ATE368666T1 - Pyrazolopyrimidinone und ihre verwendung als pde inhibitoren - Google Patents

Pyrazolopyrimidinone und ihre verwendung als pde inhibitoren

Info

Publication number
ATE368666T1
ATE368666T1 AT04006048T AT04006048T ATE368666T1 AT E368666 T1 ATE368666 T1 AT E368666T1 AT 04006048 T AT04006048 T AT 04006048T AT 04006048 T AT04006048 T AT 04006048T AT E368666 T1 ATE368666 T1 AT E368666T1
Authority
AT
Austria
Prior art keywords
pyrazolopyrimidinones
pde inhibitors
pyrazolopyrimidones
compositions
novel
Prior art date
Application number
AT04006048T
Other languages
English (en)
Inventor
Ali Adnan Badwan
Original Assignee
Jordanian Pharmaceutical Mfg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jordanian Pharmaceutical Mfg filed Critical Jordanian Pharmaceutical Mfg
Application granted granted Critical
Publication of ATE368666T1 publication Critical patent/ATE368666T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04006048T 2003-03-18 2004-03-15 Pyrazolopyrimidinone und ihre verwendung als pde inhibitoren ATE368666T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10312021 2003-03-18
DE102004005392 2004-02-04

Publications (1)

Publication Number Publication Date
ATE368666T1 true ATE368666T1 (de) 2007-08-15

Family

ID=32826216

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04006048T ATE368666T1 (de) 2003-03-18 2004-03-15 Pyrazolopyrimidinone und ihre verwendung als pde inhibitoren

Country Status (4)

Country Link
EP (1) EP1460077B1 (de)
AT (1) ATE368666T1 (de)
DE (1) DE602004007840T2 (de)
ES (1) ES2289377T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
DE10320785A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
DE102004001873A1 (de) 2004-01-14 2005-09-29 Bayer Healthcare Ag Cyanopyrimidinone
DK2152712T3 (da) 2007-05-11 2012-03-26 Pfizer Aminoheterocykliske fobindelser
EP2217602B1 (de) 2007-11-30 2018-08-29 Boehringer Ingelheim International GmbH 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-on- derivative und ihre verwendung als pde9a modulatoren zur behandlung von erkrankungen des zns
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
CN102164604A (zh) 2008-07-24 2011-08-24 百时美施贵宝公司 用作激酶调节剂的稠合杂环化合物
PE20110383A1 (es) 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
CA2757231A1 (en) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
CA2807687C (en) 2010-08-12 2019-01-08 Boehringer Ingelheim International Gmbh 6-cycloalkyl-1, 5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
EP3253759A1 (de) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Isothiazolpyrimidinone, pyrazolopyrimidinone und pyrrolopyrimidinone als ubiquitin-spezifische protease-7-hemmer
JP2018504431A (ja) 2015-02-05 2018-02-15 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的プロテアーゼ７阻害物質としてのチエノピリミジノン
JP2018504430A (ja) 2015-02-05 2018-02-15 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的プロテアーゼ７阻害物質としてのキナゾリノン及びアザキナゾリノン
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
JP7254078B2 (ja) 2017-11-27 2023-04-07 ダート・ニューロサイエンス・エルエルシー Ｐｄｅ１阻害剤としての置換フラノピリミジン化合物
KR20210056827A (ko) * 2019-11-11 2021-05-20 일동제약(주) 신규한 벤젠설폰아미드 유도체 및 그의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939161A (en) * 1973-10-29 1976-02-17 Abbott Laboratories 1,3-Dimethyl- 1H-pyrazolo(4,3-D) pyrimidine-7 (6H)-ones
US4666908A (en) * 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
US6225315B1 (en) * 1998-11-30 2001-05-01 Pfizer Inc Method of treating nitrate-induced tolerance
JP3940290B2 (ja) * 2000-12-22 2007-07-04 ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド 新規化合物

Also Published As

Publication number Publication date
ES2289377T3 (es) 2008-02-01
DE602004007840T2 (de) 2008-04-10
EP1460077B1 (de) 2007-08-01
EP1460077A1 (de) 2004-09-22
DE602004007840D1 (de) 2007-09-13

Similar Documents

Publication Publication Date Title
ATE368666T1 (de) Pyrazolopyrimidinone und ihre verwendung als pde inhibitoren
CY1107747T1 (el) Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
ATE384061T1 (de) Imidazo- und thiazolopyridine als jak3-kinase- inhibitoren
EA200700189A1 (ru) Производные хиназолина в качестве ингибиторов parp
EA200700185A1 (ru) Производные хиназолиндиона в качестве ингибиторов parp
WO2006123113A3 (en) Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
ECSP066886A (es) Compuestos y métodos para el tratamiento de dislipidemia
EA200700192A1 (ru) Производные фталазина в качестве ингибиторов parp
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
TW200718422A (en) 1,6-Dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
WO2006065686A3 (en) Spiro derivatives as lipoxygenase inhibitors
IL181271A0 (en) Triazolophthalazine derivatives and pharmaceutical compositions containing the same
WO2004106293A3 (en) Oxazolyl - and thiazolyl - purine based tricyclic compounds.
NO20056192L (no) Kapaseinhibitorer og anvendelse derav
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
EA200701328A1 (ru) Замещенные триазольные производные в качестве антагонистов окситоцина
EA200600100A1 (ru) Производные никотинамида, полезные в качестве ингибиторов pde4
WO2005011609A3 (en) Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
BR0318521A (pt) arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
HRP20050082A2 (en) 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
ATE462703T1 (de) Bicyclononen-derivate als renin-inhibitoren
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1460077

Country of ref document: EP

REN Ceased due to non-payment of the annual fee