ATE544463T1 - Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen - Google Patents
Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungenInfo
- Publication number
- ATE544463T1 ATE544463T1 AT05851326T AT05851326T ATE544463T1 AT E544463 T1 ATE544463 T1 AT E544463T1 AT 05851326 T AT05851326 T AT 05851326T AT 05851326 T AT05851326 T AT 05851326T AT E544463 T1 ATE544463 T1 AT E544463T1
- Authority
- AT
- Austria
- Prior art keywords
- scf
- treatment
- polypeptide
- brain
- combination
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 3
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 title abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 3
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 201000006474 Brain Ischemia Diseases 0.000 abstract 2
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 2
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000007658 neurological function Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62518904P | 2004-11-05 | 2004-11-05 | |
PCT/US2005/039792 WO2006055260A2 (en) | 2004-11-05 | 2005-11-04 | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE544463T1 true ATE544463T1 (de) | 2012-02-15 |
Family
ID=36407603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05851326T ATE544463T1 (de) | 2004-11-05 | 2005-11-04 | Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen |
Country Status (6)
Country | Link |
---|---|
US (2) | US20060153799A1 (de) |
EP (1) | EP1817047B1 (de) |
AT (1) | ATE544463T1 (de) |
AU (1) | AU2005306894B2 (de) |
CA (1) | CA2586365A1 (de) |
WO (1) | WO2006055260A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006315601A1 (en) | 2005-11-14 | 2007-05-24 | Enterprise Partners Venture Capital | Stem cell factor therapy for tissue injury |
DE102006004142A1 (de) * | 2006-01-27 | 2007-08-02 | Axaron Bioscience Ag | Neue therapeutische Indikationen von Koloniestimulierenden Faktoren |
US9770485B2 (en) * | 2006-02-21 | 2017-09-26 | Academia Sinica | Methods for rescuing learning and/or memory deficits caused by alzheimer's disease by G-CSF |
US7618938B2 (en) * | 2007-02-07 | 2009-11-17 | Academia Sinica | Treating cerebrovascular diseases with erythropoietin and granulocyte-colony stimulating factor jointly |
WO2010017224A2 (en) | 2008-08-05 | 2010-02-11 | University Of South Florida | Methods of treating cognitive impairment |
US9132168B2 (en) | 2008-08-05 | 2015-09-15 | University Of South Florida | Methods of treating cognitive impairment |
KR20100020125A (ko) * | 2008-08-12 | 2010-02-22 | 한양대학교 산학협력단 | G-csf를 유효성분으로 하는 신경병증성 통증 예방 또는치료제 |
CN102260343A (zh) | 2010-05-25 | 2011-11-30 | 健能隆医药技术(上海)有限公司 | 重组人g-csf二聚体在治疗神经损伤疾病中的用途 |
CA2842969C (en) | 2011-07-25 | 2018-03-27 | Generon (Shanghai) Corporation Ltd. | Use of g-csf dimer in preparation of medicament for treatment of neurodegenerative diseases |
JP6156889B2 (ja) | 2013-02-06 | 2017-07-05 | Ncメディカルリサーチ株式会社 | 神経変性の治療のための不均質な骨髄細胞の亜集団を調製する方法 |
LT6161B (lt) | 2013-09-27 | 2015-06-25 | Uab Profarma | Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas |
US10039808B2 (en) * | 2014-10-22 | 2018-08-07 | Michael Chez | Method of treating or improving neurological function in a human subject |
US9925244B1 (en) | 2015-02-17 | 2018-03-27 | Michael Chez | Treatment of warts in non-immunosuppressed patients |
WO2023158681A1 (en) * | 2022-02-16 | 2023-08-24 | Vasogenesis Inc. | Methods of using a blood cell growth factor to treat impaired blood flow |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
EP0256843A1 (de) | 1986-08-11 | 1988-02-24 | Cetus Corporation | Expression von G-CSF, Muteine davon und deren Verwendung |
NO176799C (no) | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
EP0719860B1 (de) | 1988-05-13 | 2009-12-16 | Amgen Inc. | Verfahren zur Isolierung und Reinigung von G-CSF |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
CA2006596C (en) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
SE464482C (sv) | 1989-08-25 | 1997-09-08 | Teknoskand Invent Ab | Med spärr försett svängarmsbeslag till fönster, luckor o d |
WO1991005798A1 (en) | 1989-10-10 | 1991-05-02 | Amgen Inc. | Compositions and methods for treating or preventing infections in canine and feline animals |
GEP20002145B (en) | 1989-10-16 | 2000-06-25 | Amgen Inc Us | Stem Cell Factor |
US6207454B1 (en) * | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
US6204363B1 (en) * | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
US6248319B1 (en) * | 1989-10-16 | 2001-06-19 | Krisztina M. Zsebo | Method for increasing hematopoietic progenitor cells by stem cell factor polypeptides |
ATE194651T1 (de) * | 1989-10-16 | 2000-07-15 | Amgen Inc | Stammzellenfaktor |
NZ236819A (en) | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
JPH04164098A (ja) | 1990-03-07 | 1992-06-09 | Kirin Amgen Inc | 化学修飾顆粒球コロニー刺激因子誘導体 |
GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
DE4014750A1 (de) | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
US5241072A (en) | 1990-05-25 | 1993-08-31 | Genzyne Corporation | Oligosaccharide oxazolines, oligosaccharide conjugates and methods of preparation thereof |
WO1992000376A1 (en) | 1990-06-25 | 1992-01-09 | Immunex Corporation | Mast cell growth factor |
IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
US20030125519A1 (en) | 1990-08-27 | 2003-07-03 | Peter Besmer | Ligand for the c-kit receptor and methods of use thereof |
DK0546124T4 (da) | 1990-08-29 | 2003-05-19 | Inst Genetics Llc | Hæmatopoiese-stimulatorer med flere domæner |
EP0503050A4 (en) | 1990-09-28 | 1994-07-06 | Ortho Pharma Corp | Hybrid growth factors |
DE4105480A1 (de) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
DE69227693T2 (de) | 1991-08-30 | 1999-07-22 | Fred Hutchinson Cancer Research Center, Seattle, Wash. | Hybride cytokine |
FR2686900B1 (fr) | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
AU1916295A (en) | 1994-02-08 | 1995-08-29 | Amgen, Inc. | Oral delivery of chemically modified proteins |
US5525708A (en) | 1994-03-28 | 1996-06-11 | Cytomed, Inc. | Covalent dimer of kit ligand |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6017876A (en) * | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
DE69821011T3 (de) | 1997-10-02 | 2009-01-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Modulierung der Neovaskularisierung und/oder des Wachstums kollateraler Arterien und/oder anderer Arterien aus bestehenden arteriolären Verbindungen |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
CA2395713C (en) | 2000-01-10 | 2012-04-10 | Torben Lauesgaard Nissen | G-csf conjugates |
DE10033219A1 (de) * | 2000-07-07 | 2002-01-24 | Univ Heidelberg | Neuroprotektive Wirkung von Granulocyten-Colony Stimmulierendem Faktor (G-CSF) |
JP4444652B2 (ja) | 2001-07-11 | 2010-03-31 | マキシゲン・ホールディングズ・リミテッド | G−csf結合体 |
WO2003030821A2 (en) | 2001-10-05 | 2003-04-17 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2003213078A1 (en) * | 2002-02-14 | 2003-09-04 | Buck Institute | Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia |
AU2003268484A1 (en) * | 2002-09-06 | 2004-03-29 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
US7785601B2 (en) * | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
-
2005
- 2005-11-04 WO PCT/US2005/039792 patent/WO2006055260A2/en active Application Filing
- 2005-11-04 CA CA002586365A patent/CA2586365A1/en not_active Abandoned
- 2005-11-04 US US11/267,820 patent/US20060153799A1/en not_active Abandoned
- 2005-11-04 AU AU2005306894A patent/AU2005306894B2/en not_active Ceased
- 2005-11-04 AT AT05851326T patent/ATE544463T1/de active
- 2005-11-04 EP EP05851326A patent/EP1817047B1/de not_active Not-in-force
-
2010
- 2010-02-26 US US12/714,068 patent/US8524655B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2006055260A2 (en) | 2006-05-26 |
US20060153799A1 (en) | 2006-07-13 |
CA2586365A1 (en) | 2006-05-26 |
AU2005306894B2 (en) | 2011-11-24 |
US8524655B2 (en) | 2013-09-03 |
EP1817047A2 (de) | 2007-08-15 |
WO2006055260A3 (en) | 2006-07-27 |
US20100286039A1 (en) | 2010-11-11 |
EP1817047B1 (de) | 2012-02-08 |
AU2005306894A1 (en) | 2006-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE544463T1 (de) | Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen | |
WO2008097861A3 (en) | MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS | |
ATE545422T1 (de) | Beta-glycolipide als immunomodulatoren | |
EA201270591A1 (ru) | ДВУЗАМЕЩЕННЫЕ ОКТАГИДРОПИРРОЛ[3,4-c]ПИРРОЛЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ ОРЕКСИНОВЫХ РЕЦЕПТОРОВ | |
WO2007098089A3 (en) | Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs | |
WO2008021196A3 (en) | Methods and compositions for the treatment of medical disorders | |
WO2007047978A3 (en) | Modulation of neurogenesis by pde inhibition | |
WO2008083204A3 (en) | Modulation of neurogenesis by melatoninergic ligands | |
MXPA04001187A (es) | Receptores de interleucina-1 en el tratamiento de enfermedades. | |
EP2698166A3 (de) | Komplementhemmung für verbesserte Nervenregeneration | |
WO2005113590A3 (en) | Bmp10 propeptides and related methods | |
WO2007098091A3 (en) | Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs | |
IL180725A0 (en) | Inhibitors of angiopoietin-like 4 protein, combinations, and their use | |
WO2006073484A3 (en) | Treating inflammatory disorders by electrical vagus nerve stimulation | |
EA200900874A1 (ru) | Применение эритропоэтина в низкой дозировке для стимуляции эндотелиальных клеток-предшественников, а также для регенерации органов и замедления прогрессирования повреждений конечных органов | |
WO2004084835A3 (en) | Treating immunological disorder using agonists of interleukin-21/ interleukin-21 receptor | |
WO2013025997A3 (en) | Brain stimulation methods for treating central sensitivity | |
TW200744629A (en) | Treatments for neurological disorders | |
WO2006091459A3 (en) | Compositions and methods for treating vascular permeability | |
WO2005030240A3 (en) | Vege-cor vege-d materials and methods for stimulation of neural stem cells | |
WO2005079848A3 (en) | Agonists and antagonists of p28 ebi3 and wsx/tccr for treating immune disorders | |
WO2008011083A9 (en) | Compounds for enhancing arginase activity and methods of use thereof | |
NZ741780A (en) | Anti-htra1 antibodies and methods of use thereof | |
WO2006023452A3 (en) | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | |
ATE542535T1 (de) | Verwendung von azapaullonen zur vorbeugung und behandlung pankreatischer autoimmunkrankheiten |