AU1987000A - Method for preparing an aza-macrolide with 4'' (r) nh2 - Google Patents

Method for preparing an aza-macrolide with 4'' (r) nh2

Info

Publication number
AU1987000A
AU1987000A AU19870/00A AU1987000A AU1987000A AU 1987000 A AU1987000 A AU 1987000A AU 19870/00 A AU19870/00 A AU 19870/00A AU 1987000 A AU1987000 A AU 1987000A AU 1987000 A AU1987000 A AU 1987000A
Authority
AU
Australia
Prior art keywords
macrolide
aza
preparing
stereoselective
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU19870/00A
Other versions
AU768838B2 (en
Inventor
Laurent Garel
Ronan Guevel
Patrick Leon
Frederic Lhermitte
Gilles Oddon
Denis Pauze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial SAS filed Critical Merial SAS
Publication of AU1987000A publication Critical patent/AU1987000A/en
Application granted granted Critical
Publication of AU768838B2 publication Critical patent/AU768838B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4'' position in a corresponding derivative of formula II.
AU19870/00A 1999-01-18 2000-01-17 Method for preparing an aza-macrolide with 4'' (R) NH2 Expired AU768838B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9900459 1999-01-18
FR9900459A FR2788524B1 (en) 1999-01-18 1999-01-18 USEFUL PROCESS FOR TRANSFORMING THE 4 "(S) -OH FUNCTION OF THE CLADINOSIS PATTERN OF A MACROLIDE AZA INTO 4" (R) -NH2
PCT/FR2000/000089 WO2000042056A1 (en) 1999-01-18 2000-01-17 Method for preparing an aza-macrolide with 4'' (r) nh¿2?

Publications (2)

Publication Number Publication Date
AU1987000A true AU1987000A (en) 2000-08-01
AU768838B2 AU768838B2 (en) 2004-01-08

Family

ID=9540950

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19870/00A Expired AU768838B2 (en) 1999-01-18 2000-01-17 Method for preparing an aza-macrolide with 4'' (R) NH2

Country Status (15)

Country Link
US (1) USRE40040E1 (en)
EP (1) EP1144428B1 (en)
JP (1) JP2003505340A (en)
AT (1) ATE279426T1 (en)
AU (1) AU768838B2 (en)
BR (1) BRPI0007593B8 (en)
CA (1) CA2359967C (en)
DE (1) DE60014849T2 (en)
DK (1) DK1144428T3 (en)
ES (1) ES2232414T3 (en)
FR (1) FR2788524B1 (en)
NZ (1) NZ513025A (en)
PT (1) PT1144428E (en)
WO (1) WO2000042056A1 (en)
ZA (1) ZA200105825B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151598A (en) * 1979-05-11 1980-11-26 Taisho Pharmaceut Co Ltd Erythromycin a derivative and its preparation
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
DK0679657T3 (en) * 1994-04-27 2003-10-27 Novartis Ag Nucleosides and oligonucleotides with 2'-ether groups
GB9806029D0 (en) * 1998-03-20 1998-05-20 Merck & Co Inc 8a-Azalides as veterinary antimicrobial agents
JP2003512290A (en) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 8a-azalide as a livestock antibacterial agent

Also Published As

Publication number Publication date
DK1144428T3 (en) 2005-02-14
BR0007593B1 (en) 2014-01-28
EP1144428B1 (en) 2004-10-13
CA2359967A1 (en) 2000-07-20
DE60014849T2 (en) 2006-03-09
CA2359967C (en) 2011-08-30
PT1144428E (en) 2005-02-28
ZA200105825B (en) 2002-05-08
BRPI0007593B8 (en) 2021-05-25
DE60014849D1 (en) 2004-11-18
WO2000042056A1 (en) 2000-07-20
FR2788524A1 (en) 2000-07-21
ATE279426T1 (en) 2004-10-15
AU768838B2 (en) 2004-01-08
ES2232414T3 (en) 2005-06-01
JP2003505340A (en) 2003-02-12
NZ513025A (en) 2003-11-28
EP1144428A1 (en) 2001-10-17
BR0007593A (en) 2001-11-06
USRE40040E1 (en) 2008-01-29
FR2788524B1 (en) 2002-04-26

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired