HUP0004510A1 - Eljárás L-dihidroorotsav előállítására és a vegyület alkalmazása - Google Patents

Eljárás L-dihidroorotsav előállítására és a vegyület alkalmazása

Info

Publication number
HUP0004510A1
HUP0004510A1 HU0004510A HUP0004510A HUP0004510A1 HU P0004510 A1 HUP0004510 A1 HU P0004510A1 HU 0004510 A HU0004510 A HU 0004510A HU P0004510 A HUP0004510 A HU P0004510A HU P0004510 A1 HUP0004510 A1 HU P0004510A1
Authority
HU
Hungary
Prior art keywords
obtaining
trifluoromethyl
mpa
phenyl
dihydroorotic acid
Prior art date
Application number
HU0004510A
Other languages
English (en)
Inventor
Robert Bartlett
Claude Fudali
Ulrike Milbert
Eric Ruuth
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HUP0004510A1 publication Critical patent/HUP0004510A1/hu
Publication of HUP0004510A3 publication Critical patent/HUP0004510A3/hu

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed

Abstract

A találmány tárgya eljárás L-dihidroortosav előállítására víz ésvalamely bázis elegyével, anionos ioncserélőn végzett kromatografálásútján, 1,1 MPa és körülbelül 40 MPa közötti nyomáson. A találmányszerinti eljárás alkalmas N-(4-trifluor-metil-fenil)-5-metil-izoxazol-4-karboxamid, N-(4-trifluor-metil-fenil)-2-ciano-3-hidroxi-krotonamidés hasonló vegyületek in vitro<>, valamint in vivo aktivitásánakfölderítésére. Ó
HU0004510A 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof HUP0004510A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121848A EP0933633A1 (en) 1997-12-11 1997-12-11 Process for obtaining L-dihydroorotic acid and use thereof
PCT/EP1998/007972 WO1999030146A1 (en) 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof

Publications (2)

Publication Number Publication Date
HUP0004510A1 true HUP0004510A1 (hu) 2001-04-28
HUP0004510A3 HUP0004510A3 (en) 2003-05-28

Family

ID=8227782

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004510A HUP0004510A3 (en) 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof

Country Status (21)

Country Link
US (1) US6545006B1 (hu)
EP (2) EP0933633A1 (hu)
JP (1) JP4189124B2 (hu)
KR (1) KR100700906B1 (hu)
CN (1) CN1237345C (hu)
AR (1) AR016430A1 (hu)
AT (1) ATE305610T1 (hu)
AU (1) AU747993B2 (hu)
BR (1) BR9813559A (hu)
CA (1) CA2315326A1 (hu)
CZ (1) CZ299968B6 (hu)
DE (1) DE69831752T2 (hu)
DK (1) DK1036319T3 (hu)
ES (1) ES2248927T3 (hu)
HK (1) HK1033171A1 (hu)
HU (1) HUP0004510A3 (hu)
ID (1) ID24807A (hu)
PL (1) PL194068B1 (hu)
RU (1) RU2228932C2 (hu)
TR (1) TR200001671T2 (hu)
WO (1) WO1999030146A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001043742A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceuticals Industries Ltd. Novel processes for making- and a new crystalline form of- leflunomide
US20150166498A1 (en) * 2012-05-29 2015-06-18 Nai Inc. Dihydroorotic acid dehydrogenase inhibitor
US10708575B2 (en) 2012-06-25 2020-07-07 Sharp Kabushiki Kaisha Display system with diffuse and specular reflective modes
US9679506B2 (en) 2012-06-25 2017-06-13 Sharp Kabushiki Kaisha Multiple function display system
CN102787147B (zh) * 2012-08-31 2014-10-08 南京工业大学 一种酶法制备l-二氢乳清酸的方法
US10699612B2 (en) 2014-10-27 2020-06-30 Sharp Kabushiki Kaisha Display system with specular reflective mode
CN112305097A (zh) * 2020-09-30 2021-02-02 辰欣药业股份有限公司 一种特立氟胺片有关物质的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773872A (en) * 1954-04-12 1956-12-11 Merck & Co Inc Dihydroorotic acid
HU178201B (en) * 1977-08-05 1982-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted orto-acids and dihydro-orto-acids and derivatives thereof
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen

Also Published As

Publication number Publication date
CZ20002134A3 (cs) 2000-10-11
JP4189124B2 (ja) 2008-12-03
ATE305610T1 (de) 2005-10-15
TR200001671T2 (tr) 2000-11-21
HK1033171A1 (en) 2001-08-17
ID24807A (id) 2000-08-24
WO1999030146A1 (en) 1999-06-17
EP1036319B1 (en) 2005-09-28
PL194068B1 (pl) 2007-04-30
DK1036319T3 (da) 2006-01-16
KR20010032978A (ko) 2001-04-25
DE69831752T2 (de) 2006-06-22
CZ299968B6 (cs) 2009-01-07
KR100700906B1 (ko) 2007-03-29
EP0933633A1 (en) 1999-08-04
JP2001526387A (ja) 2001-12-18
AU1877599A (en) 1999-06-28
EP1036319A1 (en) 2000-09-20
CN1237345C (zh) 2006-01-18
RU2228932C2 (ru) 2004-05-20
CN1281550A (zh) 2001-01-24
DE69831752D1 (de) 2006-02-09
PL341205A1 (en) 2001-03-26
ES2248927T3 (es) 2006-03-16
HUP0004510A3 (en) 2003-05-28
US6545006B1 (en) 2003-04-08
AU747993B2 (en) 2002-05-30
AR016430A1 (es) 2001-07-04
BR9813559A (pt) 2000-10-10
CA2315326A1 (en) 1999-06-17

Similar Documents

Publication Publication Date Title
ES2124373T3 (es) Procedimiento para la preparacion de derivados del acido n-acil-n,n&#39;,n&#39;-etilendiamintriacetico.
HUP0000527A2 (hu) Eljárás tolterodin előállítására és az intermedier
FR2627696B1 (fr) Nouvelle forme galenique du fenofibrate
LV10575A (lv) Izoksazoi-4-karbonskabes amids un hidroksialkiliden-cianetikskabes amids sos savienojumus saturosi astniecibas lidzekli un to pielietojums
GT199800197AA (es) Proceso para la sintesis de 1,3-dioles
FI906438A0 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
HUP0204010A2 (hu) Új szertralin-hidroklorid polimorfok, eljárás az előállításukra, az új polimorfokat tartalmazó gyógyszerkészítmények és alkalmazásuk
TR200100426T2 (tr) Nematisit pirazoller
YU7804A (sh) Stabilni polimorf flibanserina,postupak za njegovo dobijanje u industrijskim razmerama i njegova primena za pripremanje lekova
BR9912010A (pt) Polimorfo de um produto farmacêutico
HUP0004510A1 (hu) Eljárás L-dihidroorotsav előállítására és a vegyület alkalmazása
HUP0201152A2 (hu) Eljárás nem proteinogén L-aminosavak előállítására
PL336640A1 (en) Substituted 3,3-diamino-2- propenonitriles, their production and application
TR200000697T2 (tr) İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin-10-OL&#39;ler, üretim yöntemleri ve farmasötik preparat olarak kullanımları.
AU2003255355A1 (en) Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
BG104243A (en) Method for the synthesis of quinoline derivatives
BR0001342A (pt) Processo para a produção de l-aminoácidos por meio de fermentação usando bactérias corineformes
AR016168A1 (es) Nuevo procedimiento para preparar n-[4-(3,4-diclorofenil)-3-4-dihidro-1(2h)-naftaleniliden]metanamina y procedimientos para preparar mezclas del mismo
HUT76303A (en) Process for making racem piperazine carboxamide derivatives
PT984922E (pt) Preparacao de composto de tri-iodo benzeno
BR0111711A (pt) Processo para a preparação de p-amino-fenóis
NO20001404D0 (no) Nye stereoselektive fremgangsmåter for fremstilling av gabapentinanaloger
DK1001929T3 (da) Fremgangsmåde til fremstilling af 3-cyano-2,4-dihalogen-5-flour-benzoesyrer
WO2001083423A3 (en) 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof
DK1334176T3 (da) Mikroorganismer, der producerer L-glutamin, og fremgangsmåder til produktion af L-glutamin under anvendelse af samme

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees