AR059905A1 - Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto - Google Patents

Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto

Info

Publication number
AR059905A1
AR059905A1 ARP070101063A ARP070101063A AR059905A1 AR 059905 A1 AR059905 A1 AR 059905A1 AR P070101063 A ARP070101063 A AR P070101063A AR P070101063 A ARP070101063 A AR P070101063A AR 059905 A1 AR059905 A1 AR 059905A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
group
histamine
compound
independently
Prior art date
Application number
ARP070101063A
Other languages
English (en)
Inventor
Joseph Raymond Stock
Magda Asselin
Ji-In Kim
William R Solvibile
Derek Cecil Cole
Albert J Robichaud
Johnathan L Gross
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR059905A1 publication Critical patent/AR059905A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Son compuestos utiles para el tratamiento de un trastorno del sistema nervioso central relacionado con o afectado por el receptor de histamina-3. Reivindicacion 1: Un compuesto de formula 1 caracterizado porque X es CO, CH2 o SOm; p y n son cada uno individualmente un entero de 1, 2 o 3; m es 0 o un entero de 1 o 2; R1 y R2 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido o R1 y R2 pueden ser tomados juntos con el átomo al cual ellos están unidos para formar un anillo de 4 a 7 miembros opcionalmente sustituido que contiene opcionalmente uno o dos heteroátomos adicionales seleccionados de N, O o S; R3 es NR4R5 o un grupo arilo o heteroarilo cada grupo opcionalmente sustituido; R4 y R5 son tomados juntos con el átomo al cual ellos están unidos para formar un sistema de anillo bicíclico, tricíclico o tetracíclico de 9 a 15 miembros opcionalmente sustituido que contiene opcionalmente uno a tres heteroátomos adicionales seleccionados de N, O o S; R6 y R7 son cada uno independientemente H, halogeno, OR10 o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; R8 y R9 son cada uno independientemente H, o un grupo alquilo, cicloalquilo, o arilo cada uno opcionalmente sustituido; y R10 es H o un grupo alquilo opcionalmente sustituido; o un estereoisomero de éstos o una sal farmacéuticamente aceptable de éstos.
ARP070101063A 2006-03-15 2007-03-15 Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto AR059905A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78251306P 2006-03-15 2006-03-15
US85907906P 2006-11-15 2006-11-15

Publications (1)

Publication Number Publication Date
AR059905A1 true AR059905A1 (es) 2008-05-07

Family

ID=38353957

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101063A AR059905A1 (es) 2006-03-15 2007-03-15 Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto

Country Status (11)

Country Link
US (1) US7820825B2 (es)
EP (1) EP1994022A2 (es)
JP (1) JP2009530274A (es)
AR (1) AR059905A1 (es)
AU (1) AU2007227681A1 (es)
BR (1) BRPI0709612A2 (es)
CA (1) CA2645731A1 (es)
MX (1) MX2008011791A (es)
PE (1) PE20071023A1 (es)
TW (1) TW200800958A (es)
WO (1) WO2007108936A2 (es)

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WO2007108936A2 (en) 2006-03-15 2007-09-27 Wyeth N-substituted-azacyclylamines as histamine-3 antagonists
CA2649913A1 (en) 2006-05-19 2007-11-29 Wyeth N-benzoyl- and n-benzylpyrrolidin-3-ylamines as histamine-3 antagonists
MX2008015365A (es) * 2006-05-30 2008-12-16 Janssen Pharmaceutica Nv Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.
EP2038269A1 (en) * 2006-06-29 2009-03-25 Janssen Pharmaceutica N.V. Substituted benzamide modulators of the histamine h3 receptor
PE20081152A1 (es) 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
PE20090720A1 (es) * 2007-05-24 2009-06-11 Wyeth Corp Derivados de azaciclilbenzamida como antagonistas de histamina-3
CL2008002088A1 (es) 2007-07-16 2008-09-05 Wyeth Corp Compuestos derivados de fenilo sustituido, moduladores del receptor de histamina 3; proceso de preparacion; composicion farmaceutica; y uso en el tratamiento de trastornos cognitivos tales como demencia, alzheimer, entre otros.
AU2008326561B2 (en) 2007-11-20 2013-12-05 Janssen Pharmaceutica N.V. Cycloalkyloxy-and heterocycloalky-loxypyridine compounds as modulators of the histamine H3 receptor
WO2009067406A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
KR101804749B1 (ko) * 2009-06-26 2017-12-05 사노피 히스타민 ｈ3 수용체 길항제의 신규 푸마레이트 염
EP2669271A4 (en) 2011-01-25 2014-08-13 Kissei Pharmaceutical INDOLE DERIVATIVE AND PHARMACEUTICAL ACCEPTABLE SALT THEREOF
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WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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Also Published As

Publication number Publication date
PE20071023A1 (es) 2007-10-03
JP2009530274A (ja) 2009-08-27
MX2008011791A (es) 2008-09-25
WO2007108936A3 (en) 2007-11-01
EP1994022A2 (en) 2008-11-26
US7820825B2 (en) 2010-10-26
WO2007108936A2 (en) 2007-09-27
CA2645731A1 (en) 2007-09-27
US20070219240A1 (en) 2007-09-20
TW200800958A (en) 2008-01-01
BRPI0709612A2 (pt) 2011-07-19
AU2007227681A1 (en) 2007-09-27

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