TR200001671T2 - L-Dihidroorotik asit elde etmek için işlem ve kullanımı. - Google Patents

L-Dihidroorotik asit elde etmek için işlem ve kullanımı.

Info

Publication number
TR200001671T2
TR200001671T2 TR2000/01671T TR200001671T TR200001671T2 TR 200001671 T2 TR200001671 T2 TR 200001671T2 TR 2000/01671 T TR2000/01671 T TR 2000/01671T TR 200001671 T TR200001671 T TR 200001671T TR 200001671 T2 TR200001671 T2 TR 200001671T2
Authority
TR
Turkey
Prior art keywords
dihydroorotic acid
trifluoromethylphenyl
mpa
dihydroorotic
acid
Prior art date
Application number
TR2000/01671T
Other languages
English (en)
Inventor
Milbert Ulrike
Bartlett Robert
Fudali Claude
Ruuth Eric
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200001671T2 publication Critical patent/TR200001671T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Bulus, yaklasik olarak 1.1 MPa ila yaklasik olarak 40 MPa arasindaki basinçta, bir baz su karisimi içinde, anyonik degistirme maddesi üzerinde, kromatografi yolu ile, L-dihidroorotik asit elde etmek için bir islem ile ilgilidir. islem, N-(4-triflorometilfenil)-5-metilizoksazol-4-karboksamid, N-(4-triflorometilfenil)-2-Siyano-3-hidroksikrotonamid ve benzer bilesiklerin invitro ve in vivo aktivitesini arastirmak üzere de kullanilabilir.
TR2000/01671T 1997-12-11 1998-12-08 L-Dihidroorotik asit elde etmek için işlem ve kullanımı. TR200001671T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97121848A EP0933633A1 (en) 1997-12-11 1997-12-11 Process for obtaining L-dihydroorotic acid and use thereof

Publications (1)

Publication Number Publication Date
TR200001671T2 true TR200001671T2 (tr) 2000-11-21

Family

ID=8227782

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01671T TR200001671T2 (tr) 1997-12-11 1998-12-08 L-Dihidroorotik asit elde etmek için işlem ve kullanımı.

Country Status (21)

Country Link
US (1) US6545006B1 (tr)
EP (2) EP0933633A1 (tr)
JP (1) JP4189124B2 (tr)
KR (1) KR100700906B1 (tr)
CN (1) CN1237345C (tr)
AR (1) AR016430A1 (tr)
AT (1) ATE305610T1 (tr)
AU (1) AU747993B2 (tr)
BR (1) BR9813559A (tr)
CA (1) CA2315326A1 (tr)
CZ (1) CZ299968B6 (tr)
DE (1) DE69831752T2 (tr)
DK (1) DK1036319T3 (tr)
ES (1) ES2248927T3 (tr)
HK (1) HK1033171A1 (tr)
HU (1) HUP0004510A3 (tr)
ID (1) ID24807A (tr)
PL (1) PL194068B1 (tr)
RU (1) RU2228932C2 (tr)
TR (1) TR200001671T2 (tr)
WO (1) WO1999030146A1 (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2397601A1 (en) * 1999-12-16 2001-06-21 Teva Pharmaceutical Industries, Ltd. Novel processes for making- and a new crystalline form of- leflunomide
US20150166498A1 (en) * 2012-05-29 2015-06-18 Nai Inc. Dihydroorotic acid dehydrogenase inhibitor
US9679506B2 (en) 2012-06-25 2017-06-13 Sharp Kabushiki Kaisha Multiple function display system
US10708575B2 (en) 2012-06-25 2020-07-07 Sharp Kabushiki Kaisha Display system with diffuse and specular reflective modes
CN102787147B (zh) * 2012-08-31 2014-10-08 南京工业大学 一种酶法制备l-二氢乳清酸的方法
US10699612B2 (en) 2014-10-27 2020-06-30 Sharp Kabushiki Kaisha Display system with specular reflective mode
CN112305097A (zh) * 2020-09-30 2021-02-02 辰欣药业股份有限公司 一种特立氟胺片有关物质的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773872A (en) * 1954-04-12 1956-12-11 Merck & Co Inc Dihydroorotic acid
HU178201B (en) * 1977-08-05 1982-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted orto-acids and dihydro-orto-acids and derivatives thereof
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen

Also Published As

Publication number Publication date
WO1999030146A1 (en) 1999-06-17
CN1237345C (zh) 2006-01-18
CN1281550A (zh) 2001-01-24
RU2228932C2 (ru) 2004-05-20
DK1036319T3 (da) 2006-01-16
AR016430A1 (es) 2001-07-04
CZ299968B6 (cs) 2009-01-07
JP2001526387A (ja) 2001-12-18
KR20010032978A (ko) 2001-04-25
AU747993B2 (en) 2002-05-30
AU1877599A (en) 1999-06-28
CZ20002134A3 (cs) 2000-10-11
EP0933633A1 (en) 1999-08-04
EP1036319A1 (en) 2000-09-20
ES2248927T3 (es) 2006-03-16
DE69831752T2 (de) 2006-06-22
US6545006B1 (en) 2003-04-08
ATE305610T1 (de) 2005-10-15
HUP0004510A1 (hu) 2001-04-28
KR100700906B1 (ko) 2007-03-29
DE69831752D1 (de) 2006-02-09
PL341205A1 (en) 2001-03-26
HK1033171A1 (en) 2001-08-17
JP4189124B2 (ja) 2008-12-03
PL194068B1 (pl) 2007-04-30
EP1036319B1 (en) 2005-09-28
ID24807A (id) 2000-08-24
BR9813559A (pt) 2000-10-10
HUP0004510A3 (en) 2003-05-28
CA2315326A1 (en) 1999-06-17

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