DE69509628T2 - N-terminal chemisch modifizierte protein-zusammensetzungen und methoden - Google Patents
N-terminal chemisch modifizierte protein-zusammensetzungen und methodenInfo
- Publication number
- DE69509628T2 DE69509628T2 DE69509628T DE69509628T DE69509628T2 DE 69509628 T2 DE69509628 T2 DE 69509628T2 DE 69509628 T DE69509628 T DE 69509628T DE 69509628 T DE69509628 T DE 69509628T DE 69509628 T2 DE69509628 T2 DE 69509628T2
- Authority
- DE
- Germany
- Prior art keywords
- csf
- monopegylated
- preparation
- analogue
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
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Landscapes
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- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/321,510 US5824784A (en) | 1994-10-12 | 1994-10-12 | N-terminally chemically modified protein compositions and methods |
| PCT/US1995/001729 WO1996011953A1 (en) | 1994-10-12 | 1995-02-08 | N-terminally chemically modified protein compositions and methods |
Publications (2)
| Publication Number | Publication Date |
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| DE69509628D1 DE69509628D1 (de) | 1999-06-17 |
| DE69509628T2 true DE69509628T2 (de) | 1999-09-16 |
Family
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| DE69509628T Expired - Lifetime DE69509628T2 (de) | 1994-10-12 | 1995-02-08 | N-terminal chemisch modifizierte protein-zusammensetzungen und methoden |
| DE69533556T Revoked DE69533556T2 (de) | 1994-10-12 | 1995-02-08 | N-terminal modifizierte Polypeptide, und Herstellungsprozess |
| DE2002199044 Pending DE10299044I1 (de) | 1994-10-12 | 1995-02-08 | n-Terminal chemisch modifizierte Protein-Zusammensetzungen und Methoden |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69533556T Revoked DE69533556T2 (de) | 1994-10-12 | 1995-02-08 | N-terminal modifizierte Polypeptide, und Herstellungsprozess |
| DE2002199044 Pending DE10299044I1 (de) | 1994-10-12 | 1995-02-08 | n-Terminal chemisch modifizierte Protein-Zusammensetzungen und Methoden |
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| EP (5) | EP1564219A1 (enExample) |
| JP (8) | JP3177251B2 (enExample) |
| KR (2) | KR100248111B1 (enExample) |
| CN (4) | CN101381409B (enExample) |
| AT (2) | ATE277078T1 (enExample) |
| CA (3) | CA2472085A1 (enExample) |
| DE (3) | DE69509628T2 (enExample) |
| DK (1) | DK0733067T3 (enExample) |
| ES (2) | ES2224197T3 (enExample) |
| GR (1) | GR3030526T3 (enExample) |
| IL (3) | IL112585A (enExample) |
| LU (1) | LU91006I2 (enExample) |
| MX (1) | MX9602259A (enExample) |
| NL (1) | NL300106I2 (enExample) |
| NZ (1) | NZ281469A (enExample) |
| PT (1) | PT822199E (enExample) |
| WO (1) | WO1996011953A1 (enExample) |
| ZA (1) | ZA951008B (enExample) |
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| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| DK1090645T3 (da) * | 1994-02-08 | 2006-03-27 | Amgen Inc | Oral tilförsel af kemisk modificerede proteiner |
| US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| US6429290B1 (en) | 1994-08-17 | 2002-08-06 | The Rockefeller University | OB polypeptides, modified forms and derivatives |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| WO1996041813A2 (en) * | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
| US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| AU7473096A (en) | 1995-11-02 | 1997-05-22 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| ES2615357T3 (es) | 1996-12-06 | 2017-06-06 | Amgen Inc. | Terapia de combinación usando un inhibidor de IL-1 para tratar enfermedades mediadas por IL-1 |
| EP0921817B1 (en) * | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
| AU744085B2 (en) | 1997-06-06 | 2002-02-14 | Kyowa Hakko Kirin Co., Ltd. | Chemically modified polypeptides |
| EP1012184B1 (en) * | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| WO2000042175A1 (en) | 1999-01-14 | 2000-07-20 | Bolder Biotechnology Inc. | Methods for making proteins containing free cysteine residues |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US6017876A (en) * | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US5981709A (en) * | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
| NZ507456A (en) | 1998-04-28 | 2003-10-31 | Applied Research Systems | Process and conjugated forms of PEGylated interferon- beta with polyethylene glycol (PEG) wherein the thiol reactive polyol agent is mono-methoxylated |
| BR9910505A (pt) * | 1998-05-15 | 2001-01-02 | Schering Corp | Terapia de combinação compreendendo ribavirina e interferon alfa em pacientes cândidos de tratamento antiviral tendo infecção crÈnica por hepatite c |
| NL1009601C2 (nl) * | 1998-07-09 | 2000-01-11 | Univ Utrecht | Verbinding welke de binding van een eiwit aan mestcellen kan remmen, toepassing van de verbinding voor de bereiding van een geneesmiddel, een farmaceutisch preparaat, een werkwijze voor het diagnostiseren van een ziekte en een selectiewerkwijze. |
| EP1133563A2 (en) * | 1998-07-16 | 2001-09-19 | Hyseq, Inc. | Methods and molecules relating to cd39-like polypeptides |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| CA2338665C (en) * | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| ES2265693T3 (es) * | 1998-10-16 | 2007-02-16 | Biogen Idec Ma Inc. | Proteinas de fusion con interferon-beta y usos. |
| AU762616B2 (en) * | 1998-10-16 | 2003-07-03 | Biogen Ma Inc. | Polymer conjugates of interferon beta-1a and uses |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| DK1783222T3 (da) | 1998-10-23 | 2012-07-09 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2000032772A2 (en) * | 1998-11-30 | 2000-06-08 | Eli Lilly And Company | Erythropoietic compounds |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| IL144361A0 (en) * | 1999-01-29 | 2002-05-23 | Hoffmann La Roche | Gcsf conjugates |
| EP1369429A1 (en) * | 1999-01-29 | 2003-12-10 | F. Hoffmann-La Roche Ag | GCSF conjugates |
| WO2000051626A1 (en) * | 1999-03-01 | 2000-09-08 | Kyowa Hakko Kogyo Co., Ltd. | Chemically modified g-csf preparations |
| US6485718B1 (en) * | 1999-04-13 | 2002-11-26 | Pharmacia Corporation | Site specific ligation of proteins to synthetic particles |
| US6924264B1 (en) * | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
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| US7074878B1 (en) | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
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| US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
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| DE60139110D1 (de) | 2000-01-10 | 2009-08-13 | Maxygen Holdings Ltd | G-csf konjugate |
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1994
- 1994-10-12 US US08/321,510 patent/US5824784A/en not_active Expired - Lifetime
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1995
- 1995-02-08 EP EP04015640A patent/EP1564219A1/en not_active Withdrawn
- 1995-02-08 CN CN2008101276757A patent/CN101381409B/zh not_active Expired - Lifetime
- 1995-02-08 JP JP51319196A patent/JP3177251B2/ja not_active Expired - Lifetime
- 1995-02-08 ZA ZA951008A patent/ZA951008B/xx unknown
- 1995-02-08 IL IL11258595A patent/IL112585A/xx not_active IP Right Cessation
- 1995-02-08 CN CNB001309749A patent/CN1229388C/zh not_active Expired - Lifetime
- 1995-02-08 CA CA002472085A patent/CA2472085A1/en not_active Abandoned
- 1995-02-08 NZ NZ281469A patent/NZ281469A/en not_active IP Right Cessation
- 1995-02-08 DE DE69509628T patent/DE69509628T2/de not_active Expired - Lifetime
- 1995-02-08 ES ES97117514T patent/ES2224197T3/es not_active Expired - Lifetime
- 1995-02-08 CN CN95191454A patent/CN1071760C/zh not_active Expired - Lifetime
- 1995-02-08 DE DE69533556T patent/DE69533556T2/de not_active Revoked
- 1995-02-08 WO PCT/US1995/001729 patent/WO1996011953A1/en not_active Ceased
- 1995-02-08 AT AT97117514T patent/ATE277078T1/de active
- 1995-02-08 EP EP10180124A patent/EP2399930A1/en not_active Withdrawn
- 1995-02-08 ES ES95910233T patent/ES2131811T3/es not_active Expired - Lifetime
- 1995-02-08 KR KR1019960703099A patent/KR100248111B1/ko not_active Expired - Lifetime
- 1995-02-08 PT PT97117514T patent/PT822199E/pt unknown
- 1995-02-08 CA CA002178752A patent/CA2178752C/en not_active Expired - Lifetime
- 1995-02-08 CN CNA2005101137680A patent/CN1896103A/zh active Pending
- 1995-02-08 MX MX9602259A patent/MX9602259A/es active IP Right Grant
- 1995-02-08 DE DE2002199044 patent/DE10299044I1/de active Pending
- 1995-02-08 EP EP95910233A patent/EP0733067B1/en not_active Expired - Lifetime
- 1995-02-08 EP EP97117514A patent/EP0822199B1/en not_active Revoked
- 1995-02-08 IL IL134754A patent/IL134754A/en not_active IP Right Cessation
- 1995-02-08 CA CA2307142A patent/CA2307142C/en not_active Expired - Lifetime
- 1995-02-08 EP EP10183858A patent/EP2392594A1/en not_active Withdrawn
- 1995-02-08 DK DK95910233T patent/DK0733067T3/da active
- 1995-02-08 AT AT95910233T patent/ATE179991T1/de active
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1996
- 1996-07-22 JP JP19257696A patent/JP3177449B2/ja not_active Expired - Lifetime
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1997
- 1997-06-20 US US08/879,760 patent/US5985265A/en not_active Expired - Lifetime
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1999
- 1999-03-19 JP JP11076959A patent/JPH11310600A/ja active Pending
- 1999-06-16 GR GR990401601T patent/GR3030526T3/el unknown
- 1999-10-23 KR KR1019997009836A patent/KR100261030B1/ko not_active Expired - Lifetime
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2000
- 2000-02-27 IL IL13475400A patent/IL134754A0/xx unknown
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2001
- 2001-03-26 US US09/817,725 patent/US7090835B2/en not_active Expired - Fee Related
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2002
- 2002-10-01 JP JP2002288746A patent/JP2003155299A/ja not_active Withdrawn
- 2002-11-04 NL NL300106C patent/NL300106I2/nl unknown
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2003
- 2003-01-29 LU LU91006C patent/LU91006I2/fr unknown
- 2003-04-10 JP JP2003106520A patent/JP2003327600A/ja active Pending
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2005
- 2005-09-30 JP JP2005286189A patent/JP2006045243A/ja not_active Withdrawn
- 2005-09-30 JP JP2005286188A patent/JP2006077021A/ja not_active Withdrawn
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2006
- 2006-04-26 US US11/411,321 patent/US7662933B2/en not_active Expired - Fee Related
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2009
- 2009-12-16 US US12/639,398 patent/US8258262B2/en not_active Expired - Fee Related
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2010
- 2010-06-14 JP JP2010134726A patent/JP5350330B2/ja not_active Expired - Lifetime
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2012
- 2012-08-02 US US13/565,447 patent/US20120296072A1/en not_active Abandoned
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2013
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