DE3680613D1 - Menschlicher granuloxcyt-kolonie-stimulierungsfaktor. - Google Patents
Menschlicher granuloxcyt-kolonie-stimulierungsfaktor.Info
- Publication number
- DE3680613D1 DE3680613D1 DE8686901138T DE3680613T DE3680613D1 DE 3680613 D1 DE3680613 D1 DE 3680613D1 DE 8686901138 T DE8686901138 T DE 8686901138T DE 3680613 T DE3680613 T DE 3680613T DE 3680613 D1 DE3680613 D1 DE 3680613D1
- Authority
- DE
- Germany
- Prior art keywords
- human
- granuloxcyt
- stimulation factor
- colony stimulation
- csf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60023777A JPH0615477B2 (ja) | 1985-02-08 | 1985-02-08 | 感染防禦剤 |
JP20606685 | 1985-09-17 | ||
JP20963885 | 1985-09-20 | ||
JP26945685 | 1985-12-02 | ||
JP60269455A JPS62129298A (ja) | 1985-12-02 | 1985-12-02 | 新規ポリペプチド |
JP60270838A JPH06102021B2 (ja) | 1985-12-03 | 1985-12-03 | 新規なポリペプチド |
JP27083985 | 1985-12-03 | ||
PCT/JP1986/000052 WO1986004605A1 (en) | 1985-02-08 | 1986-02-07 | Human granulocyte colony stimulating factor |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3680613D1 true DE3680613D1 (de) | 1991-09-05 |
Family
ID=27564006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686901138T Expired - Lifetime DE3680613D1 (de) | 1985-02-08 | 1986-02-07 | Menschlicher granuloxcyt-kolonie-stimulierungsfaktor. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0215126B1 (de) |
AT (1) | ATE65798T1 (de) |
BG (1) | BG61925B2 (de) |
DE (1) | DE3680613D1 (de) |
HK (1) | HK66293A (de) |
WO (1) | WO1986004605A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
EP1018552B1 (de) * | 1985-08-23 | 2006-07-05 | Kirin-Amgen, Inc. | Produktion des pluripotenten Granulozyten-Koloniestimulierungsfaktors |
US6004548A (en) * | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
ATE67517T1 (de) * | 1985-09-30 | 1991-10-15 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
JPH0618778B2 (ja) * | 1985-10-04 | 1994-03-16 | 中外製薬株式会社 | 白血球減少症治療剤 |
ES2039209T5 (es) * | 1986-01-22 | 1996-07-16 | Chugai Pharmaceutical Co Ltd | Compuesto farmaceutico que promueve el restablecimiento de la capacidad hemopoyetica. |
EP0231819B1 (de) * | 1986-01-22 | 1992-04-01 | Chugai Seiyaku Kabushiki Kaisha | Pharmazeutischer Stoff für die Behandlung von myelogener Leukämie |
DK203187A (da) * | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
WO1988001297A1 (en) * | 1986-08-11 | 1988-02-25 | Cetus Corporation | Expression of g-csf and muteins thereof |
JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
DK174044B1 (da) * | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US5391706A (en) * | 1987-07-16 | 1995-02-21 | Schering Plough Corporation | Purification of GM-CSF |
KR930007430B1 (ko) * | 1987-07-16 | 1993-08-10 | 쉐링 코포레이션 | 크로마토그래피 단계에 의한 과립구-대식세포 콜로니-자극 인자의 정제방법 |
GB2213821B (en) * | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
KR920701252A (ko) * | 1989-10-10 | 1992-08-11 | 스티븐 엠. 오드레 | 과립구 군체 자극인자 및 그를 이용하여 개 및 고양이과 동물의 전염병을 치료하거나 예방하는 방법 |
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
WO1994005679A1 (en) * | 1992-09-09 | 1994-03-17 | Nippon Kayaku Kabushiki Kaisha | Novel physiologically active substance nk175203, process for producing the same, and pharmaceutical use thereof |
US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
MXPA04000231A (es) | 2001-07-11 | 2004-05-04 | Maxygen Holdings Ltd | Conjugados del factor de estimulacion de colonias de granulocitos. |
SI21102A (sl) | 2001-12-19 | 2003-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika |
AU2003261723A1 (en) | 2002-08-27 | 2004-03-19 | Takeda Chemical Industries, Ltd. | Cxcr4 antagonist and use thereof |
CA2607844C (en) | 2005-06-01 | 2012-07-10 | Maxygen Holdings Ltd. | Pegylated g-csf polypeptides and methods of producing same |
EP2094274A4 (de) | 2006-12-21 | 2011-05-11 | Biokine Therapeutics Ltd | T-140 peptid-analoga mit cxcr4 superagonisten-aktivität für knochenmarkserholung |
UA118536C2 (uk) | 2008-07-23 | 2019-02-11 | Амбркс, Інк. | Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування |
CN102164955B (zh) * | 2008-10-02 | 2015-05-13 | 奥克塔法马股份有限公司 | 重组人g-csf的改进的加工 |
EP2396023A2 (de) | 2009-02-11 | 2011-12-21 | Yeda Research and Development Co. Ltd. | Kurze peptide aus beta-defensin |
CN102481332A (zh) | 2009-06-14 | 2012-05-30 | 拜欧肯疗法有限公司 | 用于提高血小板水平的肽疗法 |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
EP2841084B1 (de) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptid zur verwendung in der behandlung von lungenkrebs |
WO2017009842A2 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
ES2830726T3 (es) | 2016-02-23 | 2021-06-04 | Biolinerx Ltd | Método para seleccionar un régimen de tratamiento para la leucemia mieloide aguda (LMA) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54140789A (en) * | 1978-04-22 | 1979-11-01 | Jitsuken Doubutsu Chuo Kenkiyu | Culturing of colony stimulating factor producing tumor cell |
JPS6030654B2 (ja) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | ヒトコロニ−刺激因子の製造方法 |
JPS5978122A (ja) * | 1982-10-27 | 1984-05-04 | Ajinomoto Co Inc | コロニ−刺激因子の製造法 |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
-
1986
- 1986-02-07 WO PCT/JP1986/000052 patent/WO1986004605A1/ja active IP Right Grant
- 1986-02-07 DE DE8686901138T patent/DE3680613D1/de not_active Expired - Lifetime
- 1986-02-07 AT AT86901138T patent/ATE65798T1/de not_active IP Right Cessation
- 1986-02-07 EP EP86901138A patent/EP0215126B1/de not_active Expired - Lifetime
-
1993
- 1993-07-08 HK HK662/93A patent/HK66293A/xx not_active IP Right Cessation
-
1994
- 1994-02-28 BG BG98614A patent/BG61925B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
ATE65798T1 (de) | 1991-08-15 |
EP0215126A1 (de) | 1987-03-25 |
EP0215126A4 (de) | 1987-10-05 |
HK66293A (en) | 1993-07-16 |
EP0215126B1 (de) | 1991-07-31 |
BG61925B2 (bg) | 1998-09-30 |
WO1986004605A1 (en) | 1986-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8364 | No opposition during term of opposition |