WO2004106293A3 - Oxazolyl - and thiazolyl - purine based tricyclic compounds. - Google Patents

Oxazolyl - and thiazolyl - purine based tricyclic compounds. Download PDF

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Publication number
WO2004106293A3
WO2004106293A3 PCT/US2004/015623 US2004015623W WO2004106293A3 WO 2004106293 A3 WO2004106293 A3 WO 2004106293A3 US 2004015623 W US2004015623 W US 2004015623W WO 2004106293 A3 WO2004106293 A3 WO 2004106293A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxazolyl
thiazolyl
tricyclic compounds
compounds
purine based
Prior art date
Application number
PCT/US2004/015623
Other languages
French (fr)
Other versions
WO2004106293A2 (en
Inventor
William J Pitts
Makonen Belema
Patrice Gill
James Kempson
Yuping Qiu
Claude Quesnelle
Steven H Spergel
Christopher Zusi
Original Assignee
Bristol Myers Squibb Co
William J Pitts
Makonen Belema
Patrice Gill
James Kempson
Yuping Qiu
Claude Quesnelle
Steven H Spergel
Christopher Zusi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, William J Pitts, Makonen Belema, Patrice Gill, James Kempson, Yuping Qiu, Claude Quesnelle, Steven H Spergel, Christopher Zusi filed Critical Bristol Myers Squibb Co
Publication of WO2004106293A2 publication Critical patent/WO2004106293A2/en
Publication of WO2004106293A3 publication Critical patent/WO2004106293A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Abstract

The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
PCT/US2004/015623 2003-05-21 2004-05-19 Oxazolyl - and thiazolyl - purine based tricyclic compounds. WO2004106293A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47224603P 2003-05-21 2003-05-21
US60/472,246 2003-05-21
US10/848,412 2004-05-18
US10/848,412 US7176214B2 (en) 2003-05-21 2004-05-18 Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
WO2004106293A2 WO2004106293A2 (en) 2004-12-09
WO2004106293A3 true WO2004106293A3 (en) 2005-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015623 WO2004106293A2 (en) 2003-05-21 2004-05-19 Oxazolyl - and thiazolyl - purine based tricyclic compounds.

Country Status (2)

Country Link
US (2) US7176214B2 (en)
WO (1) WO2004106293A2 (en)

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RS58187B1 (en) 2012-11-08 2019-03-29 Bristol Myers Squibb Co Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn-alpha
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AR094537A1 (en) 2013-11-07 2015-08-12 Bristol Myers Squibb Co PIRIDIL COMPOUNDS REPLACED WITH USEFUL ALQUILAMIDE AS MODULATORS OF THE ANSWERS OF IL-12, IL-23 AND / OR IFNa
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US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
WO2017087590A1 (en) 2015-11-18 2017-05-26 Bristol-Myers Squibb Company Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
WO2017097216A1 (en) * 2015-12-07 2017-06-15 杭州雷索药业有限公司 Five-membered heterocyclic amides wnt pathway inhibitor
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Also Published As

Publication number Publication date
US20050101626A1 (en) 2005-05-12
WO2004106293A2 (en) 2004-12-09
US20060217412A1 (en) 2006-09-28
US7176214B2 (en) 2007-02-13

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