BR0116381A - Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina - Google Patents

Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina

Info

Publication number
BR0116381A
BR0116381A BR0116381-7A BR0116381A BR0116381A BR 0116381 A BR0116381 A BR 0116381A BR 0116381 A BR0116381 A BR 0116381A BR 0116381 A BR0116381 A BR 0116381A
Authority
BR
Brazil
Prior art keywords
conjugate
erythropoietin
group
compounds
poly
Prior art date
Application number
BR0116381-7A
Other languages
English (en)
Inventor
Josef Burg
Alfred Engel
Hartmut Ernst Schurig
Reinhard Franze
Wilhelm Tischer
Bernd Hilger
Manfred Wozny
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority claimed from PCT/EP2001/014434 external-priority patent/WO2002049673A2/en
Publication of BR0116381A publication Critical patent/BR0116381A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Abstract

"CONJUGADO, COMPOSIçãO FARMACêUTICA QUE COMPREENDE O MESMO E SUA UTILIZAçãO, PROCESSO PARA O TRATAMENTO PROFILáTICO E/OU TERAPêUTICO DE DISTúRBIOS, PROCESSO PARA A PREPARAçãO DE UM CONJUGADO, COMPOSTOS E GLICOPROTEìNAS DE ERITROPOETINA". A presente invenção refere-se a conjugados de eritropoetina com poli(etileno glicol) que compreendem uma glicoproteína de eritropoetína dotada de um grupo N-terminal a-amino e tendo a atividade biológica in vivo de fazer com que as células da medula espinhal aumentem a produção de reticulócitos e células vermelhas do sangue e selecionada a partir do grupo que consiste de eritropoetina humana e seus análogos que possuem a seq³ência da eritropoetina humana modificada pela adição de 1 a 6 locais de glicosilação ou uma reordenação de pelo menos um local de glicosilação; sendo a dita glicoproteína ligada covalentemente a um grupo de poli(etileno glicol) da fórmula -CO-(CH~ 2~)~ x~-(OCH~ 2~CH~ 2~)~ m~-OR, com o -CO do grupo de poli(etileno glicol) formando uma aglutinação de amida com o dito grupo N-terminal (<244>-amino; em que R é alquila inferior; x é 2 ou 3; e m varia de cerca de 450 até cerca de 1350.
BR0116381-7A 2000-12-20 2001-12-08 Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina BR0116381A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00127891 2000-12-20
PCT/EP2001/014434 WO2002049673A2 (en) 2000-12-20 2001-12-08 Conjugates of erythropoietin (pep) with polyethylene glycol (peg)

Publications (1)

Publication Number Publication Date
BR0116381A true BR0116381A (pt) 2004-02-25

Family

ID=8170728

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116381-7A BR0116381A (pt) 2000-12-20 2001-12-08 Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina

Country Status (11)

Country Link
US (1) US7128913B2 (pt)
JP (2) JP4656814B2 (pt)
KR (1) KR100645843B1 (pt)
CN (1) CN100528235C (pt)
AR (1) AR035407A1 (pt)
AU (2) AU3323002A (pt)
BR (1) BR0116381A (pt)
CA (1) CA2431964C (pt)
ES (1) ES2361824T3 (pt)
MX (1) MXPA03005406A (pt)
ZA (1) ZA200304647B (pt)

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Also Published As

Publication number Publication date
KR100645843B1 (ko) 2006-11-14
AU3323002A (en) 2002-07-01
MXPA03005406A (es) 2003-09-25
JP2004525097A (ja) 2004-08-19
JP4656814B2 (ja) 2011-03-23
CN100528235C (zh) 2009-08-19
AR035407A1 (es) 2004-05-26
CA2431964A1 (en) 2002-06-27
US7128913B2 (en) 2006-10-31
JP2008069155A (ja) 2008-03-27
JP4563434B2 (ja) 2010-10-13
ES2361824T3 (es) 2011-06-22
KR20030074667A (ko) 2003-09-19
CA2431964C (en) 2013-09-10
ZA200304647B (en) 2004-09-13
US20020115833A1 (en) 2002-08-22
AU2002233230B2 (en) 2007-02-01
CN1527726A (zh) 2004-09-08

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