DE69922792D1 - Verfahren zur herstellung von (r)-2-brom-3-phenylpropionsäure - Google Patents
Verfahren zur herstellung von (r)-2-brom-3-phenylpropionsäureInfo
- Publication number
- DE69922792D1 DE69922792D1 DE69922792T DE69922792T DE69922792D1 DE 69922792 D1 DE69922792 D1 DE 69922792D1 DE 69922792 T DE69922792 T DE 69922792T DE 69922792 T DE69922792 T DE 69922792T DE 69922792 D1 DE69922792 D1 DE 69922792D1
- Authority
- DE
- Germany
- Prior art keywords
- brom
- preparation
- phenylpropionic acid
- phenyl
- alanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WDRSCFNERFONKU-MRVPVSSYSA-N (2r)-2-bromo-3-phenylpropanoic acid Chemical compound OC(=O)[C@H](Br)CC1=CC=CC=C1 WDRSCFNERFONKU-MRVPVSSYSA-N 0.000 title abstract 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000010288 sodium nitrite Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI000302A IT1298268B1 (it) | 1998-02-18 | 1998-02-18 | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
| PCT/EP1999/000468 WO1999042431A1 (en) | 1998-02-18 | 1999-01-26 | Process for preparing (r)-2-bromo-3-phenyl-propionic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69922792D1 true DE69922792D1 (de) | 2005-01-27 |
Family
ID=11378968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69922792T Expired - Fee Related DE69922792D1 (de) | 1998-02-18 | 1999-01-26 | Verfahren zur herstellung von (r)-2-brom-3-phenylpropionsäure |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6103931A (de) |
| EP (1) | EP1056707B1 (de) |
| AT (1) | ATE285393T1 (de) |
| CA (1) | CA2321001A1 (de) |
| DE (1) | DE69922792D1 (de) |
| HU (1) | HUP0100253A3 (de) |
| IL (1) | IL137120A (de) |
| IT (1) | IT1298268B1 (de) |
| WO (1) | WO1999042431A1 (de) |
| ZA (1) | ZA99812B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1014353C2 (nl) * | 2000-02-11 | 2001-08-15 | Dsm Nv | Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur. |
| EP1138671B1 (de) * | 2000-03-30 | 2004-09-01 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von aromatischen Acylthiocarbonsäurederivaten |
| US6620600B2 (en) * | 2000-09-15 | 2003-09-16 | Bristol-Myers Squibb Co. | Enzymatic resolution of aryl and thio-substituted acids |
| US7388098B2 (en) | 2000-09-29 | 2008-06-17 | Bristol-Myers Squibb Company | Dynamic resolution of isomers and resolved isomers |
| WO2003014056A1 (en) * | 2001-08-08 | 2003-02-20 | Kaneka Corporation | Process for producing optically active 2-substituted carboxylic acid |
| AU2003244467A1 (en) | 2002-02-04 | 2003-09-02 | Kaneka Corporation | Process for production of optically active 2-halogeno- carboxylic acids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4339600A (en) * | 1976-05-10 | 1982-07-13 | E. R. Squibb & Sons, Inc. | Compounds for alleviating angiotensin related hypertension |
| JPS56158732A (en) * | 1980-05-14 | 1981-12-07 | Toyo Soda Mfg Co Ltd | Preparation of alpha-halogeno-beta-phenylpropionic acid |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| ES2138622T3 (es) * | 1992-05-15 | 2000-01-16 | Merrell Pharma Inc | Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
-
1998
- 1998-02-18 IT IT98MI000302A patent/IT1298268B1/it active IP Right Grant
-
1999
- 1999-01-26 DE DE69922792T patent/DE69922792D1/de not_active Expired - Fee Related
- 1999-01-26 EP EP99903680A patent/EP1056707B1/de not_active Expired - Lifetime
- 1999-01-26 WO PCT/EP1999/000468 patent/WO1999042431A1/en active IP Right Grant
- 1999-01-26 HU HU0100253A patent/HUP0100253A3/hu unknown
- 1999-01-26 IL IL13712099A patent/IL137120A/xx active IP Right Grant
- 1999-01-26 CA CA002321001A patent/CA2321001A1/en not_active Abandoned
- 1999-01-26 AT AT99903680T patent/ATE285393T1/de not_active IP Right Cessation
- 1999-02-02 ZA ZA9900812A patent/ZA99812B/xx unknown
- 1999-02-17 US US09/251,432 patent/US6103931A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100253A3 (en) | 2002-09-30 |
| ITMI980302A1 (it) | 1999-08-18 |
| WO1999042431A1 (en) | 1999-08-26 |
| IT1298268B1 (it) | 1999-12-20 |
| IL137120A0 (en) | 2001-06-14 |
| ZA99812B (en) | 1999-08-02 |
| IL137120A (en) | 2005-06-19 |
| HUP0100253A2 (hu) | 2001-05-28 |
| US6103931A (en) | 2000-08-15 |
| EP1056707B1 (de) | 2004-12-22 |
| CA2321001A1 (en) | 1999-08-26 |
| ATE285393T1 (de) | 2005-01-15 |
| EP1056707A1 (de) | 2000-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |