BRPI0408999A - comprimidos prensados de multiparticulados de liberação oral prolongada - Google Patents
comprimidos prensados de multiparticulados de liberação oral prolongadaInfo
- Publication number
- BRPI0408999A BRPI0408999A BRPI0408999-5A BRPI0408999A BRPI0408999A BR PI0408999 A BRPI0408999 A BR PI0408999A BR PI0408999 A BRPI0408999 A BR PI0408999A BR PI0408999 A BRPI0408999 A BR PI0408999A
- Authority
- BR
- Brazil
- Prior art keywords
- release
- compressed tablets
- therapeutic agent
- compressed
- agglutinating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
Abstract
"COMPRIMIDOS PRENSADOS DE MULTIPARTICULADOS DE LIBERAçãO ORAL PROLONGADA". A presente invenção refere-se a uma formulação multiparticulada de um agente terapêutico de liberação prolongada, em que as partículas dos núcleos revestidos do multiparticulado do agente terapêutico são sobrerevestidas com um agente de aglutinação-dispersão, tal como povidona ou povidona reticulada. A invenção é também dirigida a comprimidos prensados da formulação de multiparticulado de liberação prolongada da invenção, e a um método de administração oral dos comprimidos prensados de clindamicina a um sujeito para tratar ou prevenir uma infecção deste com bactérias gram-positivas. O agente de aglutinação-dispersão nas formulações da presente invenção assegura que os comprimidos prensados formados a partir daquelas permanecem intactos através da administração oral, e se dissolvem pouco tempo depois, permitindo que os multiparticulados liberem o agente terapêutico contido neles durante um período de tempo prolongado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46085103P | 2003-04-04 | 2003-04-04 | |
PCT/IB2004/001117 WO2004087175A1 (en) | 2003-04-04 | 2004-03-29 | Oral extended release compressed tablets of multiparticulates |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0408999A true BRPI0408999A (pt) | 2006-03-28 |
Family
ID=33131934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408999-5A BRPI0408999A (pt) | 2003-04-04 | 2004-03-29 | comprimidos prensados de multiparticulados de liberação oral prolongada |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040228915A1 (pt) |
EP (1) | EP1613333A1 (pt) |
JP (1) | JP2006522099A (pt) |
BR (1) | BRPI0408999A (pt) |
CA (1) | CA2520321A1 (pt) |
MX (1) | MXPA05010636A (pt) |
WO (1) | WO2004087175A1 (pt) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
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US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
KR101061351B1 (ko) | 2002-04-09 | 2011-08-31 | 플라멜 테크놀로지스 | 활성 성분 마이크로캡슐의 경구 현탁액 |
US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
CA2507685A1 (en) * | 2002-11-28 | 2004-06-10 | Themis Laboratories Private Limited | Process for manufacturing sustained release microbeads containing venlafaxine hci |
ATE388698T1 (de) | 2003-04-29 | 2008-03-15 | Orexigen Therapeutics Inc | Zusammensetzungen zur beeinflussung des gewichtsverlusts |
CN1893956A (zh) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | 多西环素金属络合物固体剂型 |
AP1899A (en) * | 2003-08-08 | 2008-10-10 | Biovail Lab Int Srl | Modified-release tablet of bupropion hydrochloride |
KR20130003040A (ko) | 2004-08-13 | 2013-01-08 | 베링거 인겔하임 인터내셔날 게엠베하 | 프라미펙솔 또는 약제학적으로 허용되는 이의 염을 포함하는 연장 방출형 펠렛 제형, 이의 제조방법 및 이의 용도 |
AU2011244902B2 (en) * | 2004-08-13 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
DK1781260T4 (da) | 2004-08-13 | 2014-06-23 | Boehringer Ingelheim Int | Tabletformulering med forlænget frigivelse indeholdende pramipexol eller et farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf og anvendelse deraf |
WO2006046256A1 (en) * | 2004-10-27 | 2006-05-04 | Alembic Limited | Extended release formulation of pramipexole dihydrochloride |
JP2008525313A (ja) | 2004-12-27 | 2008-07-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗痴呆薬の安定化方法 |
JP5235416B2 (ja) * | 2005-01-21 | 2013-07-10 | ワーナー・チルコット・カンパニー・エルエルシー | 固体投与形中のテトラサイクリン金属錯体 |
US20090123536A1 (en) * | 2005-02-21 | 2009-05-14 | Flamel Technologies, S.A. | Oral Pharmaceutical Form of Losartan |
FR2882259A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee de losartan |
FR2882260A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii |
FR2884145A1 (fr) * | 2005-04-06 | 2006-10-13 | Flamel Technologies Sa | Forme pharmaceutique orale de losartan |
FR2882522B1 (fr) * | 2005-02-25 | 2007-04-13 | Aventis Pharma Sa | Composition pharmaceutique solide comprenant de la telithromycine |
KR101213345B1 (ko) * | 2005-04-28 | 2012-12-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항치매약을 함유하는 조성물 |
WO2007002518A1 (en) * | 2005-06-23 | 2007-01-04 | Spherics, Inc. | Delayed release or extended-delayed release dosage forms of pramipexole |
RU2408368C2 (ru) | 2005-06-27 | 2011-01-10 | Биовэйл Лэборэториз Интернэшнл С.Р.Л. | Препараты соли бупропиона с модифицированным высвобождением |
RU2008104638A (ru) | 2005-07-07 | 2009-08-20 | Фарнэм Компаниз, Инк. (Us) | Фармацевтические композиции хорошо растворимых в воде лекарственных средств, обеспечивающих их замедленное высвобождение |
WO2007067341A2 (en) | 2005-11-22 | 2007-06-14 | Orexigen Therapeutics, Inc. | Compositions and methods for increasing insulin sensitivity |
WO2007062228A1 (en) * | 2005-11-28 | 2007-05-31 | Orexigen Therapeutics, Inc. | Sustained-release formulation of zonisamide |
WO2007090883A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Extended release formulation |
US9023400B2 (en) * | 2006-05-24 | 2015-05-05 | Flamel Technologies | Prolonged-release multimicroparticulate oral pharmaceutical form |
US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
WO2008001311A2 (en) * | 2006-06-26 | 2008-01-03 | Ranbaxy Laboratories Limited | Pharmaceutical composition containing fixed dose combination of atenolol with isosorbide mononitrate |
US8703191B2 (en) | 2006-07-25 | 2014-04-22 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
US7674479B2 (en) * | 2006-07-25 | 2010-03-09 | Intelgenx Corp. | Sustained-release bupropion and bupropion/mecamylamine tablets |
WO2008038155A2 (en) * | 2006-07-25 | 2008-04-03 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
GB0616794D0 (en) * | 2006-08-24 | 2006-10-04 | Arrow Int Ltd | Solid dosage form |
WO2008062446A2 (en) * | 2006-09-14 | 2008-05-29 | Alembic Limited | An extended release composition of levetiracetam, which exhibits no adverse food effect |
RU2452471C2 (ru) | 2006-11-09 | 2012-06-10 | Ориксиджен Терапьютикс, Инк. [Сша/Сша] | Слоистые фармацевтические составы |
KR20180066272A (ko) | 2006-11-09 | 2018-06-18 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
WO2008068778A2 (en) * | 2006-12-05 | 2008-06-12 | Alembic Limited | Extended release pharmaceutical composition of pramipexole |
CA2725930A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
DE102008048729A1 (de) * | 2008-09-24 | 2010-03-25 | Add Technologies Ltd Advanced Drug Delivery | Multipartikuläre Tabletten und Verfahren zur deren Herstellung |
EP2385769A4 (en) * | 2008-12-15 | 2014-08-20 | Valeant Pharmaceuticals Luxembourg S R L | QUICKLY SOLUBLE VITAMIN FORMULATION AND METHOD FOR THEIR USE |
EP2253306A1 (en) * | 2009-05-18 | 2010-11-24 | Royal College of Surgeons in Ireland | Orodispersible dosage forms containing solid drug dispersions |
GB0909680D0 (en) | 2009-06-05 | 2009-07-22 | Euro Celtique Sa | Dosage form |
US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
WO2011085331A1 (en) | 2010-01-11 | 2011-07-14 | Orexigen Therapeutics, Inc. | Methods of providing weight loss therapy in patients with major depression |
WO2011148243A1 (en) | 2010-05-24 | 2011-12-01 | Lupin Limited | Extended release formulation of pramipexole |
GB201020895D0 (en) * | 2010-12-09 | 2011-01-26 | Euro Celtique Sa | Dosage form |
CN102579384B (zh) * | 2011-01-17 | 2015-09-02 | 杭州赛利药物研究所有限公司 | 别嘌醇缓释微丸片及其制备方法 |
EP2717860A4 (en) | 2011-06-08 | 2014-11-05 | Sti Pharma Llc | FORMULATION FROM A WATER SOLUBLE AND PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND WITH CONTROLLED ABSORPTION FOR ONLY DAILY APPLICATION |
US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
KR20210012056A (ko) | 2012-06-06 | 2021-02-02 | 오렉시젠 세러퓨틱스 인크. | 과체중 및 비만의 치료 방법 |
US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
CN107875136B (zh) * | 2017-12-27 | 2021-03-05 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种阿莫西林药物制剂及其制备方法 |
CN113350315B (zh) * | 2021-06-10 | 2022-09-06 | 黑龙江澳利达奈德制药有限公司 | 一种别嘌醇缓释胶囊及其制备方法 |
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UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
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NZ511442A (en) * | 1998-11-02 | 2003-02-28 | Elan Corp Plc | Multiparticulate modified release composition for multiple dosing of ADD patients with methylphenidate HCl |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6406745B1 (en) * | 1999-06-07 | 2002-06-18 | Nanosphere, Inc. | Methods for coating particles and particles produced thereby |
US20030073647A1 (en) * | 2001-08-28 | 2003-04-17 | Chao Robert S. | Crystaline clindamycin free base |
-
2004
- 2004-03-29 BR BRPI0408999-5A patent/BRPI0408999A/pt not_active IP Right Cessation
- 2004-03-29 MX MXPA05010636A patent/MXPA05010636A/es not_active Application Discontinuation
- 2004-03-29 WO PCT/IB2004/001117 patent/WO2004087175A1/en not_active Application Discontinuation
- 2004-03-29 EP EP04724081A patent/EP1613333A1/en not_active Withdrawn
- 2004-03-29 JP JP2006506463A patent/JP2006522099A/ja not_active Withdrawn
- 2004-03-29 CA CA002520321A patent/CA2520321A1/en not_active Abandoned
- 2004-04-02 US US10/816,699 patent/US20040228915A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004087175A1 (en) | 2004-10-14 |
MXPA05010636A (es) | 2005-12-12 |
EP1613333A1 (en) | 2006-01-11 |
JP2006522099A (ja) | 2006-09-28 |
US20040228915A1 (en) | 2004-11-18 |
CA2520321A1 (en) | 2004-10-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |