MX2009013259A - Proceso mejorado para la produccion de azucares de nucleotidos. - Google Patents

Proceso mejorado para la produccion de azucares de nucleotidos.

Info

Publication number
MX2009013259A
MX2009013259A MX2009013259A MX2009013259A MX2009013259A MX 2009013259 A MX2009013259 A MX 2009013259A MX 2009013259 A MX2009013259 A MX 2009013259A MX 2009013259 A MX2009013259 A MX 2009013259A MX 2009013259 A MX2009013259 A MX 2009013259A
Authority
MX
Mexico
Prior art keywords
poly
nucleotide sugars
production
moieties
improved process
Prior art date
Application number
MX2009013259A
Other languages
English (en)
Inventor
Shawn Defrees
Caryn Bowe
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2009013259A publication Critical patent/MX2009013259A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

La presente invención proporciona métodos (por ejemplo, procesos a gran escala) para la producción de azucares de nucleótidos, que son modificados con un grupo modificador polimérico, tales como las porciones de poli(óxido de alquileno) (por ejemplo poli(etilenglicol) o porciones de poli(propilenglicol). Un proceso típico de la invención incluye cromatografía de intercambio aniónico seguido por un procedimiento de ultrafiltración, tal como filtración de flujo tangencial. El proceso de la invención proporciona azúcares de nucleótidos modificados con una pureza inesperadamente elevada y con rendimientos totales elevados.
MX2009013259A 2007-06-12 2008-06-12 Proceso mejorado para la produccion de azucares de nucleotidos. MX2009013259A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94352707P 2007-06-12 2007-06-12
US96827407P 2007-08-27 2007-08-27
US97024707P 2007-09-05 2007-09-05
PCT/US2008/066749 WO2008154639A2 (en) 2007-06-12 2008-06-12 Improved process for the production of nucleotide sugars

Publications (1)

Publication Number Publication Date
MX2009013259A true MX2009013259A (es) 2010-01-25

Family

ID=40130494

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013259A MX2009013259A (es) 2007-06-12 2008-06-12 Proceso mejorado para la produccion de azucares de nucleotidos.

Country Status (8)

Country Link
US (1) US9493499B2 (es)
EP (1) EP2170919B8 (es)
JP (2) JP5876649B2 (es)
CN (1) CN101778859B (es)
CA (1) CA2690611C (es)
ES (1) ES2551123T3 (es)
MX (1) MX2009013259A (es)
WO (1) WO2008154639A2 (es)

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