2006-06-13 2006-07-26 Novartis Ag Organic compounds
GB0611697D0 (en) * 2006-06-13 2006-07-26 Novartis Ag Organic compounds
EP1958666A1 (en) * 2007-02-13 2008-08-20 Speedel Experimenta AG Heterocyclic-substituted alkanamides as therapeutic compounds
BRPI0813900A2 (pt) 2007-06-25 2014-12-30 Novartis Ag Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina
CA2791226C (en) * 2009-12-22 2014-04-15 Dow Global Technologies, Inc. Novel diamino-alcohol compounds and processes for their manufacture
CN108218735A (zh) * 2018-02-08 2018-06-29 陕西师范大学 1,4-氨基醇衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272268A (en) 1990-06-28 1993-12-21 Shionogi & Co., Ltd. Dipeptide derivatives
JP2997095B2 (ja) * 1990-06-28 2000-01-11 塩野義製薬株式会社 レニン阻害活性を有するジペプチド誘導体
US5223615A (en) 1990-06-28 1993-06-29 Shionogi & Co., Ltd. Dipeptide derivatives
TW225540B (pt) * 1990-06-28 1994-06-21 Shionogi & Co
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
US20020002152A1 (en) * 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
US8168616B1 (en) * 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
MXPA04005428A (es) * 2001-12-06 2004-12-06 Elan Pharm Inc Hidroxietilaminas substituidas.
US20050147629A1 (en) * 2002-06-28 2005-07-07 Jutta Riedl Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant

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DE602005022060D1 (de) 2010-08-12
AR047447A1 (es) 2006-01-18
ATE472524T1 (de) 2010-07-15
EP1735270A1 (en) 2006-12-27
EP1735270B1 (en) 2010-06-30
US20070161622A1 (en) 2007-07-12
ES2348016T3 (es) 2010-11-26
WO2005070877A1 (en) 2005-08-04
PT1735270E (pt) 2010-08-27
US7718675B2 (en) 2010-05-18
JP4764833B2 (ja) 2011-09-07
HK1097517A1 (en) 2007-06-29
JP2007522123A (ja) 2007-08-09
CA2553831A1 (en) 2005-08-04
PL1735270T3 (pl) 2010-12-31
IL176900A0 (en) 2006-12-10
CN1910141A (zh) 2007-02-07
TW200535131A (en) 2005-11-01

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