TR200300510A2 - Dağılan alendronat mikropartikül formülasyonu - Google Patents
Dağılan alendronat mikropartikül formülasyonuInfo
- Publication number
- TR200300510A2 TR200300510A2 TR2003/00510A TR200300510A TR200300510A2 TR 200300510 A2 TR200300510 A2 TR 200300510A2 TR 2003/00510 A TR2003/00510 A TR 2003/00510A TR 200300510 A TR200300510 A TR 200300510A TR 200300510 A2 TR200300510 A2 TR 200300510A2
- Authority
- TR
- Turkey
- Prior art keywords
- alendronate
- dispersing
- microparticle formulation
- glass
- water
- Prior art date
Links
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title abstract 2
- 229940062527 alendronate Drugs 0.000 title abstract 2
- 239000011859 microparticle Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000011521 glass Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 239000000783 alginic acid Substances 0.000 abstract 1
- 229960001126 alginic acid Drugs 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 150000004781 alginic acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003238 esophagus Anatomy 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000661 sodium alginate Substances 0.000 abstract 1
- 235000010413 sodium alginate Nutrition 0.000 abstract 1
- 229940005550 sodium alginate Drugs 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bu bulus alendronatin özefagus ve midede ortaya çikabilecek yan etkilerini azaltmak için oral yolla bir bardak suda disperse edilerek uygulanan tükrük PH'sina dayanikli polimer ile kaplanmis alendronat mikropartikülleri, tedavi edici miktarda aljinik asit veya sodyum aljinat ile en az bir tatlandirici veya karisimini içeren paket formülasyonun hazirlanmasi ile iliskilidir.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2003/00510A TR200300510A2 (tr) | 2003-04-18 | 2003-04-18 | Dağılan alendronat mikropartikül formülasyonu |
US10/824,695 US20040208925A1 (en) | 2003-04-18 | 2004-04-14 | Dispersible alendronate microparticle formulation |
ES04760192T ES2308215T3 (es) | 2003-04-18 | 2004-04-19 | Formulacion dispersable de microparticulas de alendronato. |
EP04760192A EP1617826B1 (en) | 2003-04-18 | 2004-04-19 | The dispersible alendronate microparticle formulation |
DE602004014606T DE602004014606D1 (de) | 2003-04-18 | 2004-04-19 | Dispergierbare alendronat-mikroteilchenformulierung |
AT04760192T ATE399003T1 (de) | 2003-04-18 | 2004-04-19 | Dispergierbare alendronat- mikroteilchenformulierung |
DK04760192T DK1617826T3 (da) | 2003-04-18 | 2004-04-19 | Dispergerbar alendronatmikropartikelformulering |
PL04760192T PL1617826T3 (pl) | 2003-04-18 | 2004-04-19 | Dyspergowalna formulacja mikrocząsteczek alendronianu |
SI200430813T SI1617826T1 (sl) | 2003-04-18 | 2004-04-19 | Disperzibilen pripravek mikrodelcev alendronata |
PCT/TR2004/000024 WO2004096189A2 (en) | 2003-04-18 | 2004-04-19 | The dispersible alendronate microparticle formulation |
PT04760192T PT1617826E (pt) | 2003-04-18 | 2004-04-19 | Formulação dispersível de micropartículas de alendronato |
CY20081100921T CY1108298T1 (el) | 2003-04-18 | 2008-08-28 | Το διασπειρομενο παρασκευασμα μικροσωματιδιων αλενδρονατης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2003/00510A TR200300510A2 (tr) | 2003-04-18 | 2003-04-18 | Dağılan alendronat mikropartikül formülasyonu |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200300510A2 true TR200300510A2 (tr) | 2004-11-22 |
Family
ID=33157605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2003/00510A TR200300510A2 (tr) | 2003-04-18 | 2003-04-18 | Dağılan alendronat mikropartikül formülasyonu |
Country Status (12)
Country | Link |
---|---|
US (1) | US20040208925A1 (tr) |
EP (1) | EP1617826B1 (tr) |
AT (1) | ATE399003T1 (tr) |
CY (1) | CY1108298T1 (tr) |
DE (1) | DE602004014606D1 (tr) |
DK (1) | DK1617826T3 (tr) |
ES (1) | ES2308215T3 (tr) |
PL (1) | PL1617826T3 (tr) |
PT (1) | PT1617826E (tr) |
SI (1) | SI1617826T1 (tr) |
TR (1) | TR200300510A2 (tr) |
WO (1) | WO2004096189A2 (tr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101198316A (zh) * | 2005-03-17 | 2008-06-11 | 伊兰制药国际有限公司 | 纳米微粒双膦酸盐组合物 |
ATE525065T1 (de) * | 2006-07-10 | 2011-10-15 | Pfleger R Chem Fab | Pharmazeutische zubereitung für die orale verabreichung mit gesteuerter wirkstofffreisetzung im dünndarm und verfahren zu ihrer herstellung |
DE102008022520A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
KR101118794B1 (ko) | 2009-11-10 | 2012-06-13 | 동아제약주식회사 | 비스포스포네이트를 함유하는 약학 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1524740A (en) * | 1976-11-09 | 1978-09-13 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions for use in the suppression of gastric reflux |
PL181304B1 (pl) * | 1994-07-22 | 2001-07-31 | Lilly Co Eli | Preparat farmaceutyczny do hamowania zmniejszania masy kosci PL PL PL PL PL PL PL PL PL PL |
DE19615812A1 (de) * | 1996-04-20 | 1997-10-23 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
US5773429A (en) * | 1996-12-11 | 1998-06-30 | Fuisz Technologies Ltd. | Drug combination for treating calcium loss |
KR100400053B1 (ko) * | 1997-06-11 | 2003-09-29 | 더 프록터 앤드 갬블 캄파니 | 향상된 상부 위장관 안전용 필름 피복 정제 |
DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
GB0005743D0 (en) * | 2000-03-10 | 2000-05-03 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions including alginates |
HUP0303700A3 (en) * | 2000-07-17 | 2006-07-28 | Astellas Pharma Inc Chuo Ku | Pharmaceutical composition improved in peroral absorbability |
BR0209360A (pt) * | 2001-05-02 | 2004-06-08 | Novartis Ag | Método de administração de bisfosfonatos por inalação no tratamento ou prevenção de reabsorção óssea e osteoporose |
WO2003043641A1 (en) * | 2001-11-19 | 2003-05-30 | Nobel Ilaç Sanayii Ve Ticaret A.S. | New pharmaceutical combinations prepared with alginates and biphosphonates in order to prevent gastroesophageal reflux during use of oral biphoshonates |
-
2003
- 2003-04-18 TR TR2003/00510A patent/TR200300510A2/tr unknown
-
2004
- 2004-04-14 US US10/824,695 patent/US20040208925A1/en not_active Abandoned
- 2004-04-19 PL PL04760192T patent/PL1617826T3/pl unknown
- 2004-04-19 SI SI200430813T patent/SI1617826T1/sl unknown
- 2004-04-19 WO PCT/TR2004/000024 patent/WO2004096189A2/en active Search and Examination
- 2004-04-19 DK DK04760192T patent/DK1617826T3/da active
- 2004-04-19 ES ES04760192T patent/ES2308215T3/es not_active Expired - Lifetime
- 2004-04-19 PT PT04760192T patent/PT1617826E/pt unknown
- 2004-04-19 AT AT04760192T patent/ATE399003T1/de active
- 2004-04-19 EP EP04760192A patent/EP1617826B1/en not_active Expired - Lifetime
- 2004-04-19 DE DE602004014606T patent/DE602004014606D1/de not_active Expired - Lifetime
-
2008
- 2008-08-28 CY CY20081100921T patent/CY1108298T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE399003T1 (de) | 2008-07-15 |
WO2004096189A2 (en) | 2004-11-11 |
US20040208925A1 (en) | 2004-10-21 |
CY1108298T1 (el) | 2014-02-12 |
DE602004014606D1 (de) | 2008-08-07 |
SI1617826T1 (sl) | 2008-12-31 |
PT1617826E (pt) | 2008-09-09 |
DK1617826T3 (da) | 2008-10-06 |
EP1617826B1 (en) | 2008-06-25 |
WO2004096189A3 (en) | 2005-03-03 |
EP1617826A2 (en) | 2006-01-25 |
ES2308215T3 (es) | 2008-12-01 |
PL1617826T3 (pl) | 2008-11-28 |
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