ATE194651T1 - Stammzellenfaktor - Google Patents

Stammzellenfaktor

Info

Publication number
ATE194651T1
ATE194651T1 AT90310899T AT90310899T ATE194651T1 AT E194651 T1 ATE194651 T1 AT E194651T1 AT 90310899 T AT90310899 T AT 90310899T AT 90310899 T AT90310899 T AT 90310899T AT E194651 T1 ATE194651 T1 AT E194651T1
Authority
AT
Austria
Prior art keywords
scf
dna sequence
stem cell
cell factor
biological activity
Prior art date
Application number
AT90310899T
Other languages
English (en)
Inventor
Krisztina M Zsebo
Sidney Vaughn Suggs
Robert A Bosselman
Francis Hall Martin
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1990/005548 external-priority patent/WO1991005795A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE194651T1 publication Critical patent/ATE194651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hall/Mr Elements (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT90310899T 1989-10-16 1990-10-04 Stammzellenfaktor ATE194651T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42238389A 1989-10-16 1989-10-16
US53719890A 1990-06-11 1990-06-11
US57361690A 1990-08-24 1990-08-24
PCT/US1990/005548 WO1991005795A1 (en) 1989-10-16 1990-09-28 Stem cell factor
US58970190A 1990-10-01 1990-10-01

Publications (1)

Publication Number Publication Date
ATE194651T1 true ATE194651T1 (de) 2000-07-15

Family

ID=27503703

Family Applications (2)

Application Number Title Priority Date Filing Date
AT90310899T ATE194651T1 (de) 1989-10-16 1990-10-04 Stammzellenfaktor
AT99122861T ATE403713T1 (de) 1989-10-16 1990-10-04 Stamzellfaktor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99122861T ATE403713T1 (de) 1989-10-16 1990-10-04 Stamzellfaktor

Country Status (11)

Country Link
US (3) US6218148B1 (de)
EP (4) EP1241258A3 (de)
CN (2) CN1075078C (de)
AT (2) ATE194651T1 (de)
CZ (3) CZ286305B6 (de)
DE (2) DE69034258D1 (de)
DK (1) DK0423980T3 (de)
GR (1) GR3034559T3 (de)
HK (1) HK1010397A1 (de)
SG (2) SG43009A1 (de)
SK (2) SK281487B6 (de)

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US6759215B1 (en) * 1989-10-16 2004-07-06 Amgen Inc. Method of preparing human stem cell factor polypeptide
EP0536317A1 (de) * 1990-06-25 1993-04-14 Immunex Corporation Wachstumsfaktor der mastzellen
US20030125519A1 (en) * 1990-08-27 2003-07-03 Peter Besmer Ligand for the c-kit receptor and methods of use thereof
US20050276784A1 (en) * 1990-08-27 2005-12-15 Solan-Kettering Institute For Cancer Research Ligand for the c-kit receptor and methods of use thereof
US5767074A (en) * 1990-08-27 1998-06-16 Sloan-Kettering Institute For Cancer Research Compositions of soluble C-kit ligand and hematopoietic factors
DE4224050A1 (de) * 1991-07-31 1993-02-04 Hoffmann La Roche Loesliche kit-liganden
EP0639979B1 (de) * 1992-04-23 2001-10-04 Sloan-Kettering Institute For Cancer Research Ligand für den c-kit-rezepten und verfahren zu seiner nutzung
US6001803A (en) * 1992-04-23 1999-12-14 Sloan-Kettering Institute For Cancer Research Composition of c-kit ligand, GM-CSF, and TNF-α and method of use
US6288030B1 (en) * 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
US5525708A (en) * 1994-03-28 1996-06-11 Cytomed, Inc. Covalent dimer of kit ligand
US6177556B1 (en) 1994-11-04 2001-01-23 Applied Research Systems Ars Holdings N.V. Human SCF, a splice variant thereof, its pharmaceutical use
US5824789A (en) * 1995-06-07 1998-10-20 Systemix, Inc. Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
CN1172718C (zh) 1995-10-04 2004-10-27 依默耐克斯有限公司 树突状细胞刺激因子
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
US5885962A (en) * 1996-04-05 1999-03-23 Amgen Inc. Stem cell factor analog compositions and method
US6495365B1 (en) * 1996-08-13 2002-12-17 Fujisawa Pharmaceutical Co., Ltd. Hematopoietic stem cell proliferating agents
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
US5969105A (en) * 1996-10-25 1999-10-19 Feng; Yiqing Stem cell factor receptor agonists
JPH10158188A (ja) * 1996-11-29 1998-06-16 Senju Pharmaceut Co Ltd 角膜治療用組成物
AU2511901A (en) * 1999-12-23 2001-07-09 Universite De Geneve Basolateral sorting signal and inhibitors thereof
US7767197B2 (en) 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
WO2002000173A2 (en) * 2000-06-26 2002-01-03 Rxkinetix, Inc. Methods for use of delivery composition for expanding, activating, committing or mobilizing one or more pluripotent, self-renewing and committed stem cells
JP2004529740A (ja) * 2001-06-15 2004-09-30 ジョーンズ ホプキンズ シンガポール ピーティーイー リミテッド 生体機能繊維
US20030124091A1 (en) * 2001-10-26 2003-07-03 Large Scale Biology Corporation Endothelial cell derived hematopoietic growth factor
JP2005510243A (ja) * 2001-11-27 2005-04-21 ネクシーテ アクチボラゲット シー・エレガンス（Ｃ．ｅｌｅｇａｎｓ）中の真核生物タンパク質と核酸分子の産生
CA2515608C (en) * 2003-02-14 2013-04-30 Istituto Superiore Di Sanita Stem cell factor for preventing chemotherapy-induced depletion of blood cells
CN100345971C (zh) * 2003-07-14 2007-10-31 第二军医大学免疫学研究所 重组人干细胞因子的原核表达载体、工程菌及制备方法
CA2547635C (en) 2003-12-12 2016-02-09 Jeffrey Schlom A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1
US7943308B2 (en) * 2004-06-23 2011-05-17 Epigenomics Ag Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
EP1773981A1 (de) * 2004-07-12 2007-04-18 Sorin Group Italia S.R.L. Vorrichtung und verfahren zur anzucht menschlicher zellen
ATE544463T1 (de) * 2004-11-05 2012-02-15 Univ Northwestern Verwendung von scf und g-scf bei der behandlung von hirnischämie und neurologischen störungen
MX2007015476A (es) 2005-06-14 2008-02-25 Amgen Inc Formulaciones de proteina autoamortiguadoras.
EP1916997B1 (de) * 2005-08-05 2018-04-18 Amgen Inc. Pharmazeutische formulierungen aus stabilen wässrigen proteinen und ihre herstellung
JP2009517343A (ja) * 2005-11-14 2009-04-30 エンタープライズ パートナーズ ベンチャー キャピタル 組織損傷のための幹細胞因子療法
WO2007102814A2 (en) * 2006-03-07 2007-09-13 Regenetech, Inc. Recombinant mammalian molecules and method for production thereof
US8921050B2 (en) 2006-03-17 2014-12-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of diagnosing renal cell carcinoma
CN101495623B (zh) * 2006-03-24 2013-09-11 儿童医疗中心有限公司 调节造血干细胞生长的方法
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
EP1872790A1 (de) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft Neue Zusammensetzung zur Erhöhung der Bioverfügbarkeit von Neurturin
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WO2014150602A1 (en) 2013-03-15 2014-09-25 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
WO2015006554A1 (en) 2013-07-10 2015-01-15 The Regents Of The University Of Michigan Therapeutic antibodies and uses thereof
US9889451B2 (en) 2013-08-16 2018-02-13 ADA-ES, Inc. Method to reduce mercury, acid gas, and particulate emissions
LT6161B (lt) 2013-09-27 2015-06-25 Uab Profarma Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas
JP6383216B2 (ja) * 2014-08-08 2018-08-29 シスメックス株式会社 血液分析方法、血液分析装置およびプログラム
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US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
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CN112771162A (zh) * 2018-08-27 2021-05-07 北卡罗来纳州立大学 用剪接转换寡核苷酸靶向kit诱导肥大细胞凋亡

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Also Published As

Publication number Publication date
US6207802B1 (en) 2001-03-27
CN1306007A (zh) 2001-08-01
CN1075078C (zh) 2001-11-21
CZ49197A3 (cs) 2000-01-12
CZ48897A3 (cs) 2000-01-12
CZ49097A3 (cs) 2000-01-12
CN1289526C (zh) 2006-12-13
SK98199A3 (en) 2001-04-09
CN1051937A (zh) 1991-06-05
DK0423980T3 (da) 2000-10-09
DE69033584T2 (de) 2001-03-08
DE69033584D1 (de) 2000-08-17
EP0423980A1 (de) 1991-04-24
US6218148B1 (en) 2001-04-17
SK281484B6 (sk) 2001-04-09
EP0992579A1 (de) 2000-04-12
GR3034559T3 (en) 2001-01-31
SG43009A1 (en) 1997-10-17
HK1010397A1 (en) 1999-06-17
CZ286304B6 (cs) 2000-03-15
EP0676470A1 (de) 1995-10-11
EP0423980B1 (de) 2000-07-12
EP1241258A3 (de) 2003-12-10
CZ286303B6 (cs) 2000-03-15
SK281487B6 (sk) 2001-04-09
EP0992579B1 (de) 2008-08-06
DE69034258D1 (de) 2008-09-18
SK500890A3 (en) 2001-04-09
CZ286305B6 (cs) 2000-03-15
US6207417B1 (en) 2001-03-27
ATE403713T1 (de) 2008-08-15
EP1241258A2 (de) 2002-09-18
SG59931A1 (en) 1999-02-22

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UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time