MXPA05006279A - Proceso para la preparacion de pregnanos. - Google Patents

Proceso para la preparacion de pregnanos.

Info

Publication number
MXPA05006279A
MXPA05006279A MXPA05006279A MXPA05006279A MXPA05006279A MX PA05006279 A MXPA05006279 A MX PA05006279A MX PA05006279 A MXPA05006279 A MX PA05006279A MX PA05006279 A MXPA05006279 A MX PA05006279A MX PA05006279 A MXPA05006279 A MX PA05006279A
Authority
MX
Mexico
Prior art keywords
preparation
formula
pregnanes
derivatives
fluoropregnane
Prior art date
Application number
MXPA05006279A
Other languages
English (en)
Inventor
Pierluigi Rossetto
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of MXPA05006279A publication Critical patent/MXPA05006279A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Un proceso estereoselectivo mejorado para la preparacion de derivados de 6a-fluoropregnano de la formula (I), que comprende la reaccion de derivados de 3-benzoiloxi-?3,5-pregnano de la formula (II), con un agente de fluoracion electrofilo en una mezcla de la reaccion sustancialmente libre de agua y en la presencia de una sal de un acido fuerte con una base nitrogenosa.
MXPA05006279A 2002-12-09 2003-12-02 Proceso para la preparacion de pregnanos. MXPA05006279A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02027534 2002-12-09
PCT/EP2003/050925 WO2004052911A1 (en) 2002-12-09 2003-12-02 Process for the preparation of pregnanes

Publications (1)

Publication Number Publication Date
MXPA05006279A true MXPA05006279A (es) 2006-01-27

Family

ID=32479719

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006279A MXPA05006279A (es) 2002-12-09 2003-12-02 Proceso para la preparacion de pregnanos.

Country Status (10)

Country Link
US (1) US20060252926A1 (es)
EP (1) EP1474435B1 (es)
JP (1) JP4481831B2 (es)
AT (1) ATE318274T1 (es)
AU (1) AU2003298339A1 (es)
CA (1) CA2509366C (es)
DE (1) DE60303687D1 (es)
IL (1) IL169073A (es)
MX (1) MXPA05006279A (es)
WO (1) WO2004052911A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1465855A2 (en) 2001-11-29 2004-10-13 Taro Pharmaceuticals U.S.A., Inc. Method for the production of 6-alpha-fluoro corticosteroids
ITMI20122200A1 (it) 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani
CN103073613B (zh) * 2012-12-31 2016-04-13 浙江工业大学 一种氟替卡松衍生物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2961441A (en) * 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3379743A (en) * 1965-06-07 1968-04-23 Sterling Drug Inc 17-enol esters of 3-oxy-17-hydroxy-polyunsaturated steroids and preparation thereof
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
IT1319654B1 (it) * 2000-11-15 2003-10-23 Farmabios S R L Ora Farmabios Processo di isomerizzazione di 6beta-fluoro steroidi neicorrispondenti 6alfa-fluoro derivati.
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno

Also Published As

Publication number Publication date
AU2003298339A1 (en) 2004-06-30
US20060252926A1 (en) 2006-11-09
IL169073A (en) 2010-04-15
EP1474435B1 (en) 2006-02-22
CA2509366A1 (en) 2004-06-24
WO2004052911A1 (en) 2004-06-24
JP4481831B2 (ja) 2010-06-16
JP2006515582A (ja) 2006-06-01
EP1474435A1 (en) 2004-11-10
ATE318274T1 (de) 2006-03-15
CA2509366C (en) 2008-04-15
DE60303687D1 (de) 2006-04-27

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