MA39837B1 - Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 - Google Patents
Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1Info
- Publication number
- MA39837B1 MA39837B1 MA39837A MA39837A MA39837B1 MA 39837 B1 MA39837 B1 MA 39837B1 MA 39837 A MA39837 A MA 39837A MA 39837 A MA39837 A MA 39837A MA 39837 B1 MA39837 B1 MA 39837B1
- Authority
- MA
- Morocco
- Prior art keywords
- thf
- amines
- pde1 inhibitors
- quinazolin
- halogenated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Abstract
La présente invention concerne des quinazoline-thf-amines halogénées utilisées en tant qu'inhibiteurs de la pde1 ainsi que leur utilisation en tant que médicament, en particulier pour le traitement de troubles neurodégénératifs et de troubles psychiatriques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201400194 | 2014-04-04 | ||
PCT/EP2015/056713 WO2015150254A1 (fr) | 2014-04-04 | 2015-03-27 | Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39837B1 true MA39837B1 (fr) | 2020-05-29 |
Family
ID=52779655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39837A MA39837B1 (fr) | 2014-04-04 | 2015-03-27 | Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 |
Country Status (38)
Country | Link |
---|---|
US (2) | US10005764B2 (fr) |
EP (1) | EP3126354B1 (fr) |
JP (1) | JP6554116B2 (fr) |
KR (1) | KR20160138084A (fr) |
CN (2) | CN106132953B (fr) |
AP (1) | AP2016009521A0 (fr) |
AR (1) | AR101155A1 (fr) |
AU (1) | AU2015239696B2 (fr) |
CA (1) | CA2943011A1 (fr) |
CL (1) | CL2016002515A1 (fr) |
CR (1) | CR20160463A (fr) |
CY (1) | CY1122784T1 (fr) |
DK (1) | DK3126354T3 (fr) |
DO (1) | DOP2016000263A (fr) |
EA (1) | EA032579B1 (fr) |
EC (1) | ECSP16082599A (fr) |
ES (1) | ES2776359T3 (fr) |
GE (1) | GEP20186920B (fr) |
GT (1) | GT201600213A (fr) |
HR (1) | HRP20200369T1 (fr) |
IL (1) | IL248078B (fr) |
JO (1) | JO3628B1 (fr) |
LT (1) | LT3126354T (fr) |
MA (1) | MA39837B1 (fr) |
MX (1) | MX364519B (fr) |
PE (1) | PE20161380A1 (fr) |
PH (1) | PH12016501938A1 (fr) |
PL (1) | PL3126354T3 (fr) |
PT (1) | PT3126354T (fr) |
RS (1) | RS60017B1 (fr) |
RU (1) | RU2692808C2 (fr) |
SG (1) | SG11201608190YA (fr) |
SI (1) | SI3126354T1 (fr) |
SV (1) | SV2016005297A (fr) |
TW (1) | TWI664178B (fr) |
UA (1) | UA119166C2 (fr) |
WO (1) | WO2015150254A1 (fr) |
ZA (1) | ZA201606566B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3126354T (lt) | 2014-04-04 | 2020-03-25 | H. Lundbeck A/S | Halogeninti kvinazolin-thf-aminai kaip pde1 inhibitoriai |
KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
MX2020005447A (es) * | 2017-11-27 | 2020-12-03 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituida como inhibidores de pde1. |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
GB0229281D0 (en) * | 2002-12-16 | 2003-01-22 | Novartis Ag | Organic compounds |
ZA200507979B (en) * | 2003-03-03 | 2007-03-28 | Vertex Pharma Inc | Quinazolines useful as modulators of ion channels |
GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
US20060019975A1 (en) * | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
WO2007096743A1 (fr) * | 2006-02-23 | 2007-08-30 | Pfizer Products Inc. | Quinazolines substituées en tant qu'inhibiteurs de pde10 |
US20070265258A1 (en) * | 2006-03-06 | 2007-11-15 | Ruiping Liu | Quinazoline derivatives as phosphodiesterase 10 inhibitors |
JP2013505909A (ja) * | 2009-09-24 | 2013-02-21 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物害虫を駆除するためのアミノキナゾリン化合物 |
US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
TW201609713A (zh) * | 2013-12-19 | 2016-03-16 | H 朗德貝克公司 | 作爲pde1抑制劑之喹唑啉-thf-胺 |
TW201611834A (en) * | 2014-02-07 | 2016-04-01 | Lundbeck & Co As H | Hexahydrofuropyrroles as PDE1 inhibitors |
SG11201608108SA (en) | 2014-04-04 | 2016-10-28 | Hoffmann La Roche | Pyridine-2-amides useful as cb2 agonists |
MA52856B1 (fr) | 2014-04-04 | 2022-03-31 | Pfizer | Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4 |
LT3126354T (lt) | 2014-04-04 | 2020-03-25 | H. Lundbeck A/S | Halogeninti kvinazolin-thf-aminai kaip pde1 inhibitoriai |
TW201623286A (zh) | 2014-04-04 | 2016-07-01 | 賽諾菲公司 | 作為gpr119調控劑用於治療糖尿病、肥胖、血脂異常及相關病症之異吲哚啉酮化合物 |
EA030032B1 (ru) | 2014-04-04 | 2018-06-29 | Ф. Хоффманн-Ля Рош Аг | 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов |
TW201625605A (zh) | 2014-04-04 | 2016-07-16 | 賽諾菲公司 | 用於治療糖尿病、肥胖、血脂異常及相關病症之作為gpr119調節劑的經取代之稠合雜環類 |
-
2015
- 2015-03-27 LT LTEP15713186.3T patent/LT3126354T/lt unknown
- 2015-03-27 RS RS20200239A patent/RS60017B1/sr unknown
- 2015-03-27 MX MX2016012955A patent/MX364519B/es active IP Right Grant
- 2015-03-27 GE GEAP201514286A patent/GEP20186920B/en unknown
- 2015-03-27 CN CN201580017454.2A patent/CN106132953B/zh active Active
- 2015-03-27 AP AP2016009521A patent/AP2016009521A0/en unknown
- 2015-03-27 CN CN201910110735.2A patent/CN109999039A/zh active Pending
- 2015-03-27 EA EA201691773A patent/EA032579B1/ru not_active IP Right Cessation
- 2015-03-27 EP EP15713186.3A patent/EP3126354B1/fr active Active
- 2015-03-27 WO PCT/EP2015/056713 patent/WO2015150254A1/fr active Application Filing
- 2015-03-27 CR CR20160463A patent/CR20160463A/es unknown
- 2015-03-27 RU RU2016138743A patent/RU2692808C2/ru active
- 2015-03-27 ES ES15713186T patent/ES2776359T3/es active Active
- 2015-03-27 PE PE2016001906A patent/PE20161380A1/es unknown
- 2015-03-27 SI SI201531112T patent/SI3126354T1/sl unknown
- 2015-03-27 UA UAA201610191A patent/UA119166C2/uk unknown
- 2015-03-27 DK DK15713186.3T patent/DK3126354T3/da active
- 2015-03-27 AU AU2015239696A patent/AU2015239696B2/en not_active Ceased
- 2015-03-27 CA CA2943011A patent/CA2943011A1/fr not_active Abandoned
- 2015-03-27 KR KR1020167027262A patent/KR20160138084A/ko not_active Application Discontinuation
- 2015-03-27 PT PT157131863T patent/PT3126354T/pt unknown
- 2015-03-27 JP JP2016560728A patent/JP6554116B2/ja active Active
- 2015-03-27 US US15/301,210 patent/US10005764B2/en active Active
- 2015-03-27 MA MA39837A patent/MA39837B1/fr unknown
- 2015-03-27 SG SG11201608190YA patent/SG11201608190YA/en unknown
- 2015-03-27 PL PL15713186T patent/PL3126354T3/pl unknown
- 2015-03-30 JO JOP/2015/0058A patent/JO3628B1/ar active
- 2015-03-31 TW TW104110439A patent/TWI664178B/zh not_active IP Right Cessation
- 2015-04-01 AR ARP150101009A patent/AR101155A1/es unknown
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2016
- 2016-09-22 ZA ZA2016/06566A patent/ZA201606566B/en unknown
- 2016-09-27 DO DO2016000263A patent/DOP2016000263A/es unknown
- 2016-09-27 IL IL248078A patent/IL248078B/en active IP Right Grant
- 2016-09-29 PH PH12016501938A patent/PH12016501938A1/en unknown
- 2016-10-03 GT GT201600213A patent/GT201600213A/es unknown
- 2016-10-03 SV SV2016005297A patent/SV2016005297A/es unknown
- 2016-10-03 CL CL2016002515A patent/CL2016002515A1/es unknown
- 2016-10-20 EC ECIEPI201682599A patent/ECSP16082599A/es unknown
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2018
- 2018-06-13 US US16/007,561 patent/US10526319B2/en active Active
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2020
- 2020-03-04 CY CY20201100196T patent/CY1122784T1/el unknown
- 2020-03-04 HR HRP20200369TT patent/HRP20200369T1/hr unknown
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